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You searched for: Journal name Journal of natural products Remove constraint Journal name: Journal of natural products Subject term Danio rerio Remove constraint Subject term: Danio rerio
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1. 4β-Hydroxywithanolide E from Goldenberry (Whole Fruits of Physalis peruviana L.) as a Promising Agent against Chronic Obstructive Pulmonary Disease

Author:
Wen-Jing Yang; Xue-Mei Chen; Shu-Qi Wang; Hui-Xin Hu; Xin-Ping Cheng; Lin-Tao Xu; Dong-Mei Ren; Xiao-Ning Wang; Bao-Bing Zhao; Hong-Xiang Lou; Tao Shen
Source:
Journal of natural products 2020 v.83 no.4 pp. 1217-1228
ISSN:
1520-6025
Subject:
Danio rerio; Physalis peruviana; animal models; antioxidant activity; cigarettes; cysteine; epithelium; fruits; humans; inflammation; lungs; macrophages; mice; oxidative stress; protein-protein interactions; respiratory tract diseases; smoke; transcription factor NF-kappa B; ubiquitination
Abstract:
... Environmental toxicant- and oxidant-induced [e.g., cigarette smoke (CS)] respiratory oxidative stress and inflammatory response play a vital role in the onset and progression of COPD. The nuclear factor erythroid 2-related factor 2 (Nrf2) represents an important mechanism for regulating intracellular oxidative stress and inflammatory response and is a promising target for developing agents against ...
DOI:
10.1021/acs.jnatprod.9b01265

2. 9-Hydroxycanthin-6-one, a β-Carboline Alkaloid from Eurycoma longifolia, Is the First Wnt Signal Inhibitor through Activation of Glycogen Synthase Kinase 3β without Depending on Casein Kinase 1α

Author:
Ohishi Kensuke; Toume Kazufumi; Arai Midori A.; Koyano Takashi; Kowithayakorn Thaworn; Mizoguchi Takamasa; Itoh Motoyuki; Ishibashi Masami
Source:
Journal of natural products 2015 v.78 no.5 pp. 1139-1146
ISSN:
1520-6025
Subject:
Danio rerio; Eurycoma longifolia; alkaloids; cell proliferation; embryogenesis; fractionation; glycogen synthase kinases; luciferase; methanol; non-specific serine/threonine protein kinase; plant extracts; tau-protein kinase; transcription (genetics)
Abstract:
... Wnt signaling regulates various processes such as cell proliferation, differentiation, and embryo development. However, numerous diseases have been attributed to the aberrant transduction of Wnt signaling. We screened a plant extract library targeting TCF/β-catenin transcriptional modulating activity with a cell-based luciferase assay. Activity-guided fractionation of the MeOH extract of the E. lo ...
DOI:
10.1021/acs.jnatprod.5b00153

3. Agaricus bisporus-Derived Glucosamine Hydrochloride Facilitates Skeletal Injury Repair through Bmp Signaling in Zebrafish Osteoporosis Model

Author:
Wei Peng; Wenjuan Zhang; Qici Wu; Shunyou Cai; Tingting Jia; Jiarui Sun; Zhichao Lin; Gulimiran Alitongbieke; Yixuan Chen; Yi Su; Jinmei Lin; Lisheng Cai; Yuqin Sun; Yutian Pan; Yu Xue
Source:
Journal of natural products 2021 v.84 no.4 pp. 1294-1305
ISSN:
1520-6025
Subject:
Agaricus bisporus; Danio rerio; adults; bone formation; bone morphogenetic proteins; cartilage; cell walls; chitin; dose response; fins; fish; glucosamine; hydrochloric acid; hydrolysis; larvae; models; osteoporosis; skeletal development
Abstract:
... Glucosamine hydrochloride (GAH), one of the most basic and important derivatives of chitin, is obtained by hydrolysis of chitin in concentrated hydrochloric acid. At present, little is known about how GAH functions in skeletal development. In this report, we demonstrate that GAH, extracted from the cell wall of Agaricus bisporus, acts in a dose-dependent manner to promote not only cartilage and bo ...
DOI:
10.1021/acs.jnatprod.1c00002

