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You searched for: Journal Journal of proteomics Remove constraint Journal: Journal of proteomics Publication Year 2015 Remove constraint Publication Year: 2015 Source 2015 v.116 Remove constraint Source: 2015 v.116
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1. A signature for immune response correlates with HCV treatment outcome in Caucasian subjects

Author:
Hare, Brian J.; Haseltine, Eric; Fleming, Mark; Chelsky, Daniel; McIntosh, Laura; Allard, Rene; Botfield, Martyn
Source:
Journal of proteomics 2015 v.116 pp. 59-67
ISSN:
1874-3919
Subject:
antiviral agents; blood serum; gene expression regulation; immune response; integrins; microfilaments; monitoring; prediction; proteomics
Abstract:
... Broad proteomic profiling was performed on serum samples of phase 2 studies (PROVE1, PROVE2, and PROVE3) of the direct-acting antiviral drug telaprevir in combination with peg-interferon and ribavirin in subjects with HCV. Using only profiling data from subjects treated with peg-interferon and ribavirin, a signature composed of pretreatment levels of 13 components was identified that correlated we ...
DOI:
10.1016/j.jprot.2014.12.015

2. Characterization of ampicillin-stressed proteomics and development of a direct method for detecting drug-binding proteins in Edwardsiella tarda

Author:
Liu, Xian-jie; Zhu, Wei-cong; Su, Yu-bin; Guo, Chang; Zeng, Zhao-hai; Zhu, Hai; Li, Hui; Peng, Xuan-xian
Source:
Journal of proteomics 2015 v.116 pp. 97-105
ISSN:
1874-3919
Subject:
Edwardsiella tarda; ampicillin; antibiotic resistance; bacteria; bioinformatics; energy metabolism; genes; gluconeogenesis; glycolysis; methodology; proteome; proteomics; recombinant proteins; tricarboxylic acid cycle
Abstract:
... Antibiotic-resistant Edwardsiella tarda poses a severe challenge to aquaculture. An understanding for antibiotic-resistant mechanisms is crucial to control the disease. The present study characterizes E. tarda ampicillin-stressed proteome and shows the importance of energy metabolism including the TCA cycle and glycolysis/gluconeogenesis in the antibiotic resistance. Further combination with antib ...
DOI:
10.1016/j.jprot.2014.12.018

3. Combinatorial Peptide Ligand Library and two dimensional electrophoresis: New frontiers in the study of peritoneal dialysis effluent in pediatric patients

Author:
Bruschi, Maurizio; Candiano, Giovanni; Santucci, Laura; D'Ambrosio, Chiara; Scaloni, Andrea; Bonsano, Marco; Ghiggeri, Gian Marco; Verrina, Enrico
Source:
Journal of proteomics 2015 v.116 pp. 68-80
ISSN:
1874-3919
Subject:
biomarkers; dialysis; fibrosis; inflammation; ligands; patients; peptides; proteins; proteome; proteomics; two-dimensional gel electrophoresis
Abstract:
... Peritoneal dialysis effluent (PDE) is a fluid resulting from the close contact of peritoneal dialysis (PD) solutions with the peritoneal membrane (PM) and represents a readily available material for the search of biomarkers of PM function or damage.Our laboratory has developed a method for the in-depth proteomic characterization of PDE, which involves Combinatorial Peptides Ligand Library (CPLL) t ...
DOI:
10.1016/j.jprot.2015.01.003

4. Comparative secretome analysis of rat stomach under different nutritional status

Author:
Senin, Lucia L.; Roca-Rivada, Arturo; Castelao, Cecilia; Alonso, Jana; Folgueira, Cintia; Casanueva, Felipe F.; Pardo, Maria; Seoane, Luisa M.
Source:
Journal of proteomics 2015 v.116 pp. 44-58
ISSN:
1874-3919
Subject:
appetite; bariatric surgery; body weight changes; descriptive studies; energy balance; fasting; food intake; glyceraldehyde-3-phosphate dehydrogenase; homeostasis; industrialization; mechanism of action; models; nutritional status; obesity; protein secretion; proteins; proteomics; public health; rats; stomach; weight control
Abstract:
... Obesity is a major public health threat for many industrialised countries. Bariatric surgery is the most effective treatment against obesity, suggesting that gut derived signals are crucial for energy balance regulation. Several descriptive studies have proven the presence of gastric endogenous systems that modulate energy homeostasis; however, these systems and the interactions between them are s ...
DOI:
10.1016/j.jprot.2015.01.001

5. Extreme venom variation in Middle Eastern vipers: A proteomics comparison of Eristicophis macmahonii, Pseudocerastes fieldi and Pseudocerastes persicus

Author:
Ali, Syed A.; Jackson, Timothy N.W.; Casewell, Nicholas R.; Low, Dolyce H.W.; Rossi, Sarah; Baumann, Kate; Fathinia, Behzad; Visser, Jeroen; Nouwens, Amanda; Hendrikx, Iwan; Jones, Alun; Undheim, Eivind AB; Fry, Bryan G.
Source:
Journal of proteomics 2015 v.116 pp. 106-113
ISSN:
1874-3919
Subject:
Viperidae; antivenoms; gene flow; proteomics; venoms
Abstract:
... Venoms of the viperid sister genera Eristicophis and Pseudocerastes are poorly studied despite their anecdotal reputation for producing severe or even lethal envenomations. This is due in part to the remote and politically unstable regions that they occupy. All species contained are sit and wait ambush feeders. Thus, this study examined their venoms through proteomics techniques in order to establ ...
DOI:
10.1016/j.jprot.2014.09.003

