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- Murata, Takatsugu; Kuboki, Teppei; Ishikawa, Ryo; Saito, Takahiro; Taguchi, Shotaro; Takeuchi, Kazuma; Hatano, Emiko; Shimonaka, Motoyuki; Shiina, Isamu
- Journal of natural products 2018 v.81 no.11 pp. 2364-2370
- Lewis bases; alcohols; breast neoplasms; catalysts; cytotoxicity; human cell lines; humans; moieties; neoplasm cells
- ... The first total synthesis of violaceoid A, a cytotoxic agent, and the asymmetric total synthesis of (−)- and (+)-violaceoid B are reported. The precursor was accessed by desymmetrization of a substituted quinol moiety, and the racemic secondary alcohol was kinetically resolved using a chiral nucleophilic catalyst. The asymmetric synthesis of (−)- and (+)-violaceoid B elucidated the absolute config ...