4. Antiangiogenic Activity of Compounds Isolated from Anarrhinum pedatum

Author:
Khadidja Aya Beladjila; Djemaa Berrehal; Zahia Kabouche; Maria Paola Germanò; Valeria D’Angelo; Nunziatina De Tommasi; Felicia D’Andrea; Alessandra Braca; Marinella De Leo
Source:
Journal of natural products 2019 v.82 no.3 pp. 510-519
ISSN:
1520-6025
Subject:
Anarrhinum; Danio rerio; aerial parts; blood vessels; butanol; chickens; embryo (animal); iridoid glycosides; models; monoterpenoids; nuclear magnetic resonance spectroscopy; spectral analysis
Abstract:
... Ten new iridoid glycosides (1–10) and two new monoterpenoids (11 and 12), together with nine known compounds (13–21), were isolated from the n-butanol extract of the aerial parts of Anarrhinum pedatum. The structural characterization of all compounds was performed by spectroscopic analysis, including 1D and 2D NMR and HRESIMS experiments. The isolates were assayed for their antiangiogenic activity ...
DOI:
10.1021/acs.jnatprod.8b00893

5. Antimalarial Activities of Alkyl Cyclohexenone Derivatives Isolated from the Leaves of Poupartia borbonica

Author:
Ledoux Allison; St-Gelais Alexis; Cieckiewicz Ewa; Jansen Olivia; Bordignon Annélise; Illien Bertrand; Di Giovanni Nicolas; Marvilliers Arnaud; Hoareau Floriane; Pendeville Hélène; Quetin-Leclercq Joëlle; Frédérich Michel
Source:
Journal of natural products 2017 v.80 no.6 pp. 1750-1757
ISSN:
1520-6025
Subject:
Danio rerio; Plasmodium falciparum; antimalarials; antiparasitic properties; cytotoxicity; ellagic acid; ethyl acetate; fibroblasts; fractionation; growth retardation; hemolysis; humans; inhibitory concentration 50; isoquercitrin; larvae; leaves; methanol; mice; models; nuclear magnetic resonance spectroscopy; quercetin; quercitrin; spectral analysis; uterine cervical neoplasms
Abstract:
... Bioactivity-guided fractionation of the ethyl acetate extract of the leaves of Poupartia borbonica led to the isolation of three new alkyl cyclohexenone derivatives 1–3, and named Poupartone A–C. The structures of the new compounds were elucidated by 1D and 2D NMR spectroscopic data analysis and MS, whereas calculated and experimental ECD spectra were used to define the absolute configurations. Th ...
DOI:
10.1021/acs.jnatprod.6b01019

6. Bioactive C21 Steroidal Glycosides from the Roots of Cynanchum otophyllum That Suppress the Seizure-like Locomotor Activity of Zebrafish Caused by Pentylenetetrazole

Author:
Li Jin-Long; Zhou Juan; Chen Zhen-Hua; Guo Sheng-Ya; Li Chun-Qi; Zhao Wei-Min
Source:
Journal of natural products 2015 v.78 no.7 pp. 1548-1555
ISSN:
1520-6025
Subject:
Cynanchum; Danio rerio; chemical structure; glycosides; locomotion; roots; spectral analysis; sugars
Abstract:
... Six new C₂₁ steroidal glycosides, cynotophyllosides A–F (1–6), together with 16 known compounds, were isolated from the roots of Cynanchum otophyllum. The structures of the new compounds were elucidated by spectroscopic analysis and chemical methods. The three major components, otophylloside F (15), otophylloside B (17), and rostratamine 3-O-β-d-oleandropyranosyl-(1→4)-β-d-cymaropyranosyl-(1→4)-β- ...
DOI:
10.1021/np501058b

7. Bufadienolides from the Eggs of the Toad Bufo bufo gargarizans and Their Antimelanoma Activities

Author:
Shi-wen Zhou; Jing-yu Quan; Zi-wei Li; Ge Ye; Zhuo Shang; Ze-ping Chen; Lei Wang; Xin-yuan Li; Xiao-qi Zhang; Jie Li; Jun-shan Liu; Hai-yan Tian
Source:
Journal of natural products 2021 v.84 no.5 pp. 1425-1433
ISSN:
1520-6025
Subject:
Bufo bufo; Danio rerio; X-ray diffraction; angiogenesis; apoptosis; bioassays; bufadienolides; cell growth; cytotoxicity; humans; melanoma; spectral analysis; toads
Abstract:
... Toads produce potent toxins, named bufadienolides, to defend against their predators. Pharmacological research has revealed that bufadienolides are potential anticancer drugs. In this research, we reported nine bufadienolides from the eggs of the toad Bufo bufo gargarizans, including two new compounds (1 and 3). The chemical structures of 1 and 3, as well as of one previously reported semisynthesi ...
DOI:
10.1021/acs.jnatprod.0c00840

