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You searched for: Journal Journal of materials chemistry B Remove constraint Journal: Journal of materials chemistry B Publication Year 2016 Remove constraint Publication Year: 2016 Source 2016 v.4 no.13 Remove constraint Source: 2016 v.4 no.13
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1. Amino acid side chains affect the bioactivity of designed short peptide amphiphiles

Author:
Chen, Cuixia; Hu, Jing; Yang, Cheng; Zhang, Yu; Wang, Fang; Mu, Quanmeng; Pan, Fang; Xu, Hai; Lu, Jian Ren
Source:
Journal of materials chemistry B 2016 v.4 no.13 pp. 2359-2368
ISSN:
2050-7518
Subject:
amino acids; antibacterial properties; antineoplastic activity; bacteria; carbon; cytotoxicity; hydrophobicity; mammals; neoplasm cells; peptides; surfactants
Abstract:
... The artificially designed amphiphilic peptide G(IIKK)₃I-NH₂ has been shown to be highly effective at killing bacteria and inhibiting the growth of tumor cells whilst remaining benign to normal mammalian cells. Herein we report how the side chain length and branching of constituent amino acids affect these bioactivities. Two peptide groups were designed by utilizing G(IIKK)₃I-NH₂ as the base templa ...
DOI:
10.1039/c6tb00155f

2. A multiscale study of bacterial proliferation modes within novel E. coli@Si(HIPE) hybrid macrocellular living foams

Author:
DepardieuPresent address: Max Planck Institute of Colloids and Interfaces, Potsdam-Golm Science Park, Am Mühlenberg 1 OT Golm 14476 Potsdam, Germany., Martin; Viaud, Mélanie; Buguin, Axel; Livage, Jacques; Sanchez, Clément; Backov, Rénal
Source:
Journal of materials chemistry B 2016 v.4 no.13 pp. 2290-2303
ISSN:
2050-7518
Subject:
Escherichia coli; bacteria; bacterial growth; foams; growth models; nutrients; silica gel; silicon
Abstract:
... For the first time the study at various length scales of E. coli proliferation modes within Si(HIPE) inorganic macrocellular foams is proposed. Both qualitatively and semi-quantitatively, bacterial proliferation within the foam is not homogeneous and is directly linked to the random distribution of Si(HIPE) macroscopic cells. When inoculated in a nutrient loaded Si(HIPE), the bacterial growth is e ...
DOI:
10.1039/c5tb02554k

3. Anisamide-targeted gold nanoparticles for siRNA delivery in prostate cancer – synthesis, physicochemical characterisation and in vitro evaluation

Author:
Fitzgerald, Kathleen A.; Rahme, Kamil; Guo, Jianfeng; Holmes, Justin D.; O'DriscollCavanagh Pharmacy Building, School of Pharmacy, College Road, University College Cork, Cork, Ireland. E-mail: caitriona.odriscoll@ucc.ie; Fax: +353 21 490 1656; Tel: +35321490 1396., Caitriona M.
Source:
Journal of materials chemistry B 2016 v.4 no.13 pp. 2242-2252
ISSN:
2050-7518
Subject:
adsorption; blood proteins; blood serum; death; genes; in vitro studies; ligands; men; metastasis; moieties; nanogold; nanoparticles; nanospheres; neoplasm cells; prostatic neoplasms; small interfering RNA; therapeutics; toxicity; translation (genetics)
Abstract:
... Metastatic prostate cancer is a leading cause of cancer-related death in men and current chemotherapies are largely inadequate in terms of efficacy and toxicity. Hence improved treatments are required. The application of siRNA as a cancer therapeutic holds great promise. However, translation of siRNA into the clinic is dependent on the availability of an effective delivery system. Gold nanoparticl ...
DOI:
10.1039/c6tb00082g

4. A synergic nanoantioxidant based on covalently modified halloysite–trolox nanotubes with intra-lumen loaded quercetin

Author:
Massaro, Marina; Riela, Serena; Guernelli, Susanna; Parisi, Filippo; Lazzara, Giuseppe; Baschieri, Andrea; Valgimigli, Luca; Amorati, Riccardo
Source:
Journal of materials chemistry B 2016 v.4 no.13 pp. 2229-2241
ISSN:
2050-7518
Subject:
2,2-diphenyl-1-picrylhydrazyl; acetonitrile; alpha-tocopherol; antioxidant activity; antioxidants; autoxidation; chemical bonding; chlorobenzene; free radicals; halloysite; nanotubes; quercetin; synergism
Abstract:
... We describe the preparation and properties of the first example of a synergic nanoantioxidant, obtained by different functionalizations of the external surface and the inner lumen of halloysite nanotubes (HNTs). Trolox, a mimic of natural α-tocopherol, was selectively grafted on the HNT external surface; while quercetin, a natural polyphenolic antioxidant, was loaded into the inner lumen to afford ...
DOI:
10.1039/c6tb00126b

