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You searched for: Journal Journal of materials chemistry B Remove constraint Journal: Journal of materials chemistry B Publication Year 2018 Remove constraint Publication Year: 2018 Source 2018 v.6 no.44 Remove constraint Source: 2018 v.6 no.44
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1. A biodegradable polyphosphoester-functionalized poly(disulfide) nanocarrier for reduction-triggered intracellular drug delivery

Author:
JuThese authors contribute equally to this work., Pengfei; Hu, Jian; Li, Fei; Cao, Youwen; Li, Lei; Shi, Dongjian; Hao, Ying; Zhang, Mingzu; He, Jinlin; Ni, Peihong
Source:
Journal of materials chemistry B 2018 v.6 no.44 pp. 7263-7273
ISSN:
2050-7518
Subject:
Fourier transform infrared spectroscopy; aqueous solutions; beta-mercaptoethanol; biodegradability; cell proliferation; chemical structure; cleavage (chemistry); composite polymers; condensation reactions; desorption; doxorubicin; drug therapy; encapsulation; ethylene; gel chromatography; human cell lines; hydrophobicity; image analysis; light scattering; matrix-assisted laser desorption-ionization mass spectrometry; nanocarriers; nanoparticles; nuclear magnetic resonance spectroscopy; phosphates; polymerization; tetrazolium; transmission electron microscopy
Abstract:
... Stimuli-responsive and biodegradable polymeric carriers are of great importance for safe delivery and efficient release of chemotherapeutic agents. In this work, given the unique advantages of poly(disulfide)s and biodegradable polyphosphoesters, we designed and constructed a reduction-sensitive amphiphilic triblock copolymer poly(ethyl ethylene phosphate)-b-poly(disulfide)-b-poly(ethyl ethylene p ...
DOI:
10.1039/c8tb01566j

2. An injectable dipeptide–fullerene supramolecular hydrogel for photodynamic antibacterial therapy

Author:
ZhangThese authors contributed equally to this work., Yuankai; Zhang, Han; Zou, Qianli; Xing, Ruirui; Jiao, Tifeng; Yan, Xuehai
Source:
Journal of materials chemistry B 2018 v.6 no.44 pp. 7335-7342
ISSN:
2050-7518
Subject:
Staphylococcus aureus; antibiotic resistance; bacteria; fullerene; hydrogels; mechanical properties; peptides; photochemotherapy; photosensitizing agents; solubility; tissue repair
Abstract:
... Photodynamic therapy (PDT) is a promising treatment against multiantibiotic-resistant bacteria with the advantage of a low tendency towards antibiotic resistance. Due to their high PDT efficiencies and superior chemical stabilities, fullerenes have been proposed as effective photosensitizers for the photodynamic inactivation of bacteria. However, the biomedical applications of fullerenes are hinde ...
DOI:
10.1039/c8tb01487f

3. Barcoding chemical modifications into nucleic acids improves drug stability in vivo

Author:
Sago, Cory D.; Kalathoor, Sujay; Fitzgerald, Jordan P.; Lando, Gwyneth N.; Djeddar, Naima; Bryksin, Anton V.; Dahlman, James E.
Source:
Journal of materials chemistry B 2018 v.6 no.44 pp. 7197-7203
ISSN:
2050-7518
Subject:
DNA barcoding; blood serum; chemistry; drugs; in vivo studies; nucleic acids; screening
Abstract:
... The efficacy of nucleic acid therapies can be limited by unwanted degradation. Chemical modifications are known to improve nucleic acid stability, but the (i) types, (ii) positions, and (iii) numbers of modifications all matter, making chemically optimizing nucleic acids a combinatorial problem. As a result, in vivo studies of nucleic acid stability are time consuming and expensive. We reasoned th ...
DOI:
10.1039/c8tb01642a