8. Caspase-Dependent Apoptosis in Prostate Cancer Cells and Zebrafish by Corchorusoside C from Streptocaulon juventas

Author:
Gerardo D. Anaya-Eugenio; Ermias Mekuria Addo; Nathan Ezzone; Joshua M. Henkin; Tran Ngoc Ninh; Yulin Ren; Djaja D. Soejarto; A. Douglas Kinghorn; Esperanza J. Carcache de Blanco
Source:
Journal of natural products 2019 v.82 no.6 pp. 1645-1655
ISSN:
1520-6025
Subject:
Danio rerio; antineoplastic agents; apoptosis; caspases; cell lines; colon; cytotoxicity; dose response; inhibitory concentration 50; intercellular adhesion molecule-1; models; neoplasm cells; population growth; prostatic neoplasms; protein content; protein synthesis; shrinkage; transcription factor NF-kappa B; Vietnam
Abstract:
... Corchorusoside C (1), isolated from Streptocaulon juventas collected in Vietnam, was found to be nontoxic in a zebrafish (Danio rerio) model and to induce cytotoxicity in several cancer cell lines with notable selective activity against prostate DU-145 cancer cells (IC₅₀ 0.08 μM). Moreover, corchorusoside C induced DU-145 cell shrinkage and cell detachment. In CCD-112CoN colon normal cells, 1 show ...
DOI:
10.1021/acs.jnatprod.9b00140
PubMed:
31120251
PubMed Central:
PMC6615048

9. Cholinesterase Inhibitory Arisugacins L–Q from a Penicillium sp. Isolate Obtained through a Citizen Science Initiative and Their Activities in a Phenotype-Based Zebrafish Assay

Author:
Wentao Dai; Imelda T. Sandoval; Shengxin Cai; Kaylee A. Smith; Richard Glenn C. Delacruz; Kevin A. Boyd; Jessica J. Mills; David A. Jones; Robert H. Cichewicz
Source:
Journal of natural products 2019 v.82 no.9 pp. 2627-2637
ISSN:
1520-6025
Subject:
Danio rerio; Penicillium; acetylcholinesterase; bioactive properties; cholinesterase; embryo (animal); enzyme inhibition; fungi; in vitro studies; inhibitory concentration 50; lactones; locomotion; meroterpenoids; metabolites; muscles; nuclear magnetic resonance spectroscopy; phenotype; screening; therapeutics
Abstract:
... Phenotype-based screening of a fungal extract library yielded an active sample from a Penicillium sp. isolate that impaired zebrafish motility. Bioassay-guided purification led to the identification of 14 meroterpenoids including six new metabolites, arisugacins L–Q (4, 5, 8, and 12–14), seven known arisugacins (1–3, 6, 7, 9, and 10), and one known terreulactone (11). Their structures were determi ...
DOI:
10.1021/acs.jnatprod.9b00563

10. Cytotoxic and Antiangiogenetic Xanthones Inhibiting Tumor Proliferation and Metastasis from Garcinia xipshuanbannaensis

Author:
Xuke Zhang; Ziteng Song; Ying Li; Huimei Wang; Shaojie Zhang; Anna-Mari Reid; Namrita Lall; Jie Zhang; Chunyan Wang; Dongho Lee; Yasushi Ohizumi; Jing Xu; Yuanqiang Guo
Source:
Journal of natural products 2021 v.84 no.5 pp. 1515-1523
ISSN:
1520-6025
Subject:
Danio rerio; Garcinia; active ingredients; apoptosis; cell cycle; cytotoxicity; humans; metastasis; neoplasms; xanthones
Abstract:
... Eight prenylated xanthones including four new analogues were extracted and purified from the leaves of Garcinia xipshuanbannaensis. Multiple techniques including UV, 1D and 2D NMR, and HRESIMS were used to determine the structures of the isolated xanthones. These xanthones were evaluated for their cytotoxicity toward human cancer cells, and compound 4 exhibited activity against HeLa cells. A cytot ...
DOI:
10.1021/acs.jnatprod.0c01354

11. Dammarane-Type Triterpenoids from the Roots of Rhus chinensis and Their Preventive Effects on Zebrafish Heart Failure and Thrombosis

