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- Author:
- Ccana-Ccapatinta, Gari V.; Stolz, Eveline D.; da Costa, Paola
F.; Rates, Stela M. K.; von Poser, Gilsane L.
- Source:
- Journal of natural products 2014 v.77 no.10 pp. 2321-2325
- ISSN:
- 1520-6025
- Subject:
- Hypericum; mice; nuclear magnetic resonance spectroscopy; plant anatomy
- Abstract:
- ... A new dimeric acylphloroglucinol derivative, andinin A (1), was isolated from the underground plant parts of Hypericum andinum, along with three known dimeric acylphloroglucinols, uliginosin A (2), uliginosin B (3), and isouliginosin B (4). The structure of 1 was elucidated using 1D and 2D NMR and MS experiments and by comparison with previously reported data for Hypericum dimeric acylphloroglucin ...
- DOI:
- 10.1021/np500426m
-
http://dx.doi.org/10.1021%2Fnp500426m
- Author:
- Li, Man-Man; Su, Xiao-Qin; Sun, Jing; Gu, Yu-Fan; Huang, Zheng; Zeng, Ke-Wu; Zhang, Qian; Zhao, Yun-Fang; Ferreira, Daneel; Zjawiony, Jordan K.; Li, Jun; Tu, Peng-Fei
- Source:
- Journal of natural products 2014 v.77 no.10 pp. 2248-2254
- ISSN:
- 1520-6025
- Subject:
- Vitex negundo; X-ray diffraction; anti-inflammatory activity; inhibitory concentration 50; leaves; macrophages; nitric oxide; triterpenoids
- Abstract:
- ... Six new polyoxygenated triterpenoids, cannabifolins A–F (1–6), and eight known triterpenoids, 7–14, were isolated from the leaves of Vitex negundo var. cannabifolia. The absolute configuration of cannabifolin A (1) was determined by single-crystal X-ray crystallographic analysis. Compounds 1 and 2 represent a class of rare natural pentacyclic triterpenoids bearing cis-fused C/D rings and are the f ...
- DOI:
- 10.1021/np500509q
-
http://dx.doi.org/10.1021%2Fnp500509q
- Author:
- Cretton, Sylvian; Breant, Lise; Pourrez, Lucie; Ambuehl, Chiara; Marcourt, Laurence; Ebrahimi, Samad
Nejad; Hamburger, Matthias; Perozzo, Remo; Karimou, Soumana; Kaiser, Marcel; Cuendet, Muriel; Christen, Philippe
- Source:
- Journal of natural products 2014 v.77 no.10 pp. 2304-2311
- ISSN:
- 1520-6025
- Subject:
- Trypanosoma cruzi; antiparasitic properties; chemical structure; cytotoxicity; growth retardation; inhibitory concentration 50; methylene chloride; mice; nuclear magnetic resonance spectroscopy; quinoline alkaloids; roots; spectral analysis
- Abstract:
- ... Chemical investigation of the dichloromethane root extract of Waltheria indica led to the isolation and characterization of 10 quinoline alkaloids, namely, 8-deoxoantidesmone (1), waltheriones E–L (2–9), and antidesmone (10). Among these, compounds 2–9 have not yet been described in the literature. Their chemical structures were established by means of spectroscopic data interpretation including ¹ ...
- DOI:
- 10.1021/np5006554
-
http://dx.doi.org/10.1021%2Fnp5006554
- Author:
- Audoin, Coralie; Sánchez, Jon Andoni; Genta-Jouve, Grégory; Alfonso, Amparo; Rios, Laurent; Vale, Carmen; Thomas, Olivier P.; Botana, Luis M.
- Source:
- Journal of natural products 2014 v.77 no.10 pp. 2196-2205
- ISSN:
- 1520-6025
- Subject:
- Cyanobacterium (genus); Phormidium autumnale; arginine; calcium; enantiomers; gas chromatography-mass spectrometry; guanidines; mitochondria; models; nuclear magnetic resonance spectroscopy; permeability; sodium; spectral analysis
- Abstract:
- ... Filamentous cyanobacteria of the genus Phormidium have been rarely studied for their chemical diversity. For the first time, the cultivable Phormidium autumnale was shown to produce a prenylated cyclic peptide named autumnalamide (1). The structure of this peptide was fully determined after a deep exploration of the spectroscopic data, including NMR and HRMS. Interestingly, a prenyl moiety was loc ...
