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- Author:
- Baer, D.J.; Judd, J.T.; Kris-Etherton, P.M.; Zhao, G.; Emken, E.A.
- Source:
- Journal of nutrition 2003 v.133 no.12 pp. 4129
- ISSN:
- 0022-3166
- Subject:
- human nutrition; men; experimental diets; dietary fat; dietary nutrient sources; fatty acids; stearic acid; trans fatty acids; oleic acid; saturated fatty acids; food intake; nutrient availability; fat intake; intestinal absorption; metabolizable energy; feces
- Abstract:
- ... Compared with other saturated fatty acids, stearic acid appears to have different metabolic effects with respect to its impact on risk for cardiovascular disease. These differences may in part reflect biologically important differences in absorption. This study was designed to compare the absorption and the metabolizable energy value of stearic acid with other fatty acids from mixed diets fed to h ...
- Handle:
- 10113/25909
- PubMed:
- 14652360
-
- Author:
- Swain, James H.; Newman, Samuel M.; Hunt, Janet R.
- Source:
- Journal of nutrition 2003 v.133 no.11 pp. 3546
- ISSN:
- 0022-3166
- Subject:
- baked goods; fortified foods; ferrous sulfate; dietary minerals; structure-activity relationships; nutrient availability; iron absorption; food fortification; rats; animal models; heme iron; hemoglobin; iron; water solubility; physicochemical properties
- Abstract:
- ... Foods are fortified with elemental forms of iron to reduce iron deficiency. However, the nutritional efficacy of current, commercially produced elemental iron powders has not been verified. We determined the bioavailability of six commercial elemental iron powders and examined how physicochemistry influences bioavailability. Relative biological value (RBV) of the iron powders was determined using ...
- Handle:
- 10113/46505
- PubMed:
- 14608072
-
- Author:
- Bakken, Naomi A.; Hunt, Curtiss D.
- Source:
- Journal of nutrition 2003 v.133 no.11 pp. 3577
- ISSN:
- 0022-3166
- Subject:
- dietary minerals; boron; vitamin D; nutrient deficiencies; adverse effects; hyperinsulinemia; vitamin deficiencies; hormone metabolism; insulin; chicks; rats; animal models; nutrition-genotype interaction; insulin secretion; pancreas; magnesium; nutritional status
- Abstract:
- ... Because dietary boron deprivation induces hyperinsulinemia in vitamin D–deprived rats, the influence of dietary boron on insulin metabolism as modified by nutritional stressors was examined in two animal models. Male weanling Sprague-Dawley rats were assigned to each of four (Experiment 1) or 8 (Experiment 2) dietary groups for 35 d: the basal diet (< 0.2 mg B; <1.0 mg Mg/kg) was supplemented with ...
- Handle:
- 10113/46506
- PubMed:
- 14608076
-
- Author:
- Hawkes, W.C.; Keim, N.L.
- Source:
- Journal of nutrition 2003 v.133 no.11 pp. 3443
- ISSN:
- 0022-3166
- Subject:
- selenium; nutrient intake; dietary minerals; triiodothyronine; energy metabolism; thyrotropin; weight gain; weight loss; hypothyroidism; blood lipids; triacylglycerols; humans
- Abstract:
- ... Most studies of selenium and thyroid hormone have used sodium selenite in rats. However, rats regulate thyroid hormone differently, and selenite, which has unique pharmacologic activities, does not occur in foods. We hypothesized that selenium in food would have different effects in humans. Healthy men were fed foods naturally high or low in selenium for 120 d while confined to a metabolic researc ...
- Handle:
- 10113/8905
- PubMed:
- 14608056
-
- Author:
- Hunt, Janet R.
- Source:
- Journal of nutrition 2003 v.133 no.11 pp. 3686–3689
- ISSN:
- 1541-6100
- Subject:
- nutritionists; nutrition science; nutrition research; women; vitamins; dietary minerals; food research; history; homes and home furnishings
- Handle:
- 10113/46249
-
- Author:
- Davies, Michael J.; Judd, Joseph T.; Baer, David J.; Clevidence, Beverly A.; Paul, David R.; Edwards, Alison J.; Wiseman, Shelia A.; Muesing, Richard A.; Chen, Shirley C.
