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1. (-)-Epicatechin and β-glucan from highland barley grain modulated glucose metabolism and showed synergistic effect via Akt pathway

Author:
Ze-Hua Liu; Bo Li
Source:
Journal of functional foods 2021 v.87 pp. 104793
ISSN:
1756-4646
Subject:
barley; carboxy-lyases; dietary supplements; epicatechin; gluconeogenesis; glucose; glucose tolerance; glucose transporters; glycemic effect; glycogen; glycogen (starch) synthase; insulin receptor substrate proteins; insulin receptors; non-specific serine/threonine protein kinase; noninsulin-dependent diabetes mellitus; protein synthesis; rapamycin; synergism
Abstract:
... In this study, (-)epicatechin (EC) and β-glucan (BG) were identified as the active compounds in highland barley grain that modulated glucose metabolism. The mechanism underlying EC may target on insulin receptor and regulate target on insulin receptor substrate-1 /phosphatidylinositol 3-kinase / protein kinase B (Akt) pathway, and BG may target on mammalian rapamycin receptor and regulate the Akt ...
DOI:
10.1016/j.jff.2021.104793

2. Anti-diabetic effect by walnut (Juglans mandshurica Maxim.)-derived peptide LPLLR through inhibiting α-glucosidase and α-amylase, and alleviating insulin resistance of hepatic HepG2 cells

Author:
Ji Wang; Tong Wu; Li Fang; Chunlei Liu; Xiaoting Liu; Hongmei Li; Junhua Shi; Meihe Li; Weihong Min
Source:
Journal of functional foods 2020 v.69 pp. 103944
ISSN:
1756-4646
Subject:
Juglans mandshurica; alpha-amylase; alpha-glucosidase; enzyme inhibition; gluconeogenesis; glucose; glucose transporters; glycemic effect; glycogen; insulin resistance; mass spectrometry; peptides; phosphatidylinositol 3-kinase; phosphorylation; protein hydrolysates; reversed-phase high performance liquid chromatography; signal transduction; tau-protein kinase; walnuts
Abstract:
... In the present study, a novel pentapeptide LPLLR (Leu-Pro-Leu-Leu-Arg) was purified and identified from walnut protein hydrolysates (3–10 kDa) by SEC, RP-HPLC, and LC-MS/MS. Its inhibitory actions against α-glucosidase and α-amylase were evaluated. Then its beneficial effects on glucose metabolism and the underlying molecular mechanism were determined in high glucose-induced insulin resistant (IR) ...
DOI:
10.1016/j.jff.2020.103944

3. Anti-diabetic effects of Bifidobacterium animalis 01 through improving hepatic insulin sensitivity in type 2 diabetic rat model

Author:
Jinlan Zhang; Shibo Wang; Zhu Zeng; Yuxuan Qin; Qian Shen; Pinglan Li
Source:
Journal of functional foods 2020 v.67 pp. 103843
ISSN:
1756-4646
Subject:
Bifidobacterium animalis; animal disease models; antioxidants; blood glucose; blood serum; cytokines; gene expression; glucose; glycemic effect; glycogen; glycosylation; hemoglobin; hepatoprotective effect; high fat diet; insulin resistance; lipid composition; liver; males; noninsulin-dependent diabetes mellitus; oral administration; phosphatidylinositol 3-kinase; rats; streptozotocin; tissues
Abstract:
... The anti-diabetic effects of Bifidobacterium animalis 01 and its potential mechanisms were investigated. Male SD rats were given a high-fat chow diet with low-dose streptozotocin (30 mg/kg BW) to induce T2DM. The supplements with B. animalis 01 were given in a pre- and post-treatment method. Oral administration of B. animalis 01 decreased food and water intake, blood glucose concentration, and gly ...
DOI:
10.1016/j.jff.2020.103843

4. Anti-fatigue activities of hairtail (Trichiurus lepturus) hydrolysate in an endurance swimming mice model

Author:
Peixin Wang; Hongliang Zeng; Shaoling Lin; Zhigang Zhang; Yi Zhang; Jiamiao Hu
Source:
Journal of functional foods 2020 v.74 pp. 104207
ISSN:
1756-4646
Subject:
Trichiurus lepturus; athletic performance; blood; butyrates; catalase; creatine kinase; energy; glutathione peroxidase; glycogen; hydrolysates; lactic acid; malondialdehyde; metabolites; peptides; propionic acid; superoxide dismutase; urea nitrogen
Abstract:
... Hairtail (Trichiurus lepturus) is a nutritious marine product that has attracted increasing attention due to its bioactive compounds. In this study, the anti-fatigue properties of hairtail hydrolysate were evaluated by exhaustive swimming experiments. Results indicate hairtail peptide supplementation increased the exhaustive weight-loaded swimming time. Furthermore, decreases in blood lactic acid ...
DOI:
10.1016/j.jff.2020.104207

5. Anti-fatigue activity of purified anthocyanins prepared from purple passion fruit (P. edulis Sim) epicarp in mice

Author:
Min Hu; Juan Du; Lianduo Du; Qiushui Luo; Jianhua Xiong
Source:
Journal of functional foods 2020 v.65 pp. 103725
ISSN:
1756-4646
Subject:
Passiflora edulis f. edulis; anthocyanins; antioxidant enzymes; bioactive properties; biomarkers; blood; color; exocarp; gene expression; gene expression regulation; glycogen; human health; interleukin-1beta; interleukin-6; lactate dehydrogenase; lactic acid; liver; messenger RNA; mice; oxidative stress; peroxisome proliferator-activated receptor alpha; skeletal muscle; swimming; tumor necrosis factor-alpha; urea nitrogen
Abstract:
... Demands for anthocyanins are steadily growing due to their positive bioactivities in human health and food coloration. This study was performed to evaluate the characteristics of purified purple passion fruit epicarp anthocyanins (PFEA) as well as its anti-fatigue activity and underlying mechanisms in mice. The result showed that three major anthocyanins including cyanidin-3-O-glucoside, cyanidin- ...
DOI:
10.1016/j.jff.2019.103725

6. Anti-fatigue activity of purified flavonoids prepared from chestnut (Castanea mollissima) flower

Author:
Fei Peng; Hongyang Yin; Bin Du; Kui Niu; Xin Ren; Yuedong Yang
Source:
Journal of functional foods 2021 v.79 pp. 104365
ISSN:
1756-4646
Subject:
Castanea mollissima; Oriental traditional medicine; blood; creatine kinase; energy; flowers; free radicals; glycogen; kaempferol; lactate dehydrogenase; lactic acid; liver; mice; muscles; oxidative stress; skeletal muscle; urea nitrogen
Abstract:
... Castanea mollissima Blume has been used to treat a variety of diseases in Chinese traditional medicine. This study was aimed to examine the anti-fatigue effect of purified Chestnut flower flavonoids (CFF) in mice and its underlying mechanisms using the weight-loaded swimming test. The study revealed that the content of total flavonoids in CFF was 754.20 mgRE/gdₘ, which identified six main types of ...
DOI:
10.1016/j.jff.2021.104365

