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- Sun, Cheng-Peng, et al. Show all 11 Authors
- Journal of natural products 2019 v.82 no.12 pp. 3302-3310
- Uncaria rhynchophylla; agonists; amino acids; circular dichroism spectroscopy; computer simulation; indole alkaloids; mechanism of action; median effective concentration; monoterpenoids; nuclear magnetic resonance spectroscopy
- ... Nine new monoterpenoid indole alkaloids, uncarialins A–I (1–9), were isolated from Uncaria rhynchophylla as well as 14 known analogues (10–23). Their structures were determined by HRESIMS, 1D and 2D NMR, and experimental and calculated electronic circular dichroism data. Compounds 5, 7, 15, and 22 displayed significant agonistic effects against the 5-HT₁A receptor with EC₅₀ values of 2.2 ± 0.1, 0. ...