5. Facile synthesis of highly uniform selenium nanoparticles using glucose as the reductant and surface decorator to induce cancer cell apoptosis

Author:
NieThese authors contributed equally to the work., Tianqi; Wu, Hualian; Wong, Ka-Hing; Chen, Tianfeng
Source:
Journal of materials chemistry B 2016 v.4 no.13 pp. 2351-2358
ISSN:
2050-7518
Subject:
apoptosis; aqueous solutions; biocompatibility; cytotoxicity; drug delivery systems; glucose; humans; mitochondria; nanoparticles; neoplasm cells; neoplasms; reducing agents; selenium; sodium selenite; temperature
Abstract:
... Selenium nanoparticles (SeNPs) have attracted increasing attention due to their potential application as an effective drug delivery system. However, the conventional synthetic methods are mostly confined to solution-based synthesis that are time consuming and with low efficiency. Herein, we demonstrate the facile synthesis of highly uniform SeNPs using glucose as the reductant and surface decorato ...
DOI:
10.1039/c5tb02710a

6. Functionalized halloysite nanotube by chitosan grafting for drug delivery of curcumin to achieve enhanced anticancer efficacy

Author:
LiuThe authors contributed equally to this work., Mingxian; Chang, Yanzhou; Yang, Jing; You, Yuanyuan; He, Rui; Chen, Tianfeng; Zhou, Changren
Source:
Journal of materials chemistry B 2016 v.4 no.13 pp. 2253-2263
ISSN:
2050-7518
Subject:
Fourier transform infrared spectroscopy; antineoplastic activity; antineoplastic agents; apoptosis; blood circulation; blood serum; cell lines; chitosan; coatings; contact angle; curcumin; cytotoxicity; flow cytometry; fluorescence microscopy; halloysite; inhibitory concentration 50; nanotubes; neoplasm cells; neoplasms; therapeutics; thermogravimetry; transmission electron microscopy; zeta potential
Abstract:
... Halloysite nanotubes (HNTs) have a unique tubular structure in nanoscale, and have shown potential as novel carriers for various drugs. Coating the nanotubes with a hydrophilic polymer shell can significantly decrease the toxicity and provide colloidal stability during blood circulation. Here, we synthesized chitosan grafted HNTs (HNTs-g-CS) and investigated their potential as a nano-formulation f ...
DOI:
10.1039/c5tb02725j

7. Gelatin methacrylate/carboxybetaine methacrylate hydrogels with tunable crosslinking for controlled drug release

Author:
Lai, T. C.; YuThese two authors contributed equally to the work., J.; Tsai, W. B.
Source:
Journal of materials chemistry B 2016 v.4 no.13 pp. 2304-2313
ISSN:
2050-7518
Subject:
angiogenesis; cell viability; crosslinking; drug delivery systems; drugs; gelatin; hydrogels; in vivo studies; mechanical properties; tissue engineering; vascular endothelial growth factors
Abstract:
... In this work, methacrylated gelatin (GelMA) based hydrogels were fabricated with carboxybetaine methacrylate (CBMA) to manipulate the properties of the gelatin-based hydrogels, since CBMA is a much smaller compound compared to gelatin. With the incorporation of CBMA, these hydrogels demonstrated better mechanical properties, a slower degradation rate, and a controlled drug release rate compared wi ...
DOI:
10.1039/c5tb02518d

8. Preparation of nanosized coacervates of positive and negative starch derivatives intended for pulmonary delivery of proteins

Author:
Barthold, S.; Kletting, S.; Taffner, J.; de Souza Carvalho-Wodarz, C.; Lepeltier, E.; Loretz, B.; Lehr, C.-M.
Source:
Journal of materials chemistry B 2016 v.4 no.13 pp. 2377-2386
ISSN:
2050-7518
Subject:
alpha-amylase; aqueous solutions; atomization; biocompatibility; biodegradability; drug delivery systems; drugs; encapsulation; humans; immunoglobulin G; insulin; isoelectric point; liquid-air interface; molecular weight; nanoparticles; pH; peptides; polymers; ribonucleases; stabilizers; starch; vancomycin; water solubility; zeta potential
Abstract:
... Proteins and peptides represent a large fraction of the compounds currently in drug development pipelines. Their application however often depends on the use of carrier systems. Nanoparticles (NPs) are widely used such carrier systems for protein delivery. The aim of this study was to design a new drug delivery system (DDS), prepared under mild conditions in aqueous solution without the requiremen ...
DOI:
10.1039/c6tb00178e