7. Anti-fatigue activity of the polysaccharides isolated from Ribes stenocarpum Maxim

Author:
Yangbo Qiao; Ying Ye; Tingxiu Cai; Shan Li; Xiaoqian Liu
Source:
Journal of functional foods 2022 v.89 pp. 104947
ISSN:
1756-4646
Subject:
Ribes; arabinose; blood; exercise; galactose; galacturonic acid; glucose; glucuronic acid; glutathione peroxidase; glycogen; lactate dehydrogenase; lactic acid; liver; malondialdehyde; mannose; molecular weight; oxidative stress; ribose; stress response; superoxide dismutase; urea nitrogen; xylose
Abstract:
... In the present study, the crude polysaccharides from Ribes stenocarpum Maxim. (RPs) were isolated by ultrasonic-assisted extraction. The physicochemical analysis revealed that RPs is a pyranose configuration connected by β-glycosidic bonds without three-stranded helical conformation, and is composed of mannose, ribose, glucuronic acid, galactose, glucose, arabinose, galacturonic acid, and xylose w ...
DOI:
10.1016/j.jff.2022.104947

8. Antidiabetic effects and mechanisms of action of γ-conglutin from lupin seeds

Author:
Mrunmai Tapadia; Stuart Johnson; Ranjeet Utikar; Philip Newsholme; Rodrigo Carlessi
Source:
Journal of functional foods 2021 v.87 pp. 104786
ISSN:
1756-4646
Subject:
Lupinus; gastrointestinal system; glucose; glycogen; half life; healthy diet; humans; insulin; insulin secretion; markets; myotubes; oral administration; protein synthesis; proteolysis; secretin; skeletal muscle; value added
Abstract:
... The glucose modulating properties of lupin have been attributed to its seed protein γ-conglutin. Here we explored the antidiabetic potential of γ-conglutin purified from lupin seeds in-vitro. To mimic the effects of an orally administered supplement, purified γ-conglutin was hydrolysed by gastrointestinal proteolytic enzymes and the resulting peptides evaluated for their antidiabetic effects in pa ...
DOI:
10.1016/j.jff.2021.104786

9. Antiglycemic and anticomplementary potential of an edible plant Gnaphalium hypoleucum DC

Author:
Qun Sun; Nai-Yu Xu; Qi-Run Li; Shi Yao; Meng Li; He-Ran Li; Jian Zhang; Dao-Feng Chen
Source:
Journal of functional foods 2017 v.38 pp. 321-328
ISSN:
1756-4646
Subject:
Gnaphalium; animal disease models; blood glucose; cholesterol; diabetes; flavonoids; food plants; functional foods; glucose tolerance; glycemic effect; glycogen; malondialdehyde; mice; muscles; streptozotocin; superoxide dismutase; traditional medicine; triacylglycerols; vegetables; China
Abstract:
... Gnaphalium hypoleucum DC is used asa wild vegetable, named “Qing Ming Cai”, as well asa folk medicine in China. One new compound, Gnaphaliin C, and nineteen known compounds were isolated and indentified from G. hypoleucum, total flavonoids were analyzed by UHPLC-Q-TOF/MS. The α-glucosidase inhibitory and anti-complementary activities of all compounds and total flavonoids were evaluated. Total flav ...
DOI:
10.1016/j.jff.2017.09.006

10. Antihyperglycaemic efficacy of kombucha in streptozotocin-induced rats

Author:
Thummala Srihari; Krishnamoorthy Karthikesan; Natarajan Ashokkumar; Uppala Satyanarayana
Source:
Journal of functional foods 2013 v.5 no.4 pp. 1794-1802
ISSN:
1756-4646
Subject:
animal disease models; bacteria; black tea; diabetes mellitus; dietary supplements; freeze drying; functional foods; glucose-6-phosphatase; glycemic effect; glycogen; glycolysis; glycosylation; hemoglobin; hexokinase; hyperglycemia; insulin; insulin secretion; rats; streptozotocin; tea (beverage); tissues; yeasts
Abstract:
... Kombucha is a fermented tea beverage produced by fermenting sugared black tea with kombucha mat (consists of bacteria and yeast strains). Diabetes mellitus is group of metabolic disorders characterized by hyperglycaemia resulting from defects in insulin secretion, action or both. The present study was aimed to delineate the antihyperglycaemic effect of lyophilized extract of kombucha in streptozot ...
DOI:
10.1016/j.jff.2013.08.008

11. Antihyperglycemic effect of Codariocalyx motorius modulated carbohydrate metabolic enzyme activities in streptozotocin-induced diabetic rats

Author:
C. Uma; N. Suganya; P. Vanitha; E. Bhakkiyalakshmi; S. Suriyanarayanan; K.M. Maria John; S. Sivasubramanian; P. Gunasekaran; K.M. Ramkumar
Source:
Journal of functional foods 2014 v.11 pp. 517-527
ISSN:
1756-4646
Subject:
Codariocalyx; animal disease models; blood glucose; blood serum; carbohydrate metabolism; chlorogenic acid; diabetes; enzyme activity; gallic acid; glucose-6-phosphatase; glycemic effect; glycogen; glycosylation; hemoglobin; hexokinase; immunohistochemistry; insulin; islets of Langerhans; liver; myricetin; quercetin; rats; reversed-phase high performance liquid chromatography; staining
Abstract:
... In the present study, the effects of ethanolic root extract of Codariocalyx motorius (CMRt) on blood glucose, insulin, and carbohydrate metabolic enzymes were studied in experimental diabetic rats. Streptozotocin-induced diabetic rats received CMRt orally at the doses of 100 and 200 mg/kg bw daily for 30 days. CMRt treatment showed decrease in blood glucose and glycosylated hemoglobin with improve ...
DOI:
10.1016/j.jff.2014.08.008

12. Antioxidant and anti-fatigue activities of selenium-enriched peptides isolated from Cardamine violifolia protein hydrolysate

Author:
Song Zhu; Wei Yang; Yue Lin; Chaodong Du; Dejian Huang; Shangwei Chen; Tian Yu; Xin Cong
Source:
Journal of functional foods 2021 v.79 pp. 104412
ISSN:
1756-4646
Subject:
Cardamine; antioxidant activity; antioxidants; blood; enzymatic hydrolysis; galactose; glutathione; glutathione peroxidase; glycogen; ingredients; lactic acid; malondialdehyde; models; oxidative stress; protein hydrolysates; selenium; superoxide dismutase; ultrafiltration; urea nitrogen; China
Abstract:
... Cardamine violifolia is a selenium (Se)-enriched plant in China. In this study, we prepared Se-enriched peptides (SPE) from C. violifolia by enzymatic hydrolysis. The peptides were then separated by ultrafiltration. The fraction with the highest in vitro antioxidant activity, SPE4, was obtained. Mice treated with SPE4 in D-galactose induced oxidative stress model showed significantly increased sup ...
DOI:
10.1016/j.jff.2021.104412

