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- Lecleire, Stéphane; Hassan, Aktham; Marion-Letellier, Rachel; Antonietti, Michel; Savoye, Guillaume; Bôle-Feysot, Christine; Lerebours, Eric; Ducrotté, Philippe; Déchelotte, Pierre; Coëffier, Moïse
- Journal of nutrition 2008 v.138 no.12 pp. 2481-2486
- glutamine; arginine; inflammation; cytokines; biopsy; Crohn disease; patients; enzyme activity; biochemical pathways; mitogen-activated protein kinase; immunomodulators; cell culture
- ... Glutamine (Gln) and arginine (Arg) are conditionally essential amino acids with immunomodulatory properties. The aim of the study was to assess the effects of Gln and Arg alone or in combination on cytokine release by cultured colonic biopsies from patients with active Crohn's disease (CD). Ten consecutive patients [mean (range) age 26 (18-39) y] with active colonic CD (mean CD activity index: 383 ...