Author:
Miao Ye; Wen Xu; Da-Qing He; Xian Wu; Wen-Fang Lai; Xiao-Qin Zhang; Yu Lin; Wei Xu; Xu-Wen Li
Source:
Journal of natural products 2020 v.83 no.2 pp. 362-373
ISSN:
1520-6025
Subject:
Danio rerio; Oriental traditional medicine; Rhus; bioassays; blood flow; cardiac output; coronary vessels; drugs; heart; heart failure; heart rate; liquid chromatography; mass spectrometry; moieties; quantum mechanics; roots; spectral analysis; therapeutics; thrombosis; triterpenoids
Abstract:
... Eight new dammarane-type triterpenoids (1–8), together with a related known analogue (9), were isolated from the roots of Rhus chinensis, a traditional Chinese medicine for treating coronary artery heart disease, guided by LC-MS analysis. Their structures were elucidated based on extensive spectroscopic analysis and quantum chemical calculations. Notably, compounds 1–7 and 9 possess an unusual 17α ...
DOI:
10.1021/acs.jnatprod.9b00857

12. Discovery of a Potent Conorfamide from Conus episcopatus Using a Novel Zebrafish Larvae Assay

Author:
Gabriel D. Bosse; Cristoval Urcino; Maren Watkins; Paula Flórez Salcedo; Sabrina Kozel; Kevin Chase; April Cabang; Samuel S. Espino; Helena Safavi-Hemami; Shrinivasan Raghuraman; Baldomero M. Olivera; Randall T. Peterson; Joanna Gajewiak
Source:
Journal of natural products 2021 v.84 no.4 pp. 1232-1243
ISSN:
1520-6025
Subject:
Conus; Danio rerio; biomedical research; conotoxins; humans; mice; neurons; peptides; snails
Abstract:
... Natural products such as conotoxins have tremendous potential as tools for biomedical research and for the treatment of different human diseases. Conotoxins are peptides present in the venoms of predatory cone snails that have a rich diversity of pharmacological functions. One of the major bottlenecks in natural products research is the rapid identification and evaluation of bioactive molecules. T ...
DOI:
10.1021/acs.jnatprod.0c01297

13. Dolabellane Diterpenes and Elemane Alkaloids from the Soft Coral Clavularia inflata Collected in the South China Sea

Author:
Xiao Han; Xiangchao Luo; Lei Xue; Leen van Ofwegen; Wenjie Zhang; Kechun Liu; Yun Zhang; Xuli Tang; Pinglin Li; Guoqiang Li
Source:
Journal of natural products 2022 v.85 no.1 pp. 276-283
ISSN:
1520-6025
Subject:
Danio rerio; anti-inflammatory activity; corals; diterpenoids; probability; South China Sea
Abstract:
... Five new dolabellane diterpenes, clavularinlides A–E (1–5), and four new racemic elemane alkaloids, clavulacylides A–D (7–10), together with one known compound (6), were isolated from the soft coral Clavularia inflata collected in the South China Sea. Their structures were elucidated by 1D and 2D NMR, HRESIMS, calculated ECD, and DP4+ probability analyses. Compounds 1–7 showed anti-inflammatory ac ...
DOI:
10.1021/acs.jnatprod.1c01103

14. Emerimicins V–X, 15-Residue Peptaibols Discovered from an Acremonium sp. through Integrated Genomic and Chemical Approaches

Author:
Guangwei Wu; Bryn T. M. Dentinger; Jason R. Nielson; Randall T. Peterson; Jaclyn M. Winter
Source:
Journal of natural products 2021 v.84 no.4 pp. 1113-1126
ISSN:
1520-6025
Subject:
Acremonium; Danio rerio; Enterococcus faecalis; Enterococcus faecium; amino acids; bioinformatics; biosynthesis; cytotoxicity; embryotoxicity; fermentation; genome; hybrids; methicillin-resistant Staphylococcus aureus; peptaibols; soil; Utah
Abstract:
... Fermentation of Acremonium tubakii W. Gams isolated from a soil sample collected from the University of Utah led to the isolation and characterization of six new linear pentadecapeptides, emerimicins V–X (1–6). Peptaibols containing 15-residues are quite rare, with only 22 reported. Genome mining and bioinformatic analysis were used to identify the emerimicin 60 kbp eme biosynthetic cluster harbor ...
DOI:
10.1021/acs.jnatprod.0c01186

15. Eudesmacarbonate, a Eudesmane-Type Sesquiterpene from a Marine Filamentous Cyanobacterial Mat (Oscillatoriales) in the Florida Keys