13. Aronia melanocarpa anthocyanin extracts are an effective regulator of suppressor of cytokine signaling 3-dependent insulin resistance in HepG2 and C2C12 cells

Author:
Jing Chen; Jinyan Zhu; Xianjun Meng
Source:
Journal of functional foods 2020 v.75 pp. 104258
ISSN:
1756-4646
Subject:
Aronia melanocarpa; anthocyanins; cytokines; glucose; glucose transporters; glycogen; insulin; insulin resistance; noninsulin-dependent diabetes mellitus; palmitic acid; transfection
Abstract:
... Insulin resistance (IR) is involved in the development of type 2 diabetes mellitus (T2DM). Plant anthocyanins can attenuate IR, but the related mechanisms are still incompletely understood. We found that Aronia melanocarpa anthocyanin extracts (AMAE) could improve glucose uptake by upregulating glucose transporter-4, enhance insulin action in IR HepG2 and C2C12 cells, increase IRS-1 and p-GSK-3β ( ...
DOI:
10.1016/j.jff.2020.104258

14. Baicalein improves insulin resistance via regulating SOCS3 and enhances the effect of acarbose on diabetes prevention

Author:
Wenlong Sun; Jin Sun; Bowei Zhang; Yan Xing; Xiaoxia Yu; Xia Li; Zhilong Xiu; Yuesheng Dong
Source:
Journal of functional foods 2017 v.37 pp. 339-353
ISSN:
1756-4646
Subject:
Oroxylum indicum; Scutellaria baicalensis; acarbose; adverse effects; diabetes; dietary supplements; glycogen; hyperglycemia; insulin resistance; lipid metabolism; mice; oxidative stress; phosphorylation; relative risk; tau-protein kinase; therapeutics; Asia
Abstract:
... Baicalein, a major component in Scutellaria baicalensis and Oroxylum indicum, is used as dietary supplement in Asia. In this study, we characterized the insulin-sensitizing activity of baicalein and found that baicalein improved insulin resistance by reducing the expression of SOCS3, increasing the phosphorylation of IRS1 and Akt1, reducing the phosphorylation of GSK3β and increasing hepatic glyco ...
DOI:
10.1016/j.jff.2017.08.005

15. Casein glycomacropeptide hydrolysates ameliorate hepatic insulin resistance of C57BL/6J mice challenged with high-fat diet

Author:
Jia-jia Song; Jing Gao; Min Du; Xue-ying Mao
Source:
Journal of functional foods 2018 v.45 pp. 190-198
ISSN:
1756-4646
Subject:
blood glucose; blood serum; body weight; casein; fatty liver; glucose tolerance; glycogen; high fat diet; homeostasis; hydrolysates; insulin; insulin resistance; liver; macrophages; mice; mitogen-activated protein kinase; models; noninsulin-dependent diabetes mellitus; papain; phosphorylation; serine; tau-protein kinase; therapeutics
Abstract:
... Hepatic insulin resistance plays a vital role in the development of type 2 diabetes. In the current study, the reduction effects of casein glycomacropeptide hydrolysates obtained with papain (GHP) on hepatic insulin resistance were investigated in high-fat diet (HFD)-fed C57BL/6J mice. Mice were fed with HFD for 8 weeks and then gavaged with GHP at doses of 100, 200 and 400 mg/kg body weight daily ...
DOI:
10.1016/j.jff.2018.03.044

16. Chemical and biological properties of puffed Dendrobium officinale extracts: Evaluation of antioxidant and anti-fatigue activities

Author:
Singeun Kim; Kyungae Jo; Bum Sun Byun; Sung Hee Han; Kwang-Won Yu; Hyung Joo Suh; Ki-Bae Hong
Source:
Journal of functional foods 2020 v.73 pp. 104144
ISSN:
1756-4646
Subject:
Dendrobium officinale; antioxidant activity; antioxidants; blood glucose; gene expression; glycogen; lactic acid; liver; medicinal plants; oxidation; phytochemicals; skeletal muscle; China
Abstract:
... Dendrobium officinale (D. officinale, DO) is a traditional medicinal herb used in China. Phytochemicals and its antioxidant activity of puffed dendrobium extract was measured for antioxidant capacity. Physiological mechanism on skeletal muscle was analyzed by blood glucose, lactic acid, glycogen and ATP content and mRNA gene expression. Antioxidant effect of the extract on liver were measured. The ...
DOI:
10.1016/j.jff.2020.104144

17. Cocoa polyphenols exhibit antioxidant, anti-inflammatory, anticancerogenic, and anti-necrotic activity in carbon tetrachloride-intoxicated mice

Author:
Jasminka Giacometti; Damir Muhvić; Adriano Pavletić; Luka Ðudarić
Source:
Journal of functional foods 2016 v.23 pp. 177-187
ISSN:
1756-4646
Subject:
anticarcinogenic activity; antioxidants; blood serum; carbon; carbon tetrachloride; epicatechin; glucose; glycogen; hepatotoxicity; inflammation; lactic acid; liver; metabolism; mice; mitochondria; polyphenols; therapeutics
Abstract:
... The therapeutic effects of cocoa polyphenols on acute carbon tetrachloride (CCl4)-intoxicated mice were investigated. After determining polyphenols profile in the cocoa extract (CE), CE at a dose of 34.5 mg/kg and epicatechin (EC) at a dose of 2.24 mg/kg were intraperitoneally (i.p.) administered to BALB/cN mice following CCl4 treatment. CE and EC post-treatments suppressed hepatotoxicity and infl ...
DOI:
10.1016/j.jff.2016.02.036

18. Dendrobium officinale polysaccharide attenuates type 2 diabetes mellitus via the regulation of PI3K/Akt-mediated glycogen synthesis and glucose metabolism

Author:
Kaiping Wang; Hanxiang Wang; Yage Liu; Weizhi Shui; Junfeng Wang; Peng Cao; Hongjing Wang; Ruxu You; Yu Zhang
Source:
Journal of functional foods 2017 pp. -
ISSN:
1756-4646
Subject:
Dendrobium officinale; active ingredients; blood glucose; enzyme activity; glucose; glucose transporters; glycogen; glycogen (starch) synthase; hexokinase; hyperglycemia; hyperlipidemia; insulin resistance; liver; metabolism; mice; muscles; noninsulin-dependent diabetes mellitus; pyruvate kinase; streptozotocin; tau-protein kinase; therapeutics
Abstract:
... This study aimed to explore the therapeutic effects of Dendrobium officinale polysaccharide (DOP), an active ingredient isolated from the water extract of Dendrobium officinale, in streptozotocin (STZ)-induced type 2 diabetic BALB/c mice and its potential mechanisms. Our results showed that DOP had beneficial effects in ameliorating hyperglycemia, insulin resistance and dyslipidemia. Additionally, ...
DOI:
10.1016/j.jff.2017.11.004

