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You searched for: Journal Journal of materials chemistry B Remove constraint Journal: Journal of materials chemistry B Publication Year 2017 Remove constraint Publication Year: 2017 Source 2017 v.5 no.13 Remove constraint Source: 2017 v.5 no.13
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1. A biomaterial approach to cell reprogramming and differentiation

Author:
Long, Joseph; Kim, Hyejin; Kim, Dajeong; Lee, Jong Bum; Kim, Deok-Ho
Source:
Journal of materials chemistry B 2017 v.5 no.13 pp. 2375-2389
ISSN:
2050-7518
Subject:
biocompatible materials; electroporation; medicine; nanoparticles; nucleic acids; phenotype; somatic cells; viability
Abstract:
... The cell reprogramming of somatic cells into pluripotent states and subsequent differentiation into certain phenotypes has helped progress regenerative medicine research and other medical applications. Recent research has used viral vectors to induce this reprogramming; however, limitations include low efficiency and safety concerns. In this review, we discuss how biomaterial methods offer potenti ...
DOI:
10.1039/c6tb03130g
PubMed:
28966790
PubMed Central:
PMC5616208

2. A core–shell metal–organic-framework (MOF)-based smart nanocomposite for efficient NIR/H₂O₂-responsive photodynamic therapy against hypoxic tumor cells

Author:
Cai, Hui-Juan; Shen, Ting-Ting; Zhang, Jian; Shan, Chang-Fu; Jia, Jian-Guo; Li, Xiang; Liu, Wei-Sheng; Tang, Yu
Source:
Journal of materials chemistry B 2017 v.5 no.13 pp. 2390-2394
ISSN:
2050-7518
Subject:
catalase; methylene blue; nanocomposites; nanoparticles; nanopores; neoplasm cells; oxygen; photochemotherapy; photosensitizing agents
Abstract:
... Core–shell MOF-based smart nanocomposite UCNPs/MB@ZIF-8@catalase (UCNPs = upconversion nanoparticles; MB = methylene blue; ZIF = zeolitic imidazolate framework) has been constructed for bio-imaging and efficient NIR/H₂O₂-responsive photodynamic therapy against hypoxic tumor cells. The nanoporous MOF shell can prevent aggregation of photosensitizers and serve as an efficient self-sufficient oxygen ...
DOI:
10.1039/c7tb00314e

3. A facile supramolecular approach to fabricate multifunctional upconversion nanoparticles as a versatile platform for drug loading, in vivo delivery and tumor imaging

Author:
Yuan, Yingying; Xu, Li; Dai, Shuyun; Wang, Min; Wang, Hangxiang
Source:
Journal of materials chemistry B 2017 v.5 no.13 pp. 2425-2435
ISSN:
2050-7518
Subject:
lipophilicity; water solubility; image analysis; aqueous solutions; intravenous injection; neoplasms; drugs; cytotoxicity; luminescence; polyethylene glycol; animal models; nanoparticles; solubilization; permeability; phospholipids
Abstract:
... Multifunctional upconversion nanoparticles (UCNPs) that can be implemented in theranostic applications are particularly attractive scaffolds for precise drug delivery. However, most of the current methods for drug formulation are technically complicated, thereby impeding their use in the clinic. Here, we report on the preparation of a lipophilic cytotoxic prodrug-integrated and polyethylene glycol ...
DOI:
10.1039/c6tb03381d

4. A facile water-stable MOF-based “off–on” fluorescent switch for label-free detection of dopamine in biological fluid

Author:
Cheng, Yue; Wu, Jie; Guo, Chao; Li, Xin-Ge; Ding, Bin; Li, Yan
Source:
Journal of materials chemistry B 2017 v.5 no.13 pp. 2524-2535
ISSN:
2050-7518
Subject:
amino acids; ascorbic acid; cadmium; coordination polymers; dopamine; fluorescence; fluorescent dyes; functional properties; iodine; metal ions; potassium permanganate; triazoles; uric acid
Abstract:
... As an emerging class of fluorescent probes, metal–organic frameworks (MOFs) have recently received great interest owing to their fascinating functional properties, intriguing tunable structures, high selectivity and good sensitivity. Herein, we present a novel strategy based on the application of a facile water-stable MOF {[Cd(μ₃-abtz)·2I]}ₙ (Abtz–CdI₂–MOF, abtz = 1-(4-aminobenzyl)-1,2,4-triazole) ...
DOI:
10.1039/c7tb00099e