6. Novel identification of matrix proteins involved in calcitic biomineralization

Author:
Rose-Martel, Megan; Smiley, Sandy; Hincke, Maxwell T.
Source:
Journal of proteomics 2015 v.116 pp. 81-96
ISSN:
1874-3919
Subject:
biomineralization; calcification; calcium carbonate; calcium phosphates; calcium-binding proteins; chickens; collagen; egg shell; extracellular matrix; fibronectins; gravity; humans; hyaluronic acid; models; otoliths; proteoglycans; proteomics
Abstract:
... Calcitic biomineralization is essential for otoconia formation in vertebrates. This process is characterized by protein–crystal interactions that modulate crystal growth on an extracellular matrix. An excellent model for the study of calcitic biomineralization is the avian eggshell, the fastest known biomineralization process. The objective of this study is to identify and characterize matrix prot ...
DOI:
10.1016/j.jprot.2015.01.002

7. Proteomic characterization and comparison of mammalian milk fat globule proteomes by iTRAQ analysis

Author:
Yang, Yongxin; Zheng, Nan; Zhao, Xiaowei; Zhang, Yangdong; Han, Rongwei; Ma, Lu; Zhao, Shengguo; Li, Songli; Guo, Tongjun; Wang, Jiaqi
Source:
Journal of proteomics 2015 v.116 pp. 34-43
ISSN:
1874-3919
Subject:
Holstein; Jersey; biosynthesis; breast milk; buffaloes; camels; catalytic activity; cluster analysis; dairy cows; fatty acids; gluconeogenesis; glycolysis; goat milk; goats; horses; humans; milk; milk fat; peroxisome proliferator-activated receptors; principal component analysis; protein composition; proteome; proteomics; signal transduction; yaks
Abstract:
... Milk fat globule membrane (MFGM) proteins are known to be involved in many biological functions; however, their components and inter-species complexity have not yet been completely elucidated. We investigated the protein composition of the MFGM-enriched fraction from Holstein, Jersey, yak, buffalo, goat, camel, horse, and human. Extracted proteins from the MFGM-enriched fractions were identified a ...
DOI:
10.1016/j.jprot.2014.12.017

8. Quantitative analysis of immunoglobulin subclasses and subclass specific glycosylation by LC–MS–MRM in liver disease

Author:
Yuan, Wei; Sanda, Miloslav; Wu, Jing; Koomen, John; Goldman, Radoslav
Source:
Journal of proteomics 2015 v.116 pp. 24-33
ISSN:
1874-3919
Subject:
affinity chromatography; disease course; glycosylation; hepatoma; human diseases; immunoglobulin G; immunoglobulin M; ions; patients; quantitative analysis
Abstract:
... Aberrant glycosylation of IgGs has been linked to human diseases, including liver disease. In this study, we have quantified plasma immunoglobulins in cirrhosis (CIR) and hepatocellular carcinoma (HCC) and employed a novel LC–MS–MRM assay to quantify glycoforms of IgG subclasses 1–4. Glycan oxonium ions and peptide-GlcNAc fragment ions were utilized to quantify the IgG glycoforms purified by affin ...
DOI:
10.1016/j.jprot.2014.12.020
PubMed:
25582524
PubMed Central:
PMC4329072

9. Quantitative mass spectrometric immunoassay for the chemokine RANTES and its variants

Author:
Trenchevska, Olgica; Sherma, Nisha D.; Oran, Paul E.; Reaven, Peter D.; Nelson, Randall W.; Nedelkov, Dobrin
Source:
Journal of proteomics 2015 v.116 pp. 15-23
ISSN:
1874-3919
Subject:
T-lymphocytes; blood serum; chemokine CCL5; enzyme-linked immunosorbent assay; genes; humans; inflammation; mass spectrometry
Abstract:
... The chemokine RANTES plays a key role in inflammation, cell recruitment and T cell activation. RANTES is heterogenic and exists as multiple variants in vivo. Herein we describe the development and characterization of a fully quantitative mass spectrometric immunoassay (MSIA) for analysis of intact RANTES and its proteoforms in human serum and plasma samples. The assay exhibits linearity over a wid ...
DOI:
10.1016/j.jprot.2014.12.011
PubMed:
25549571
PubMed Central:
PMC4356132

10. Quantitative proteomic analysis of sub-MIC erythromycin inhibiting biofilm formation of S. suis in vitro

Author:
Zhao, Yu-Lin; Zhou, Yong-Hui; Chen, Jian-Qing; Huang, Quan-Yong; Han, Qiang; Liu, Bing; Cheng, Guang-Dong; Li, Yan-Hua
Source:
Journal of proteomics 2015 v.116 pp. 1-14
ISSN:
1874-3919
Subject:
ABC transporters; Streptococcus suis; bacteria; biofilm; chronic diseases; erythromycin; fucose; gene expression regulation; immune system; pathogens; plankton; protein synthesis; proteomics; quorum sensing; signal transduction; stress response; surface proteins; swine
Abstract:
... Streptococcus suis (S. suis) is a swine pathogen and also a zoonotic agent. Biofilms of S. suis may cause persistent infections by the host immune system and antibiotics. Sub-minimal inhibitory concentration (sub-MIC) of erythromycin can inhibit biofilm formation in bacteria. Here, we performed comparative proteomic analyses of cells at two different conditions: sub-MIC erythromycin treated and no ...
DOI:
10.1016/j.jprot.2014.12.019