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You searched for: Subject "median effective concentration" Remove constraint Subject: "median effective concentration" Journal Journal of natural products Remove constraint Journal: Journal of natural products Publication Year 2017 Remove constraint Publication Year: 2017 Subject antiviral agents Remove constraint Subject: antiviral agents Text Availability Citation in PubAg Remove constraint Text Availability: Citation in PubAg
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1. Environmentally Friendly Procedure Based on Supercritical Fluid Chromatography and Tandem Mass Spectrometry Molecular Networking for the Discovery of Potent Antiviral Compounds from Euphorbia semiperfoliata

Author:
Nothias, Louis-Félix; Boutet-Mercey, Stéphanie; Cachet, Xavier; De La Torre, Erick; Laboureur, Laurent; Gallard, Jean-François; Retailleau, Pascal; Brunelle, Alain; Dorrestein, Pieter C.; Costa, Jean; Bedoya, Luis M.; Roussi, Fanny; Leyssen, Pieter; Alcami, José; Paolini, Julien; Litaudon, Marc; Touboul, David
Source:
Journal of natural products 2017 v.80 no.10 pp. 2620-2629
ISSN:
1520-6025
Subject:
median effective concentration,   etc   ; Chikungunya virus; Euphorbia; Human immunodeficiency virus 1; X-ray diffraction; antiviral agents; antiviral properties; diterpenoids; esters; plant extracts; secondary metabolites; solvents; supercritical fluid chromatography; tandem mass spectrometry; toxicity; virus replication; viruses;     Show all 17 Subjects
Abstract:
... A supercritical fluid chromatography-based targeted purification procedure using tandem mass spectrometry and molecular networking was developed to analyze, annotate, and isolate secondary metabolites from complex plant extract mixture. This approach was applied for the targeted isolation of new antiviral diterpene esters from Euphorbia semiperfoliata whole plant extract. The analysis of bioactive ...
DOI:
10.1021/acs.jnatprod.7b00113