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- Cao, Ping; Tu, Ling-Hsien; Abedini, Andisheh; Levsh, Olesya; Akter, Rehana; Patsalo, Vadim; Schmidt, Ann Marie; Raleigh, Daniel P.
- Journal of molecular biology 2012 v.421 no.2-3 pp. 282-295
- rats, etc ; amyloid; humans; missense mutation; models; mutants; noninsulin-dependent diabetes mellitus; polypeptides; risk; toxicity; transmission electron microscopy; Show all 11 Subjects
- ... Islet amyloid polypeptide (IAPP, amylin) is responsible for amyloid formation in type 2 diabetes and in islet cell transplants. The only known natural mutation found in mature human IAPP is a Ser20-to-Gly missense mutation, found with small frequency in Chinese and Japanese populations. The mutation appears to be associated with increased risk of early-onset type 2 diabetes. Early measurements in ...
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