- Source:
- Journal of nutrition 2003 v.133 no.10 pp. 3298S–3302S
- ISSN:
- 1541-6100
- Subject:
- black tea; food intake; cholesteremic effect; cholesterol; low density lipoprotein; blood lipids; antioxidants; hypercholesterolemia; humans; adults
- Abstract:
- ... Despite epidemiological evidence that tea consumption is associated with the reduced risk of coronary heart disease, experimental studies designed to show that tea affects oxidative stress or blood cholesterol concentration have been unsuccessful. We assessed the effects of black tea consumption on lipid and lipoprotein concentrations in mildly hypercholesterolemic adults. Tea and other beverages ...
- Handle:
- 10113/48390
-
- Author:
- Palencia, Edwin; Torres, Olga; Hagler, Winston; Meredith, Filmore I.; Williams, Lonnie D.; Riley, Ronald T.
- Source:
- Journal of nutrition 2003 v.133 no.10 pp. 3200
- ISSN:
- 1541-6100
- Subject:
- corn; nixtamalization; traditional technology; fumonisin B1; fumonisin B2; fumonisin B3; detoxification (processing); tortillas; food contamination; masa; Guatemala
- Abstract:
- ... Fumonisin B1 (FB1) is a maize mycotoxin. In tortilla preparation, maize is treated with lime (nixtamalization), producing hydrolyzed FB1 (HFB1) due to loss of the tricarballylic acid side chains. This study determined the following: 1) whether nixtamalization by Mayan communities reduces total fumonisins, and 2) the steps in the process at which reduction occurs. Tortillas prepared by the traditio ...
- Handle:
- 10113/48160
-
- Author:
- Davis, Cindy D.; Uthus, Eric O.
- Source:
- Journal of nutrition 2003 v.133 no.9 pp. 2907
- ISSN:
- 0022-3166
- Subject:
- dietary minerals; vitamin supplements; folic acid; selenium; oxidative stress; antioxidant activity; DNA methylation; carcinogenesis; vitamin deficiencies; DNA damage; nutrient-nutrient interactions; weanlings; rats; animal models; chromosome aberrations; methyltransferases; betaine; homocysteine; glutathione
- Abstract:
- ... Several observations suggest a role for DNA methylation in cancer pathogenesis. Although both selenium and folate deficiency have been shown to cause global DNA hypomethylation and increased cancer susceptibility, the nutrients have different effects on one-carbon metabolism. Thus, the purpose of this study was to investigate the interactive effects of dietary selenium and folate. Weanling, Fische ...
- Handle:
- 10113/46758
- PubMed:
- 12949386
-
- Author:
- Finley, John W.; Penland, James G.; Pettit, Ross E.; Davis, Cindy D.
- Source:
- Journal of nutrition 2003 v.133 no.9 pp. 2849
- ISSN:
- 0022-3166
- Subject:
- dietary minerals; manganese; dietary mineral supplements; women; young adults; mineral metabolism; intestinal absorption; nutrient excess; toxicity; neurophysiology; neuroprotective effect; lipolysis; diet; dietary energy sources; dietary nutrient sources; cocoa butter; corn oil; dietary fat; psychology; nutrient deficiencies
- Abstract:
- ... Because manganese (Mn) is potentially toxic, and because dietary fat type may affect Mn absorption, the objectives of the current study were to determine whether diets containing very low or very high amounts of Mn and enriched in either saturated or unsaturated fats affected measures of neuropsychological and basic metabolic function. Healthy young women were fed for 8 wk each, in a crossover des ...
- Handle:
- 10113/46933
- PubMed:
- 12949376
-
- Author:
- Hintze, Korry J.; Wald, Karl A.; Zeng, Huawei; Jeffery, Elizabeth H.; Finley, John W.
- Source:
- Journal of nutrition 2003 v.133 no.9 pp. 2721
- ISSN:
- 0022-3166
- Subject:
- hepatoma; human diseases; human cell lines; antioxidants; dietary nutrient sources; broccoli; nutrient-nutrient interactions; anticarcinogenic activity; sigma factors; antioxidant activity; luciferase; enzyme activity; reporter genes; synergism; transcription factors; selenium; organic sulfur compounds; seleno amino acids; nutritional intervention; glutathione-disulfide reductase
- Abstract:
- ... We previously reported the in vitro and in vivo induction of thioredoxin reductase (TR) by sulforaphane (SF) purified from broccoli. The present study was designed to determine whether this induction is mediated by putative antioxidant response elements (ARE) found in the promoter. Luciferase reporter constructs were built using the TR promoter sequence. Sulforaphane, tert-butylhydroquinone and ss ...
