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You searched for: Journal name Journal of natural products Remove constraint Journal name: Journal of natural products Publication year rev 7981-2019 Remove constraint Publication year rev: 7981-2019 Subject term liquid chromatography Remove constraint Subject term: liquid chromatography
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1. Antiproliferative Cardenolides from the Aerial Parts of Pergularia tomentosa

Author:
Seyed Hamzeh Hosseini; Milena Masullo; Antonietta Cerulli; Stefania Martucciello; Mahdi Ayyari; Cosimo Pizza; Sonia Piacente
Source:
Journal of natural products 2019 v.82 no.1 pp. 74-79
ISSN:
1520-6025
Subject:
Pergularia; aerial parts; cardenolides; cell cycle; flavonols; glycosides; human cell lines; inhibitory concentration 50; liquid chromatography; mass spectrometry; methanol; neoplasm cells; nuclear magnetic resonance spectroscopy; prostatic neoplasms; roots; spectral analysis
Abstract:
... The LC-MS analysis of the MeOH extract of the aerial parts of Pergularia tomentosa led to the isolation of 23 compounds, of which the structures were elucidated unambiguously by NMR spectroscopic data analysis. Three new doubly linked cardenolides (4, 13, 14) along with several known cardenolides (1–3, 5, 7, 8, 15–23) and flavonol glycosides (6, 9–12) were identified. LC-HRESIMS analysis, in the n ...
DOI:
10.1021/acs.jnatprod.8b00630

2. Colletopeptides A–D, Anti-inflammatory Cyclic Tridepsipeptides from the Plant Endophytic Fungus Colletotrichum sp. S8

Author:
Li Feng; Jia Wang; Shuai Liu; Xue-Jia Zhang; Qi-Rui Bi; Yan-Yun Hu; Zhe Wang; Ning-Hua Tan
Source:
Journal of natural products 2019 v.82 no.6 pp. 1434-1441
ISSN:
1520-6025
Subject:
Colletotrichum; IKappaB kinase; Rubia; X-ray diffraction; dodecanoic acid; endophytes; fungi; inhibitory concentration 50; interleukin-6; liquid chromatography; macrophages; nitric oxide; phosphorylation; proteins; spectral analysis; stems; tumor necrosis factor-alpha
Abstract:
... Four new hybrid peptide-polyketide cyclic tridepsipeptides, colletopeptides A–D (1–4), were isolated and characterized from the endophytic fungus Colletotrichum sp. S8 derived from the stems of Rubia podantha with the guidance of LC-UV-MS detection. Their structures were elucidated by extensive spectroscopic analysis and X-ray crystallography. Compounds 1–4 are rare natural 12-membered cyclic trid ...
DOI:
10.1021/acs.jnatprod.8b00829

3. Cytotoxic Microcolin Lipopeptides from the Marine Cyanobacterium Moorea producens

Author:
Hao-Bing Yu; Evgenia Glukhov; Yueying Li; Arihiro Iwasaki; Lena Gerwick; Pieter C. Dorrestein; Bing-Hua Jiao; William H. Gerwick
Source:
Journal of natural products 2019 v.82 no.9 pp. 2608-2619
ISSN:
1520-6025
Subject:
Cyanobacterium (genus); Moorea producens; amino acids; catalytic activity; cytotoxicity; hydrogenation; inhibitory concentration 50; lipopeptides; liquid chromatography; lung neoplasms; mass spectrometry; metabolites; neoplasm cells; structure-activity relationships
Abstract:
... Nine new linear lipopeptides, microcolins E–M (1–9), together with four known related compounds, microcolins A–D (10–13), were isolated from the marine cyanobacterium Moorea producens using bioassay-guided and LC-MS/MS molecular networking approaches. Catalytic hydrogenation of microcolins A–D (10–13) yielded two known compounds, 3,4-dihydromicrocolins A and B (14, 15), and two new derivatives, 3, ...
DOI:
10.1021/acs.jnatprod.9b00549

