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- Lammertsma, Koop, et al. Show all 11 Authors
- Journal of organic chemistry 2014 v.79 no.11 pp. 5219-5226
- chemical reactions; chemical structure; diastereoselectivity; imines; organic chemistry; synthesis
- ... A convenient trans-selective one-pot synthesis of tetrafunctionalized 2-imidazolines is described. Our approach to these valuable heterocyclic scaffolds involves a formal 1,3-dipolar cycloaddition between nitrile ylides or nitrilium triflates and imines. A detailed experimental study in combination with a high-level computational exploration of reaction routes reveals a plausible reaction pathway ...