- Handle:
- 10113/46862
- PubMed:
- 12949356
-
- Author:
- Zeng, Huawei; Davis, Cindy D.
- Source:
- Journal of nutrition 2003 v.133 no.8 pp. 2682–2687
- ISSN:
- 0022-3166
- Subject:
- proliferating cell nuclear antigen; gene expression regulation; cell cycle; colorectal neoplasms; cultured cells; human health; feces composition; cell growth; human diseases
- Abstract:
- ... Cancer is a disease in which the cell cycle is altered, and the elucidation of the mechanisms by which constituents of human fecal water influence the cell cycle can lead to noninvasive measurement of colon cancer risk. The purpose of the present study was to investigate the effect of human fecal water on HT-29 cell-cycle progression with sodium selenite as a reference for comparison. Both human f ...
- Handle:
- 10113/46123
-
- Author:
- Bier, Dennis M.
- Source:
- Journal of nutrition 2003 v.133 no.6S-I pp. 2034S-2039S
- ISSN:
- 0022-3166
- Subject:
- amino acid metabolism; amino acids; pharmacokinetics; protein intake; safety assessment; toxicology
- Abstract:
- ... Tracer kinetic studies of amino acid metabolism during periods of high amino acid intake should allow insights into adaptive or maladaptive regulatory mechanisms controlling amino acid catabolic or disposal events before clinically evident effects. The principles of amino acid tracer kinetics have been well defined, but their application to establishing upper safe intake levels has been essentiall ...
-
- Author:
- Tomkins, Andrew
- Source:
- Journal of nutrition 2003 v.133 no.5 pp. 1649S-1655S
- ISSN:
- 0022-3166
- Subject:
- acute phase proteins; ferritin; inflammation; transferrin receptors; vitamin A
- Abstract:
- ... Measurement of micronutrient status in the presence of inflammation is difficult for several reasons. Changes in levels of acute phase proteins are associated with increased plasma levels of some indicators of micronutrient status, such as ferritin, and decrease of others, such as retinol. Alterations in the plasma levels of acute phase proteins can occur from hemodilution, sequestration and incre ...
-
- Author:
- Cogswell, Mary E.; Weisberg, Pamela; Spong, Catherine
- Source:
- Journal of nutrition 2003 v.133 no.5 pp. 1722S-1731S
- ISSN:
- 0022-3166
- Subject:
- Recommended Dietary Allowances; alcohol abuse; alcohol drinking; ascorbic acid; beta-carotene; blood serum; cadmium; energy intake; fetal development; folic acid; food intake; health services; heavy metals; humans; iron; liver; metabolism; nutrient content; nutrient deficiencies; pregnancy outcome; pregnant women; pyridoxine; smoking (habit); vitamin A; vitamin B12; zinc
- Abstract:
- ... This literature review examines whether smoking or alcohol use during pregnancy increases maternal micronutrient requirements and whether smoking or alcohol use interacts with micronutrient deficiencies to affect pregnancy outcomes. Studies suggest that vitamin C requirements increase for pregnant smokers. Studies also indicate that β-carotene, vitamin B-12, vitamin B-6 and folate concentrations a ...
-
- Author:
- Zeisel, Steven H.; Mar, Mei-Heng; Howe, Juliette C.; Holden, Joanne M.
- Source:
- Journal of nutrition 2003 v.133 no.5 pp. 1302
- ISSN:
- 0022-3166
- Subject:
- livers as food; beef; chicken meat; eggs; wheat germ; bacon; soybeans; pork; spinach; wheat bran; choline; shrimp; snacks; dietary nutrient sources; quantitative analysis; reversed-phase high performance liquid chromatography; mass spectrometry; Adequate Intakes; betaine; epidemiological studies; folic acid; phosphatidylcholines
- Abstract:
- ... Choline is important for normal membrane function, acetylcholine synthesis and methyl group metabolism; the choline requirement for humans is 550 mg/d for men (Adequate Intake). Betaine, a choline derivative, is important because of its role in the donation of methyl groups to homocysteine to form methionine. In tissues and foods, there are multiple choline compounds that contribute to total choli ...
