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- Author:
- Francesco Finamore; Jean-Luc Reny; Sarah Malacarne; Pierre Fontana; Jean-Charles Sanchez
- Source:
- Journal of proteomics 2019 v.192 pp. 258-266
- ISSN:
- 1874-3919
- Subject:
- acetylation; aspirin; blood platelets; cardiovascular diseases; diabetes; glucose; glycation; hyperglycemia; mass spectrometry; patients; prostaglandin synthase; proteins; risk factors; serine
- Abstract:
- ... Diabetes is a major risk factor for cardiovascular diseases. Although aspirin is considered a cornerstone of the prevention and treatment of atherothrombotic-related ischemic events, this antiplatelet drug appears to be less effective in patients with poorly controlled diabetes. It has been suggested that the glycation of platelet proteins plays a pivotal role in poor responsiveness to aspirin. Ho ...
- DOI:
- 10.1016/j.jprot.2018.09.007
- https://doi.org/10.1016/j.jprot.2018.09.007
- Author:
- Rafael Pérez-Pérez; Eva García-Santos; Francisco J. Ortega-Delgado; Juan A. López; Emilio Camafeita; Wifredo Ricart; José-Manuel Fernández-Real; Belén Peral
- Source:
- Journal of proteomics 2012 v.75 no.3 pp. 783-795
- ISSN:
- 1874-3919
- Subject:
- adipose tissue; biochemical pathways; cardiovascular diseases; gene expression; gene expression regulation; humans; immunoblotting; insulin resistance; noninsulin-dependent diabetes mellitus; obesity; pathophysiology; protein synthesis; proteins; proteomics; subcutaneous fat; transketolase
- Abstract:
- ... Obesity is recognized as an epidemic health problem worldwide. In humans, the accumulation of omental rather than subcutaneous fat appears to be tightly linked to insulin resistance, type 2 diabetes and cardiovascular disease. Differences in gene expression profiles in the adipose tissue comparing non-obese and obese subjects have been well documented. However, to date, no comparative proteomic st ...
- DOI:
- 10.1016/j.jprot.2011.09.016
- PubMed:
- 21989264
- https://doi.org/10.1016/j.jprot.2011.09.016
- Author:
- Marianna H. Antonelou; Hara T. Georgatzakou; Vasillis L. Tzounakas; Athanassios D. Velentzas; Apostolos C. Kokkalis; Anastasios G. Kriebardis; Issidora S. Papassideri
- Source:
- Journal of proteomics 2014 v.101 pp. 88-101
- ISSN:
- 1874-3919
- Subject:
- alkaline phosphatase; biomarkers; cardiovascular diseases; dialysis; disease course; erythrocytes; erythropoietin; glucose; hemodialysis; hemoglobin; kidney diseases; morbidity; mortality; oxidation; oxidative stress; pathophysiology; patients; proteomics; risk factors; toxins
- Abstract:
- ... Chronic kidney disease is a risk factor for cardiovascular mortality. This study uncovers pieces of hematological and erythrocyte protein variability observed in end stage renal disease (ESRD) in relation to disease progression/duration and mortality. Using a variety of experimental approaches, erythropoietin/dialysis-treated patients were compared to healthy individuals and had been followed for ...
- DOI:
- 10.1016/j.jprot.2014.02.009
- https://doi.org/10.1016/j.jprot.2014.02.009
- Author:
- Ela Shai; Isaac Rosa; Andrés F. Parguiña; Sarah Motahedeh; David Varon; Ángel García
- Source:
- Journal of proteomics 2012 v.76 no. pp. 287-296
- ISSN:
- 1874-3919
- Subject:
- Western blotting; angiogenesis; cardiovascular diseases; computer software; correlation; endothelial cells; flow cytometry; integrins; neoplasms; open reading frames; platelet activation; proteome; proteomics; receptors; thrombin
- Abstract:
- ... Platelet-derived microparticles (PMP) are elevated in a number of disorders (e.g. cardiovascular disease and cancer). In the present study, we have carried out a high-resolution 2-DE-based proteomic analysis of PMP originated following platelet activation with different stimulus. Flow cytometric analysis revealed a higher average number of microparticles when platelets are activated with shear (18 ...