Author:
Christina A. Lydon; Logesh Mathivathanan; Juanita Sanchez; Larissa A. H. dos Santos; Thomas Sauvage; Sarath P. Gunasekera; Valerie J. Paul; John P. Berry
Source:
Journal of natural products 2020 v.83 no.6 pp. 2030-2035
ISSN:
1520-6025
Subject:
Danio rerio; Oscillatoriales; X-ray diffraction; carbonates; circular dichroism spectroscopy; larvae; models; neurotoxins; sesquiterpenoids; toxicity; Florida
Abstract:
... A new, cyclic carbonate eudesmane-type sesquiterpene, eudesmacarbonate (1), was isolated from marine filamentous cyanobacterial mats associated with apparent ingestion-related intoxications of captive bottlenose dolphins in the Florida Keys. Sequencing of 16S rDNA revealed that mats were composed of closely related Oscillatoriacean species including a previously undocumented species of Neolyngbya. ...
DOI:
10.1021/acs.jnatprod.0c00203

16. Examination of the Mode of Action of the Almiramide Family of Natural Products against the Kinetoplastid Parasite Trypanosoma brucei

Author:
Sanchez Laura M.; Knudsen Giselle M.; Helbig Claudia; De Muylder Geraldine; Mascuch Samantha M.; Mackey Zachary B.; Gerwick Lena; Clayton Christine; McKerrow James H.; Linington Roger G.
Source:
Journal of natural products 2013 v.76 no.4 pp. 630-641
ISSN:
1520-6025
Subject:
African trypanosomiasis; Danio rerio; Leishmania donovani; Trypanosoma brucei; adverse effects; blood flow; fluorescence; fluorescence microscopy; glycolysis; humans; leishmaniasis; mechanism of action; microbodies; models; neuromasts; parasites; toxicity
Abstract:
... Almiramide C is a marine natural product with low micromolar activity against Leishmania donovani, the causative agent of leishmaniasis. We have now shown that almiramide C is also active against the related parasite Trypanosoma brucei, the causative agent of human African trypanosomiasis. A series of activity-based probes have been synthesized to explore both the molecular target of this compound ...
DOI:
10.1021/np300834q
PubMed:
23445522
PubMed Central:
PMC3971013

17. HPLC-Based Activity Profiling for GABAA Receptor Modulators in Extracts: Validation of an Approach Utilizing a Larval Zebrafish Locomotor Assay

Author:
Moradi-Afrapoli Fahimeh; Ebrahimi Samad Nejad; Smiesko Martin; Hamburger Matthias
Source:
Journal of natural products 2017 v.80 no.5 pp. 1548-1557
ISSN:
1520-6025
Subject:
Danio rerio; Magnolia officinalis; Valeriana officinalis; Xenopus laevis; active ingredients; agonists; antagonists; anxiety; blood-brain barrier; central nervous system; drugs; electrophysiology; epilepsy; gamma-aminobutyric acid; high performance liquid chromatography; larvae; models; neurotransmitter receptors; oocytes; permeability; prediction; sleep disorders
Abstract:
... Gamma-aminobutyric acid type A (GABAA) receptors are major inhibitory neurotransmitter receptors in the central nervous system and a target for numerous clinically important drugs used to treat anxiety, insomnia, and epilepsy. A series of allosteric GABAA receptor agonists was identified previously with the aid of HPLC-based activity profiling, whereby activity was tracked with an electrophysiolog ...
DOI:
10.1021/acs.jnatprod.7b00081

18. Hydroanthraquinones from Nigrospora sphaerica and Their Anti-inflammatory Activity Uncovered by Transcriptome Analysis

Author:
Qi-Xuan Kuang; Yan Luo; Li-Rong Lei; Wen-Xiu Guo; Xin-Ai Li; Yu-Mei Wang; Xue-Yan Huo; Meng-Dan Liu; Qi Zhang; Dan Feng; Li-Jun Huang; Dong Wang; Yu-Cheng Gu; Yun Deng; Da-Le Guo
Source:
Journal of natural products 2022 v.85 no.6 pp. 1474-1485
ISSN:
1520-6025
Subject:
Danio rerio; Nigrospora; anti-inflammatory activity; circular dichroism spectroscopy; fluorescent antibody technique; macrophages; nitric oxide; nuclear magnetic resonance spectroscopy; phosphorylation; secretion; transcriptomics; transportation
Abstract:
... Transcriptome analysis is shown to be an effective strategy to understand the potential function of natural products. Here, it is reported that 11 previously undescribed hydroanthraquinones [nigroquinones A–K (1–11)], along with eight known congeners, were isolated from Nigrospora sphaerica. Their structures were elucidated by interpreting spectroscopic and spectrometric data including high-resolu ...
DOI:
10.1021/acs.jnatprod.1c01141

