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You searched for: Journal name Journal of medicinal food Remove constraint Journal name: Journal of medicinal food Publication year rev 7981-2019 Remove constraint Publication year rev: 7981-2019 Subject term neoplasms Remove constraint Subject term: neoplasms Text availability Citation in PubAg Remove constraint Text availability: Citation in PubAg
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1. Assessing Anticancer Potential of Blueberry Flavonoids, Quercetin, Kaempferol, and Gentisic Acid, Through Oxidative Stress and Apoptosis Parameters on HCT-116 Cells

Author:
Ebru Demirel Sezer; Latife Merve Oktay; Elif Karadadaş; Hikmet Memmedov; Nur Selvi Gunel; Eser Sözmen
Source:
Journal of medicinal food 2019 v.22 no.11 pp. 1118-1126
ISSN:
1557-7600
Subject:
2,5-dihydroxybenzoic acid; Vaccinium myrtillus; antineoplastic activity; antineoplastic agents; antioxidant activity; antioxidants; apoptosis; blueberries; cytotoxicity; diet; flow cytometry; fruit extracts; kaempferol; liquid chromatography; neoplasms; oxidants; oxidative stress; polyphenols; protein composition; protein microarrays; proteins; quercetin; tandem mass spectrometry; therapeutics
Abstract:
... In recent years, natural products gained popularity with their anti-inflammatory and antioxidant effects mediated by chemical compounds within their composition. Study results offering them as palliative therapy options in cancer or as anticancer agents with high levels of cytotoxicity brought a new approach to combine cancer treatment protocols with these products. From a different perspective, e ...
DOI:
10.1089/jmf.2019.0098

2. BST-104, a Water Extract of Lonicera japonica, Has a Gastroprotective Effect via Antioxidant and Anti-Inflammatory Activities

Author:
Byoung Wook Bang; Dongsun Park; Kye Sook Kwon; Don Haeng Lee; Min-Jung Jang; Sun Kyu Park; Jeom-Yong Kim
Source:
Journal of medicinal food 2019 v.22 no.2 pp. 140-151
ISSN:
1557-7600
Subject:
Lonicera japonica; animal models; anti-inflammatory activity; antioxidant activity; antioxidants; catalase; chlorogenic acid; gastritis; gene expression regulation; glutathione; hexosamines; hydrochloric acid; interleukin-1beta; malondialdehyde; mucus; neoplasms; oral administration; oxidation; oxidative stress; prostaglandins; quantitative polymerase chain reaction; sialic acid; stomach ulcers; superoxide dismutase; tissues; transcription factor NF-kappa B; tumor necrosis factor-alpha
Abstract:
... The gastroprotective effects of BST-104 (a water extract of Lonicera japonica) and the mechanisms involved were investigated in murine models of gastritis and peptic ulcer. The gastroprotective effects of BST-104 and its active components were evaluated in rat models of HCl/ethanol-induced gastritis and acetic acid-induced gastric ulcer. After orally administering BST-104, chlorogenic acid, rebami ...
DOI:
10.1089/jmf.2018.4231

3. Chemopreventive Activity of Red Ginseng Oil in a Mouse Model of Azoxymethane/Dextran Sulfate Sodium-Induced Inflammation-Associated Colon Carcinogenesis

Author:
Van-Long Truong; Min Ji Bak; Woo-Sik Jeong
Source:
Journal of medicinal food 2019 v.22 no.6 pp. 578-586
ISSN:
1557-7600
Subject:
Panax; animal models; antioxidant enzymes; azoxymethane; carcinogenesis; catalase; chemoprevention; colitis; colon; dextran sulfate; drinking water; inducible nitric oxide synthase; inflammation; interleukin-1beta; interleukin-6; lipid peroxidation; males; mice; neoplasms; nitric oxide; oils; phosphorylation; prostaglandin synthase; superoxide dismutase; tumor necrosis factor-alpha
Abstract:
... Our previous studies have demonstrated antioxidant and cytoprotective properties of red ginseng oil (RGO). However, the role of RGO in models of intestinal inflammation has not been elucidated. In this study, we evaluated the chemopreventive effect of RGO in a mouse model of azoxymethane/dextran sulfate sodium (AOM/DSS)-induced colitis and explored its underlying mechanisms. Male C57BL/6 mice were ...
DOI:
10.1089/jmf.2018.4328