19. Dietary milk fat globule membrane regulates JNK and PI3K/Akt pathway and ameliorates type 2 diabetes in mice induced by a high-fat diet and streptozotocin

Author:
Qi-chen Yuan; Bi-yuan Zhan; Min Du; Rui Chang; Tian-ge Li; Xue-ying Mao
Source:
Journal of functional foods 2019 v.60 pp. 103435
ISSN:
1756-4646
Subject:
anti-inflammatory activity; functional foods; glucose; glycogen; glycogen (starch) synthase; high fat diet; histology; hyperglycemia; hyperlipidemia; ingredients; liver; metabolism; mice; milk fat; mitogen-activated protein kinase; noninsulin-dependent diabetes mellitus; pancreas; skeletal muscle; streptozotocin; tau-protein kinase
Abstract:
... Milk fat globule membrane (MFGM) was found to possess anti-cancer, anti-obesity and anti-inflammatory activities. The present study was carried out to evaluate the effects and possible underlying mechanisms of MFGM on type 2 diabetes (T2D) in mice. Results showed that 8-week MFGM supplementation had beneficial effects in ameliorating hyperglycemia and dyslipidemia in T2D mice induced with a high-f ...
DOI:
10.1016/j.jff.2019.103435

20. Effect of Ocimum sanctum and Crataegus pubescens aqueous extracts on obesity, inflammation, and glucose metabolism

Author:
Iza F. Pérez-Ramírez; María L. González-Dávalos; Ofelia Mora; Marco A. Gallegos-Corona; Rosalia Reynoso-Camacho
Source:
Journal of functional foods 2017 v.35 pp. 24-31
ISSN:
1756-4646
Subject:
Crataegus; Ocimum tenuiflorum; adipocytes; adipose tissue; anti-inflammatory activity; beverages; ellagic acid; epicatechin; excretion; gallic acid; gene expression; glucose; glycemic effect; glycogen; herbs; hypertrophy; inflammation; metabolism; obesity; phosphatidylinositol 3-kinase; rats; rutin; triacylglycerols
Abstract:
... This study aimed to evaluate the effect of Ocimum sanctum and Crataegus pubescens extracts on obesity, inflammation, and glucose metabolism in obese rats. Both extracts exerted anti-obesogenic effects, which was associated to increased fecal triacylglycerol excretion and decreased their accumulation in adipose tissue, decreasing adipocyte hypertrophy. O. sanctum showed the greatest hypoglycemic ef ...
DOI:
10.1016/j.jff.2017.05.028

21. Fucoidan from sea cucumber protects against high-fat high-sucrose diet-induced hyperglycaemia and insulin resistance in mice

Author:
Shiwei Hu; Guanghua Xia; Jingfeng Wang; Yuming Wang; Zhaojie Li; Changhu Xue
Source:
Journal of functional foods 2014 v.10 pp. 128-138
ISSN:
1756-4646
Subject:
Acaudina molpadioides; Phaeophyceae; acute toxicity; adiponectin; blood glucose; dietary exposure; enzyme activity; fucoidan; glucose; glucose transporters; glycogen; hexokinase; hyperglycemia; insulin; insulin resistance; leptin; metabolism; mice; phosphorylase; pyruvate kinase; resistin; tumor necrosis factor-alpha
Abstract:
... The amelioration in hyperglycaemia and insulin resistance of fucoidan from sea cucumber can be speculated due to these effects of fucoidan from marine phaeophyta. We examined the effect of fucoidan from Acaudina molpadioides (Am-FUC) on anti-hyperglycaemia and improvement in insulin resistance in high-fat high-sucrose diet-induced insulin resistant mice. Results showed that Am-FUC significantly re ...
DOI:
10.1016/j.jff.2014.05.012

22. Fucoxanthin ameliorates hyperglycemia, hyperlipidemia and insulin resistance in diabetic mice partially through IRS-1/PI3K/Akt and AMPK pathways

Author:
Yiping Zhang; Wen Xu; Xiaoqiang Huang; Youqin Zhao; Qiangqiang Ren; Zhuan Hong; Mingqing Huang; Xia Xing
Source:
Journal of functional foods 2018 v.48 pp. 515-524
ISSN:
1756-4646
Subject:
animal disease models; blood glucose; blood lipids; carnitine palmitoyltransferase; diabetes; diet; drugs; fatty-acid synthase; functional foods; glucokinase; glucose; glucose transporters; glycogen; glycogen (starch) synthase; histology; hyperglycemia; hyperlipidemia; insulin resistance; lipid metabolism; liver; messenger RNA; mice; peroxisome proliferator-activated receptors; skeletal muscle
Abstract:
... Fucoxanthin has potential anti-diabetic activities, but its precise effects and underlying mechanisms remain unclear. In this study, C57BL/KsJ-db/db mice were fed diets containing fucoxanthin (0.2% and 0.4%, w/w) for 6 weeks. Results showed dietary fucoxanthin significantly improved glucose/lipid metabolism and insulin resistance, and prevented pancreatic histological changes in db/db mice. Moreov ...
DOI:
10.1016/j.jff.2018.07.048

23. Ginsenoside Rg5 relieves type 2 diabetes by improving hepatic insulin resistance in db/db mice

Author:
Yange Wei; Haixia Yang; Chenhui Zhu; Jianjun Deng; Daidi Fan
Source:
Journal of functional foods 2020 v.71 pp. 104014
ISSN:
1756-4646
Subject:
ginsenosides; glucose; glycemic effect; glycogen; glycolipids; inflammation; insulin; insulin resistance; interleukin-1beta; interleukin-6; liver; noninsulin-dependent diabetes mellitus; pancreas; phosphatidylinositol 3-kinase; phosphorylation; public health; signal transduction; tissues; tumor necrosis factor-alpha
Abstract:
... Type 2 diabetes mellitus (T2DM) is a systemic metabolic disorder that has become a major threat to public health. Ginsenoside Rg5 (Rg5) has a putative hypoglycemic effect, but its potential mechanism remains unclear. Here, we found that Rg5 not only reduced glycolipid parameters (FBG, TC, TG, and LDL-C), relieved inflammation (TNF-α, IL-6, and IL-1β), improved hepatic lipid accumulation, and repai ...
DOI:
10.1016/j.jff.2020.104014

24. High-degree hydrolysis sea cucumber peptides improve exercise performance and exert antifatigue effect via activating the NRF2 and AMPK signaling pathways in mice