- DOI:
- 10.1016/j.jprot.2012.02.030
- PubMed:
- 22415276
- https://doi.org/10.1016/j.jprot.2012.02.030
- Author:
- Harubumi Kato; Toshihide Nishimura; Norihiko Ikeda; Tesshi Yamada; Tadashi Kondo; Nagahiro Saijo; Kazuto Nishio; Junichiro Fujimoto; Masaharu Nomura; Yoshiya Oda; Bertil Lindmark; Jiro Maniwa; Hitoshi Hibino; Michiaki Unno; Toshinori Ito; Yoshiki Sawa; Hiromasa Tojo; Shin Egawa; Goutham Edula; Mary Lopez; Murray Wigmore; Naohiko Inase; Yasuyuki Yoshizawa; Fumio Nomura; György Marko-Varga
- Source:
- Journal of proteomics 2011 v.74 no.6 pp. 759-764
- ISSN:
- 1874-3919
- Subject:
- diagnostic techniques; elderly; health care costs; drug therapy; image analysis; cardiovascular diseases; lung neoplasms; biomarkers; drugs; medicine; infrastructure; models; technology; phenotype; patients; proteomics; computed tomography; mortality; Japan
- Abstract:
- ... Lung cancer, COPD and cardiovascular diseases are highlighted as some of the most common disease that cause mortality, and for that reason are the most active areas for drug development. This perspective paper overviews the urgent need to develop a health care system for a rapidly growing patient population in Japan, including forthcoming demands on clinical care, expecting outcomes, and economics ...
- DOI:
- 10.1016/j.jprot.2010.12.006
- PubMed:
- 21184850
- https://doi.org/10.1016/j.jprot.2010.12.006
- Author:
- Hai-Tao Pan; Meng-Xi Guo; Yi-Meng Xiong; Jun Ren; Jun-Yu Zhang; Qian Gao; Zhang-Hong Ke; Gu-Feng Xu; Ya-Jing Tan; Jian-Zhong Sheng; He-Feng Huang
- Source:
- Journal of proteomics 2015 v.112 pp. 262-273
- ISSN:
- 1874-3919
- Subject:
- Western blotting; adulthood; aldehyde reductase; angiogenesis; blood pressure; cardiovascular diseases; children; cluster analysis; epidemiological studies; gene expression regulation; mothers; patients; pre-eclampsia; protein synthesis; proteins; proteomics; risk; stable isotopes; umbilical arteries
- Abstract:
- ... Epidemiological studies suggest that the impact of preeclampsia does not only affect the mother but also the children. We know that adverse events in utero may predispose individuals to premature cardiovascular disease in adulthood, but we do not know the mechanisms. To gain insights into the mechanisms of cardiovascular dysfunction in the offspring of preeclampsia, we employed a global stable iso ...
- DOI:
- 10.1016/j.jprot.2014.09.006
- https://doi.org/10.1016/j.jprot.2014.09.006
- Author:
- Toke Peter Krogager; Lone Vendel Nielsen; Steffen Bak; Clifford Young; Carla Ferreri; Ole Nørregaard Jensen; Peter Højrup; Vladimiros Thoma; Ida B. Thøgersen; Jan J. Enghild
- Source:
- Journal of proteomics 2012 v.75 no.9 pp. 2685-2696
- ISSN:
- 1874-3919
- Subject:
- amino acids; biomarkers; blood proteins; cardiovascular diseases; cell culture; elaidic acid; gel electrophoresis; gene expression; hepatocytes; humans; isotope labeling; lipoproteins; mass spectrometry; microarray technology; monitoring; oleic acid; risk; stable isotopes; stearic acid
- Abstract:
- ... Trans fatty acid intake has been correlated to an unfavorable plasma lipoprotein profile and an increased cardiovascular disease risk. The present study aimed to identify a plasma protein biomarker panel related to human intake of elaidic acid. The human liver cell line HepG2-SF was used as a model system, and the cells were maintained for seven days in serum-free medium containing 100μM elaidic a ...
- DOI:
- 10.1016/j.jprot.2012.03.023
- PubMed:
- 22483997
- https://doi.org/10.1016/j.jprot.2012.03.023
- Author:
- Scott M. Gordon; Hailong Li; Xiaoting Zhu; Patrick Tso; Catherine A. Reardon; Amy S. Shah; L. Jason Lu; W. Sean Davidson
- Source:
- Journal of proteomics 2016 v.146 pp. 184-194
- ISSN:
- 1874-3919
- Subject:
- animal models; apolipoproteins; blood lipids; blood proteins; cardiovascular diseases; gel chromatography; high density lipoprotein; mass spectrometry; mice; particle size distribution; proteomics
- Abstract:
- ... Given their association with cardiovascular disease protection, there has been intense interest in understanding the biology of high density lipoproteins (HDL). HDL is actually a family of diverse particle types, each made up of discrete - but as yet undetermined – combinations of proteins drawn from up to 95 lipophilic plasma proteins. The abundant apolipoproteins (apo) of the A class (apoA-I, ap ...