4. Cottonseed Oil Protects Against Intestinal Inflammation in Dextran Sodium Sulfate-Induced Inflammatory Bowel Disease

Author:
Jin-Sil Park; JeongWon Choi; Sun-Hee Hwang; Jae-Kyung Kim; Eun-Kyung Kim; Seon-Young Lee; Bo-In Lee; Sung-Hwan Park; Mi-La Cho
Source:
Journal of medicinal food 2019 v.22 no.7 pp. 672-679
ISSN:
1557-7600
Subject:
actin; animal models; coconut oil; colitis; collagen; colon; corn oil; cottonseed oil; dextran; dietary fat; fibrosis; inflammation; interleukin-17; interleukin-6; intestinal microorganisms; metabolism; mice; muscles; neoplasms; olive oil; oxidative stress; protective effect; sodium; sodium sulfate; therapeutics; tumor necrosis factor-alpha; weight loss
Abstract:
... Dietary products may protect against inflammatory bowel disease (IBD) through mechanisms such as forming gut microbiota structures and providing substrates for microbial metabolism. Recently, many studies have been conducted on diets that potentially alleviate or suppress IBD development. To assess the efficacy of dietary oils in treating IBD, we examined the protective effects of olive oil, cocon ...
DOI:
10.1089/jmf.2018.4323

5. Cyanidin 3-Rutinoside, an Anthocyanin Pigment of Schisandra chinensis Baill, Inhibits Allergic Inflammation

Author:
Yong-Deok Jeon; Aye Aye; Young-Jae Song; Yun-Hoe Kim; Ju-Ryoun Soh; Jong-Sik Jin
Source:
Journal of medicinal food 2019 v.22 no.7 pp. 703-712
ISSN:
1557-7600
Subject:
Schisandra chinensis; antioxidants; asthma; atopic dermatitis; bioactive properties; inflammation; interleukin-6; keracyanin; neoplasms; phosphorylation; secretion; therapeutics; transcription factor NF-kappa B; tumor necrosis factor-alpha
Abstract:
... The occurrence of allergy-mediated inflammatory diseases such as asthma and atopic dermatitis have increased, but comprehensive treatment remains difficult. Previous studies have shown that Schisandra chinensis Baill has antioxidant, antidiabetic, and antitumorigenic effects. Cyanidin 3-rutinoside (CR) is the major anthocyanin pigment of S. chinensis. However, the biological effects of CR have bee ...
DOI:
10.1089/jmf.2018.4346

6. Effect of Morinda citrifolia and Annona muricata on Erhlich Tumor Cells in Swiss Albino Mice and In Vitro Fibroblast Cells

Author:
Cleber da Silveira Torres; Francisnaira da Silva Santos; Elen Landgraf Guiguer; Adriano Cressoni de Araújo; Sandra Maria Barbalho; Patrícia Cincotto dos Santos Bueno; Maricelma Silva Soares de Souza; Danilo Antonini Alves; Marcelo Lancellott; Haydee Maria Moreira
Source:
Journal of medicinal food 2019 v.22 no.1 pp. 46-51
ISSN:
1557-7600
Subject:
Annona muricata; Morinda citrifolia; albino; ascites; carbon dioxide; carcinogenesis; cytotoxicity; fetal bovine serum; fibroblasts; fruits; juices; mechanism of action; medicine; neoplasm cells; neoplasms; patients; sodium chloride; survival rate
Abstract:
... Morinda citrifolia (MC) and Annona muricata (AM) are popularly used for the treatment of several diseases, including cancer. Our objective was to evaluate the effects of the juice of the MC fruit, and the ethanolic extract of AM leaves on Erhlich tumor cells, in mice and in vitro fibroblastic cells. The animals were divided into G1 and G2: controls; G3: treated with AM, and G4 juice: treated with ...
DOI:
10.1089/jmf.2018.0061