- DOI:
- 10.1021/np500374a
-
http://dx.doi.org/10.1021%2Fnp500374a
- Author:
- Xu, Jing; Zhang, Qiang; Wang, Meicheng; Ren, Quanhui; Sun, Yihang; Jin, Da-Qing; Xie, Chunfeng; Chen, Hongqiang; Ohizumi, Yasushi; Guo, Yuanqiang
- Source:
- Journal of natural products 2014 v.77 no.10 pp. 2182-2189
- ISSN:
- 1520-6025
- Subject:
- Casearia; branches; diterpenoids; neurites; nuclear magnetic resonance spectroscopy; spectral analysis
- Abstract:
- ... Eight new clerodane diterpenes, balanspenes A–H (1–8), along with two known analogues (9 and 10), were isolated from the twigs of Casearia balansae. The structures of 1–8 were elucidated on the basis of extensive 1D and 2D NMR spectroscopic data analysis, and the absolute configurations of compounds 1, 4, and 7 were confirmed by comparing their experimental CD spectra with those calculated by the ...
- DOI:
- 10.1021/np5003516
-
http://dx.doi.org/10.1021%2Fnp5003516
- Author:
- Shan, Tijiang; Tian, Jin; Wang, Xiaohan; Mou, Yan; Mao, Ziling; Lai, Daowan; Dai, Jungui; Peng, Youliang; Zhou, Ligang; Wang, Mingan
- Source:
- Journal of natural products 2014 v.77 no.10 pp. 2151-2160
- ISSN:
- 1520-6025
- Subject:
- Agrobacterium radiobacter; Bacillus subtilis; Dioscorea zingiberensis; Magnaporthe oryzae; Pseudomonas; Ralstonia solanacearum; Staphylococcus; Xanthomonas vesicatoria; antibacterial properties; antifungal properties; cytotoxicity; endophytes; fungi; humans; inhibitory concentration 50; medicinal plants; neoplasms; nuclear magnetic resonance spectroscopy; spore germination
- Abstract:
- ... Nine new spirobisnaphthalenes, palmarumycins B₁–B₉ (1–9), along with 13 known compounds (10–22), were isolated from cultures of the fungus Berkleasmium sp., an endophyte isolated from the medicinal plant Dioscorea zingiberensis C. H. Wright. The structures of the new compounds were elucidated by analysis of the 1D and 2D NMR and HRESIMS spectra and by comparison with known compounds. Compounds 7–9 ...
- DOI:
- 10.1021/np400988a
-
http://dx.doi.org/10.1021%2Fnp400988a
- Author:
- Cai, Shengxin; King, Jarrod B.; Du, Lin; Powell, Douglas R.; Cichewicz, Robert H.
- Source:
- Journal of natural products 2014 v.77 no.10 pp. 2280-2287
- ISSN:
- 1520-6025
- Subject:
- Alternaria; X-radiation; bioassays; cytotoxicity; mass spectrometry; metabolites; nuclear magnetic resonance spectroscopy
- Abstract:
- ... Polluxochrin (1) and dioschrin (2), two new dimers of sulochrin linked by thioether bonds, were purified from an Alternaria sp. isolate obtained from a Hawaiian soil sample. The structures of the two metabolites were established by NMR, mass spectrometry data, and X-ray analysis. Metabolite 1 was determined to be susceptible to intramolecular cyclization under aqueous conditions, resulting in the ...
- DOI:
- 10.1021/np5005449
- PubMed:
- 25265160
- PubMed Central:
- PMC4208674
-
http://dx.doi.org/10.1021%2Fnp5005449
- Author:
- Barbosa, Lilian
C.; Furtado, Ricardo A.; Bertanha, Humberto C. C.; Tomazella, Iara M.; Costa, Eveline S.; Bastos, Jairo K.; Silva, Márcio L. Andrade e; Tavares, Denise C.
- Source:
- Journal of natural products 2014 v.77 no.10 pp. 2312-2315
- ISSN:
- 1520-6025
- Subject:
- 1,2-dimethylhydrazine; anticarcinogenic activity; blood; chemoprevention; colon; comet assay; genotoxicity; lignans; mutagens; rats
- Abstract:
- ... (−)-Hinokinin (1) is a dibenzylbutyrolactone lignan obtained by the partial synthesis of (−)-cubebin. This study reports the antigenotoxic and anticarcinogenic potential of 1 by the comet and aberrant crypt focus assays in the peripheral blood and colon of 4–5-week-old Wistar rats, respectively. The rats were exposed to 1,2-dimethylhydrazine (40 mg/kg) and were treated by gavage with doses of 10, ...