9. Reduction-responsive fluorescence off–on BODIPY–camptothecin conjugates for self-reporting drug release

Author:
Liu, Yang; Pei, Qing; Chen, Li; Li, Zhensheng; Xie, Zhigang
Source:
Journal of materials chemistry B 2016 v.4 no.13 pp. 2332-2337
ISSN:
2050-7518
Subject:
aqueous solutions; boron; cyclization reactions; disulfide bonds; dithiothreitol; drugs; emissions; energy transfer; fluorescence; hydrophobicity; monitoring; nanomedicine; nanoparticles; neoplasm cells; neoplasms; permeability; therapeutics
Abstract:
... A reduction-responsive fluorescence off–on theranostic prodrug with self-reporting drug release was constructed based on boron dipyrromethene (BODIPY) and therapeutic drug camptothecin (CPT) with a long flexible disulfide linker. Treatment with dithiothreitol (DTT) induced cleavage of the disulfide bond, followed by intramolecular cyclization reaction to release free CPT, simultaneously perturbing ...
DOI:
10.1039/c6tb00009f

10. RGD-decorated redox-responsive d-α-tocopherol polyethylene glycol succinate–poly(lactide) nanoparticles for targeted drug delivery

Author:
Guo, Yuanyuan; Niu, Boning; Song, Qingle; Zhao, Yongdan; Bao, Yuling; Tan, Songwei; Si, Luqin; Zhang, Zhiping
Source:
Journal of materials chemistry B 2016 v.4 no.13 pp. 2338-2350
ISSN:
2050-7518
Subject:
P-glycoproteins; adverse effects; biodegradability; composite polymers; cytotoxicity; drugs; endocytosis; growth retardation; half life; humans; in vivo studies; integrins; melanoma; mice; nanocarriers; nanoparticles; neoplasm cells; paclitaxel; particle size; peptides; polyethylene glycol; sarcoma
Abstract:
... Developing multifunctional nanoparticles (NPs) to improve therapeutic efficacy is highly desirable in cancer therapy. In an attempt to respond to such a challenge, a novel copolymer, d-α-tocopherol polyethylene glycol succinate-SS-poly(lactide) (TPGS-SS-PLA) with a disulfide linkage between the TPGS and PLA units, was synthesized for paclitaxel (PTX) delivery. PTX-loaded NPs were fabricated using ...
DOI:
10.1039/c6tb00055j

11. Roles of calcium phosphate-mediated integrin expression and MAPK signaling pathways in the osteoblastic differentiation of mesenchymal stem cells

Author:
Chen, Xuening; Wang, Jing; Chen, Ying; Cai, Hanxu; Yang, Xiao; Zhu, Xiangdong; Fan, Yujiang; Zhang, Xingdong
Source:
Journal of materials chemistry B 2016 v.4 no.13 pp. 2280-2289
ISSN:
2050-7518
Subject:
Western blotting; adsorption; biocompatible materials; blood proteins; bone formation; calcium phosphates; cell adhesion; ceramics; fluorescent antibody technique; focal adhesions; gene expression regulation; genes; glass; integrins; mesenchymal stromal cells; mitogen-activated protein kinase; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; signal transduction; staining; transmembrane proteins
Abstract:
... Osteoinduction of calcium phosphate (CaP) ceramics has been widely confirmed and accepted, but the underlying mechanism has not been fully elucidated. This study investigates the early biomolecular events that contributed to the transduction of extracellular material cues outside in, when MSCs were cultured in osteoinductive biphasic calcium phosphate (BCP) ceramics, and explores their roles in BC ...
DOI:
10.1039/c6tb00349d

12. Squid beak inspired water processable chitosan composites with tunable mechanical properties

Author:
Zhang, Xiaolin; Hassanzadeh, Pegah; Miyake, Takeo; Jin, Jungho; Rolandi, Marco
Source:
Journal of materials chemistry B 2016 v.4 no.13 pp. 2273-2279
ISSN:
2050-7518
Subject:
beak; catecholamines; chitin; chitosan; crosslinking; exoskeleton; hardness; mechanical properties; mineralization; mouth; nanofibers; squid
Abstract:
... Natural biological composites often couple light weight with tunable and spatially controlled mechanical properties including stiffness, toughness, and hardness. Examples include the toughness of seashells, the hardness of the chiton tooth, and the stiffness gradient of the squid beak. While seashells and the chiton tooth have a mineralized inorganic component, the squid beak is entirely organic. ...
DOI:
10.1039/c6tb00106h