19. In Vivo Screening of Xanthones from Garcinia oligantha Identified Oliganthin H as a Novel Natural Inhibitor of Convulsions

Author:
Guiyi Gong; Hanbin Chen; Hiotong Kam; Ging Chan; Yue-xun Tang; Man Wu; Hongsheng Tan; Yu-chung Tse; Hong-xi Xu; Simon Ming-yuen Lee
Source:
Journal of natural products 2020 v.83 no.12 pp. 3706-3716
ISSN:
1520-6025
Subject:
Danio rerio; Garcinia; X-ray diffraction; anticonvulsants; computer simulation; drug resistance; epilepsy; genes; markets; skeleton; structure-activity relationships; xanthone
Abstract:
... Epilepsy is a chronic neurological disorder, characterized by recurrent, spontaneous, and transient seizures, and affects more than 70 million people worldwide. Although two dozen antiepileptic drugs (AEDs) are approved and available in the market, seizures remain poorly controlled in one-third of epileptic patients who are suffering from drug resistance or various adverse effects. Recently, the x ...
DOI:
10.1021/acs.jnatprod.0c00963

20. Ingol and Ingenol Diterpenes from the Aerial Parts of Euphorbia royleana and Their Antiangiogenic Activities

Author:
Li, Xiao-Li; Li, Yang; Wang, Si-Feng; Zhao, Yan-Li; Liu, Ke-Chun; Wang, Xi-Min; Yang, Yong-Ping
Source:
Journal of natural products 2009 v.72 no.6 pp. 1001-1005
ISSN:
0163-3864
Subject:
Euphorbia; medicinal plants; medicinal properties; aerial parts; diterpenoids; chemical structure; nuclear magnetic resonance spectroscopy; X-ray diffraction; Danio rerio; animal models; bioassays
DOI:
10.1021/np800816n
PubMed:
19438253

21. Jatropholane-Type Diterpenes from Euphorbia sikkimensis

Author:
Yang Da-Song; Zhang You-Li; Peng Wei-Bing; Wang Li-Yan; Li Zi-Lei; Wang Xue; Liu Ke-Chun; Yang Yong-Ping; Li Hong-Lin; Li Xiao-Li
Source:
Journal of natural products 2013 v.76 no.2 pp. 265-269
ISSN:
1520-6025
Subject:
Danio rerio; Euphorbia; aerial parts; diterpenoids; inhibitory concentration 50; models; nuclear magnetic resonance spectroscopy
Abstract:
... Four new jatropholane-type diterpenes (1–4), named sikkimenoids A–D, were isolated from the aerial parts of Euphorbia sikkimensis. The structural elucidations of 1–4 were accomplished by extensive NMR analyses, and their absolute configurations were established by ECD calculations. Compound 2 exhibited weak antiangiogenic activity with an IC₅₀ value of 43.0 μM when evaluated using a zebrafish mode ...
DOI:
10.1021/np300799n

22. Neopetrosins A–D and Haliclorensin D, Indole-C-Mannopyranosides and a Diamine Alkaloid Isolated from the South China Sea Marine Sponge Neopetrosia chaliniformis

Author:
Di Zhang; Yueying Li; Xiaolei Li; Xiao Han; Zhe Wang; Wenze Zhang; Beibei Dou; Zhongyu Lu; Pinglin Li; Guoqiang Li
Source:
Journal of natural products 2022 v.85 no.6 pp. 1626-1633
ISSN:
1520-6025
Subject:
Danio rerio; Porifera; X-ray diffraction; alkaloids; circular dichroism spectroscopy; hepatoprotective effect; models; probability; spectral analysis; South China Sea
Abstract:
... Four new indole-C-mannopyranoside alkaloids, neopetrosins A–D (1–4), together with one new diamine alkaloid, haliclorensin D (6), were isolated from the marine sponge Neopetrosia chaliniformis collected off Xisha Island in the South China Sea. Their structures and absolute configurations were determined by spectroscopic analysis, single-crystal X-ray diffraction, calculated electronic circular dic ...
DOI:
10.1021/acs.jnatprod.2c00292