- DOI:
- 10.1016/j.jprot.2016.06.035
- PubMed:
- 27385375
- PubMed Central:
- PMC4987197
- https://doi.org/10.1016/j.jprot.2016.06.035
- Author:
- Yan Zhao; Gang Yang; Ningyuan Wu; Xiaojuan Cao; Jian Gao
- Source:
- Journal of proteomics 2020 v.229 pp. 103967
- ISSN:
- 1874-3919
- Subject:
- Danio rerio; alpha-linolenic acid; cardiovascular diseases; catalytic activity; chronic diseases; disease occurrence; docosahexaenoic acid; endoplasmic reticulum; gamma-linolenic acid; gene expression regulation; genes; homeostasis; human diseases; linoleic acid; long chain polyunsaturated fatty acids; noninsulin-dependent diabetes mellitus; obesity; omega-3 fatty acids; peroxisome proliferator-activated receptors; phosphoproteome; phosphotransferases (kinases); protein synthesis; proteomics; signal transduction; spliceosomes; stearoyl-CoA desaturase; therapeutics; transcriptome; transcriptomics
- Abstract:
- ... Fatty acid desaturate 2 (Fads2) is associated with many chronic diseases. Nevertheless, comprehensive researches on its role have not been performed. We here conducted an integrated analysis of long-chain polyunsaturated fatty acid (LC-PUFA) metabolism of fads2-deletion zebrafish (fads2⁻/⁻) by transcriptomics, proteomics and phosphoproteomics. Compared with wild type zebrafish (WT), fads2⁻/⁻ showe ...
- DOI:
- 10.1016/j.jprot.2020.103967
- https://doi.org/10.1016/j.jprot.2020.103967
- Author:
- Nico P.M. Smit; Fred P.H.T.M. Romijn; Irene van den Broek; Jan W. Drijfhout; Martin Haex; Arnoud van der Laarse; Yuri E.M. van der Burgt; Christa M. Cobbaert
- Source:
- Journal of proteomics 2014 v.109 pp. 143-161
- ISSN:
- 1874-3919
- Subject:
- antibodies; apolipoproteins; biomarkers; blood serum; cardiovascular diseases; liquid chromatography; low density lipoprotein cholesterol; mass spectrometry; monitoring; patients; peptides; proteomics; quantitative analysis; risk assessment; stable isotopes; traceability
- Abstract:
- ... In this study, we have followed up on previous liquid chromatography (LC) multiple reaction monitoring (MRM) mass spectrometry (MS) approaches for measurement of apolipoprotein (apo) A-I and apo B100 in serum aiming for implementation of a multiplexed assay in a clinical chemistry laboratory with full metrological traceability. Signature peptides were selected and detected by dynamic MRM, and stab ...
- DOI:
- 10.1016/j.jprot.2014.06.015
- https://doi.org/10.1016/j.jprot.2014.06.015
- Author:
- Lara Stolzenburg-Veeser; Olga Golubnitschaja
- Source:
- Journal of proteomics 2018 v.188 pp. 71-84
- ISSN:
- 1874-3919
- Subject:
- aesthetics; cardiovascular diseases; chronic diseases; drug therapy; elderly; endocrinology; general practitioners; health services; irradiation; medicine; pain; patients; proteomics; psychology; radiology; surgery; tissue repair
- Abstract:
- ... Wound healing is a highly complex life-important repair process triggered by plenty of local and/or systemic organ and tissue damaging events, such as an acute surgical invasion, accidental organ and tissue damages, acute and chronic diseases, aggressive local and systemic therapeutic approaches (e.g. irradiation and systemic chemotherapy). Individual health condition determines over the quality o ...
