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You searched for: Journal Journal of natural products Remove constraint Journal: Journal of natural products Publication Year 2018 Remove constraint Publication Year: 2018 Source 2018 v.82 no.1 Remove constraint Source: 2018 v.82 no.1
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1. Divirensols: Sesquiterpene Dimers from the Australian Termite Nest-Derived Fungus Trichoderma virens CMB-TN16

Author:
Jiao, Wei-Hua; Dewapriya, Pradeep; Mohamed, Osama; Khalil, Zeinab G.; Salim, Angela A.; Lin, Hou-Wen; Capon, Robert J.
Source:
Journal of natural products 2018 v.82 no.1 pp. 87-95
ISSN:
1520-6025
Subject:
Isoptera; Trichoderma virens; biochemical pathways; biosynthesis; cytotoxicity; fungi; ions; metabolites; sesquiterpenoids; spectral analysis; termite mounds
Abstract:
... A chemical investigation of the Australian termite nest-derived fungus Trichoderma virens CMB-TN16 yielded the known sesquiterpene gliocladic acid (1), together with two new acetylated analogues, 3-acetylgliocladic acid (2) and 14-acetylgliocladic acid (3), and seven new dimeric congeners, divirensols A–G (4–10). All metabolites were identified by detailed spectroscopic analysis, supported by bios ...
DOI:
10.1021/acs.jnatprod.8b00746

2. Hypalocrinins, Taurine-Conjugated Anthraquinone and Biaryl Pigments from the Deep Sea Crinoid Hypalocrinus naresianus

Author:
Wolkenstein, Klaus; Fuentes-Monteverde, Juan Carlos; Nath, Nilamoni; Oji, Tatsuo; Griesinger, Christian
Source:
Journal of natural products 2018 v.82 no.1 pp. 163-167
ISSN:
1520-6025
Subject:
anthraquinones; mass spectrometry; nuclear magnetic resonance spectroscopy; pigments; sulfates; taurine; water solubility; Japan
Abstract:
... Five new water-soluble amido- and aminoanthraquinone pigments, hypalocrinins A–E (1–5), the new amidoanthraquinone biaryls hypalocrinin F (6) and hypalocrinin G (7), and the known compounds 6-bromoemodic acid (8), crinemodin (9), and crinemodin sulfate (10) were isolated from the deep sea crinoid Hypalocrinus naresianus collected off Japan. The structures of the compounds were elucidated by NMR sp ...
DOI:
10.1021/acs.jnatprod.8b00803

3. 3,4-seco-Norclerodane Diterpenoids from the Roots of Polyalthia laui

Author:
Yu, Zhang-Xin; Zheng, Cai-Juan; Chen, Guang-Ying; Huang, Rong-Li; Zhou, Xue-Ming; Niu, Zhi-Gang; Li, Xiao-Bao; Han, Chang-Ri; Song, Xiao-Ping
Source:
Journal of natural products 2018 v.82 no.1 pp. 27-34
ISSN:
1520-6025
Subject:
Polyalthia; X-ray diffraction; antiretroviral properties; biosynthesis; circular dichroism spectroscopy; diterpenoids; median effective concentration; nuclear magnetic resonance spectroscopy; roots; spectral analysis
Abstract:
... Ten new clerodane diterpenoids, polylauioids A–J (1–10), and five known analogues (11–15) were isolated from the roots of Polyalthia laui. Among the new compounds, 3 and 8 are artifacts. The structures were elucidated using spectroscopic methods and by comparison with published NMR spectroscopic data. The absolute configurations of 4, 5, and 7 were defined based on single-crystal X-ray diffraction ...
DOI:
10.1021/acs.jnatprod.8b00243

4. Chemical Synthesis Study Establishes the Correct Structure of the Potent Anti-Inflammatory Agent Myrsinoic Acid F

Author:
Mikusek, Jiri; Nugent, Jeremy; Lan, Ping; Banwell, Martin G.
Source:
Journal of natural products 2018 v.82 no.1 pp. 96-100
ISSN:
1520-6025
Subject:
edema; indomethacin; nonsteroidal anti-inflammatory agents; synthesis
Abstract:
... A total synthesis of compound 3 from p-bromophenol is reported and thereby establishing that this, rather than its cyclodehydrated counterpart 1 (as postulated originally), is the correct structure of the natural product myrsinoic acid F. The biological evaluation of compound 3 in a mouse-ear edema assay established that it is a significantly more potent anti-inflammatory agent than the NSAID indo ...
DOI:
10.1021/acs.jnatprod.8b00778

5. Complex Structures of Monoglucosylrutin with ent-Gallocatechin-3-O-gallate and Epigallocatechin-3-O-gallate in Aqueous Solutions and the Mechanism of Color Change Induced by Complexation

Author:
Ujihara, Tomomi; Hayashi, Nobuyuki
Source:
Journal of natural products 2018 v.82 no.1 pp. 2-8
ISSN:
1520-6025
Subject:
absorbance; aqueous solutions; catechin; color; density functional theory; epigallocatechin gallate; molecular dynamics; photochemistry; simulation models; solvents
Abstract:
... The addition of ent-gallocatechin-3-O-gallate (ent-GCg) or epigallocatechin-3-O-gallate (EGCg) to an aqueous solution of 4ᴳ-α-glucopyranosylrutin (monoglucosylrutin, MGR) causes the color of the solution to weaken due to complexation between MGR and these flavan-3-ols. Copigmentation is a well-known color change phenomenon resulting from the complexation of flavonoids that deepens and strengthens ...
DOI:
10.1021/acs.jnatprod.7b00817

6. Ellagitannins and Related Compounds from Penthorum chinense

Author:
Era, Manami; Matsuo, Yosuke; Saito, Yoshinori; Nishida, Koyo; Jiang, Zhi-Hong; Tanaka, Takashi
Source:
Journal of natural products 2018 v.82 no.1 pp. 129-135
ISSN:
1520-6025
Subject:
Balanophora; Penthorum; carboxylic acids; chemical analysis; glucosides; metabolism; metabolites; moieties; spectroscopy
Abstract:
... Four new ellagitannin metabolites, penthorumnins A–D (1–3 and 5), were isolated from the dried stem of Penthorum chinense. The structures were determined using spectroscopic and chemical analysis as well as using computations that revealed the following: (1) the acyl group of penthorumnin A (1) has a unique cyclopentane carboxylic acid structure that is derived from a hexahydroxydiphenoyl (HHDP) g ...
DOI:
10.1021/acs.jnatprod.8b00838

7. Macrocyclic Trichothecene Mycotoxins from a Deadly Poisonous Mushroom, Podostroma cornu-damae

Author:
Lee, Seoung Rak; Seok, Soonja; Ryoo, Rhim; Choi, Sang Un; Kim, Ki Hyun
Source:
Journal of natural products 2018 v.82 no.1 pp. 122-128
ISSN:
1520-6025
Subject:
breast neoplasms; cytotoxicity; doxorubicin; esterification; human cell lines; inhibitory concentration 50; methanol; neoplasm cells; nuclear magnetic resonance spectroscopy; poisonous fungi; quantum mechanics; structure-activity relationships; trichothecenes
Abstract:
... Three new macrocyclic trichothecenes (1–3) and five known related compounds (4–8) were isolated from the MeOH extract of a plate culture of the fungus Podostroma cornu-damae, a deadly poisonous mushroom. Miophytocen D (1) is a rearranged macrocyclic type D trichothecene, featuring a bicyclo-[6.5]dodecahydrocyclopenta[b]chromene scaffold, and the structures of new compounds (1–3) were delineated by ...
DOI:
10.1021/acs.jnatprod.8b00823