4. Binding of an amphiphilic phthalocyanine to pre-formed liposomes confers light-triggered cargo release

Author:
Macháček, Miloslav; Carter, Kevin A.; Kostelanský, Filip; Miranda, Dyego; Seffouh, Amal; Ortega, Joaquin; Šimůnek, Tomáš; Zimčík, Petr; Lovell, Jonathan F.
Source:
Journal of materials chemistry B 2018 v.6 no.44 pp. 7298-7305
ISSN:
2050-7518
Subject:
aqueous solutions; doxorubicin; drug delivery systems; hydrophilicity; irradiation; near infrared radiation; near-infrared spectroscopy; photosensitizing agents
Abstract:
... Liposomes are able to load a range of cargos and have been used for drug delivery applications, including for stimuli-triggered drug release. Here, we describe an approach for imparting near infrared (NIR) light-triggered release to pre-formed liposomes, using a newly-synthesized cationic, amphiphilic phthalocyanine. When simply mixed in aqueous solution with cargo-loaded liposomes, the cationic a ...
DOI:
10.1039/c8tb01602j

5. Bioelectronics goes 3D: new trends in cell–chip interface engineering

Author:
PennacchioThese authors have equal contribution., F. A.; Garma, L. D.; Matino, L.; Santoro, F.
Source:
Journal of materials chemistry B 2018 v.6 no.44 pp. 7096-7101
ISSN:
2050-7518
Subject:
chemistry; electrophysiology; engineering; geometry; monitoring; nanomaterials
Abstract:
... Bioelectronic platforms can be used for electrophysiology, monitoring and stimulating specific cellular functions. While planar electroactive materials have been extensively used, in the past decade new approaches have focused on engineering the interface with pseudo-3D micro and nanostructures and, more recently, on 3D geometries (i.e. scaffold-like). Here, we present an overview of this transiti ...
DOI:
10.1039/c8tb01737a

6. Bioelectronics with nanocarbons

Author:
Rastogi, Sahil Kumar; Kalmykov, Anna; Johnson, Nicholas; Cohen-Karni, Tzahi
Source:
Journal of materials chemistry B 2018 v.6 no.44 pp. 7159-7178
ISSN:
2050-7518
Subject:
brain; carbon nanotubes; cardiomyocytes; chemistry; electrophysiology; graphene; nanodiamonds; neurons; physical properties
Abstract:
... Characterizing the electrical activity of cardiomyocytes and neurons is crucial in understanding the complex processes in the heart and brain tissues, both in healthy and diseased states. Micro- and nanotechnologies have significantly improved the electrophysiological investigation of cellular networks. Carbon-based nanomaterials or nanocarbons, such as carbon nanotubes (CNTs), nanodiamonds (NDs) ...
DOI:
10.1039/c8tb01600c

7. Biomolecular dynamic covalent polymers for DNA complexation and siRNA delivery

Author:
Bouillon, Camille; Bessin, Yannick; Poncet, Florian; Gary-Bobo, Magali; Dumy, Pascal; Barboiu, Mihail; Bettache, Nadir; Ulrich, Sébastien
Source:
Journal of materials chemistry B 2018 v.6 no.44 pp. 7239-7246
ISSN:
2050-7518
Subject:
DNA; amino acids; condensation reactions; dissociation; gene therapy; gene transfer; molecular dynamics; pH; polymers; small interfering RNA
Abstract:
... Synthetic delivery systems that are described as smart are considered essential for the successful development of gene therapies. Dynamic covalent polymers (DCP) are dynamic and adaptive species that can expand and shorten their main chain in a reversible fashion. In particular, polyacylhydrazone DCPs are pH-sensitive and undergo hydrolytic dissociation at acidic pH, which is an interesting featur ...
DOI:
10.1039/c8tb01278d