7. Effects of Green Wheat (Triticum turgidum) and Common Wheat (Triticum aestivum) on the Metabolic Profile of Wistar Rats

Author:
Patrícia Cincotto dos Santos Bueno; Sandra Maria Barbalho; Élen Landgraf Guiguer; Maricelma da Silva Soares de Souza; Isabela Ramos Araújo de Medeiros; Isabella Vasconcelos Zattiti; Manuela dos Santos Bueno; Giovanna Soares Nutels; Ricardo de Alvares Goulart; Adriano Cressoni Araújo
Source:
Journal of medicinal food 2019 v.22 no.12 pp. 1222-1225
ISSN:
1557-7600
Subject:
CCR1 receptor; CCR2 receptor; Triticum aestivum; Triticum turgidum; antioxidants; blood glucose; cardiovascular diseases; diabetes; diet; health promotion; high density lipoprotein cholesterol; homeostasis; laboratory animals; low density lipoprotein cholesterol; neoplasms; obesity; phytochemicals; rats; risk factors; triacylglycerols; visceral fat; wheat; whole grain foods
Abstract:
... Studies have shown that the consumption of a diet containing whole grains may improve metabolic homeostasis and is related to the reduction of risk factors for the development of obesity, diabetes, cardiovascular diseases, and cancer. We aimed to investigate the effects of Triticum aestivum and Triticum turgidum on the metabolic profile of Wistar rats. Animals were divided into G1 (control group), ...
DOI:
10.1089/jmf.2019.0089

8. Effects of Silibinin Against Prothrombin Kringle-2-Induced Neurotoxicity in the Nigrostriatal Dopaminergic System In Vivo

Author:
Eunju Leem; Yong-Seok Oh; Won-Ho Shin; Byung Kwan Jin; Jae Yeong Jeong; Minsang Shin; Dong Woon Kim; Jin-Hyeok Jang; Hyung-Jun Kim; Chang Man Ha; Un Ju Jung; Gyeong Joon Moon; Sang Ryong Kim
Source:
Journal of medicinal food 2019 v.22 no.3 pp. 277-285
ISSN:
1557-7600
Subject:
Alzheimer disease; Parkinson disease; Silybum marianum; adults; anti-inflammatory activity; brain; death; dopamine; flavonoids; immunohistochemistry; inducible nitric oxide synthase; inflammation; interleukin-1beta; metabolites; mice; mitogen-activated protein kinase; neoplasms; neuroglia; neurons; neurotoxicity; prothrombin; signal transduction; staining; therapeutics; thrombin; tumor necrosis factor-alpha
Abstract:
... Parkinson's disease (PD) and Alzheimer's disease exhibit common features of neurodegenerative diseases and can be caused by numerous factors. A common feature of these diseases is neurotoxic inflammation by activated microglia, indicating that regulation of microglial activation is a potential mechanism for preserving neurons in the adult brain. Recently, we reported that upregulation of prothromb ...
DOI:
10.1089/jmf.2018.4266

9. Isothiocyanate from Broccoli, Sulforaphane, and Its Properties

Author:
Alena Vanduchova; Pavel Anzenbacher; Eva Anzenbacherova
Source:
Journal of medicinal food 2019 v.22 no.2 pp. 121-126
ISSN:
1557-7600
Subject:
Brassicaceae; autism; biotransformation; broccoli; cabbage; cardiovascular diseases; cauliflower; clinical trials; glucoraphanin; glutathione; kale; medicine; metabolites; models; neoplasms; osteoporosis; risk; sulforaphane; thioglucosidase
Abstract:
... Sulforaphane is an isothiocyanate occurring in stored form as glucoraphanin in cruciferous vegetables such as cabbage, cauliflower, and kale, and at high levels in broccoli especially in broccoli sprouts. Glucoraphanin requires the plant enzyme myrosinase for converting it into sulforaphane. Sulforaphane is metabolized through mercapturic acid pathway, being conjugated with glutathione and undergo ...
DOI:
10.1089/jmf.2018.0024

