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You searched for: Subject "median effective concentration" Remove constraint Subject: "median effective concentration" Journal Journal of natural products Remove constraint Journal: Journal of natural products Subject median effective concentration Remove constraint Subject: median effective concentration Subject Human immunodeficiency virus 1 Remove constraint Subject: Human immunodeficiency virus 1 Text Availability Citation in PubAg Remove constraint Text Availability: Citation in PubAg
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1. Kadcotriones A–C: Tricyclic Triterpenoids from Kadsura coccinea

Author:
Liang, Cheng-Qin; Shi, Yi-Ming; Li, Xing-Yao; Luo, Rong-Hua; Li, Yan; Zheng, Yong-Tang; Zhang, Hong-Bin; Xiao, Wei-Lie; Sun, Han-Dong
Source:
Journal of natural products 2013 v.76 no.12 pp. 2350-2354
ISSN:
1520-6025
Subject:
median effective concentration,   etc   ; Human immunodeficiency virus 1; Kadsura coccinea; antiviral properties; circular dichroism spectroscopy; nuclear magnetic resonance spectroscopy; triterpenoids;     Show all 7 Subjects
Abstract:
... Three new triterpenoids, kadcotriones A–C (1–3), together with the biogenetically related lanostane-type triterpenoid (4), were isolated from Kadsura coccinea. Compound 1 features a 12,14β-dimethyl 6/6/6-fused tricyclic skeleton, while 2 and 3 are characterized by a 6/6/5-ring system. Their structures were determined by NMR and electronic circular dichroism spectroscopic methods. Compounds 2 and 4 ...
DOI:
10.1021/np400546z

2. Phenylspirodrimanes with Anti-HIV Activity from the Sponge-Derived Fungus Stachybotrys chartarum MXH-X73

Author:
Ma, Xinhua; Li, Letao; Zhu, Tianjiao; Ba, Mingyu; Li, Guoqiang; Gu, Qianqun; Guo, Ying; Li, Dehai
Source:
Journal of natural products 2013 v.76 no.12 pp. 2298-2306
ISSN:
1520-6025
Subject:
median effective concentration,   etc   ; Human immunodeficiency virus 1; RNA-directed DNA polymerase; Stachybotrys chartarum; antiretroviral properties; fungi; hydrolysis; spectral analysis; virus replication;     Show all 9 Subjects
Abstract:
... Seven new phenylspirodrimanes, named stachybotrins D–F (1, 3, 4), stachybocins E and F (5, 6), and stachybosides A and B (7, 8), and four known compounds (2, 9–11), were isolated from the sponge-derived fungus Stachybotrys chartarum MXH-X73. Their structures were determined by detailed analysis of spectroscopic data. The absolute configurations of 1–8 were determined by chemical hydrolysis and mod ...
DOI:
10.1021/np400683h

3. Jatrophane Diterpenes as Inhibitors of Chikungunya Virus Replication: Structure–Activity Relationship and Discovery of a Potent Lead

Author:
Nothias-Scaglia, Louis-Félix; Retailleau, Pascal; Paolini, Julien; Pannecouque, Christophe; Neyts, Johan; Dumontet, Vincent; Roussi, Fanny; Leyssen, Pieter; Costa, Jean; Litaudon, Marc
Source:
Journal of natural products 2014 v.77 no.6 pp. 1505-1512
ISSN:
1520-6025
Subject:
median effective concentration,   etc   ; Chikungunya virus; Euphorbia amygdaloides; Human immunodeficiency virus 1; Human immunodeficiency virus 2; Semliki Forest virus; Sindbis virus; X-radiation; antiviral properties; diterpenoids; ethyl acetate; inhibitory concentration 50; mechanism of action; spectral analysis; structure-activity relationships; virus replication; viruses;     Show all 17 Subjects
Abstract:
... Bioassay-guided purification of an EtOAc extract of the whole plant of Euphorbia amygdaloides ssp. semiperfoliata using a chikungunya virus-cell-based assay led to the isolation of six new (1–4, 9, and 10) and six known (5–7, 8, 11, and 12) jatrophane esters. Their planar structures and relative configurations were determined by extensive spectroscopic analysis, and their absolute configurations b ...
DOI:
10.1021/np500271u