4. High-Resolution Liquid Chromatography–Mass Spectrometry-Based Metabolomic Discrimination of Citrus-Type Crude Drugs and Comparison with Nuclear Magnetic Resonance Spectroscopy-Based Metabolomics

Author:
Takashi Tsujimoto; Taichi Yoshitomi; Takuro Maruyama; Yutaka Yamamoto; Takashi Hakamatsuka; Nahoko Uchiyama
Source:
Journal of natural products 2019 v.82 no.8 pp. 2116-2123
ISSN:
1520-6025
Subject:
coumarin; drugs; glucosides; liquid chromatography; mass spectrometry; metabolome; metabolomics; multivariate analysis; naringin; neohesperidin; nuclear magnetic resonance spectroscopy; secondary metabolites; stable isotopes
Abstract:
... Five Citrus-type crude drugs (40 samples) were classified using liquid chromatography–mass spectrometry (LC-MS)-based metabolomics. The following six flavonoid derivatives were identified as contributors from the loading plots of multivariate analysis: naringin (1), neohesperidin (2), neoeriocitrin (3), narirutin (9), hesperidin (10), and 3,5,6,7,8,3′,4′-heptamethoxyflavone (12). Three coumarin de ...
DOI:
10.1021/acs.jnatprod.8b00977

5. Identification of Narciclasine as an in Vitro Anti-Inflammatory Component of Cyrtanthus contractus by Correlation-Based Metabolomics

Author:
Lucie Rárová; Bhekumthetho Ncube; Johannes Van Staden; Robert Fürst; Miroslav Strnad; Jiri Gruz
Source:
Journal of natural products 2019 v.82 no.5 pp. 1372-1376
ISSN:
1520-6025
Subject:
Cyrtanthus contractus; anti-inflammatory activity; bulbs; liquid chromatography; mass spectrometry; metabolites; metabolomics
Abstract:
... In this study, an extract from the bulbs of Cyrtanthus contractus showed strong anti-inflammatory activity in vitro. The extract was partially separated into 14 fractions and analyzed by ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry metabolomics, and the correlation coefficients were calculated between biological activities and metabolite levels. As a res ...
DOI:
10.1021/acs.jnatprod.8b00973

6. Investigation of Premyrsinane and Myrsinane Esters in Euphorbia cupanii and Euphobia pithyusa with MS2LDA and Combinatorial Molecular Network Annotation Propagation

Author:
Mélissa Nothias-Esposito; Louis Felix Nothias; Ricardo R. Da Silva; Pascal Retailleau; Zheng Zhang; Pieter Leyssen; Fanny Roussi; David Touboul; Julien Paolini; Pieter C. Dorrestein; Marc Litaudon
Source:
Journal of natural products 2019 v.82 no.6 pp. 1459-1470
ISSN:
1520-6025
Subject:
Chikungunya virus; Euphorbia; X-ray diffraction; databases; diterpenoids; esters; liquid chromatography; nuclear magnetic resonance spectroscopy; tandem mass spectrometry; virus replication
Abstract:
... The species Euphorbia pithyusa and Euphorbia cupanii are two closely related Mediterranean spurges for which their taxonomic relationships are still being debated. Herein, the diterpene ester content of E. cupanii was investigated using liquid chromatography coupled to tandem mass spectrometry. The use of molecular networking coupled to unsupervised substructure annotation (MS2LDA) indicated the p ...
DOI:
10.1021/acs.jnatprod.8b00916

