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You searched for: Author "Beck, Alain" Remove constraint Author: "Beck, Alain" Journal Journal of mass spectrometry Remove constraint Journal: Journal of mass spectrometry
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1. Independent highly sensitive characterization of asparagine deamidation and aspartic acid isomerization by sheathless CZE‐ESI‐MS/MS

Author:
Beck, Alain,   et al.   ; Gahoual, Rabah; François, Yannis‐Nicolas; Leize‐Wagner, Emmanuelle;     Show all 4 Authors
Source:
Journal of mass spectrometry 2016 v.51 no.2 pp. 150-158
ISSN:
1076-5174
Subject:
asparagine; aspartic acid; capillary zone electrophoresis; deamidation; electrospray ionization mass spectrometry; ionization; isomerization; monoclonal antibodies; pH; post-translational modification; protein structure; synthetic peptides; temperature
Abstract:
... Amino acids residues are commonly submitted to various physicochemical modifications occurring at physiological pH and temperature. Post‐translational modifications (PTMs) require comprehensive characterization because of their major influence on protein structure and involvement in numerous in vivo process or signaling. Mass spectrometry (MS) has gradually become an analytical tool of choice to c ...
DOI:
10.1002/jms.3735

2. Cutting‐edge mass spectrometry characterization of originator, biosimilar and biobetter antibodies

Author:
Beck, Alain,   et al.   ; Debaene, François; Diemer, Hélène; Wagner‐Rousset, Elsa; Colas, Olivier; Dorsselaer, Alain Van; Cianférani, Sarah;     Show all 7 Authors
Source:
Journal of mass spectrometry 2015 v.50 no.2 pp. 285-297
ISSN:
1076-5174
Subject:
antibodies; deuterium; dissociation; electron transfer; electrophoresis; liquid chromatography; mass spectrometry
Abstract:
... The approval process for antibody biosimilars relies primarily on comprehensive analytical data to establish comparability and high similarity with the originator. Mass spectrometry (MS) in combination with liquid chromatography (LC) and electrophoretic methods are the corner stone for comparability and biosimilarity evaluation. In this special feature we report head‐to‐head comparison of trastuzu ...
DOI:
10.1002/jms.3554