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- Johnson, W. Thomas; Dufault, Steven N.; Newman, Samuel M. Jr.
- Journal of nutritional biochemistry 1995 v.6 no.10 pp. 551
- copper; mitochondria; liver; blood plasma; hemoglobin; experimental diets; adenosine monophosphate; adenosine diphosphate; adenosine triphosphate; guanosine triphosphate; purine nucleotides; energy; rats; blood platelets; nutrient deficiencies; hematocrit; ferroxidase
- ... Dietary copper deficiency severely reduces platelet cytochrome c oxidase activity, but the effect of this perturbation on platelet energy metabolism is unknown. In this study, the effect of copper deficiency on platelet adenine nucleotide and GTP content was determined. Structural changes in platelet mitochondria during copper deficiency also were examined. Copper deficiency caused a 24% reduction ...