8. Conductive silk–polypyrrole composite scaffolds with bioinspired nanotopographic cues for cardiac tissue engineering

Author:
Tsui, Jonathan H.; Ostrovsky-Snider, Nicholas A.; Yama, David M. P.; Donohue, Jordan D.; Choi, Jong Seob; Chavanachat, Rakchanok; Larson, Jesse D.; MurphyDepartment of Chemistry, Western Washington University, Morse Hall Chemistry Building CB342, Bellingham, WA 98225, USA. E-mail: Amanda.Murphy@wwu.edu; Fax: +1-718-881-2666; Tel: +1-360-650-3138., Amanda R.; KimDepartment of Bioengineering, University of Washington, Box 355061, Seattle, WA 98195, USA. E-mail: deokho@uw.edu; Fax: +1-206-685-3300; Tel: +1-206-616-1133., Deok-Ho
Source:
Journal of materials chemistry B 2018 v.6 no.44 pp. 7185-7196
ISSN:
2050-7518
Subject:
anisotropy; biomimetics; cell viability; connexins; delamination; electrical conductivity; electrophysiology; extracellular matrix; functional properties; gene expression; humans; nanomaterials; pyrroles; sarcomeres; silk; stem cells; tissue engineering; topography
Abstract:
... We report on the development of bioinspired cardiac scaffolds made from electroconductive acid-modified silk fibroin–poly(pyrrole) (AMSF + PPy) substrates patterned with nanoscale ridges and grooves reminiscent of native myocardial extracellular matrix (ECM) topography to enhance the structural and functional properties of cultured human pluripotent stem cells (hPSC)-derived cardiomyocytes. Nanopa ...
DOI:
10.1039/c8tb01116h

9. Design and fabrication of reduction-sensitive cell penetrating nanofibers for enhanced drug efficacy

Author:
Yang, Su; Xu, Dawei; Dong, He
Source:
Journal of materials chemistry B 2018 v.6 no.44 pp. 7179-7184
ISSN:
2050-7518
Subject:
chemistry; drugs; nanofibers; neoplasm cells; neoplasms; peptides; therapeutics
Abstract:
... This work demonstrates a modular design strategy based on the supramolecular assembly of multidomain peptides to fabricate reduction-responsive cell penetrating nanofibers (CPNs), which hold great promise for selective targeting of cancer therapeutics to tumor cells. ...
DOI:
10.1039/c8tb00728d

10. Enhancing anti-thrombogenicity of biodegradable polyurethanes through drug molecule incorporation

Author:
Xu, Cancan; Kuriakose, Aneetta E.; Truong, Danh; Punnakitikashem, Primana; Nguyen, Kytai T.; Hong, Yi
Source:
Journal of materials chemistry B 2018 v.6 no.44 pp. 7288-7297
ISSN:
2050-7518
Subject:
adhesion; biocompatibility; biodegradability; blood coagulation; blood platelets; carboxylic ester hydrolases; cell adhesion; chemical bonding; crosslinking; dipyridamole; drugs; human umbilical vein endothelial cells; hydrophilicity; hydrophobicity; mechanical properties; mixing; moieties; polyurethanes; thrombosis; tissue repair
Abstract:
... Sufficient and sustained anti-thrombogenicity is essential for blood-contacting materials because blood coagulation and thrombosis caused by platelet adhesion and activation on material surfaces may lead to functional failure and even fatal outcomes. Covalently conjugating anti-thrombogenic moieties into a polymer, instead of surface modification or blending, can maintain the anti-thrombogenicity ...
DOI:
10.1039/c8tb01582a

11. Enhancing the sensitivity of colorimetric lateral flow assay (CLFA) through signal amplification techniques

Author:
Ye, Haihang; Xia, Xiaohu
Source:
Journal of materials chemistry B 2018 v.6 no.44 pp. 7102-7111
ISSN:
2050-7518
Subject:
chemistry; colorimetry; detection limit; equipment; human resources; infectious diseases; nanotechnology; neoplasms; point-of-care testing
Abstract:
... Colorimetric lateral flow assay (CLFA) is one of a handful of diagnostic technologies that can be truly taken out of the laboratory for point-of-care testing without the need for any equipment and skilled personnel. Despite its simplicity and practicality, it remains a grand challenge to substantially enhance the detection sensitivity of CLFA without adding complexity. Such a limitation in sensiti ...
DOI:
10.1039/c8tb01603h

12. Highly selective, red emitting BODIPY-based fluorescent indicators for intracellular Mg²⁺ imaging

Author:
Lin, Qitian; Buccella, Daniela
Source:
Journal of materials chemistry B 2018 v.6 no.44 pp. 7247-7256
ISSN:
2050-7518
Subject:
absorption; binding properties; calcium; carboxylic acids; cations; extrusion; fluorescence; fluorescent dyes; image analysis; magnesium; moieties; pH; transporters
Abstract:
... Most fluorescent indicators for Mg²⁺ suffer from poor selectivity against other divalent cations, especially Ca²⁺, thus do not provide reliable information on cellular Mg²⁺ concentrations in processes in which such metals are involved. We report a new set of highly selective fluorescent indicators based on alkoxystyryl-functionalized BODIPY fluorophores decorated with a 4-oxo-4H-quinolizine-3-carb ...
DOI:
10.1039/c8tb01599f

