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- Francesco Finamore; Jean-Luc Reny; Sarah Malacarne; Pierre Fontana; Jean-Charles Sanchez
- Journal of proteomics 2019 v.192 pp. 258-266
- acetylation; aspirin; blood platelets; cardiovascular diseases; diabetes; glucose; glycation; hyperglycemia; mass spectrometry; patients; prostaglandin synthase; proteins; risk factors; serine
- ... Diabetes is a major risk factor for cardiovascular diseases. Although aspirin is considered a cornerstone of the prevention and treatment of atherothrombotic-related ischemic events, this antiplatelet drug appears to be less effective in patients with poorly controlled diabetes. It has been suggested that the glycation of platelet proteins plays a pivotal role in poor responsiveness to aspirin. Ho ...
- Reema Banarjee; Akshay Sharma; Shakuntala Bai; Arati Deshmukh; Mahesh Kulkarni
- Journal of proteomics 2018 pp. -
- advanced glycation end products; apoptosis; bioinformatics; blood coagulation; blood glucose; cardiovascular diseases; cell adhesion; diabetes; genes; human serum albumin; human umbilical vein endothelial cells; humans; intercellular adhesion molecule-1; oxidative stress; patients; proteome; proteomics; quantitative polymerase chain reaction; receptors; therapeutics; transcription (genetics); transcription factor NF-kappa B
- ... Endothelial dysfunction is one of the primary steps in the development of diabetes associated cardiovascular diseases. Hyperglycemic condition in diabetes promotes accumulation of advanced glycation end products (AGEs) in the plasma, that interact with the receptor for AGEs (RAGE) present on the endothelial cells and negatively affect their function. Using Human umbilical vascular endothelial cell ...