- DOI:
- 10.1021/np500093u
-
http://dx.doi.org/10.1021%2Fnp500093u
- Author:
- Fan, Bo-Yi; Gu, Yu-Cheng; He, Ye; Li, Zhong-Rui; Luo, Jian-Guang; Kong, Ling-Yi
- Source:
- Journal of natural products 2014 v.77 no.10 pp. 2264-2272
- ISSN:
- 1520-6025
- Subject:
- Ipomoea aquatica; acids; apoptosis; calcium; cell cycle; cytotoxicity; glycosides; human cell lines; humans; inhibitory concentration 50; neoplasms; rhamnose; spectroscopy
- Abstract:
- ... Eleven new resin glycosides, aquaterins I–XI (1–11), were isolated from the whole plants of Ipomoea aquatica. The structures of 1–11 were elucidated by a combination of spectroscopic and chemical methods. They were found to be partially acylated tetra- or pentasaccharides derived from simonic acid B and operculinic acids A and C. The site of the aglycone macrolactonization was placed at C-2 or C-3 ...
- DOI:
- 10.1021/np5005246
-
http://dx.doi.org/10.1021%2Fnp5005246
- Author:
- Zhao, Jin-Xin; Liu, Cui-Ping; Qi, Wei-Yan; Han, Mei-Ling; Han, Ying-Shan; Wainberg, Mark A; Yue, Jian-Min
- Source:
- Journal of natural products 2014 v.77 no.10 pp. 2224-2233
- ISSN:
- 1520-6025
- Subject:
- Euphorbia neriifolia; antiretroviral properties; diterpenoids; median effective concentration
- Abstract:
- ... Eighteen new diterpenoids, named eurifoloids A–R (1–18), including ingenane (1 and 2), abietane (3–7), isopimarane (8–12), and ent-atisane (13–18) types, along with four known analogues were isolated from Euphorbia neriifolia. Eurifoloid M (13) represents a rare class of ent-atisane-type norditerpenoid. Eurifoloids E (5) and F (6) exhibited significant anti-HIV activities, with EC₅₀ values of 3.58 ...
- DOI:
- 10.1021/np5004752
-
http://dx.doi.org/10.1021%2Fnp5004752
- Author:
- Slanina, Jiří; Páchniková, Gabriela; Čarnecká, Martina; Porubová Koubíková, Ludmila; Adámková, Lenka; Humpa, Otakar; Šmejkal, Karel; Slaninová, Iva
- Source:
- Journal of natural products 2014 v.77 no.10 pp. 2255-2263
- ISSN:
- 1520-6025
- Subject:
- P-glycoproteins; Schisandra chinensis; cytotoxicity; doxorubicin; enantiomers; humans; leukemia; lignans; quantitative structure-activity relationships
- Abstract:
- ... The aim of the present study was to determine the structural requirements for dibenzocyclooctadiene lignans essential for P-glycoprotein inhibition. Altogether 15 structurally related lignans isolated from Schisandra chinensis or prepared by modification of their backbone were investigated, including three pairs of enantiomers. P-Glycoprotein inhibition was quantified using a doxorubicin accumulat ...
- DOI:
- 10.1021/np500521v
-
http://dx.doi.org/10.1021%2Fnp500521v
- Author:
- Yuan, Tao; Nahar, Pragati; Sharma, Meenakshi; Liu, Ke; Slitt, Angela; Aisa, H. A.; Seeram, Navindra P.
- Source:
- Journal of natural products 2014 v.77 no.10 pp. 2316-2320
- ISSN:
- 1520-6025
- Subject:
- AMP-activated protein kinase; Nigella sativa; alkaloids; glucose; glycemic effect; hepatocytes; human cell lines; liver; seeds
- Abstract:
- ... Six rare naturally occurring indazole-type alkaloids including two new compounds, 17-O-(β-d-glucopyranosyl)-4-O-methylnigellidine (1) and nigelanoid (2), and four known compounds (3–6) were isolated from a defatted extract of Nigella sativa (black cumin) seeds. 17-O-(β-d-Glucopyranosyl)-4-O-methylnigellidine (1) increased glucose consumption by liver hepatocytes (HepG2 cells) through activation of ...
