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1. A high glucose level is associated with decreased aspirin-mediated acetylation of platelet cyclooxygenase (COX)-1 at serine 529: A pilot study

Author:
Finamore, Francesco; Reny, Jean-Luc; Malacarne, Sarah; Fontana, Pierre; Sanchez, Jean-Charles
Source:
Journal of proteomics 2019 v.192 pp. 258-266
ISSN:
1874-3919
Subject:
acetylation; aspirin; blood platelets; cardiovascular diseases; diabetes; glucose; glycation; hyperglycemia; mass spectrometry; patients; prostaglandin synthase; proteins; risk factors; serine
Abstract:
... Diabetes is a major risk factor for cardiovascular diseases. Although aspirin is considered a cornerstone of the prevention and treatment of atherothrombotic-related ischemic events, this antiplatelet drug appears to be less effective in patients with poorly controlled diabetes. It has been suggested that the glycation of platelet proteins plays a pivotal role in poor responsiveness to aspirin. Ho ...
DOI:
10.1016/j.jprot.2018.09.007