13. Synthesis of a three-layered SiO₂@Au nanoparticle@polyaniline nanocomposite and its application in simultaneous electrochemical detection of uric acid and ascorbic acid

Author:
Hou, Ting; Gai, Panpan; Song, Mengmeng; Zhang, Shuhan; Li, Feng
Source:
Journal of materials chemistry B 2016 v.4 no.13 pp. 2314-2321
ISSN:
2050-7518
Subject:
ascorbic acid; catalytic activity; dielectric spectroscopy; dispersibility; electrical conductivity; electrochemistry; electrodes; nanocomposites; nanomaterials; oxidation; uric acid
Abstract:
... Novel nanocomposites fabricated by incorporating different types of nanomaterials, especially inorganic and organic nanomaterials, have attracted much attention, and shown promising prospects in the applications in biological research fields. Herein, we propose a facile method to synthesize a novel three-layered SiO₂@Au nanoparticle@polyaniline nanocomposite, which exhibited excellent electrical c ...
DOI:
10.1039/c5tb02765a

14. The immobilization of a direct thrombin inhibitor to a polyurethane as a nonthrombogenic surface coating for extracorporeal circulation

Author:
Yu, Jane; Brisbois, Elizabeth; Handa, Hitesh; Annich, Gail; Meyerhoff, Mark; Bartlett, Robert; Major, Terry
Source:
Journal of materials chemistry B 2016 v.4 no.13 pp. 2264-2272
ISSN:
2050-7518
Subject:
anticoagulant activity; biocompatible materials; blood platelets; cell adhesion; coatings; crosslinking; fibrin; models; poly(vinyl chloride); polyurethanes; rabbits; thrombin; thrombosis
Abstract:
... A biomaterial with both antithrombin and antiplatelet properties is the ideal surface for use in extracorporeal circulation (ECC) as it targets both fibrin generation and platelet adhesion. A hemocompatible surface coating avoids the need for systemic anticoagulation by providing a local anticoagulant effect at the polymer–blood interface. Previous work has demonstrated the potential use of argatr ...
DOI:
10.1039/c5tb02419f

15. The potential of peptide dendron functionalized and gadolinium loaded mesoporous silica nanoparticles as magnetic resonance imaging contrast agents

Author:
Guo, Chunhua; Hu, Jiani; Bains, Ashika; Pan, Dayi; Luo, Kui; Li, Ning; Gu, Zhongwei
Source:
Journal of materials chemistry B 2016 v.4 no.13 pp. 2322-2331
ISSN:
2050-7518
Subject:
biosafety; copper; copper nanoparticles; gadolinium; image analysis; magnetic resonance imaging; nanohybrids; peptides; porous media; silica; toxicity testing
Abstract:
... In this study, an MSN–dendron–Gd conjugate based nanoprobe was synthesized using an easy and efficient method with high purity and the nanoprobe was studied for its efficiency in contrast imaging applications. The nanoprobe was synthesized using the Cu(i)-catalyzed azide–alkyne based method, which overcame the challenges of stereospecific blockade of mesoporous silica nanohybrid synthesis. Moreove ...
DOI:
10.1039/c5tb02709h

16. The stimulation of osteogenic differentiation of embryoid bodies from human induced pluripotent stem cells by akermanite bioceramics

Author:
DongThese authors contributed equally., Xixi; Li, Haiyan; Zhou, Yanling; Ou, Long; Cao, Junkai; Chang, Jiang
Source:
Journal of materials chemistry B 2016 v.4 no.13 pp. 2369-2376
ISSN:
2050-7518
Subject:
alkaline phosphatase; ascorbic acid; biocompatible materials; bone formation; bones; cell growth; ceramics; collagen; culture media; dexamethasone; genetic markers; humans; induced pluripotent stem cells; osteocalcin; sowing; tissue engineering
Abstract:
... Induced pluripotent stem cells (iPSCs) have great potential as seed cells for tissue engineering applications. Previous studies have shown that iPSCs could be induced to differentiate into bone forming cells. However, in a tissue engineering approach, seeding cells in biomaterials is required, and the effect of biomaterials on cell growth and differentiation is critical for the success of the form ...
DOI:
10.1039/c6tb00398b