- DOI:
- 10.1021/np500398m
- PubMed:
- 25299458
- PubMed Central:
- PMC4208670
-
http://dx.doi.org/10.1021%2Fnp500398m
- Author:
- Yin, Guo-Ping; Li, Liang-Chun; Zhang, Qing-Zhe; An, Yue-Wei; Zhu, Jing-Jing; Wang, Zhi-Min; Chou, Gui-Xin; Wang, Zheng-tao
- Source:
- Journal of natural products 2014 v.77 no.10 pp. 2161-2169
- ISSN:
- 1520-6025
- Subject:
- Curcuma; X-ray diffraction; inducible nitric oxide synthase; inhibitory concentration 50; monoterpenoids; nitric oxide; nuclear magnetic resonance spectroscopy; rhizomes; sesquiterpenoids
- Abstract:
- ... Eleven new sesquiterpenoids, wenyujinins A–K (1–11), and a new monoterpenoid, wenyujinin L (12), were isolated from the rhizomes of Curcuma wenyujin. Their structures and relative configurations were elucidated using 1D and 2D NMR, X-ray crystallographic analysis, and HRESIMS data. The absolute configurations of 1, 2, 3, 4, 6, 8, 9, and 10 were determined by comparison of the experimental and calc ...
- DOI:
- 10.1021/np400984c
-
http://dx.doi.org/10.1021%2Fnp400984c
- Author:
- Wang, Wen-qiong; Song, Wei-bin; Lan, Xiao-jing; Huang, Min; Xuan, Li-jiang
- Source:
- Journal of natural products 2014 v.77 no.10 pp. 2234-2240
- ISSN:
- 1520-6025
- Subject:
- Merremia; aerial parts; cytotoxicity; esters; glycosides; multiple drug resistance; vinblastine
- Abstract:
- ... Five new pentasaccharide resin glycosides, named merremins A–E (1–5), two new pentasaccharide resin glycoside methyl esters, named merremins F and G (6, 7), and four known resin glycosides, murucoidin IV, murucoidin V, stoloniferin IV, and murucoidin XVII, were obtained from the aerial parts of Merremia hederacea. This is the first report of resin glycosides obtained from M. hederacea. In addition ...
- DOI:
- 10.1021/np500483d
-
http://dx.doi.org/10.1021%2Fnp500483d
- Author:
- Kim, Min Cheol; Hwang, Eunson; Kim, Taejung; Ham, Jungyeob; Kim, Sun Yeou; Kwon, Hak Cheol
- Source:
- Journal of natural products 2014 v.77 no.10 pp. 2326-2330
- ISSN:
- 1520-6025
- Subject:
- Nocardiopsis; Porifera; collagen; culture media; models; ultraviolet radiation
- Abstract:
- ... Two new tetracenedione derivatives, nocatriones A (1) and B (2), were discovered from the culture broth of a marine actinomycete, Nocardiopsis sp. KMF-002, which was isolated from the tissue of an unidentified dark purple marine sponge. The structures of 1 and 2, which are tetracenediones containing α-pyrone substituents, were determined to be 3,8,10,11-tetrahydroxy-2-(4-hydroxy-2-oxo-2H-pyran-6-y ...
- DOI:
- 10.1021/np5006086
-
http://dx.doi.org/10.1021%2Fnp5006086
- Author:
- Wang, Bin; You, Jianlan; King, Jarrod B.; Cai, Shengxin; Park, Elizabeth; Powell, Douglas R.; Cichewicz, Robert H.
- Source:
- Journal of natural products 2014 v.77 no.10 pp. 2273-2279
- ISSN:
- 1520-6025
- Subject:
- Candida albicans; Clonostachys rosea; antibiotics; antifungal properties; bags; biofilm; breakfast cereals; candidiasis; culture flasks; glycosides; metabolome; mushrooms; pathogens; polyketides; screening; secondary metabolites
- Abstract:
- ... One of the challenges presented by Candida infections is that many of the isolates encountered in the clinic produce biofilms, which can decrease these pathogens’ susceptibilities to standard-of-care antibiotic therapies. Inhibitors of fungal biofilm formation offer a potential solution to counteracting some of the problems associated with Candida infections. A screening campaign utilizing samples ...
- DOI:
- 10.1021/np500531j
- PubMed:
- 25302529
- PubMed Central:
- PMC4208675
-
http://dx.doi.org/10.1021%2Fnp500531j
- Author:
- Nicoletti, Natália
F.; Rodrigues-Junior, Valnês; Santos, André A.; Leite, Carlos E.; Dias, Ana C. O.; Batista, Eraldo
L.; Basso, Luiz A.; Campos, Maria M.; Santos, Diógenes
S.; Souto, André A.