Author:
Qianqian Wang; Jinyuan Shi; Hao Zhong; Abdullah; Jiachen Zhuang; Junhui Zhang; Jing Wang; Xi Zhang; Fengqin Feng
Source:
Journal of functional foods 2021 v.86 pp. 104677
ISSN:
1756-4646
Subject:
Acaudina; athletic performance; energy metabolism; glycogen; hydrolysis; ingredients; metabolites; mitochondria; molecular weight; muscle strength; muscles; oxidative stress; peptides
Abstract:
... In this study, the antifatigue potential of two sea cucumber peptides (SCP), with low hydrolysis degree (SCP-1) and high hydrolysis degree (SCP-2) derived from Acaudina leucoprocta was investigated. SCP-2 had a lower molecular weight, shorter peptide length, and higher proportion of identified sequences related to branched chain amino acids than SCP-1. Both SCP-1 and SCP-2 significantly improved e ...
DOI:
10.1016/j.jff.2021.104677

25. Holothuria leucospilota polysaccharides alleviate liver injury via AMPK and NF-κB signaling pathways in type 2 diabetic rats

Author:
Fuqiang Zhao; Kexue Zhu; Qiancheng Zhao; Qibing Liu; Jun Cao; Guanghua Xia; Zhongyuan Liu; Chuan Li
Source:
Journal of functional foods 2021 v.85 pp. 104657
ISSN:
1756-4646
Subject:
AMP-activated protein kinase; Holothuria leucospilota; alanine transaminase; antioxidants; aspartate transaminase; blood proteins; glycogen; glycogen synthase kinases; glycosylation; heme oxygenase (biliverdin-producing); histology; lipids; liver; noninsulin-dependent diabetes mellitus
Abstract:
... The study evaluated the beneficial effects of orally administered Holothuria leucospilota polysaccharides (HLP) on liver injury in diabetic rats. The results showed that HLP regulated liver glycogen, glycosylated serum protein, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels. Simultaneously, HLP significantly reduced lipid accumulation in livers of diabetic rats (P < 0.0 ...
DOI:
10.1016/j.jff.2021.104657

26. Hypoglycaemic effect of capsaicinoids via elevation of insulin level and inhibition of glucose absorption in streptozotocin-induced diabetic rats

Author:
Shiqi Zhang; Yuming You; Jia Liu; Xiaoli Qin; Xiong Liu
Source:
Journal of functional foods 2018 v.51 pp. 94-103
ISSN:
1756-4646
Subject:
absorption; animal disease models; blood glucose; blood serum; body weight; capsaicinoids; diabetes; excretion; genes; glucokinase; glucose; glucose transporters; glucose-6-phosphatase; glycemic effect; glycogen; ileum; insulin; liver; pancreas; protein content; protein synthesis; rats; sodium; symporters
Abstract:
... This study investigated the hypoglycemic effect and mechanism of capsaicinoids in streptozotocin-induced diabetic rats. Diabetic rats were orally treated with 3, 6, and 9 mg/kg·bw of capsaicinoids daily for 28 days. Capsaicinoids treatment significantly increased the body weight, serum insulin level, glycogen content, and fecal sugar excretion of diabetic rats. More importantly, significant upregu ...
DOI:
10.1016/j.jff.2018.10.015

27. Hypoglycemic activity of phenols from Pleioblastus amarus (Keng) shells and its main chemical constituents identificatied using UHPLC-Q-TOF-MS

Author:
Yuan Ma; Ailian Meng; Yemei Dai; Huanhuan Yang; Yongli Huang; Xiaocui Liu; Lirong Xian; Xue Yuan
Source:
Journal of functional foods 2022 v.97 pp. 105261
ISSN:
1756-4646
Subject:
Pleioblastus; byproducts; ferulic acid; functional foods; glucose; glycemic effect; glycogen; hexokinase; inhibitory concentration 50; insulin resistance; pyruvate kinase; raw materials
Abstract:
... The aim of this study was to investigate the hypoglycemic activity of phenols extracted from Pleioblastus amarus (Keng) shells (PASs), and to isolate and identify the possible components.of which o-coumaric acid, ferulic acid, quercetin-3-0-rhamnoside, and apigenin-7-0-glucoside exhibited a strong affinity with α-glucosidase and were identified as potential The results revealed that, Pleioblastus ...
DOI:
10.1016/j.jff.2022.105261

28. Hypoglycemic and hypolipidemic effects of fermented milks with added roselle (Hibiscus sabdariffa L.) extract

Author:
Nana Su; Jinglei Li; Liuqing Yang; Guohua Hou; Ming Ye
Source:
Journal of functional foods 2018 v.43 pp. 234-241
ISSN:
1756-4646
Subject:
AMP-activated protein kinase; Hibiscus sabdariffa; adipose tissue; animal disease models; bacteria; blood glucose; blood serum; diabetes; fermented milk; glucose transporters; glucose-6-phosphatase; glycogen; glycohemoglobin; glycosylation; insulin; kidneys; lipemic effect; liver; metformin; mice; pH; pancreas; skeletal muscle; spleen; titratable acidity; water holding capacity
Abstract:
... The present study was aimed to evaluate the physicochemical properties of fermented milk containing roselle (Hibiscus sabdariffa L.) extract at different levels (0, 0.1, 0.2 and 0.3% (w/w)). Titratable acidity (TA) and pH, bacteria counts, syneresis value, water-holding capacity (WHC) and their sensory acceptance were evaluated afterwards. The fermented milk containing 0.2% roselle extract (RFM2) ...
DOI:
10.1016/j.jff.2018.02.017

29. Hypoglycemic effect of Hypericum attenuatum Choisy extracts on type 2 diabetes by regulating glucolipid metabolism and modulating gut microbiota

Author:
Du-Xin Jin; Jun-Fang He; Xue-Gang Luo; Tong-Cun Zhang
Source:
Journal of functional foods 2019 v.52 pp. 479-491
ISSN:
1756-4646
Subject:
Bacteroidetes; Firmicutes; Hypericum; Proteobacteria; blood glucose; colon; glycemic effect; glycogen; inflammation; insulin resistance; intestinal microorganisms; lipid metabolism; medicinal plants; mice; noninsulin-dependent diabetes mellitus; public health; short chain fatty acids; small intestine; therapeutics
Abstract:
... Hypericum attenuatum Choisy, as an edible medicinal plant, possesses multiple therapeutic effects. Type 2 diabetes is a metabolic disorder that has become a major threat to public health. The objective of this study was to investigate the hypoglycemic effect of Hypericum attenuatum Choisy extracts (HaC) on T2DM mice and modulatory effect of HaC on composition of intestinal microflora. T2DM mice we ...
DOI:
10.1016/j.jff.2018.11.031

