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You searched for: Subject "median effective concentration" Remove constraint Subject: "median effective concentration" Journal Journal of natural products Remove constraint Journal: Journal of natural products Publication Year 2017 Remove constraint Publication Year: 2017 Subject median effective concentration Remove constraint Subject: median effective concentration Text Availability Citation in PubAg Remove constraint Text Availability: Citation in PubAg
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1. Flavonoids from Erythrina schliebenii

Author:
Nyandoro, Stephen S.; Munissi, Joan J. E.; Kombo, Msim; Mgina, Clarence A.; Pan, Fangfang; Gruhonjic, Amra; Fitzpatrick, Paul; Lu, Yu; Wang, Bin; Rissanen, Kari; Erdélyi, Máté
Source:
Journal of natural products 2017 v.80 no.2 pp. 377-383
ISSN:
1520-6025
Subject:
median effective concentration,   etc   ; Erythrina; Mycobacterium tuberculosis; bark; breast neoplasms; humans; isoflavones; leaf extracts; toxicity;     Show all 9 Subjects
Abstract:
... Prenylated and O-methylflavonoids including one new pterocarpan (1), three new isoflavones (2–4), and nineteen known natural products (5–23) were isolated and identified from the root, stem bark, and leaf extracts of Erythrina schliebenii. The crude extracts and their constituents were evaluated for antitubercular activity against Mycobacterium tuberculosis (H37Rv strain), showing MICs of 32–64 μg ...
DOI:
10.1021/acs.jnatprod.6b00839

2. Malonylginsenosides with Potential Antidiabetic Activities from the Flower Buds of Panax ginseng

Author:
Qiu, Shi; Yang, Wen-Zhi; Yao, Chang-Liang; Shi, Xiao-Jian; Li, Jing-Ya; Lou, Yang; Duan, Ya-Nan; Wu, Wan-Ying; Guo, De-An
Source:
Journal of natural products 2017 v.80 no.4 pp. 899-908
ISSN:
1520-6025
Subject:
median effective concentration,   etc   ; Panax ginseng; buds; carbon dioxide; dissociation; ginsenosides; glucose; glycemic effect; myotubes; triterpenoid saponins;     Show all 10 Subjects
Abstract:
... LC-MS-guided phytochemical isolation of malonylginsenosides, featuring neutral elimination of CO₂ and C₃H₂O₃ by the negative mode collision-induced dissociation, from the flower buds of Panax ginseng led to the isolation of 19 malonyl-substituted triterpenoid saponins. They include 15 new malonylginsenosides, malonylfloralginsenosides-Re₁–Re₃ (1–3), -Rb₁ and -Rb₂ (4, 5), -Rd₁–Rd₆ (6–11), and -Rc₁– ...
DOI:
10.1021/acs.jnatprod.6b00789

3. Neuroprotective Activity of Cerebrosides from Typhonium giganteum by Regulating Caspase-3 and Bax/Bcl-2 Signaling Pathways in PC12 Cells

Author:
Jin, Yang; Fan, Jun-Ting; Gu, Xiao-Ling; Zhang, Li-Ying; Han, Jing; Du, Shu-Hu; Zhang, Ai-Xia
Source:
Journal of natural products 2017 v.80 no.6 pp. 1734-1741
ISSN:
1520-6025
Subject:
median effective concentration,   etc   ; Typhonium; apoptosis; caspase-3; caspase-9; cerebrosides; cytochrome c; longans; neuroprotective effect; rhizomes; signal transduction; spectral analysis;     Show all 12 Subjects
Abstract:
... An investigation of the potential neuroprotective natural product constituents of the rhizomes of Typhonium giganteum led to the isolation of two new cerebrosides, typhonosides E (1) and F (2), along with 11 known analogues (3–13). The structures of compounds 1 and 2 were elucidated by spectroscopic data interpretation. The activity of these compounds against glutamate-induced cell apoptosis was i ...
DOI:
10.1021/acs.jnatprod.6b00954

4. Isolation of Premyrsinane, Myrsinane, and Tigliane Diterpenoids from Euphorbia pithyusa Using a Chikungunya Virus Cell-Based Assay and Analogue Annotation by Molecular Networking

Author:
Esposito, Mélissa; Nothias, Louis-Félix; Retailleau, Pascal; Costa, Jean; Roussi, Fanny; Neyts, Johan; Leyssen, Pieter; Touboul, David; Litaudon, Marc; Paolini, Julien
Source:
Journal of natural products 2017 v.80 no.7 pp. 2051-2059
ISSN:
1520-6025
Subject:
median effective concentration,   etc   ; Chikungunya virus; Euphorbia; active ingredients; aerial parts; chromatography; diterpenoids; esters; nuclear magnetic resonance spectroscopy; spectral analysis;     Show all 10 Subjects
Abstract:
... Six new premyrsinol esters (1–6) and one new myrsinol ester (8) were isolated from an aerial parts extract of Euphorbia pithyusa, together with a known premyrsinol (7) and two known dideoxyphorbol esters (9 and 10), following a bioactivity-guided purification procedure using a chikungunya virus (CHIKV) cell-based assay. The structures of the new diterpene esters (1–6 and 8) were elucidated by MS a ...
DOI:
10.1021/acs.jnatprod.7b00233