- Handle:
- 10113/38734
- PubMed:
- 12730414
-
- Author:
- Catalano, Patrick M.; Kirwan, John P.; Haugel-De Mouzon, Sylvie; King, Janet
- Source:
- Journal of nutrition 2003 v.133 no.5 pp. 1674S-1683S
- ISSN:
- 0022-3166
- Subject:
- adipose tissue; adiposity; adolescents; adults; energy expenditure; epidemiological studies; fetal development; fetus; gestational diabetes; glucose; health effects assessments; insulin; insulin resistance; lipids; low birth weight; noninsulin-dependent diabetes mellitus; nutrient availability; obesity; pathophysiology; pregnancy; progeny; protein metabolism; women; Europe; United States
- Abstract:
- ... Gestational diabetes and obesity are the common metabolic abnormalities occurring during pregnancy. Decreased maternal pregravid insulin sensitivity (insulin resistance) coupled with an inadequate insulin response are the pathophysiological mechanisms underlying the development of gestational diabetes. Insulin-regulated carbohydrate, lipid and protein metabolism are all affected to a variable degr ...
-
- Author:
- Bergström, Staffan
- Source:
- Journal of nutrition 2003 v.133 no.5 pp. 1656S-1660S
- ISSN:
- 0022-3166
- Subject:
- amniotic fluid; anemia; cervix; defense mechanisms; developed countries; developing countries; extraembryonic membranes; female genitalia; fetus; growth retardation; immunocompetence; morbidity; neonates; nervous system diseases; nutrient deficiencies; placenta; pregnancy; premature birth; respiratory tract diseases; septicemia; vagina
- Abstract:
- ... Only partially understood host defense mechanisms operate against infections affecting maternal and fetal morbidity. Subclinical ascending infections through the lower female genital tract are predominant worldwide. Important micronutrient deficiencies may prevail in low-income countries where these infections are much more common than in high-income countries. Important morbidities related to poo ...
-
- Author:
- Casanueva, Esther; Viteri, Fernando E.
- Source:
- Journal of nutrition 2003 v.133 no.5 pp. 1700S-1708S
- ISSN:
- 0022-3166
- Subject:
- antioxidants; copper; diabetes; fetus; free radicals; hypertension; insulin resistance; intestines; iron; low birth weight; mitochondria; nutrient deficiencies; nutrition risk assessment; oxidative stress; placenta; pregnancy; premature birth; rats; women; Mexico
- Abstract:
- ... Pregnancy, mostly because of the mitochondria-rich placenta, is a condition that favors oxidative stress. Transitional metals, especially iron, which is particularly abundant in the placenta, are important in the production of free radicals. Protective mechanisms against free radical generation and damage increase throughout pregnancy and protect the fetus, which, however, is subjected to a degree ...
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- Author:
- Fall, Caroline H.D.; Yajnik, Chittaranjan S.; Rao, Shobha; Davies, Anna A.; Brown, Nick; Farrant, Hannah J.W.
- Source:
- Journal of nutrition 2003 v.133 no.5 pp. 1747S-1756S
- ISSN:
- 0022-3166
- Subject:
- at-risk population; birth weight; body composition; developing countries; diet; fetal death; fetal development; fetus; foods; growth retardation; infants; malnutrition; maternal nutrition; metabolism; mothers; nutrient deficiencies; nutritional adequacy; pregnancy; progeny; randomized clinical trials; tissues; Tanzania
- Abstract:
- ... Fetal undernutrition affects large numbers of infants in developing countries, with adverse consequences for their immediate survival and lifelong health. It manifests as intrauterine growth retardation (IUGR), defined as birth weight <10th percentile, which probably underestimates the number failing to achieve full growth potential. Birth weight is a crude measure of the dynamic process of fetal ...
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- Author:
- Romero, Roberto; Chaiworapongsa, Tinnakorn; Espinoza, Jimmy
- Source:
- Journal of nutrition 2003 v.133 no.5 pp. 1668S-1673S
- ISSN:
- 0022-3166
- Subject:
- ascorbic acid; bronchopulmonary dysplasia; cerebral palsy; inflammation; microbiology; morbidity; mortality; mothers; pathophysiology; premature birth
- Abstract:
- ... Prematurity is the leading cause of perinatal morbidity and mortality worldwide. Intrauterine infection has emerged as a major cause of premature labor and delivery. It has been estimated that 25% of all preterm deliveries occur to mothers who have microbial invasion of the amniotic cavity, although these infections are mostly subclinical in nature. This article describes the pathways leading to i ...
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