30. Hypoglycemic effect of inulin combined with ganoderma lucidum polysaccharides in T2DM rats

Author:
Yaping Liu; Yumeng Li; Wenlingzi Zhang; Mingzhe Sun; Zesheng Zhang
Source:
Journal of functional foods 2019 v.55 pp. 381-390
ISSN:
1756-4646
Subject:
Ganoderma lucidum; glucose; glycemic effect; glycogen; high fat diet; hypoglycemia; insulin resistance; inulin; lipid metabolism; messenger RNA; noninsulin-dependent diabetes mellitus; nutrient transport; rats; streptozotocin
Abstract:
... It has been reported that both inulin and ganoderma lucidum polysaccharides are conducive to glucose metabolism. The aim of present study was to explore the hypoglycemia effect and molecular mechanism of the inulin combined with ganoderma lucidum polysaccharides in type 2 diabetic mellitus (T2DM) rats. T2DM rats were induced by high fat diet (HFD) and streptozotocin (STZ). Then the inulin and gano ...
DOI:
10.1016/j.jff.2019.02.036

31. Hypoglycemic effects of Fu-Pen-Zi (Rubus chingii Hu) fruit extracts in streptozotocin-induced type 1 diabetic mice

Author:
Yan Huo; Xin Zhao; Jie Zhao; Xuewei Kong; Liya Li; Tao Yuan; Jialin Xu
Source:
Journal of functional foods 2021 v.87 pp. 104837
ISSN:
1756-4646
Subject:
Rubus chingii; blood glucose; body weight changes; fruits; gluconeogenesis; glucose tolerance; glycogen; hyperglycemia; hyperlipidemia; insulin; insulin secretion; insulin-dependent diabetes mellitus; liver; muscular atrophy; oxidative stress; raspberries; skeletal muscle; streptozotocin
Abstract:
... To explore the effects of Chinese raspberry (Fu-Pen-Zi) on diabetes, a polyphenol-enriched extract (FPZ) was prepared. Streptozotocin (STZ)-induced diabetic mice were daily administered FPZ (30 mg/kg body weight) for 18 days, the anti-diabetic effects were evaluated. Compared to STZ alone mice, FPZ-treatment ameliorated STZ-induced type 1 diabetes, reduced body weight loss (by 71.61%), hyperglycem ...
DOI:
10.1016/j.jff.2021.104837

32. Identification of anti-diabetes peptides from Spirulina platensis

Author:
Shuangfei Hu; Xiaodan Fan; Ping Qi; Xuewu Zhang
Source:
Journal of functional foods 2019 v.56 pp. 333-341
ISSN:
1756-4646
Subject:
Arthrospira platensis; alpha-amylase; alpha-glucosidase; drugs; enzyme activity; food additives; functional foods; glycogen; hexokinase; inhibitory concentration 50; insulin; liquid chromatography; models; noninsulin-dependent diabetes mellitus; peptides; prediction; pyruvate kinase; tandem mass spectrometry
Abstract:
... In this study, ultrasound coupled with subcritical water (USW) technology was employed to extract S. platensis protein, and its inhibitory effect on three enzymes (α-amylase, α-glucosidase and dipeptidyl peptidase-4 (DPP-IV)) was evaluated. Subsequently, using insulin resistant-HepG2 cell model, the data presented that the USW-extracted protein significantly (p < 0.01) increased glycogen content, ...
DOI:
10.1016/j.jff.2019.03.024

33. Influence of crude extract and bioactive fractions of Ilex paraguariensis A. St. Hil. (yerba mate) on the Wistar rat lipid metabolism

Author:
Pedro Ernesto de Resende; Samuel Kaiser; Vanessa Pittol; Ana Lúcia Hoefel; Raquel D'Agostini Silva; Cláudia Vieira Marques; Luiz Carlos Kucharski; George González Ortega
Source:
Journal of functional foods 2015 v.15 pp. 440-451
ISSN:
1756-4646
Subject:
Ilex paraguariensis; adipose tissue; cholesterol; excretion; fractionation; glycogen; high fat diet; lipogenesis; lipolysis; low density lipoprotein; muscles; rats; saponins; triacylglycerols; weight gain; yerba mate
Abstract:
... The influence of yerba mate extract (YME) and two concentrated fractions of methylxanthines–polyphenols (MXPL) and saponins (SFL) from yerba mate on the lipid metabolism of Wistar rats fed with a high-fat diet were examined. A Box–Behnken design was employed for the optimization of yerba mate extraction. Subsequently, one-step separation using solid phase fractionation was applied. HPLC–PDA and UP ...
DOI:
10.1016/j.jff.2015.03.040

34. Mogroside derivatives exert hypoglycemics effects by decreasing blood glucose level in HepG2 cells and alleviates insulin resistance in T2DM rats

Author:
Xuan Liu; Jingjing Zhang; Yumeng Li; Liyang Sun; Yao Xiao; Wenge Gao; Zesheng Zhang
Source:
Journal of functional foods 2019 v.63 pp. 103566
ISSN:
1756-4646
Subject:
Siraitia grosvenorii; blood glucose; fasting; gene expression regulation; glucose; glucose transporters; glycemic effect; glycogen; human cell lines; in vitro studies; in vivo studies; insulin receptor substrate proteins; insulin resistance; liver; metabolism; phosphatidylinositol 3-kinase; quantitative polymerase chain reaction; rats; triterpenoids
Abstract:
... Mogroside, a triterpenoid of Siraitia grosvenorii, has been reported to play an important role in glycometabolism processes. In this study, the mechanism of mogroside was evaluated through in vitro experiments using Mogroside III (MO3), IV (MO4), V (MO5), Siamenoside I (SO1) at 1, 5, 10 μM, and in vivo experiments using MO5 at 30, 75, 150 mg/(kg·bw·day). In cell experiments, mogrosides at 5 μM sig ...
DOI:
10.1016/j.jff.2019.103566

35. Oral administration of Lactobacillus rhamnosus CCFM0528 improves glucose tolerance and cytokine secretion in high-fat-fed, streptozotocin-induced type 2 diabetic mice

Author:
Pei Chen; Qiuxiang Zhang; Hui Dang; Xiaoming Liu; Fengwei Tian; Jianxin Zhao; Yongquan Chen; Hao Zhang; Wei Chen
Source:
Journal of functional foods 2014 v.10 pp. 318-326
ISSN:
1756-4646
Subject:
Lactobacillus rhamnosus; animal disease models; blood glucose; endotoxins; fasting; genes; glucose tolerance; glycemic effect; glycogen; glycosylation; hemoglobin; high fat diet; hyperglycemia; insulin; interleukin-10; interleukin-4; interleukin-6; interleukin-8; islets of Langerhans; mice; noninsulin-dependent diabetes mellitus; oral administration; probiotics; secretion; spleen; streptozotocin; tumor necrosis factor-alpha
Abstract:
... In this study, the effects of Lactobacillus rhamnosus CCFM0528, a new probiotic strain isolated by our laboratory, on glucose tolerance, hyperglycemia and cytokine secretion in high-fat-fed, streptozotocin-induced type 2 diabetic mice were studied. The results indicate that L. rhamnosus CCFM0528 significantly decreased fasting and postprandial 2-h blood glucose, glycosylated hemoglobin (HbA1c), en ...
DOI:
10.1016/j.jff.2014.06.014

