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- Esposito, Mélissa; Nothias, Louis-Félix; Retailleau, Pascal; Costa, Jean; Roussi, Fanny; Neyts, Johan; Leyssen, Pieter; Touboul, David; Litaudon, Marc; Paolini, Julien
- Journal of natural products 2017 v.80 no.7 pp. 2051-2059
- median effective concentration, etc ; Chikungunya virus; Euphorbia; active ingredients; aerial parts; chromatography; diterpenoids; esters; nuclear magnetic resonance spectroscopy; spectral analysis; Show all 10 Subjects
- ... Six new premyrsinol esters (1–6) and one new myrsinol ester (8) were isolated from an aerial parts extract of Euphorbia pithyusa, together with a known premyrsinol (7) and two known dideoxyphorbol esters (9 and 10), following a bioactivity-guided purification procedure using a chikungunya virus (CHIKV) cell-based assay. The structures of the new diterpene esters (1–6 and 8) were elucidated by MS a ...
- Nothias, Louis-Félix; Boutet-Mercey, Stéphanie; Cachet, Xavier; De La Torre, Erick; Laboureur, Laurent; Gallard, Jean-François; Retailleau, Pascal; Brunelle, Alain; Dorrestein, Pieter C.; Costa, Jean; Bedoya, Luis M.; Roussi, Fanny; Leyssen, Pieter; Alcami, José; Paolini, Julien; Litaudon, Marc; Touboul, David
- Journal of natural products 2017 v.80 no.10 pp. 2620-2629
- median effective concentration, etc ; Chikungunya virus; Euphorbia; Human immunodeficiency virus 1; X-ray diffraction; antiviral agents; antiviral properties; diterpenoids; esters; plant extracts; secondary metabolites; solvents; supercritical fluid chromatography; tandem mass spectrometry; toxicity; virus replication; viruses; Show all 17 Subjects
- ... A supercritical fluid chromatography-based targeted purification procedure using tandem mass spectrometry and molecular networking was developed to analyze, annotate, and isolate secondary metabolites from complex plant extract mixture. This approach was applied for the targeted isolation of new antiviral diterpene esters from Euphorbia semiperfoliata whole plant extract. The analysis of bioactive ...