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You searched for: Journal name Journal of functional foods Remove constraint Journal name: Journal of functional foods Subject term glycogen Remove constraint Subject term: glycogen Subject term glucose Remove constraint Subject term: glucose Subject term insulin resistance Remove constraint Subject term: insulin resistance Text availability Citation in PubAg Remove constraint Text availability: Citation in PubAg
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1. Anti-diabetic effect by walnut (Juglans mandshurica Maxim.)-derived peptide LPLLR through inhibiting α-glucosidase and α-amylase, and alleviating insulin resistance of hepatic HepG2 cells

Author:
Ji Wang; Tong Wu; Li Fang; Chunlei Liu; Xiaoting Liu; Hongmei Li; Junhua Shi; Meihe Li; Weihong Min
Source:
Journal of functional foods 2020 v.69 pp. 103944
ISSN:
1756-4646
Subject:
Juglans mandshurica; alpha-amylase; alpha-glucosidase; enzyme inhibition; gluconeogenesis; glucose; glucose transporters; glycemic effect; glycogen; insulin resistance; mass spectrometry; peptides; phosphatidylinositol 3-kinase; phosphorylation; protein hydrolysates; reversed-phase high performance liquid chromatography; signal transduction; tau-protein kinase; walnuts
Abstract:
... In the present study, a novel pentapeptide LPLLR (Leu-Pro-Leu-Leu-Arg) was purified and identified from walnut protein hydrolysates (3–10 kDa) by SEC, RP-HPLC, and LC-MS/MS. Its inhibitory actions against α-glucosidase and α-amylase were evaluated. Then its beneficial effects on glucose metabolism and the underlying molecular mechanism were determined in high glucose-induced insulin resistant (IR) ...
DOI:
10.1016/j.jff.2020.103944

2. Anti-diabetic effects of Bifidobacterium animalis 01 through improving hepatic insulin sensitivity in type 2 diabetic rat model

Author:
Jinlan Zhang; Shibo Wang; Zhu Zeng; Yuxuan Qin; Qian Shen; Pinglan Li
Source:
Journal of functional foods 2020 v.67 pp. 103843
ISSN:
1756-4646
Subject:
Bifidobacterium animalis; animal disease models; antioxidants; blood glucose; blood serum; cytokines; gene expression; glucose; glycemic effect; glycogen; glycosylation; hemoglobin; hepatoprotective effect; high fat diet; insulin resistance; lipid composition; liver; males; noninsulin-dependent diabetes mellitus; oral administration; phosphatidylinositol 3-kinase; rats; streptozotocin; tissues
Abstract:
... The anti-diabetic effects of Bifidobacterium animalis 01 and its potential mechanisms were investigated. Male SD rats were given a high-fat chow diet with low-dose streptozotocin (30 mg/kg BW) to induce T2DM. The supplements with B. animalis 01 were given in a pre- and post-treatment method. Oral administration of B. animalis 01 decreased food and water intake, blood glucose concentration, and gly ...
DOI:
10.1016/j.jff.2020.103843

3. Aronia melanocarpa anthocyanin extracts are an effective regulator of suppressor of cytokine signaling 3-dependent insulin resistance in HepG2 and C2C12 cells

Author:
Jing Chen; Jinyan Zhu; Xianjun Meng
Source:
Journal of functional foods 2020 v.75 pp. 104258
ISSN:
1756-4646
Subject:
Aronia melanocarpa; anthocyanins; cytokines; glucose; glucose transporters; glycogen; insulin; insulin resistance; noninsulin-dependent diabetes mellitus; palmitic acid; transfection
Abstract:
... Insulin resistance (IR) is involved in the development of type 2 diabetes mellitus (T2DM). Plant anthocyanins can attenuate IR, but the related mechanisms are still incompletely understood. We found that Aronia melanocarpa anthocyanin extracts (AMAE) could improve glucose uptake by upregulating glucose transporter-4, enhance insulin action in IR HepG2 and C2C12 cells, increase IRS-1 and p-GSK-3β ( ...
DOI:
10.1016/j.jff.2020.104258

4. Structural characterization of polysaccharide from Centipeda minima and its hypoglycemic activity through alleviating insulin resistance of hepatic HepG2 cells