36. Phenolic compounds ameliorate the glucose uptake in HepG2 cells' insulin resistance via activating AMPK

Author:
Qun Huang; Lei Chen; Hui Teng; Hongbo Song; Xiaoqi Wu; Meiyu Xu
Source:
Journal of functional foods 2015 v.19 pp. 487-494
ISSN:
1756-4646
Subject:
apigenin; cell culture; cytotoxicity; glucose; glycogen; human cell lines; humans; insulin; insulin resistance; kaempferol; luteolin; metformin; models; phenolic compounds; quercetin
Abstract:
... The preventive effects of phenolic compounds on insulin signalling and on both glucose production and uptake were studied in insulin-responsive human HepG2 cells treated with high glucose. The influence of insulin in different-dose insulin and at different action times on the IR of HepG2 cells, and changes of glucose uptake and glycogen level were detected by using cell culture glucose uptake anal ...
DOI:
10.1016/j.jff.2015.09.020

37. Phenolic profile of bayberry followed by simulated gastrointestinal digestion and gut microbiota fermentation and its antioxidant potential in HepG2 cells

Author:
Vemana Gowd; Lianghua Xie; Chongde Sun; Wei Chen
Source:
Journal of functional foods 2020 v.70 pp. 103987
ISSN:
1756-4646
Subject:
anthocyanins; antioxidant activity; bioactive compounds; dietary supplements; digestion; fermentation; fruits; functional foods; gastrointestinal system; glucose; glycemic effect; glycogen; high performance liquid chromatography; humans; in vitro digestion; intestinal microorganisms; metabolites; oxidative stress; polyphenols
Abstract:
... Bayberry (BB) fruits contain high levels of polyphenols and possess good bioactivities. However, there are no specific studies to illustrate the impact of human gut microbiota fermentation (HGMF) on BB polyphenols subjected to gastrointestinal digestion (GID). Therefore, in this study, BB was subjected to simulated GID and HGMF (0–48 h) in order to study the fate of BB bioactive components. Phenol ...
DOI:
10.1016/j.jff.2020.103987

38. Phloridzin alleviate colitis in mice by protecting the intestinal brush border and improving the expression of sodium glycogen transporter 1

Author:
Ying-yu Lu; Jian Liang; Shu-Xian Chen; Bing-xin Wang; Han Yuan; Can-tao Li; Ya-yun Wu; Yan-fang Wu; Xu-guang Shi; Jie Gao; Shao-zhen Hou
Source:
Journal of functional foods 2018 v.45 pp. 348-354
ISSN:
1756-4646
Subject:
body weight; colitis; colon; dextran sulfate; food additives; glycogen; histopathology; mice; microvilli; phloridzin; sodium; sodium-hydrogen antiporter; transportation
Abstract:
... Increasing reports showed that artificial food additives might increase the incidence of ulcerative colitis (UC). Phloridzin is a natural food additive and a pharmacologic agent, whether phloridzin could induce or treat UC is not clear. We investigated the effects of phloridzin on acute colitis in mice and elucidated the potential mechanism. Phloridzin was given to mice with acute UC induced by 4% ...
DOI:
10.1016/j.jff.2018.02.006

39. Polyphenol-rich peach (Prunus persica L.) by-product exerts a greater beneficial effect than dietary fiber-rich by-product on insulin resistance and hepatic steatosis in obese rats

Author:
Sarahí Rodríguez-González; Iza F. Pérez-Ramírez; Diana M. Amaya-Cruz; Marco A. Gallegos-Corona; Minerva Ramos-Gomez; Ofelia Mora; Rosalía Reynoso-Camacho
Source:
Journal of functional foods 2018 v.45 pp. 58-66
ISSN:
1756-4646
Subject:
Prunus persica; acids; blood serum; byproducts; dietary fiber; fatty liver; fructose; functional foods; glycemic effect; glycogen; ingredients; insulin resistance; kaempferol; obesity; peach juice; peaches; polyphenols; rats; triacylglycerols
Abstract:
... Peach juice by-product (PJBP) can prevent complications of obesity due to its high content of polyphenols and dietary fiber. This study aimed to evaluate the effect of a polyphenol-rich (PR-PJBP) and a dietary fiber-rich (DFR-PJBP) peach juice by-product on insulin resistance and hepatic steatosis in obese rats. Animals were fed with high fat and fructose diet (HFF) and supplemented with PR-PJBP a ...
DOI:
10.1016/j.jff.2018.03.010

40. Structural characterization of polysaccharide from Centipeda minima and its hypoglycemic activity through alleviating insulin resistance of hepatic HepG2 cells

Author:
Juncheng Chen; Lin Li; Xia Zhang; Liting Wan; Qingsong Zheng; Dan Xu; Yuting Li; Yi Liang; Meisi Chen; Bing Li; Zhiyi Chen
Source:
Journal of functional foods 2021 v.82 pp. 104478
ISSN:
1756-4646
Subject:
anion exchange; arabinose; free radicals; galactose; galacturonic acid; gel chromatography; glucose; glycemic effect; glycogen; insulin resistance; mannose; molecular weight; pyruvate kinase
Abstract:
... A novel polysaccharide (CMP-2B) was purified from Centipeda minima by anion-exchange and gel-permeation chromatography. Structural characterization revealed that CMP-2B was a homogeneous heteropolysaccharide with an average molecular weight of 113.193 KDa. CMP-2B was made up of mannose, galacturonic acid, galactose and arabinose with a molar ratio of 0.27:0.12:0.42:0.17. The backbone chain of CMP- ...
DOI:
10.1016/j.jff.2021.104478

41. Supplementation of beef extract improves chemotherapy-induced fatigue and toxic effects in mice

Author:
Tsung-Hsien Hsu; Shao-Wen Hung; Chun-Yun Wu; Chien-Chao Chiu; Hsin-Tai Hong; Guo-Chi Lee; Chia-Chi Chen; Jyh-Shiun Lin; Chean-Ping Wu
Source:
Journal of functional foods 2020 v.75 pp. 104232
ISSN:
1756-4646
Subject:
alanine transaminase; aspartate transaminase; beef; beef extracts; blood serum; catalase; drug therapy; fluorouracil; glutathione peroxidase; glycogen; histopathology; liver; muscle strength; muscles; tissue weight; toxicity; weight loss
Abstract:
... Physiological fatigue and toxic effects are commonly associated with chemotherapy. Beef extract (BE) is a nutritional supplement obtained by cooking beef. The present study examined the effects of several BE concentrations on 5-fluorouracil (5-FU)-induced fatigue and toxic effects in mice. Results showed BE supplementation ameliorated 5-FU-induced body and organ weight loss. All BE + 5-FU groups d ...
DOI:
10.1016/j.jff.2020.104232