4. Antiviral Activity of Flexibilane and Tigliane Diterpenoids from Stillingia lineata

Author:
Olivon, Florent; Palenzuela, Héliciane; Girard-Valenciennes, Emmanuelle; Neyts, Johan; Pannecouque, Christophe; Roussi, Fanny; Grondin, Isabelle; Leyssen, Pieter; Litaudon, Marc
Source:
Journal of natural products 2015 v.78 no.5 pp. 1119-1128
ISSN:
1520-6025
Subject:
median effective concentration,   etc   ; Chikungunya virus; Human immunodeficiency virus 1; Human immunodeficiency virus 2; Semliki Forest virus; Sindbis virus; Stillingia; anticarcinogenic activity; antiviral properties; chemical structure; cytotoxicity; diterpenoids; ethyl acetate; leaf extracts; neoplasms; spectral analysis; virus replication; viruses;     Show all 18 Subjects
Abstract:
... In an effort to identify new potent and selective inhibitors of chikungunya virus and HIV-1 and HIV-2 virus replication, the endemic Mascarene species Stillingia lineata was investigated. LC/MS and bioassay-guided purification of the EtOAc leaf extract using a chikungunya virus-cell-based assay led to the isolation of six new (4–9) and three known (1–3) tonantzitlolones possessing the rare C₂₀-fle ...
DOI:
10.1021/acs.jnatprod.5b00116

5. Antiviral Activity of Diterpene Esters on Chikungunya Virus and HIV Replication

Author:
Nothias-Scaglia, Louis-Félix; Pannecouque, Christophe; Renucci, Franck; Delang, Leen; Neyts, Johan; Roussi, Fanny; Costa, Jean; Leyssen, Pieter; Litaudon, Marc; Paolini, Julien
Source:
Journal of natural products 2015 v.78 no.6 pp. 1277-1283
ISSN:
1520-6025
Subject:
median effective concentration,   etc   ; Chikungunya virus; Euphorbiaceae; Human immunodeficiency virus 1; Human immunodeficiency virus 2; antiretroviral agents; antiviral properties; data collection; diterpenoids; esters; protein kinase C;     Show all 11 Subjects
Abstract:
... Recently, new daphnane, tigliane, and jatrophane diterpenoids have been isolated from various Euphorbiaceae species, of which some have been shown to be potent inhibitors of chikungunya virus (CHIKV) replication. To further explore this type of compound, the antiviral activity of a series of 29 commercially available natural diterpenoids was evaluated. Phorbol-12,13-didecanoate (11) proved to be t ...
DOI:
10.1021/acs.jnatprod.5b00073

6. Environmentally Friendly Procedure Based on Supercritical Fluid Chromatography and Tandem Mass Spectrometry Molecular Networking for the Discovery of Potent Antiviral Compounds from Euphorbia semiperfoliata

Author:
Nothias, Louis-Félix; Boutet-Mercey, Stéphanie; Cachet, Xavier; De La Torre, Erick; Laboureur, Laurent; Gallard, Jean-François; Retailleau, Pascal; Brunelle, Alain; Dorrestein, Pieter C.; Costa, Jean; Bedoya, Luis M.; Roussi, Fanny; Leyssen, Pieter; Alcami, José; Paolini, Julien; Litaudon, Marc; Touboul, David
Source:
Journal of natural products 2017 v.80 no.10 pp. 2620-2629
ISSN:
1520-6025
Subject:
median effective concentration,   etc   ; Chikungunya virus; Euphorbia; Human immunodeficiency virus 1; X-ray diffraction; antiviral agents; antiviral properties; diterpenoids; esters; plant extracts; secondary metabolites; solvents; supercritical fluid chromatography; tandem mass spectrometry; toxicity; virus replication; viruses;     Show all 17 Subjects
Abstract:
... A supercritical fluid chromatography-based targeted purification procedure using tandem mass spectrometry and molecular networking was developed to analyze, annotate, and isolate secondary metabolites from complex plant extract mixture. This approach was applied for the targeted isolation of new antiviral diterpene esters from Euphorbia semiperfoliata whole plant extract. The analysis of bioactive ...
DOI:
10.1021/acs.jnatprod.7b00113