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1. ent-Jungermannenone C Triggers Reactive Oxygen Species-Dependent Cell Differentiation in Leukemia Cells

Author:
Li, Houhua,   et al.   ; Yue, Zongwei; Xiao, Xinhua; Wu, Jinbao; Zhou, Xiaozhou; Liu, Weilong; Liu, Yaxi; Chen, Guoqiang; Wu, Yingli; Lei, Xiaoguang;     Show all 10 Authors
Source:
Journal of natural products 2018 v.81 no.2 pp. 298-306
ISSN:
1520-6025
Subject:
cell differentiation; cysteine; diterpenoids; drug resistance; enantiomers; mosses and liverworts; myeloid leukemia; neoplasm cells; oxygen; peroxiredoxin; reactive oxygen species; therapeutics
Abstract:
... Acute myeloid leukemia (AML) is a hematologic malignancy that is characterized by clonal proliferation of myeloid blasts. Despite the progress that has been made in the treatment of various malignant hematopoietic diseases, the effective treatment of AML remains very challenging. Differentiation therapy has emerged as a promising approach for leukemia treatment, and new and effective chemical agen ...
DOI:
10.1021/acs.jnatprod.7b00722