23. Neuroprotective Dihydro-β-agarofuran-Type Sesquiterpenes from the Seeds of Euonymus maackii

Author:
Yifan Fu; Wei Wang; Qi Gong; Haiyan Zhang; Weimin Zhao
Source:
Journal of natural products 2019 v.82 no.11 pp. 3096-3103
ISSN:
1520-6025
Subject:
Danio rerio; Euonymus hamiltonianus var. maackii; X-ray diffraction; cell viability; epigallocatechin gallate; locomotion; nuclear magnetic resonance spectroscopy; seeds; sesquiterpenoids; spectral analysis
Abstract:
... Twenty-one dihydro-β-agarofuran derivatives were purified from the seeds of Euonymus maackii, and eight compounds (1–8) were identified as new natural products. Their structures were deduced by extensive spectroscopic analysis, X-ray diffraction studies, and comparison of observed and reported NMR data. Compounds 10, 12, 17, and 18 significantly increased the cell viability of Aβ₂₅–₃₅-treated SH-S ...
DOI:
10.1021/acs.jnatprod.9b00701

24. Phenolic Compounds from the Leaves and Twigs of Osteomeles schwerinae That Inhibit Rat Lens Aldose Reductase and Vessel Dilation in Zebrafish Larvae

Author:
Lee Ik-Soo; Jung Seung-Hyun; Lee Yun Mi; Choi So-Jin; Sun Hang; Kim Jin Sook
Source:
Journal of natural products 2015 v.78 no.9 pp. 2249-2254
ISSN:
1520-6025
Subject:
Danio rerio; Osteomeles; aldehyde reductase; branches; chemical structure; enzyme inhibition; eye lens; glucose; glycosides; inhibitory concentration 50; larvae; leaves; lignans; rats; spectral analysis
Abstract:
... Three new phenolic biphenyl derivatives (1–3) and one new lignan glycoside (4) were isolated from the leaves and twigs of Osteomeles schwerinae. The structures of the new compounds were established by spectroscopic data interpretation. The inhibitory effects of 1–4 on rat lens aldose reductase in vitro were examined, and compounds 1–3 markedly inhibited the enzyme with IC₅₀ values of 3.8 to 13.8 μ ...
DOI:
10.1021/acs.jnatprod.5b00469

25. Potential of Lichen Secondary Metabolites against Plasmodium Liver Stage Parasites with FAS-II as the Potential Target

Author:
Lauinger Ina L.; Vivas Livia; Perozzo Remo; Stairiker Christopher; Tarun Alice; Zloh Mire; Zhang Xujie; Xu Hua; Tonge Peter J.; Franzblau Scott G.; Pham Duc-Hung; Esguerra Camila V.; Crawford Alexander D.; Maes Louis; Tasdemir Deniz
Source:
Journal of natural products 2013 v.76 no.6 pp. 1064-1070
ISSN:
1520-6025
Subject:
Danio rerio; Escherichia coli; Mycobacterium tuberculosis; Plasmodium berghei; Plasmodium falciparum; antibacterial properties; antimalarials; biosynthesis; blood; disease control; drugs; enzymes; fatty acids; humans; inhibitory concentration 50; lichens; liver; malaria; molecular models; neoplasm cells; neoplasms; parasites; pathogens; secondary metabolites; toxicity
Abstract:
... Chemicals targeting the liver stage (LS) of the malaria parasite are useful for causal prophylaxis of malaria. In this study, four lichen metabolites, evernic acid (1), vulpic acid (2), psoromic acid (3), and (+)-usnic acid (4), were evaluated against LS parasites of Plasmodium berghei. Inhibition of P. falciparum blood stage (BS) parasites was also assessed to determine stage specificity. Compoun ...
DOI:
10.1021/np400083k
PubMed:
23806111
PubMed Central:
PMC4119598

26. Proanthocyanidins from Spenceria ramalana and Their Effects on AGE Formation in Vitro and Hyaloid-Retinal Vessel Dilation in Larval Zebrafish in Vivo

Author:
Lee Ik-Soo; Yu Song Yi; Jung Seung-Hyun; Lee Yu-Ri; Lee Yun Mi; Kim Joo-Hwan; Sun Hang; Kim Jin Sook
Source:
Journal of natural products 2013 v.76 no.10 pp. 1881-1888
ISSN:
1520-6025
Subject:
Danio rerio; advanced glycation end products; chemical structure; glucose; inhibitory concentration 50; larvae; proanthocyanidins; spectroscopy
Abstract:
... Three new A-type proanthocyanidins (1–3), ent-epiafzelechin-(2α→O→7,4α→8)-ent-afzelechin 3′-O-β-d-glycopyranoside (1), ent-epiafzelechin-(2α→O→7,4α→8)-ent-epiafzelechin-(2α→O→7,4α→8)-ent-afzelechin (2), and ent-epiafzelechin-(2α→O→7,4α→8)-ent-epicatechin-(2α→O→7,4α→8)-ent-afzelechin (3), and three known compounds (4–6) were isolated from the whole plant of Spenceria ramalana. The structures of the ...
DOI:
10.1021/np400442b