Author:
Juncheng Chen; Lin Li; Xia Zhang; Liting Wan; Qingsong Zheng; Dan Xu; Yuting Li; Yi Liang; Meisi Chen; Bing Li; Zhiyi Chen
Source:
Journal of functional foods 2021 v.82 pp. 104478
ISSN:
1756-4646
Subject:
anion exchange; arabinose; free radicals; galactose; galacturonic acid; gel chromatography; glucose; glycemic effect; glycogen; insulin resistance; mannose; molecular weight; pyruvate kinase
Abstract:
... A novel polysaccharide (CMP-2B) was purified from Centipeda minima by anion-exchange and gel-permeation chromatography. Structural characterization revealed that CMP-2B was a homogeneous heteropolysaccharide with an average molecular weight of 113.193 KDa. CMP-2B was made up of mannose, galacturonic acid, galactose and arabinose with a molar ratio of 0.27:0.12:0.42:0.17. The backbone chain of CMP- ...
DOI:
10.1016/j.jff.2021.104478

5. Ginsenoside Rg5 relieves type 2 diabetes by improving hepatic insulin resistance in db/db mice

Author:
Yange Wei; Haixia Yang; Chenhui Zhu; Jianjun Deng; Daidi Fan
Source:
Journal of functional foods 2020 v.71 pp. 104014
ISSN:
1756-4646
Subject:
ginsenosides; glucose; glycemic effect; glycogen; glycolipids; inflammation; insulin; insulin resistance; interleukin-1beta; interleukin-6; liver; noninsulin-dependent diabetes mellitus; pancreas; phosphatidylinositol 3-kinase; phosphorylation; public health; signal transduction; tissues; tumor necrosis factor-alpha
Abstract:
... Type 2 diabetes mellitus (T2DM) is a systemic metabolic disorder that has become a major threat to public health. Ginsenoside Rg5 (Rg5) has a putative hypoglycemic effect, but its potential mechanism remains unclear. Here, we found that Rg5 not only reduced glycolipid parameters (FBG, TC, TG, and LDL-C), relieved inflammation (TNF-α, IL-6, and IL-1β), improved hepatic lipid accumulation, and repai ...
DOI:
10.1016/j.jff.2020.104014

6. Hypoglycemic effect of inulin combined with ganoderma lucidum polysaccharides in T2DM rats

Author:
Yaping Liu; Yumeng Li; Wenlingzi Zhang; Mingzhe Sun; Zesheng Zhang
Source:
Journal of functional foods 2019 v.55 pp. 381-390
ISSN:
1756-4646
Subject:
Ganoderma lucidum; glucose; glycemic effect; glycogen; high fat diet; hypoglycemia; insulin resistance; inulin; lipid metabolism; messenger RNA; noninsulin-dependent diabetes mellitus; nutrient transport; rats; streptozotocin
Abstract:
... It has been reported that both inulin and ganoderma lucidum polysaccharides are conducive to glucose metabolism. The aim of present study was to explore the hypoglycemia effect and molecular mechanism of the inulin combined with ganoderma lucidum polysaccharides in type 2 diabetic mellitus (T2DM) rats. T2DM rats were induced by high fat diet (HFD) and streptozotocin (STZ). Then the inulin and gano ...
DOI:
10.1016/j.jff.2019.02.036

7. Mogroside derivatives exert hypoglycemics effects by decreasing blood glucose level in HepG2 cells and alleviates insulin resistance in T2DM rats

Author:
Xuan Liu; Jingjing Zhang; Yumeng Li; Liyang Sun; Yao Xiao; Wenge Gao; Zesheng Zhang
Source:
Journal of functional foods 2019 v.63 pp. 103566
ISSN:
1756-4646
Subject:
Siraitia grosvenorii; blood glucose; fasting; gene expression regulation; glucose; glucose transporters; glycemic effect; glycogen; human cell lines; in vitro studies; in vivo studies; insulin receptor substrate proteins; insulin resistance; liver; metabolism; phosphatidylinositol 3-kinase; quantitative polymerase chain reaction; rats; triterpenoids
Abstract:
... Mogroside, a triterpenoid of Siraitia grosvenorii, has been reported to play an important role in glycometabolism processes. In this study, the mechanism of mogroside was evaluated through in vitro experiments using Mogroside III (MO3), IV (MO4), V (MO5), Siamenoside I (SO1) at 1, 5, 10 μM, and in vivo experiments using MO5 at 30, 75, 150 mg/(kg·bw·day). In cell experiments, mogrosides at 5 μM sig ...
DOI:
10.1016/j.jff.2019.103566

8. Fucoxanthin ameliorates hyperglycemia, hyperlipidemia and insulin resistance in diabetic mice partially through IRS-1/PI3K/Akt and AMPK pathways