42. Synergistic effect of combined oyster peptide and ginseng extracts on anti-exercise-fatigue and promotion of sexual interest activity in male ICR mice

Author:
Xianliang Luo; Wangxin Liu; Hao Zhong; Yongqiu Yan; Fengqin Feng; Minjie Zhao
Source:
Journal of functional foods 2021 v.86 pp. 104700
ISSN:
1756-4646
Subject:
Panax; antioxidant activity; blood serum; dietary supplements; energy; follicle-stimulating hormone; glycogen; lactate dehydrogenase; lactic acid; liver; males; models; oysters; peptides; synergism; testes; testosterone; urea nitrogen
Abstract:
... Traditionally, ginseng and oyster are regarded as biological tonics for enhancing vital energy. In this study, a post-exercise fatigue model and copulatory test were performed to evaluate the effects of combined oyster peptide and ginseng extracts (OPGE) on anti-fatigue and sexual function. The forced swimming time of mice was prolonged by taking OPGE. Moreover, the level of serum lactic acid, blo ...
DOI:
10.1016/j.jff.2021.104700

43. Umbelliferone stimulates glucose uptake; modulates gluconeogenic and nucleotide-hydrolyzing enzymes activities, and dysregulated lipid metabolic pathways in isolated psoas muscle

Author:
Veronica F. Salau; Ochuko L. Erukainure; Collins U. Ibeji; Neil A. Koorbanally; Md. Shahidul Islam
Source:
Journal of functional foods 2020 v.67 pp. 103847
ISSN:
1756-4646
Subject:
acetylcholinesterase; adenosinetriphosphatase; biochemical pathways; biosynthesis; catalase; chymotrypsin; enzyme activity; fatty acid metabolism; gluconeogenesis; glucose; glucose-6-phosphatase; glycogen; hydrolysis; lipids; malondialdehyde; metabolites; nitric oxide; oxidative stress; phosphorylase; psoas muscles; superoxide dismutase; umbelliferones
Abstract:
... The ability of umbelliferone to stimulate muscle glucose uptake and its effect on glucose and fatty acid metabolism as well as nucleotide hydrolysis and cholinergic activity were investigated in isolated psoas muscles. Incubation of umbelliferone with muscles led to increase glucose uptake, elevated GSH, SOD and catalase activities, as well as depleted malondialdehyde and nitric oxide levels. It a ...
DOI:
10.1016/j.jff.2020.103847

44. The amelioration of metabolic disorders in early stage diabetic rats by resveratrol is associated with mTORC1 regulation

Author:
Jeng-Yuan Yao; Chun-Kai Liu; Kuan-Hsing Chen; Jan-Kan Chen
Source:
Journal of functional foods 2015 v.18 pp. 737-745
ISSN:
1756-4646
Subject:
animal disease models; glycemic effect; glycogen; insulin; insulin-dependent diabetes mellitus; lipemic effect; lipogenesis; liver; metabolites; polyphenols; protein degradation; rats; resveratrol; streptozotocin; tandem mass spectrometry; ubiquitination; urine
Abstract:
... Resveratrol (RSV) is a natural polyphenol that exerts anti-diabetic effects. The present study was aimed to elucidate the effects of RSV treatment on type 1 diabetes mellitus (DM) induced metabolic disorders in rats. Streptozotocin (STZ) induced type 1 DM rats were treated with insulin or RSV, and the urine and plasma metabolites were analyzed by electrospray ionization-tandem mass spectrometry am ...
DOI:
10.1016/j.jff.2015.07.020

45. The effect of fermented wheat protein hydrolysate on the exercise performance in mice

Author:
Ruixue Zhang; Jiangtao Zhang; Yan Liu; Lei Fang; Ying Wei; Ruizeng Gu; Min Lin; Liang Chen; Zhengfu Zhou
Source:
Journal of functional foods 2022 v.97 pp. 105217
ISSN:
1756-4646
Subject:
Actinobacteria; Proteobacteria; athletic performance; blood; casein; creatine kinase; exercise; fermentation; glycogen; histology; intestinal microorganisms; lactic acid; liver; muscle protein; muscle tissues; muscles; protein supplements; protein synthesis; urea nitrogen; wheat protein; wheat protein hydrolysates; whey
Abstract:
... Backgrouds. Fermented wheat protein hydrolysate (FWPH) is obtained by lightly hydrolysing wheat protein and then fermented using lactic acid bacteria (LAB). Protein supplementation could stimulate muscle protein synthesis and alleviate fatigue. The objectives of this study were to assess the effects of fermented wheat protein hydrolysate (FWPH) on the capacity of exercise and intestinal flora comp ...
DOI:
10.1016/j.jff.2022.105217

46. A peptide isolated from Hippocampus abdominalis improves exercise performance and exerts anti-fatigue effects via AMPK/PGC-1α pathway in mice

Author:
Yuanyuan Zhang; Bomi Ryu; Yuhua Cui; Chengyong Li; Chunxia Zhou; Pengzhi Hong; Beajin Lee; Zhong-Ji Qian
Source:
Journal of functional foods 2019 pp. 103489
ISSN:
1756-4646
Subject:
Hippocampus abdominalis; Oriental traditional medicine; Western blotting; adenosine triphosphate; athletic performance; blood glucose; citrates; creatine; glycogen; immunohistochemistry; lactic acid; mice; mitochondria; muscle fibers; peptides; proteins; signal transduction
Abstract:
... Seahorse is been used as a traditional Chinese medicine and invigorant for many years. Among, the seahorse is considered to have anti-fatigue effects. However, few researches have demonstrated such an effect. This study, the anti-fatigue effect of a novel peptide purified (SH200) from the seahorse (Hippocampus abdominalis) was investigated in C57BL/6 mice. The effect of SH200 on exercise performan ...
DOI:
10.1016/j.jff.2019.103489

47. A simple and rapid method for the preparation of pure delphinidin-3-O-sambubioside from Roselle and its antioxidant and hypoglycemic activity

Author:
Yang Xu; Dongwen Hu; Tao Bao; Jiahong Xie; Wei Chen
Source:
Journal of functional foods 2017 v.39 pp. 9-17
ISSN:
1756-4646
Subject:
Hibiscus sabdariffa; antioxidant activity; antioxidants; diabetes; functional foods; glucose; glycemic effect; glycogen; human cell lines; humans; liver; membrane potential; mitochondrial membrane; oxidative stress; peroxidation; porous media; rapid methods; resins
Abstract:
... The present study aimed to establish a simple and rapid method for the preparation of pure delphinidin-3-O-sambubioside (D3S) from Roselle and then investigate its antioxidant and hypoglycemic activity. According to our results, 60 mg of D3S with the purity of 96.1% was finally isolated from 500 g of Roselle by combination of macroporous resins and C18 Sep-Pak cartridge techniques. Further studies ...
DOI:
10.1016/j.jff.2017.10.002