5. Aptamer-functionalized neural recording electrodes for the direct measurement of cocaine in vivo

Author:
Taylor, I. Mitch; Du, Zhanhong; Bigelow, Emma T.; Eles, James R.; Horner, Anthony R.; Catt, Kasey A.; Weber, Stephen G.; Jamieson, Brian G.; Cui5057 Bioscience Tower 3, 3501 Fifth Ave., Pittsburgh, PA, 15260, USA. E-mail: xic11@pitt.edu; Tel: +1-412-383-6672., X. Tracy
Source:
Journal of materials chemistry B 2017 v.5 no.13 pp. 2445-2458
ISSN:
2050-7518
Subject:
brain; cocaine; dopamine; electrochemistry; electrodes; electrophysiology; encapsulation; equations; microdialysis; monitoring; neuropathology; oligonucleotides; pharmacokinetics; rats; sampling; silicon; sorption isotherms
Abstract:
... Cocaine is a highly addictive psychostimulant that acts through competitive inhibition of the dopamine transporter. In order to fully understand the region specific neuropathology of cocaine abuse and addiction, it is unequivocally necessary to develop cocaine sensing technology capable of directly measuring real-time cocaine transient events local to different brain regions throughout the pharmac ...
DOI:
10.1039/c7tb00095b
PubMed:
28729901
PubMed Central:
PMC5512874

6. Aromatic primary monoamine-based fast-response and highly specific fluorescent probes for imaging the biological signaling molecule nitric oxide in living cells and organisms

Author:
HuoThese authors contributed equally., Yingying; Miao, Junfeng; Li, Yaping; Shi, Yawei; Shi, Heping; Guo, Wei
Source:
Journal of materials chemistry B 2017 v.5 no.13 pp. 2483-2490
ISSN:
2050-7518
Subject:
aerobic conditions; animal models; cell communication; cytotoxicity; deamination; dehydroascorbic acid; fluorescence; fluorescent dyes; image analysis; macrophages; metal ions; nitric oxide; permeability; reactive oxygen species
Abstract:
... Nitric oxide (NO) is an important cellular signaling molecule involved in many physiological and pathological processes. To probe its spatiotemporal information in biosystems, a large number of NO fluorescent probes have been exploited in the past ten years. Among them, the o-phenylenediamine-based probes are the earliest developed and most versatile NO fluorescent probes to date. However, there a ...
DOI:
10.1039/c6tb03382b

7. Development of a unique family of two-photon full-color-tunable fluorescent materials for imaging in live subcellular organelles, cells, and tissues

Author:
Chen, Hua; Tang, Yonghe; Shang, Huiming; Kong, Xiuqi; Guo, Rui; Lin, Weiying
Source:
Journal of materials chemistry B 2017 v.5 no.13 pp. 2436-2444
ISSN:
2050-7518
Subject:
dyes; fluorescence; image analysis; lysosomes; tissues
Abstract:
... Full-color fluorescence imaging, which utilizes multiple fluorescent imaging agents with emission covering the whole visible spectrum in the same specimen, is a powerful approach to study molecular processes in living systems. To achieve two-photon full-color bioimaging, two-photon full-color-tunable fluorescent materials (with emission from the blue to near-infrared region) are highly desirable. ...
DOI:
10.1039/c7tb00174f

8. Electroconductive nanoengineered biomimetic hybrid fibers for cardiac tissue engineering

Author:
Allison, Shelby; Ahumada, Manuel; Andronic, Cristina; McNeill, Brian; Variola, Fabio; Griffith, May; Ruel, Marc; Hamel, Veronique; Liang, Wenbin; Suuronen, Erik J.; Alarcon, Emilio I.
Source:
Journal of materials chemistry B 2017 v.5 no.13 pp. 2402-2406
ISSN:
2050-7518
Subject:
biofilm; biomimetics; cardiomyocytes; collagen; electrical conductivity; electrical treatment; macrophages; nanosilver; tissue engineering
Abstract:
... We report for the first time the preparation of a fibrous material composed of surface grafted spherical nanosilver and collagen using one-step electrospinning. The resulting composite showed comparable morphology to the control without nanosilver, but had improved electrical conductivity. Under electrical stimulation, fibrous materials containing nanosilver increased connexin-43 expression and pr ...
DOI:
10.1039/c7tb00405b