- DOI:
- 10.1016/j.jprot.2017.07.017
- https://doi.org/10.1016/j.jprot.2017.07.017
- Author:
- Giulia Speziali; Laura Liesinger; Juergen Gindlhuber; Christina Leopold; Bettina Pucher; Jessica Brandi; Annalisa Castagna; Tamara Tomin; Petra Krenn; Gerhard G. Thallinger; Oliviero Olivieri; Nicola Martinelli; Dagmar Kratky; Matthias Schittmayer; Ruth Birner-Gruenberger; Daniela Cecconi
- Source:
- Journal of proteomics 2018 v.181 pp. 118-130
- ISSN:
- 1874-3919
- Subject:
- cardiovascular diseases; cholesterol; cytoskeleton; droplets; endoplasmic reticulum stress; exosomes; hepatocytes; hepatoma; human cell lines; humans; liver; mice; microRNA; mortality; myristic acid; protein metabolism; protein secretion; proteins; proteomics; risk
- Abstract:
- ... Myristic acid, the 14-carbon saturated fatty acid (C14:0), is associated to an increased cardiovascular disease risk. Since it is found in low concentration in cells, its specific properties have not been fully analyzed. The aim of this study was to explore the cell response to this fatty acid to help explaining clinical findings on the relationship between C14:0 and cardiovascular disease. The hu ...
- DOI:
- 10.1016/j.jprot.2018.04.008
- https://doi.org/10.1016/j.jprot.2018.04.008
13. Novel molecular plasma signatures on cardiovascular disease can stratify patients throughout life
- Author:
- Nerea Corbacho-Alonso; Montserrat Baldán-Martín; Juan Antonio López; Elena Rodríguez-Sánchez; Paula J. Martínez; Laura Mourino-Alvarez; Tatiana Martin-Rojas; Tamara Sastre-Oliva; Felipe Madruga; Jesús Vázquez; Luis R. Padial; Gloria Alvarez-Llamas; Fernando Vivanco; Gema Ruiz-Hurtado; Luis M. Ruilope; Maria G. Barderas
- Source:
- Journal of proteomics 2020 v.222 pp. 103816
- ISSN:
- 1874-3919
- Subject:
- algorithms; cardiovascular diseases; elderly; models; pathogenesis; patients; population dynamics; prediction; proteomics; risk assessment; risk factors; spectroscopy; turbidimetry
- Abstract:
- ... Several models are available to calculate the risk of developing cardiovascular complications in mid-life. The estimation of lifetime risk in the long-term remains an unmet clinical need. We previously identified new molecular plasma signatures for cardiovascular risk stratification in a young population (30–50-years old). The aim of the present study was to determine if the specific signature fou ...
- DOI:
- 10.1016/j.jprot.2020.103816
- https://doi.org/10.1016/j.jprot.2020.103816
- Author:
- Christopher A Toth; Zsuzsanna Kuklenyik; Jeffrey I Jones; Bryan A Parks; Michael S Gardner; David M Schieltz; Jon C Rees; Michael L Andrews; Lisa G McWilliams; James L Pirkle; John R Barr
- Source:
- Journal of proteomics 2017 v.150 pp. 258-267
- ISSN:
- 1874-3919
- Subject:
- apolipoproteins; biomarkers; blood serum; cardiovascular diseases; cohort studies; immobilized enzymes; immunoassays; lipid composition; proteomics; quantitative analysis; temperature; trypsin
- Abstract:
- ... Apolipoproteins measured in plasma or serum are potential biomarkers for assessing metabolic irregularities that are associated with the development of cardiovascular disease (CVD). LC-MS/MS allows quantitative measurement of multiple apolipoproteins in the same sample run. However, the accuracy and precision of the LC-MS/MS measurement depends on the reproducibility of the enzymatic protein diges ...
- DOI:
- 10.1016/j.jprot.2016.09.011
- https://doi.org/10.1016/j.jprot.2016.09.011
- Author:
- Graziella E. Ronsein; Nathalie Pamir; Priska D. von Haller; Daniel S. Kim; Michael N. Oda; Gail P. Jarvik; Tomas Vaisar; Jay W. Heinecke
- Source:
- Journal of proteomics 2015 v.113 pp. 388-399
- ISSN:
- 1874-3919
- Subject:
- apolipoprotein A-I; cardioprotective effect; cardiovascular diseases; cholesterol; high density lipoprotein; ions; monitoring; nanoparticles; proteome; proteomics; risk; risk assessment; translation (genetics)
- Abstract:
- ... High-density lipoprotein (HDL), a lipid nanoparticle containing many different low abundance proteins, is an attractive target for clinical proteomics because its compositional heterogeneity is linked to its cardioprotective effects. Selected reaction monitoring (SRM) is currently the method of choice for targeted quantification of proteins in such a complex biological matrix. However, model syste ...
