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- Penland, J.G.; Prohaska, J.R.
- Journal of nutrition 2004 v.134 no.8 pp. 1984
- copper; nutrient deficiencies; repletion; rats; animal models; perinatal period; motor development; pregnancy; females; litter size; pregnancy outcome; dams (mothers); brain; iron; maternal nutrition; fetal development; males; animal age
- ... What are the biochemical and behavioral consequences of perinatal copper deficiency? Pregnant Holtzman rats were fed a modified AIN-76A diet low in copper (0.34 mg Cu/kg and 42 mg Fe/kg) starting on gestation d 7. Seven rats received copper in their drinking water (20 mg Cu/L) (+Cu) and 7 drank deionized water (–Cu). Treatments did not affect litter size or pregnancy outcome. Compared with +Cu dam ...
- Reeves, Philip G.; DeMars, Lana C.S.
- Journal of nutrition 2004 v.134 no.8 pp. 1953
- rats; animal models; half life; iron; intestinal absorption; copper; nutrient deficiencies; males; gender differences; isotopes; weanlings; hematocrit; hemoglobin; nutritional status; erythrocyte count; nutrient-nutrient interactions; nutrient retention; iron deficiency anemia; diet-related diseases; human diseases
- ... Dietary copper deficiency (CuD) in rats leads to iron (Fe) deficiency anemia. Is this because CuD reduces Fe absorption? Fe absorption in CuD rats was determined by feeding diets labeled with 59Fe and using whole-body counting (WBC) to assess the amount retained over time. Two groups, each with 45 male weanling rats, were fed an AIN-93G diet low in Cu (<0.3 mg/kg; CuD) or one containing adequate C ...