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1. Structure Elucidation and Relative Toxicity of (24R)-24-Hydroxyyessotoxin from a Namibian Isolate of Gonyaulax spinifera

Author:
Ellis, Lee D.,   et al.   ; Rajotte, Isabelle; Rafuse, Cheryl; Wright, Elliott J.; Achenbach, John C.; McCarron, Pearse;     Show all 6 Authors
Source:
Journal of natural products 2019 v.82 no.7 pp. 1945-1952
ISSN:
1520-6025
Subject:
Danio rerio; Gonyaulax; biomass; hydroxylation; liquid chromatography; mass spectrometry; nuclear magnetic resonance spectroscopy; solvents; toxicity; yessotoxin
Abstract:
... Liquid chromatography–high-resolution mass spectrometry (LC-HRMS) analysis of a Namibian strain of Gonyaulax spinifera showed the presence of a number of yessotoxins (YTXs). Principal among these were YTX (1), homoYTX (2), and a tentative hydroxylated analogue that did not correspond to any previously confirmed YTX structures. Culturing the G. spinifera strain afforded sufficient biomass for purif ...
DOI:
10.1021/acs.jnatprod.9b00318