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- Yao, Ran; Chen, Zhaoli; Zhou, Chengcheng; Luo, Mei; Shi, Xuejiao; Li, Jiagen; Gao, Yibo; Zhou, Fang; Pu, Jianxin; Sun, Handong; He, Jie
- Journal of natural products 2015 v.78 no.1 pp. 10-16
- adverse effects; antineoplastic activity; apoptosis; caspase-3; caspase-9; cell cycle checkpoints; diterpenoids; dose response; drug therapy; drugs; esophageal neoplasms; humans; in vivo studies; mice; mitochondria; mortality; neoplasm cells; prognosis; squamous cell carcinoma; toxicity; traditional medicine
- ... Esophageal cancer is the eighth most common cancer in the world and ranks as the sixth leading cause of cancer-related mortality. Esophageal cancer has a poor prognosis partially due to its low sensitivity to chemotherapy agents, and the development of new therapeutic agents is urgently needed. Here, the antitumor activity of a natural ent-kaurane diterpenoid, xerophilusin B (1), which was isolate ...