7. Occurrence of Mycotoxins in Botanical Dietary Supplement Infusion Beverages

Author:
Noelia Pallarés; Josefa Tolosa; Jordi Mañes; Emilia Ferrer
Source:
Journal of natural products 2019 v.82 no.2 pp. 403-406
ISSN:
1520-6025
Subject:
15-acetyldeoxynivalenol; Mentha pulegium; aflatoxins; anise; chamomile; dietary supplements; herbal tea; honey; liquid chromatography; liquid-phase microextraction; mint; nivalenol; ochratoxin A; risk assessment; tandem mass spectrometry; tea (beverage); thyme; zearalenone
Abstract:
... The aim of the present work was to study the occurrence of mycotoxins [aflatoxins (1–4), 3-acetyldeoxyniavlenol (5), 15-acetyldeoxynivalenol (6), nivalenol (7), HT-2 (8), T-2 (9), ochratoxin A (10), zearalenone (11), enniatin A (12), enniatin A1 (13), enniatin B (14), enniatin B1 (15), and beauvericin (16)] present in potable products derived from herbal teas. Analysis was carried out by liquid ch ...
DOI:
10.1021/acs.jnatprod.8b00283

8. Phallusialides A–E, Pyrrole-Derived Alkaloids Discovered from a Marine-Derived Micromonospora sp. Bacterium Using MS-Based Metabolomics Approaches

Author:
Fan Zhang; Doug R. Braun; Shaurya Chanana; Scott R. Rajski; Tim S. Bugni
Source:
Journal of natural products 2019 v.82 no.12 pp. 3432-3439
ISSN:
1520-6025
Subject:
Escherichia coli; Micromonospora; alkaloids; antibacterial properties; bacteria; liquid chromatography; metabolomics; methicillin-resistant Staphylococcus aureus; minimum inhibitory concentration; nuclear magnetic resonance spectroscopy; spectral analysis; tandem mass spectrometry
Abstract:
... Integrating MS-based metabolomics approaches, LC–MS–PCA and molecular networking enabled the targeted isolation of five new pyrrole-derived alkaloids, phallusialides A–E (1–5), from a marine-derived Micromonospora sp. bacterium. The structures of 1–5 were elucidated by analysis of their HRMS, MS/MS, and NMR spectroscopic data. The absolute configuration of phallusialide A (1) was determined on the ...
DOI:
10.1021/acs.jnatprod.9b00808

9. Structure Elucidation and Relative Toxicity of (24R)-24-Hydroxyyessotoxin from a Namibian Isolate of Gonyaulax spinifera

Author:
Isabelle Rajotte; Cheryl Rafuse; Elliott J. Wright; John C. Achenbach; Lee D. Ellis; Pearse McCarron
Source:
Journal of natural products 2019 v.82 no.7 pp. 1945-1952
ISSN:
1520-6025
Subject:
Danio rerio; Gonyaulax; biomass; hydroxylation; liquid chromatography; mass spectrometry; nuclear magnetic resonance spectroscopy; solvents; toxicity; yessotoxin
Abstract:
... Liquid chromatography–high-resolution mass spectrometry (LC-HRMS) analysis of a Namibian strain of Gonyaulax spinifera showed the presence of a number of yessotoxins (YTXs). Principal among these were YTX (1), homoYTX (2), and a tentative hydroxylated analogue that did not correspond to any previously confirmed YTX structures. Culturing the G. spinifera strain afforded sufficient biomass for purif ...
DOI:
10.1021/acs.jnatprod.9b00318

10. Synthesis of [3,3-²H₂]-Dihydroartemisinic Acid to Measure the Rate of Nonenzymatic Conversion of Dihydroartemisinic Acid to Artemisinin

Author:
Kaitlyn Varela; Hadi D. Arman; Francis K. Yoshimoto
Source:
Journal of natural products 2019 v.83 no.1 pp. 66-78
ISSN:
1520-6025
Subject:
artemisinin; biosynthesis; chemical bonding; cleavage (chemistry); deuterium; liquid chromatography; mass spectrometry
Abstract:
... Dihydroartemisinic acid is the biosynthetic precursor to artemisinin, the endoperoxide-containing natural product used to treat malaria. The conversion of dihydroartemisinic acid to artemisinin is a cascade reaction that involves C–C bond cleavage, hydroperoxide incorporation, and polycyclization to form the endoperoxide. Whether or not this reaction is enzymatically controlled has been controvers ...
DOI:
10.1021/acs.jnatprod.9b00686
PubMed:
31859509
PubMed Central:
PMC6988128