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You searched for: Author "Liu, Hongwei" Remove constraint Author: "Liu, Hongwei" Journal Journal of natural products Remove constraint Journal: Journal of natural products
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1. Identification and Characterization of a Membrane-Bound Sesterterpene Cyclase from Streptomyces somaliensis

Author:
Liu, Hongwei,   et al.   ; Yang, Yanlong; Zhang, Yuting; Zhang, Shasha; Chen, Qingwen; Ma, Ke; Bao, Li; Tao, Yong; Yin, Wenbing; Wang, Guodong;     Show all 10 Authors
Source:
Journal of natural products 2018 v.81 no.4 pp. 1089-1092
ISSN:
1520-6025
Subject:
Escherichia coli; Streptomyces somaliensis; bacteria; genes; mass spectrometry; nuclear magnetic resonance spectroscopy; plants (botany); spectral analysis
Abstract:
... Sesterterpenes are usually found in plants and fungi, but are rare in bacteria. Here, we present the identification of StsC from Streptomyces somaliensis, a member of the UbiA superfamily, as a membrane-bound sesterterpene cyclase in bacteria. The cyclized products for StsC, somaliensenes A (1) and B (2), were identified by expressing the corresponding gene in an engineered Escherichia coli strain ...
DOI:
10.1021/acs.jnatprod.7b01033

2. Two Sarcoviolins with Antioxidative and α-Glucosidase Inhibitory Activity from the Edible Mushroom Sarcodon leucopus Collected in Tibet

Author:
Liu, Hongwei,   et al.   ; Ma, Ke; Han, Junjie; Bao, Li; Wei, Tiezheng;     Show all 5 Authors
Source:
Journal of natural products 2014 v.77 no.4 pp. 942-947
ISSN:
1520-6025
Subject:
2,2-diphenyl-1-picrylhydrazyl; DNA; Sarcodon; alpha-glucosidase; antioxidant activity; antioxidants; ethyl acetate; fruiting bodies; inhibitory concentration 50; lipid peroxidation; mushrooms; spectroscopy; China
Abstract:
... Edible mushrooms are known as an important source of natural antioxidants. The ethyl acetate extract of the edible mushroom Sarcodon leucopus (Zangzi mushroom) possesses strong antioxidative activity. Bioactivity-guided isolation afforded 10 compounds from its fruiting bodies, including two new sarcoviolins, sarcoviolin β (1) and episarcoviolin β (2), and one new p-terphenyl derivative (3) along w ...
DOI:
10.1021/np401026b

3. Lanostane Triterpenes from the Tibetan Medicinal Mushroom Ganoderma leucocontextum and Their Inhibitory Effects on HMG-CoA Reductase and α-Glucosidase

Author:
Liu, Hongwei,   et al.   ; Wang, Kai; Bao, Li; Xiong, Weiping; Ma, Ke; Han, Junjie; Wang, Wenzhao; Yin, Wenbing;     Show all 8 Authors
Source:
Journal of natural products 2015 v.78 no.8 pp. 1977-1989
ISSN:
1520-6025
Subject:
Ganoderma lucidum; alpha-glucosidase; cytotoxicity; fruiting bodies; hydroxymethylglutaryl-CoA reductases; inhibitory concentration 50; medicinal fungi; paclitaxel; secondary metabolites; spectral analysis; triterpenoids; yeasts
Abstract:
... Sixteen new lanostane triterpenes, ganoleucoins A–P (1–16), together with 10 known tripterpenes (17–26), were isolated from the cultivated fruiting bodies of Ganoderma leucocontextum, a new member of the Ganoderma lucidum complex. The structures of the new compounds were elucidated by extensive spectroscopic analysis and chemical transformation. The inhibitory effects of 1–26 on HMG-CoA reductase ...
DOI:
10.1021/acs.jnatprod.5b00331

4. Erinacerins C–L, Isoindolin-1-ones with α-Glucosidase Inhibitory Activity from Cultures of the Medicinal Mushroom Hericium erinaceus

Author:
Liu, Hongwei,   et al.   ; Wang, Kai; Bao, Li; Qi, Qiuyue; Zhao, Feng; Ma, Ke; Pei, Yunfei;     Show all 7 Authors
Source:
Journal of natural products 2015 v.78 no.1 pp. 146-154
ISSN:
1520-6025
Subject:
Hericium; alpha-glucosidase; cytotoxicity; inhibitory concentration 50; isomers; medicinal fungi; secondary metabolites; spectroscopy; terpenoids
Abstract:
... The well-known edible and medicinal mushroom Hericium erinaceus produces various bioactive secondary metabolites. Ten new isoindolin-1-ones, named erinacerins C–L (1–10), together with (E)-5-(3,7-dimethylocta-2,6-dien-1-yl)-4-hydroxy-6-methoxy-2-phenethylisoindolin-1-one (11) were isolated from the solid culture of H. erinaceus. The structures of new metabolites were established by spectroscopic m ...
DOI:
10.1021/np5004388

5. Ganoboninketals A–C, Antiplasmodial 3,4-seco-27-Norlanostane Triterpenes from Ganoderma boninense Pat.

Author:
Liu, Hongwei,   et al.   ; Ma, Ke; Ren, Jinwei; Han, Junjie; Bao, Li; Li, Li; Yao, Yijian; Sun, Chen; Zhou, Bing;     Show all 9 Authors
Source:
Journal of natural products 2014 v.77 no.8 pp. 1847-1852
ISSN:
1520-6025
Subject:
Ganoderma boninense; Plasmodium falciparum; antimalarials; antiparasitic properties; circular dichroism spectroscopy; cytotoxicity; inhibitory concentration 50; macrophages; medicinal fungi; metabolites; nitric oxide; triterpenoids
Abstract:
... Three new nortriterpenes, ganoboninketals A–C (1–3), featuring rearranged 3,4-seco-27-norlanostane skeletons and highly complex polycyclic systems were isolated from the medicinal mushroom Ganoderma boninense. The structures of the new metabolites were established by spectroscopic methods. The absolute configurations in 1–3 were assigned by electronic circular dichroism (ECD) calculations. Compoun ...
DOI:
10.1021/np5002863