10. LB-9, Novel Probiotic Lactic Acid Bacteria, Ameliorates Dextran Sodium Sulfate-Induced Colitis in Mice by Inhibiting TNF-α-Mediated Apoptosis of Intestinal Epithelial Cells

Author:
Jung Min Chae; Moon Han Chang; Wan Heo; Hyung Taek Cho; Dong Hun Lee; Bo Byeol Hwang; Jin Woo Kim; Seok Min Yoon; Siyoung Yang; Jin Hyup Lee; Young Jun Kim
Source:
Journal of medicinal food 2019 v.22 no.3 pp. 271-276
ISSN:
1557-7600
Subject:
Crohn disease; animal models; apoptosis; colitis; dextran; immune response; intestinal mucosa; lactic acid bacteria; mice; neoplasms; probiotics; signs and symptoms (animals and humans); sodium; sodium sulfate; therapeutics; tumor necrosis factor-alpha
Abstract:
... Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease, is a group of chronic and relapsing inflammatory conditions within the gastrointestinal tract. An increase in intestinal epithelial cell (IEC) apoptosis is a major characteristic of UC. Tumor necrosis factor-α (TNF-α) plays an essential role in the regulation of apoptosis. Aberrant activation of the immune res ...
DOI:
10.1089/jmf.2018.4236

11. Lycopene and Tomato Sauce Improve Hepatic and Cardiac Cell Biomarkers in Rats

Author:
Vanessa Azevedo de Jesuz; Monique de Barros Elias Campos; Vanessa Rosse de Souza; Teresa Palmiciano Bede; Bianca Portugal Tavares de Moraes; Adriana Ribeiro Silva; Cassiano Felippe Gonçalves de Albuquerque; Vilma Blondet de Azeredo; Anderson Junger Teodoro
Source:
Journal of medicinal food 2019 v.22 no.11 pp. 1175-1182
ISSN:
1557-7600
Subject:
biomarkers; blood glucose; blood serum; cardiovascular diseases; enzymes; fatty liver; flow cytometry; heart; hepatocytes; high density lipoprotein cholesterol; high fat diet; interleukin-1beta; interphase; liver; lycopene; metabolism; mitosis; neoplasms; rats; tomato sauce; tumor necrosis factor-alpha
Abstract:
... This study evaluated the effects of tomato sauce and lycopene on hepatic and cardiac cell biomarkers in rats fed a high-fat diet. Animals were split into five groups: control group, high-fat group (HG), high-fat tomato sauce group, high-fat lycopene 2 mg, and high-fat lycopene 4 mg. Food and water were offered ad libitum, whereas tomato sauce and lycopene (2 and 4 mg/day) were offered daily for 60 ...
DOI:
10.1089/jmf.2019.0014

12. Molecular Mechanism of the Protective Effect of Zerumbone on Lipopolysaccharide-Induced Inflammation of THP-1 Cell-Derived Macrophages

Author:
Min-Ju Kim; Jung-Mi Yun
Source:
Journal of medicinal food 2019 v.22 no.1 pp. 62-73
ISSN:
1557-7600
Subject:
Toll-like receptors; Zingiber zerumbet; atherosclerosis; chemokines; diabetes; essential oils; gene expression; ginger; histone deacetylase; humans; immunity; inflammation; lipopolysaccharides; macrophages; messenger RNA; models; monocytes; neoplasms; pathogens; protective effect; protein content; secretion; therapeutics; transcription factor NF-kappa B
Abstract:
... Unregulated inflammatory responses lead to massive production of macrophages-activating inflammatory cytokines and chemokines, which may induce diabetes, cancer, and atherosclerosis. Macrophages differentiated from human monocyte (THP-1) have been extensively used in in vitro inflammation models in recent studies. Zerumbone is a major component of the essential oil of Zingiber zerumbet Smith, a ty ...
DOI:
10.1089/jmf.2018.4253

