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- Finley, John W.; Davis, Cindy D.; Feng, Yi
- Journal of nutrition 2000 v.130 no.9 pp. 2384
- rats, etc ; dietary minerals; selenium; dietary nutrient sources; broccoli; anticarcinogenic activity; fortified foods; colorectal neoplasms; seleno amino acids; animal disease models; chemoprevention; nutritional intervention; Show all 12 Subjects
- ... Colon cancer is the third most common newly diagnosed cancer in the United States and the third most common cause of cancer-related deaths. Previous supplementation studies have demonstrated the efficacy of selenium (Se) for prevention of colon cancer in humans. The metabolism of Se depends on its chemical form, and studies have shown that the chemical form of Se in broccoli does not accumulate in ...
- Davis, Cindy D.; Uthus, Eric O.; Finley, John W.
- Journal of nutrition 2000 v.130 no.12 pp. 2903
- rats, etc ; selenium; dietary minerals; arsenic; DNA methylation; cell lines; colorectal neoplasms; liver; colon; diet; DNA; blood; blood plasma; homocysteine; nutritional status; adenosylhomocysteine; adenosylmethionine; glutathione peroxidase; cytosol; hepatocytes; animal models; dietary mineral supplements; nutrient deficiencies; Show all 23 Subjects
- ... Selenium is an essential trace element for human health, and it has received considerable attention for its possible role as an anticarcinogenic agent. The purpose of the present study was to determine whether changes in the amount and the chemical form of selenium would affect DNA methylation and whether this effect would be modified by arsenic. Caco-2 cells, a human colon cancer cell line, were ...