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- Author:
- Jiao, Wei-Hua; Dewapriya, Pradeep; Mohamed, Osama; Khalil, Zeinab G.; Salim, Angela A.; Lin, Hou-Wen; Capon, Robert J.
- Source:
- Journal of natural products 2018 v.82 no.1 pp. 87-95
- ISSN:
- 1520-6025
- Subject:
- Isoptera; Trichoderma virens; biochemical pathways; biosynthesis; cytotoxicity; fungi; ions; metabolites; sesquiterpenoids; spectral analysis; termite mounds
- Abstract:
- ... A chemical investigation of the Australian termite nest-derived fungus Trichoderma virens CMB-TN16 yielded the known sesquiterpene gliocladic acid (1), together with two new acetylated analogues, 3-acetylgliocladic acid (2) and 14-acetylgliocladic acid (3), and seven new dimeric congeners, divirensols A–G (4–10). All metabolites were identified by detailed spectroscopic analysis, supported by bios ...
- DOI:
- 10.1021/acs.jnatprod.8b00746
-
http://dx.doi.org/10.1021/acs.jnatprod.8b00746
- Author:
- Wolkenstein, Klaus; Fuentes-Monteverde, Juan Carlos; Nath, Nilamoni; Oji, Tatsuo; Griesinger, Christian
- Source:
- Journal of natural products 2018 v.82 no.1 pp. 163-167
- ISSN:
- 1520-6025
- Subject:
- anthraquinones; mass spectrometry; nuclear magnetic resonance spectroscopy; pigments; sulfates; taurine; water solubility; Japan
- Abstract:
- ... Five new water-soluble amido- and aminoanthraquinone pigments, hypalocrinins A–E (1–5), the new amidoanthraquinone biaryls hypalocrinin F (6) and hypalocrinin G (7), and the known compounds 6-bromoemodic acid (8), crinemodin (9), and crinemodin sulfate (10) were isolated from the deep sea crinoid Hypalocrinus naresianus collected off Japan. The structures of the compounds were elucidated by NMR sp ...
- DOI:
- 10.1021/acs.jnatprod.8b00803
-
http://dx.doi.org/10.1021/acs.jnatprod.8b00803
- Author:
- Yu, Zhang-Xin; Zheng, Cai-Juan; Chen, Guang-Ying; Huang, Rong-Li; Zhou, Xue-Ming; Niu, Zhi-Gang; Li, Xiao-Bao; Han, Chang-Ri; Song, Xiao-Ping
- Source:
- Journal of natural products 2018 v.82 no.1 pp. 27-34
- ISSN:
- 1520-6025
- Subject:
- Polyalthia; X-ray diffraction; antiretroviral properties; biosynthesis; circular dichroism spectroscopy; diterpenoids; median effective concentration; nuclear magnetic resonance spectroscopy; roots; spectral analysis
- Abstract:
- ... Ten new clerodane diterpenoids, polylauioids A–J (1–10), and five known analogues (11–15) were isolated from the roots of Polyalthia laui. Among the new compounds, 3 and 8 are artifacts. The structures were elucidated using spectroscopic methods and by comparison with published NMR spectroscopic data. The absolute configurations of 4, 5, and 7 were defined based on single-crystal X-ray diffraction ...
- DOI:
- 10.1021/acs.jnatprod.8b00243
-
http://dx.doi.org/10.1021/acs.jnatprod.8b00243
- Author:
- Mikusek, Jiri; Nugent, Jeremy; Lan, Ping; Banwell, Martin G.
- Source:
- Journal of natural products 2018 v.82 no.1 pp. 96-100
- ISSN:
- 1520-6025
- Subject:
- edema; indomethacin; nonsteroidal anti-inflammatory agents; synthesis
- Abstract:
- ... A total synthesis of compound 3 from p-bromophenol is reported and thereby establishing that this, rather than its cyclodehydrated counterpart 1 (as postulated originally), is the correct structure of the natural product myrsinoic acid F. The biological evaluation of compound 3 in a mouse-ear edema assay established that it is a significantly more potent anti-inflammatory agent than the NSAID indo ...
- DOI:
- 10.1021/acs.jnatprod.8b00778
-
http://dx.doi.org/10.1021/acs.jnatprod.8b00778
- Author:
- Ujihara, Tomomi; Hayashi, Nobuyuki
- Source:
- Journal of natural products 2018 v.82 no.1 pp. 2-8
- ISSN:
- 1520-6025
- Subject:
- absorbance; aqueous solutions; catechin; color; density functional theory; epigallocatechin gallate; molecular dynamics; photochemistry; simulation models; solvents
- Abstract:
- ... The addition of ent-gallocatechin-3-O-gallate (ent-GCg) or epigallocatechin-3-O-gallate (EGCg) to an aqueous solution of 4ᴳ-α-glucopyranosylrutin (monoglucosylrutin, MGR) causes the color of the solution to weaken due to complexation between MGR and these flavan-3-ols. Copigmentation is a well-known color change phenomenon resulting from the complexation of flavonoids that deepens and strengthens ...
- DOI:
- 10.1021/acs.jnatprod.7b00817
-
http://dx.doi.org/10.1021/acs.jnatprod.7b00817
- Author:
- Era, Manami; Matsuo, Yosuke; Saito, Yoshinori; Nishida, Koyo; Jiang, Zhi-Hong; Tanaka, Takashi
- Source:
- Journal of natural products 2018 v.82 no.1 pp. 129-135
- ISSN:
- 1520-6025
- Subject:
- Balanophora; Penthorum; carboxylic acids; chemical analysis; glucosides; metabolism; metabolites; moieties; spectroscopy
- Abstract:
- ... Four new ellagitannin metabolites, penthorumnins A–D (1–3 and 5), were isolated from the dried stem of Penthorum chinense. The structures were determined using spectroscopic and chemical analysis as well as using computations that revealed the following: (1) the acyl group of penthorumnin A (1) has a unique cyclopentane carboxylic acid structure that is derived from a hexahydroxydiphenoyl (HHDP) g ...
- DOI:
- 10.1021/acs.jnatprod.8b00838
-
http://dx.doi.org/10.1021/acs.jnatprod.8b00838
- Author:
- Lee, Seoung Rak; Seok, Soonja; Ryoo, Rhim; Choi, Sang Un; Kim, Ki Hyun
- Source:
- Journal of natural products 2018 v.82 no.1 pp. 122-128
- ISSN:
- 1520-6025
- Subject:
- breast neoplasms; cytotoxicity; doxorubicin; esterification; human cell lines; inhibitory concentration 50; methanol; neoplasm cells; nuclear magnetic resonance spectroscopy; poisonous fungi; quantum mechanics; structure-activity relationships; trichothecenes
- Abstract:
- ... Three new macrocyclic trichothecenes (1–3) and five known related compounds (4–8) were isolated from the MeOH extract of a plate culture of the fungus Podostroma cornu-damae, a deadly poisonous mushroom. Miophytocen D (1) is a rearranged macrocyclic type D trichothecene, featuring a bicyclo-[6.5]dodecahydrocyclopenta[b]chromene scaffold, and the structures of new compounds (1–3) were delineated by ...
- DOI:
- 10.1021/acs.jnatprod.8b00823
-
http://dx.doi.org/10.1021/acs.jnatprod.8b00823