13. In vitro and in vivo toxicity evaluation of halloysite nanotubes

Author:
LongThese authors contributed equally to this work., Zheru; Wu, Yan-Ping; Gao, Hua-Ying; Zhang, Jun; Ou, Xianfeng; He, Rong-Rong; Liu, Mingxian
Source:
Journal of materials chemistry B 2018 v.6 no.44 pp. 7204-7216
ISSN:
2050-7518
Subject:
Danio rerio; adenocarcinoma; breasts; chemistry; confocal laser scanning microscopy; early development; embryo (animal); fluorescein; fluorescence; gastrointestinal system; halloysite; human health; human umbilical vein endothelial cells; humans; isothiocyanates; larvae; manufacturing; metabolism; nanotubes; toxicity; toxicity testing
Abstract:
... Because of their outstanding properties, increasing numbers of research studies and emerging applications for manufacturing products are currently in progress for halloysite nanotubes (HNTs). Therefore, the impact of HNTs on the environment and human health should be taken into consideration. In order to clearly show the cell uptake of HNTs and the biodistribution of HNTs in zebrafish, HNTs are la ...
DOI:
10.1039/c8tb01382a

14. Lipid nanoemulsion passive tumor accumulation dependence on tumor stage and anatomical location: a new mathematical model for in vivo imaging biodistribution studies

Author:
Radicchi, Marina Arantes; de Oliveira, Jaqueline Vaz; Mendes, Ana Clara Pova; de Oliveira, Daniela Mara; Muehlmann, Luís Alexandre; Morais, Paulo Cesar; Azevedo, Ricardo Bentes; Longo, João Paulo Figueiró
Source:
Journal of materials chemistry B 2018 v.6 no.44 pp. 7306-7316
ISSN:
2050-7518
Subject:
breast neoplasms; fluorescence; hydrophobicity; image analysis; lipids; mathematical models; metastasis; mice; nanoemulsions; nanomedicine; nanoparticles; tissues
Abstract:
... Nanoparticle delivery to tumor tissue is one of the most important applications of nanomedicine. However, the literature shows that this pharmacological event is highly-affected by several tumor biology characteristics, including tumor size and maturation. Thus, the objective of the present study is to report on the investigation of the biodistribution of a lipid nanoemulsion (NE) in a breast canc ...
DOI:
10.1039/c8tb01577e

15. Mechanical determination of particle–cell interactions and the associated biomedical applications

Author:
ZhangThese authors equally contributed to this work., Xiao; Song, Cui; Ma, Guanghui; Wei, Wei
Source:
Journal of materials chemistry B 2018 v.6 no.44 pp. 7129-7143
ISSN:
2050-7518
Subject:
drugs; immune response; mechanical properties; nanoparticles; physicochemical properties; physiological response
Abstract:
... As new materials, micro/nanoscale particles have been verified to have many novel and significant physicochemical properties as a result of their specific scale effects, and hence have received increasing amounts of attention. The understanding of the physiological effects of these particles on cells is fundamental to the biomedical field. Currently, it has been proven that the mechanical properti ...
DOI:
10.1039/c8tb01590b

16. Nanostructured interfaces for probing and facilitating extracellular electron transfer

Author:
Hsu, Leo (Huan-Hsuan); Deng, Pu; Zhang, Yixin; Nguyen, Han N.; Jiang, Xiaocheng
Source:
Journal of materials chemistry B 2018 v.6 no.44 pp. 7144-7158
ISSN:
2050-7518
Subject:
bacteria; biocompatibility; biosynthesis; electrochemistry; electron transfer; electronic equipment; electrons; energy conversion; nanowires; renewable energy sources; research planning
Abstract:
... Extracellular electron transfer (EET) is a process performed by electrochemically active bacteria (EAB) to transport metabolically-generated electrons to external solid-phase acceptors through specific molecular pathways. Naturally bridging biotic and abiotic charge transport systems, EET offers ample opportunities in a wide range of bio-interfacing applications, from renewable energy conversion, ...
DOI:
10.1039/c8tb01598h