9. Injectable tissue adhesive composite hydrogel with fibroblasts for treating skin defects

Author:
Zhu, Feiyan; Wang, Chen; Yang, Saina; Wang, Qian; Liang, Fuxin; Liu, Chenyang; Qiu, Dong; Qu, Xiaozhong; Hu, Zhongbo; Yang, Zhenzhong
Source:
Journal of materials chemistry B 2017 v.5 no.13 pp. 2416-2424
ISSN:
2050-7518
Subject:
adhesion; animal models; aqueous solutions; chitosan; crosslinking; encapsulation; fibroblasts; gelation; hair follicles; hydrogels; mice; nanoparticles; polymers; rheology; silica; solubilization
Abstract:
... In this work, an injectable composite hydrogel was synthesized via a unique way of crosslinking glycol chitosan (GC) with silica nano-particles (SiNP) through non-chemical interactions, and was then applied as a kind of wound dressing. Gelation was achieved through the incorporation of SiNPs with the GC segments in aqueous solution, therefore strictly confining the movement of the solubilized poly ...
DOI:
10.1039/c7tb00384f

10. In vitro osteogenic induction of bone marrow mesenchymal stem cells with a decellularized matrix derived from human adipose stem cells and in vivo implantation for bone regeneration

Author:
WeiThese authors contributed equally., Wei; Li, Jipeng; Chen, Shuo; Chen, Mingjiao; Xie, Qing; Sun, Hao; Ruan, Jing; Zhou, Huifang; Bi, Xiaoping; Zhuang, Ai; You, Zhengwei; Gu, Ping; Fan, Xianqun
Source:
Journal of materials chemistry B 2017 v.5 no.13 pp. 2468-2482
ISSN:
2050-7518
Subject:
alizarin; alkaline phosphatase; bone formation; bone marrow; diacylglycerols; extracellular matrix; fluorescent labeling; gene expression regulation; histology; humans; mesenchymal stromal cells; micro-computed tomography; proteins; rats; staining; stem cells; tissue engineering; tissue repair
Abstract:
... Tissue engineering technology that adopts mesenchymal stem cells combined with scaffolds presents a promising strategy for tissue regeneration. Human adipose-derived stem cells (hADSCs) have attracted considerable attention in bone engineering for their osteogenic potential. The extracellular matrix (ECM) is critical for the stem cell niche as a physical support and is known to be able to maintain ...
DOI:
10.1039/c6tb03150a

11. In vivo toxicological assessment of electrochemically engineered anodic alumina nanotubes: a study of biodistribution, subcutaneous implantation and intravenous injection

Author:
Wang, Ye; Zinonos, Irene; Zysk, Aneta; Panagopoulos, Vasilios; Kaur, Gagandeep; Santos, Abel; Losic, Dusan; Evdokiou, Andreas
Source:
Journal of materials chemistry B 2017 v.5 no.13 pp. 2511-2523
ISSN:
2050-7518
Subject:
aluminum oxide; animal models; biocompatibility; body weight; electrochemistry; fluorescence; hepatotoxicity; histopathology; image analysis; inflammation; intravenous injection; liver; mice; mortality; nanotubes; spleen; toxicity testing
Abstract:
... Electrochemically engineered anodic alumina nanotubes (AANTs) have recently shown good in vitro biocompatibility. However, in vivo toxicological and pathological studies are required to clarify the bio-safety of this novel nanomaterial. Herein, we present a pioneering pilot toxicity study on AANTs in immune-competent murine models (Balb/c mice, 8 weeks). AANTs were administered by intravenous (IV) ...
DOI:
10.1039/c7tb00222j

12. Linker-free covalent immobilization of nisin using atmospheric pressure plasma induced grafting

Author:
Aveyard, Jenny; Bradley, James W.; McKay, Kirsty; McBride, Fiona; Donaghy, David; Raval, Rasmita; D'Sa, Raechelle A.
Source:
Journal of materials chemistry B 2017 v.5 no.13 pp. 2500-2510
ISSN:
2050-7518
Subject:
Fourier transform infrared spectroscopy; Listeria monocytogenes; Staphylococcus aureus; X-ray photoelectron spectroscopy; antimicrobial peptides; antimicrobial properties; atmospheric pressure; atomic force microscopy; chemical bonding; contact angle; food pathogens; mass spectrometry; nisin; pH; plate count; polystyrenes
Abstract:
... The linker-free covalent immobilization of polymers on surfaces has the potential to impart new properties and functions to surfaces for a wide range of applications. However, most current methods for the production of these surfaces involve multiple chemical steps and do not have a high degree of control over the chemical functionalities at the surface. A comprehensive study detailing the facile ...
DOI:
10.1039/c7tb00113d