- Source:
- Journal of natural products 2014 v.77 no.10 pp. 2190-2195
- ISSN:
- 1520-6025
- Subject:
- alanine transaminase; aspartate transaminase; blood serum; catalase; drugs; gene expression; glutathione; hepatotoxicity; histopathology; interleukin-10; interleukin-12; isoniazid; liver; liver diseases; males; messenger RNA; mice; myeloperoxidase; oxidative stress; protective effect; resveratrol; rifampicin; tumor necrosis factor-alpha
- Abstract:
- ... Acute liver injury was induced in male BALB/c mice by coadministering isoniazid and rifampicin. In this work, the effects of resveratrol (1) were investigated in the hepatotoxicity caused by isoniazid–rifampicin in mice. Compound 1 was administered 30 min prior to isoniazid–rifampicin. Serum biochemical tests, liver histopathological examination, oxidative stress, myeloperoxidase activity, cytokin ...
- DOI:
- 10.1021/np5003143
-
http://dx.doi.org/10.1021%2Fnp5003143
- Author:
- Peng, Jixing; Gao, Huquan; Zhang, Xiaomin; Wang, Shuai; Wu, Chongming; Gu, Qianqun; Guo, Peng; Zhu, Tianjiao; Li, Dehai
- Source:
- Journal of natural products 2014 v.77 no.10 pp. 2218-2223
- ISSN:
- 1520-6025
- Subject:
- Aspergillus versicolor; X-ray diffraction; anthranilic acid; cyclic peptides; cytotoxicity; fungi; nitrogen; nuclear magnetic resonance spectroscopy
- Abstract:
- ... Four new cyclic peptides, psychrophilins E–H (1–4), possessing a rare amide linkage between the carboxylic acid in anthranilic acid (ATA) and the nitrogen from an indole moiety, along with a new ATA-containing hexapeptide, versicotide C (5), were obtained from the culture of the marine-derived fungus Aspergillus versicolor ZLN-60. The structures, including absolute configurations, were elucidated ...
- DOI:
- 10.1021/np500469b
-
http://dx.doi.org/10.1021%2Fnp500469b
- Author:
- Hindra,; Huang, Tingting; Yang, Dong; Rudolf, Jeffrey D.; Xie, Pengfei; Xie, Guangbo; Teng, Qihui; Lohman, Jeremy
R.; Zhu, Xiangcheng; Huang, Yong; Zhao, Li-Xing; Jiang, Yi; Duan, Yanwen; Shen, Ben
- Source:
- Journal of natural products 2014 v.77 no.10 pp. 2296-2303
- ISSN:
- 1520-6025
- Subject:
- diterpenoids; genome mining; prioritization; quantitative polymerase chain reaction; sequence analysis
- Abstract:
- ... Natural products offer unmatched chemical and structural diversity compared to other small-molecule libraries, but traditional natural product discovery programs are not sustainable, demanding too much time, effort, and resources. Here we report a strain prioritization method for natural product discovery. Central to the method is the application of real-time PCR, targeting genes characteristic to ...
- DOI:
- 10.1021/np5006168
- PubMed:
- 25238028
- PubMed Central:
- PMC4208669
-
http://dx.doi.org/10.1021%2Fnp5006168
- Author:
- Tungen, Jørn
E.; Aursnes, Marius; Vik, Anders; Ramon, Sesquile; Colas, Romain
A.; Dalli, Jesmond; Serhan, Charles N.; Hansen, Trond V.
- Source:
- Journal of natural products 2014 v.77 no.10 pp. 2241-2247
- ISSN:
- 1520-6025
- Subject:
- anti-inflammatory activity; chemotaxis; hydrolysis; macrophages; metabolism; metabolites; phagocytosis; polyunsaturated fatty acids
- Abstract:
- ... Protectin D1 (PD1 (3)), a C22-dihydroxylated polyunsaturated fatty acid biosynthesized from all-Z-docosahexaenoic acid, belongs to the new family of endogenous mediators referred to as specialized pro-resolving lipid mediators. PD1 (3) is a natural product that displays potent anti-inflammatory properties together with pro-resolving actions including inhibition of polymorphonuclear leukocyte (PMN) ...
- DOI:
- 10.1021/np500498j
- PubMed:
- 25247845
- PubMed Central:
- PMC4208671
-
http://dx.doi.org/10.1021%2Fnp500498j