13. Pelargonidin Protects Against Renal Injury in a Mouse Model of Sepsis

Author:
In-Chul Lee; Jong-Sup Bae
Source:
Journal of medicinal food 2019 v.22 no.1 pp. 57-61
ISSN:
1557-7600
Subject:
animal models; antioxidant activity; blood serum; catalase; creatinine; death; enzyme activity; glutathione; glutathione peroxidase; human health; interleukin-6; kidneys; lipid peroxidation; mice; neoplasms; nitric acid; nitric oxide synthase; pelargonidin; sepsis (infection); superoxide dismutase; surgery; tissues; transcription factor NF-kappa B; tumor necrosis factor-alpha; urea nitrogen; urine
Abstract:
... Pelargonidin (PEL) is a well-known red pigment found in plants, and it has been reported to have important biological activities that are potentially beneficial for human health. This study was initiated to determine whether PEL could modulate renal functional damage in a mouse model of sepsis, and to elucidate the underlying mechanisms. The potential of PEL treatment to reduce renal damage induce ...
DOI:
10.1089/jmf.2018.4230

14. Protective Effect of Schisandra chinensis Polysaccharides Against the Immunological Liver Injury in Mice Based on Nrf2/ARE and TLR4/NF-κB Signaling Pathway

Author:
Yingying Shan; Bin Jiang; Jiahui Yu; Jiaye Wang; Xiaoli Wang; He Li; Chunmei Wang; Jianguang Chen; Jinghui Sun
Source:
Journal of medicinal food 2019 v.22 no.9 pp. 885-895
ISSN:
1557-7600
Subject:
Schisandra chinensis; Toll-like receptor 4; alanine transaminase; alcohols; antioxidant activity; aspartate transaminase; blood serum; carbon tetrachloride; concanavalin A; gene expression regulation; genes; glutathione; heme oxygenase (biliverdin-producing); hepatoprotective effect; high fat diet; interferon-gamma; interleukin-1beta; interleukin-6; liver; malondialdehyde; mice; neoplasms; nitric oxide; oxidative stress; polysaccharides; signal transduction; superoxide dismutase; transcription factor NF-kappa B; tumor necrosis factor-alpha
Abstract:
... We have previously demonstrated the hepatoprotective effect of Schisandra chinensis polysaccharides (SCP) against the liver injury induced by alcohol, high-fat diet, and carbon tetrachloride in mice. In this study, we investigated the effect of SCP against the immunological liver injury induced by concanavalin A (Con A) in mice. The results showed that SCP could significantly reduce the level of a ...
DOI:
10.1089/jmf.2018.4377

15. Rhamnogalacturonan-I-Type Polysaccharide Purified from Broccoli Exerts Anti-Metastatic Activities Via Innate Immune Cell Activation

Author:
Bong-Shin Kwak; Dahyun Hwang; Sue Jung Lee; Hyuk-Jun Choi; Ho-Young Park; Kwang-Soon Shin
Source:
Journal of medicinal food 2019 v.22 no.5 pp. 451-459
ISSN:
1557-7600
Subject:
arabinose; broccoli; ethanol; fractionation; galactose; galacturonic acid; interleukin-12; interleukin-6; intravenous injection; lungs; macrophages; metastasis; mice; models; natural killer cells; neoplasm cells; neoplasms; oral administration; polysaccharides; rabbits; rhamnose; secretion; tumor necrosis factor-alpha
Abstract:
... To examine the anti-metastatic activities of polysaccharides in broccoli, purified polysaccharides (BCE-I, -II, and -III) were isolated by fractionation of broccoli enzyme extracts and subsequent ethanol precipitation. BCE-I mainly consisted of galactose and arabinose, whereas BCE-II mainly consisted of galacturonic acid and rhamnose, and BCE-III mainly consisted of rhamnose and galactose. Of the ...
DOI:
10.1089/jmf.2018.4286