Author:
Yiping Zhang; Wen Xu; Xiaoqiang Huang; Youqin Zhao; Qiangqiang Ren; Zhuan Hong; Mingqing Huang; Xia Xing
Source:
Journal of functional foods 2018 v.48 pp. 515-524
ISSN:
1756-4646
Subject:
animal disease models; blood glucose; blood lipids; carnitine palmitoyltransferase; diabetes; diet; drugs; fatty-acid synthase; functional foods; glucokinase; glucose; glucose transporters; glycogen; glycogen (starch) synthase; histology; hyperglycemia; hyperlipidemia; insulin resistance; lipid metabolism; liver; messenger RNA; mice; peroxisome proliferator-activated receptors; skeletal muscle
Abstract:
... Fucoxanthin has potential anti-diabetic activities, but its precise effects and underlying mechanisms remain unclear. In this study, C57BL/KsJ-db/db mice were fed diets containing fucoxanthin (0.2% and 0.4%, w/w) for 6 weeks. Results showed dietary fucoxanthin significantly improved glucose/lipid metabolism and insulin resistance, and prevented pancreatic histological changes in db/db mice. Moreov ...
DOI:
10.1016/j.jff.2018.07.048

9. Dendrobium officinale polysaccharide attenuates type 2 diabetes mellitus via the regulation of PI3K/Akt-mediated glycogen synthesis and glucose metabolism

Author:
Kaiping Wang; Hanxiang Wang; Yage Liu; Weizhi Shui; Junfeng Wang; Peng Cao; Hongjing Wang; Ruxu You; Yu Zhang
Source:
Journal of functional foods 2017 pp. -
ISSN:
1756-4646
Subject:
Dendrobium officinale; active ingredients; blood glucose; enzyme activity; glucose; glucose transporters; glycogen; glycogen (starch) synthase; hexokinase; hyperglycemia; hyperlipidemia; insulin resistance; liver; metabolism; mice; muscles; noninsulin-dependent diabetes mellitus; pyruvate kinase; streptozotocin; tau-protein kinase; therapeutics
Abstract:
... This study aimed to explore the therapeutic effects of Dendrobium officinale polysaccharide (DOP), an active ingredient isolated from the water extract of Dendrobium officinale, in streptozotocin (STZ)-induced type 2 diabetic BALB/c mice and its potential mechanisms. Our results showed that DOP had beneficial effects in ameliorating hyperglycemia, insulin resistance and dyslipidemia. Additionally, ...
DOI:
10.1016/j.jff.2017.11.004

10. Phenolic compounds ameliorate the glucose uptake in HepG2 cells' insulin resistance via activating AMPK

Author:
Qun Huang; Lei Chen; Hui Teng; Hongbo Song; Xiaoqi Wu; Meiyu Xu
Source:
Journal of functional foods 2015 v.19 pp. 487-494
ISSN:
1756-4646
Subject:
apigenin; cell culture; cytotoxicity; glucose; glycogen; human cell lines; humans; insulin; insulin resistance; kaempferol; luteolin; metformin; models; phenolic compounds; quercetin
Abstract:
... The preventive effects of phenolic compounds on insulin signalling and on both glucose production and uptake were studied in insulin-responsive human HepG2 cells treated with high glucose. The influence of insulin in different-dose insulin and at different action times on the IR of HepG2 cells, and changes of glucose uptake and glycogen level were detected by using cell culture glucose uptake anal ...
DOI:
10.1016/j.jff.2015.09.020

11. Fucoidan from sea cucumber protects against high-fat high-sucrose diet-induced hyperglycaemia and insulin resistance in mice

Author:
Shiwei Hu; Guanghua Xia; Jingfeng Wang; Yuming Wang; Zhaojie Li; Changhu Xue
Source:
Journal of functional foods 2014 v.10 pp. 128-138
ISSN:
1756-4646
Subject:
Acaudina molpadioides; Phaeophyceae; acute toxicity; adiponectin; blood glucose; dietary exposure; enzyme activity; fucoidan; glucose; glucose transporters; glycogen; hexokinase; hyperglycemia; insulin; insulin resistance; leptin; metabolism; mice; phosphorylase; pyruvate kinase; resistin; tumor necrosis factor-alpha
Abstract:
... The amelioration in hyperglycaemia and insulin resistance of fucoidan from sea cucumber can be speculated due to these effects of fucoidan from marine phaeophyta. We examined the effect of fucoidan from Acaudina molpadioides (Am-FUC) on anti-hyperglycaemia and improvement in insulin resistance in high-fat high-sucrose diet-induced insulin resistant mice. Results showed that Am-FUC significantly re ...
DOI:
10.1016/j.jff.2014.05.012