5. Environmentally Friendly Procedure Based on Supercritical Fluid Chromatography and Tandem Mass Spectrometry Molecular Networking for the Discovery of Potent Antiviral Compounds from Euphorbia semiperfoliata

Author:
Nothias, Louis-Félix; Boutet-Mercey, Stéphanie; Cachet, Xavier; De La Torre, Erick; Laboureur, Laurent; Gallard, Jean-François; Retailleau, Pascal; Brunelle, Alain; Dorrestein, Pieter C.; Costa, Jean; Bedoya, Luis M.; Roussi, Fanny; Leyssen, Pieter; Alcami, José; Paolini, Julien; Litaudon, Marc; Touboul, David
Source:
Journal of natural products 2017 v.80 no.10 pp. 2620-2629
ISSN:
1520-6025
Subject:
median effective concentration,   etc   ; Chikungunya virus; Euphorbia; Human immunodeficiency virus 1; X-ray diffraction; antiviral agents; antiviral properties; diterpenoids; esters; plant extracts; secondary metabolites; solvents; supercritical fluid chromatography; tandem mass spectrometry; toxicity; virus replication; viruses;     Show all 17 Subjects
Abstract:
... A supercritical fluid chromatography-based targeted purification procedure using tandem mass spectrometry and molecular networking was developed to analyze, annotate, and isolate secondary metabolites from complex plant extract mixture. This approach was applied for the targeted isolation of new antiviral diterpene esters from Euphorbia semiperfoliata whole plant extract. The analysis of bioactive ...
DOI:
10.1021/acs.jnatprod.7b00113

6. Phenylpropenoids from Bupleurum fruticosum as Anti-Human Rhinovirus Species A Selective Capsid Binders

Author:
Fois, Benedetta; Bianco, Giulia; Sonar, Vijay P.; Distinto, Simona; Maccioni, Elias; Meleddu, Rita; Melis, Claudia; Marras, Luisa; Pompei, Raffaello; Floris, Costantino; Caboni, Pierluigi; Cottiglia, Filippo
Source:
Journal of natural products 2017 v.80 no.10 pp. 2799-2806
ISSN:
1520-6025
Subject:
median effective concentration,   etc   ; Bupleurum; Human rhinovirus; antiviral properties; capsid; fractionation; hydrophobicity; leaves; mass spectrometry; mechanism of action; methylene chloride; monoterpenoids; nuclear magnetic resonance spectroscopy; plant extracts; polyacetylenes; secondary metabolites; serotypes; virus replication;     Show all 18 Subjects
Abstract:
... The dichloromethane extract of the leaves of Bupleurum fruticosum was found to inhibit the replication of human rhinovirus (HRV) serotypes 14 and 39. Bioassay-guided fractionation led to the isolation of seven phenylpropenol derivatives (3–9), two polyacetylenes (1 and 2), and one monoterpene (10). Compounds 1 and 10 were identified as previously undescribed secondary metabolites after extensive 1 ...
DOI:
10.1021/acs.jnatprod.7b00648

7. Diterpenoid Alkaloids from Two Aconitum Species with Antifeedant Activity against Spodoptera exigua

Author:
Zhang, Ji-Fa; Chen, Lin; Huang, Shuai; Shan, Lian-Hai; Gao, Feng; Zhou, Xian-Li
Source:
Journal of natural products 2017 v.80 no.12 pp. 3136-3142
ISSN:
1520-6025
Subject:
median effective concentration,   etc   ; Aconitum; Spodoptera exigua; antifeedants; antifeeding activity; diterpenoid alkaloids; mass spectrometry; nuclear magnetic resonance spectroscopy; roots; structure-activity relationships;     Show all 10 Subjects
Abstract:
... Twenty-five diterpenoid alkaloids were isolated from the roots of two Aconitum species. The structures of seven new C₁₉-diterpenoid alkaloids, apetaldines A–G (1–7), and 10 known alkaloids (8–17) from Aconitum apetalum and eight known alkaloids (18–25) from Aconitum franchetii var. villosulum were elucidated via HRESIMS, IR, and NMR data. Alkaloids 1–10, 15, 16, and 18–25 were screened for their a ...
DOI:
10.1021/acs.jnatprod.7b00380