17. Near-infrared light triggered drug release from mesoporous silica nanoparticles

Author:
Zhao, Tiancong; Chen, Liang; Li, Qin; Li, Xiaomin
Source:
Journal of materials chemistry B 2018 v.6 no.44 pp. 7112-7121
ISSN:
2050-7518
Subject:
biosafety; chemistry; illicit drugs; nanocarriers; nanoparticles; near infrared radiation; neoplasms; polymers; porous media; silica; space and time; surface area
Abstract:
... Stimuli triggered drug delivery systems enable controlled release of drugs at the optimal space and time, thus achieving optimal therapeutic effects. As one of the most important stimuli used in bioapplications, near-infrared (NIR) light possesses unique advantages such as deep tissue penetration with minimum auto-fluorescence & tissue scattering and high biosafety. Mesoporous silica nanoparticles ...
DOI:
10.1039/c8tb01548a

18. Pharmaceutical crystallization in surface-modified nanocellulose organogels

Author:
Banerjee, Manali; Saraswatula, Sisira; Willows, Laura Grace; Woods, Hannah; Brettmann, Blair
Source:
Journal of materials chemistry B 2018 v.6 no.44 pp. 7317-7328
ISSN:
2050-7518
Subject:
active pharmaceutical ingredients; cellulose; crystallization; dimethyl sulfoxide; energy; gelation; mixing; moieties; nanocrystals; organogels; pharmaceutical industry; sulfamerazine; sulfamethoxazole; sulfapyridine; surface area; surfactants; water solubility
Abstract:
... A significant research focus in the pharmaceutical industry is on methods to improve drug uptake into the body by increased dissolution of poorly water soluble active pharmaceutical ingredients (APIs) or sustained drug release behavior, which results in higher overall uptake. Production of higher energy, higher solubility polymorphs is one approach to address this problem. Here we utilize natural ...
DOI:
10.1039/c8tb01554f

19. Plasmonic Janus hybrids for the detection of small metabolites

Author:
Su, Haiyang; Liu, Tingting; Huang, Lin; Huang, Jingyi; Cao, Jing; Yang, Hengquan; Ye, Jian; Liu, Jian; Qian, Kun
Source:
Journal of materials chemistry B 2018 v.6 no.44 pp. 7280-7287
ISSN:
2050-7518
Subject:
anisotropy; carbon; desorption; hydrophilicity; mass spectrometry; metabolites; nanoparticles; nanosilver; porous media; silver
Abstract:
... Advanced bio-analytical platforms rely on materials with tailored structural parameters. Herein, we assembled plasmonic Janus hybrids for laser desorption/ionization mass spectrometry (LDI MS) detection of small metabolites. We applied Janus particles (periodic mesoporous organosilica (PMO) in conjunction with carbon spheres) as core materials and loaded silver nanoparticles as nanoshells. Janus c ...
DOI:
10.1039/c8tb01587b

20. Quantum-dot-encapsulated core–shell barcode particles from droplet microfluidics

Author:
Bian, Feika; Wang, Huan; Sun, Lingyu; Liu, Yuxiao; Zhao, Yuanjin
Source:
Journal of materials chemistry B 2018 v.6 no.44 pp. 7257-7262
ISSN:
2050-7518
Subject:
barcoding; biochemical compounds; biocompatibility; droplets; emulsifying; emulsions; hydrogels; microfluidic technology; moieties; nanoparticles; polyethylene glycol; quantum dots; silica
Abstract:
... The development of robust quantum dot (QD) barcode particles with specific compositions and simple identification is important to meet the demand for high-throughput assays. Here, we present a multiple-inner phase channel capillary microfluidic approach to generate novel QD-encapsulated core–shell barcode particles with distinctive features for multiplexing analysis. By using different QD disperse ...
DOI:
10.1039/c8tb00946e