27. Spirocitromycetin, a Fungal Polyketide with an Antiosteoporotic Pharmacophore

Author:
Yong Chen; Ying Jie Wei; Nan Jiang; Hui Ming Ge; Rui Hua Jiao; Xu Cheng; Ren Xiang Tan
Source:
Journal of natural products 2022 v.85 no.5 pp. 1442-1447
ISSN:
1520-6025
Subject:
Danio rerio; Penicillium; bioassays; biochemical pathways; drugs; fungi; humans; models; mucus; pharmacology; polyketides
Abstract:
... Spirocitromycetin, an antiosteoporotic polyketide bearing a unique spirocycle, was characterized from a human mucus sputum-derived Penicillium velutinum. Its structure and absolute configuration were elucidated spectrally, with its biosynthetic pathway likely mediated via polivione, a reported heptaketide. Spirocitromycetin was shown to be antiosteoporotic at 0.1 μM in the prednisolone-induced ost ...
DOI:
10.1021/acs.jnatprod.1c01060

28. Staprexanthones, Xanthone-Type Stimulators of Pancreatic β-Cell Proliferation from a Mangrove Endophytic Fungus

Author:
Qi Gan; Chunyu Lin; Changjun Lu; Yimin Chang; Qian Che; Guojian Zhang; Tianjiao Zhu; Qianqun Gu; Zhiqiang Wu; Mingyu Li; Dehai Li
Source:
Journal of natural products 2020 v.83 no.10 pp. 2996-3003
ISSN:
1520-6025
Subject:
Danio rerio; Stachybotrys chartarum; cell cycle; endophytes; fermentation; fungi; models; moieties; therapeutics; xanthone
Abstract:
... This project was focused on the discovery of novel compounds that promote endogenous β-cell regeneration. Screening of extracts identified the fungus Stachybotrys chartarum as a promising candidate. After fermentation and extraction of S. chartarum, we isolated five new prenylated xanthones, namely, staprexanthones A–E (1–5), with staprexanthone A (1) being the first natural xanthone bearing a rar ...
DOI:
10.1021/acs.jnatprod.0c00535

29. Structure Elucidation and Relative Toxicity of (24R)-24-Hydroxyyessotoxin from a Namibian Isolate of Gonyaulax spinifera

Author:
Isabelle Rajotte; Cheryl Rafuse; Elliott J. Wright; John C. Achenbach; Lee D. Ellis; Pearse McCarron
Source:
Journal of natural products 2019 v.82 no.7 pp. 1945-1952
ISSN:
1520-6025
Subject:
Danio rerio; Gonyaulax; biomass; hydroxylation; liquid chromatography; mass spectrometry; nuclear magnetic resonance spectroscopy; solvents; toxicity; yessotoxin
Abstract:
... Liquid chromatography–high-resolution mass spectrometry (LC-HRMS) analysis of a Namibian strain of Gonyaulax spinifera showed the presence of a number of yessotoxins (YTXs). Principal among these were YTX (1), homoYTX (2), and a tentative hydroxylated analogue that did not correspond to any previously confirmed YTX structures. Culturing the G. spinifera strain afforded sufficient biomass for purif ...
DOI:
10.1021/acs.jnatprod.9b00318

30. Synthesis and Evaluation of Bakuchiol Derivatives as Potent Anti-inflammatory Agents in Vitro and in Vivo

Author:
Qianqian Ma; Ming Bian; Guohua Gong; Chunmei Bai; Chunyan Liu; Chengxi Wei; Zhe-shan Quan; Huan-huan Du
Source:
Journal of natural products 2022 v.85 no.1 pp. 15-24
ISSN:
1520-6025
Subject:
Danio rerio; anti-inflammatory activity; anti-inflammatory agents; dose response; fruits; inflammation; interleukin-6; monoterpenoids; necrosis; neoplasms; psoralen; reactive oxygen species
Abstract:
... Bakuchiol, a prenylated phenolic monoterpene derived from the fruit of Psoralen corylifolia L. (Buguzhi), is widely used to treat tumors, viruses, inflammation, and bacterial infections. In this study, we designed and synthesized 30 bakuchiol derivatives to identify new anti-inflammatory drugs. The anti-inflammatory activities of the derivatives were screened using lipopolysaccharide-induced RAW26 ...
DOI:
10.1021/acs.jnatprod.1c00377