13. Photothermally induced accumulation and retention of polymeric nanoparticles in tumors for long-term fluorescence imaging

Author:
He, Haozhe; Zheng, Xiaohua; Zhang, Jianxu; Liu, Shi; Hu, Xiuli; Xie, Zhigang
Source:
Journal of materials chemistry B 2017 v.5 no.13 pp. 2491-2499
ISSN:
2050-7518
Subject:
diagnostic techniques; fluorescence; image analysis; nanoparticles; neoplasms; particle size; phase transition; photobleaching; polymers; temperature
Abstract:
... The development of long-term tumor imaging is of great importance for effective theranostic systems. In this study, a temperature-responsive poly(ether amine) with a phase transition temperature around 43 °C was used to encapsulate indocyanine green (ICG), which is a near infrared fluorescent and photothermal agent. Upon photothermal treatment, the polymeric nanoparticles underwent an increase in ...
DOI:
10.1039/c6tb02650h

14. Preparation of an antimicrobial surface by direct assembly of antimicrobial peptide with its surface binding activity

Author:
Chen, Junjian; Zhu, Yuchen; Song, Yancheng; Wang, Lin; Zhan, Jiezhao; He, Jingcai; Zheng, Jian; Zhong, Chunting; Shi, Xuetao; Liu, Sa; Ren, Li; Wang, Yingjun
Source:
Journal of materials chemistry B 2017 v.5 no.13 pp. 2407-2415
ISSN:
2050-7518
Subject:
Escherichia coli; Staphylococcus aureus; X-ray photoelectron spectroscopy; antimicrobial peptides; antimicrobial properties; atomic force microscopy; bacterial infections; biocompatible materials; bone marrow; contact angle; cytotoxicity; gold; hydroxyapatite; mesenchymal stromal cells; polymethylmethacrylate; quartz crystal microbalance; titanium
Abstract:
... Antimicrobial peptides (AMPs) are a broad prospect for clinical application against bacterial infections of biomaterials. However, a bottleneck exists as there is a lack of simple technology to prepare AMPs on biomaterials with sufficient activity, as the activity of AMP is dependent on the correct orientation on the biomaterial. In the present study, based on the conventional AMP (Tet213: KRWWKWW ...
DOI:
10.1039/c6tb03337g

15. Targeted CT/MR dual mode imaging of human hepatocellular carcinoma using lactobionic acid-modified polyethyleneimine-entrapped gold nanoparticles

Author:
LiThese authors contributed equally to this work., Du; Yang, Jia; Wen, Shihui; Shen, Mingwu; Zheng, Linfeng; Zhang, Guixiang; Shi, Xiangyang
Source:
Journal of materials chemistry B 2017 v.5 no.13 pp. 2395-2401
ISSN:
2050-7518
Subject:
X-radiation; hepatoma; humans; image analysis; magnetic resonance imaging; nanogold; tomography
Abstract:
... We report the synthesis and characterization of lactobionic acid-modified multifunctional polyethyleneimine-entrapped gold nanoparticles for targeted dual mode computed tomography/magnetic resonance imaging. The nanodevice displays good X-ray attenuation properties, good r₁ relaxivity, and hepatocellular carcinoma targeting specificity, and can be used for targeted CT/MR imaging of hepatocellular ...
DOI:
10.1039/c7tb00286f

16. Versatile graphene-based photothermal nanocomposites for effectively capturing and killing bacteria, and for destroying bacterial biofilms

Author:
JiaThese authors contributed equally to this work., Xinghang; Ahmad, Israr; Yang, Rong; Wang, Chen
Source:
Journal of materials chemistry B 2017 v.5 no.13 pp. 2459-2467
ISSN:
2050-7518
Subject:
Escherichia coli; Staphylococcus aureus; antibacterial properties; antibiotics; bacteria; bacterial infections; biofilm; chitosan; graphene; graphene oxide; heat; hot water treatment; irradiation; magnetic materials; magnetism; nanocomposites; near infrared radiation; therapeutics
Abstract:
... Bacterial infection is a worldwide health problem. Finding new potential antibacterial materials and developing advanced treatment strategies are becoming increasingly important and urgent. Herein, a versatile graphene-based photothermal nanocomposite was prepared for rapidly capturing and effectively eliminating both Gram-positive Staphylococcus aureus (S. aureus) and Gram-negative Escherichia co ...
DOI:
10.1039/c6tb03084j