- DOI:
- 10.1016/j.jprot.2014.10.017
- PubMed:
- 25449833
- PubMed Central:
- PMC4259393
- https://doi.org/10.1016/j.jprot.2014.10.017
- Author:
- Fei Liu; Chun Zhao; Lan Liu; Hongjuan Ding; Ran Huo; Zhonghua Shi
- Source:
- Journal of proteomics 2016 v.139 pp. 38-44
- ISSN:
- 1874-3919
- Subject:
- biomarkers; birth weight; blood serum; cardiovascular diseases; detection limit; enzyme activity; enzymes; fetal macrosomia; fibrinogen; filters; gene expression regulation; gestational diabetes; liquid chromatography; molecular weight; mothers; neonates; obesity; peptides; pregnancy; tandem mass spectrometry; tissues; ultrafiltration; umbilical cord; women
- Abstract:
- ... Fetal macrosomia, defined as a birth weight ≥4000g, may affect 15–45% of newborns of women with gestational diabetes mellitus (GDM). The associations between endogenous peptides and gestational diabetes-induced macrosomia have not been investigated extensively by peptidome analysis. Here, we analyzed the umbilical cord plasma by combining ultrafiltration using molecular weight cut-off filters and ...
- DOI:
- 10.1016/j.jprot.2016.03.001
- https://doi.org/10.1016/j.jprot.2016.03.001
- Author:
- Andreas Simm
- Source:
- Journal of proteomics 2013 v.92 pp. 248-259
- ISSN:
- 1874-3919
- Subject:
- advanced glycation end products; biomarkers; body fluids; carbohydrates; cardiovascular diseases; cardiovascular system; crosslinking; extracellular matrix; glycation; inflammation
- Abstract:
- ... Advanced glycation endproducts (AGEs), pathophysiological important posttranslational modifications, are formed in vivo by a non-enzymatic reaction of proteins with reactive carbohydrates and accumulate during aging. They are discussed to be responsible for degenerative diseases. Glycation modifies the structure and function of proteins, induces tissue stiffening via crosslinking and a long-lastin ...
- DOI:
- 10.1016/j.jprot.2013.05.012
- PubMed:
- 23702329
- https://doi.org/10.1016/j.jprot.2013.05.012
- Author:
- Pamella Araujo Malagrino; Gabriela Venturini; Patrícia Schneider Yogi; Rafael Dariolli; Kallyandra Padilha; Bianca Kiers; Tamiris Carneiro Gois; Karina Helena Morais Cardozo; Valdemir Melechco Carvalho; Jéssica Silva Salgueiro; Adriana Castello Costa Girardi; Silvia Maria de Oliveira Titan; José Eduardo Krieger; Alexandre Costa Pereira
- Source:
- Journal of proteomics 2017 v.151 pp. 66-73
- ISSN:
- 1874-3919
- Subject:
- biomarkers; blood serum; cardiovascular diseases; cortex; diabetic nephropathy; dipeptidyl-peptidase IV; epithelium; gene expression regulation; ischemia; kidneys; models; patients; peptides; proteome; renal failure; screening; swine; transcription factors; urine
- Abstract:
- ... The main bottleneck in studies aiming to identify novel biomarkers in acute kidney injury (AKI) has been the identification of markers that are organ and process specific. Here, we have used different tissues from a controlled porcine renal ischemia/reperfusion (I/R) model to identify new, predominantly renal biomarker candidates for kidney disease. Urine and serum samples were analyzed in pre-isc ...
- DOI:
- 10.1016/j.jprot.2016.07.019
- https://doi.org/10.1016/j.jprot.2016.07.019
- Author:
- Arundhathi Sriharshan; Karsten Boldt; Hakan Sarioglu; Zarko Barjaktarovic; Omid Azimzadeh; Ludwig Hieber; Horst Zitzelsberger; Marius Ueffing; Michael J. Atkinson; Soile Tapio
- Source:
- Journal of proteomics 2012 v.75 no.8 pp. 2319-2330
- ISSN:
- 1874-3919
- Subject:
- DNA repair; amino acids; cardiovascular diseases; cell culture; cell movement; endothelial cells; endothelium; gamma radiation; gene expression regulation; gluconeogenesis; glycolysis; humans; irradiation; isotope labeling; ketone bodies; models; oxidative phosphorylation; protein synthesis; proteins; proteomics; risk; stable isotopes; tandem mass spectrometry
- Abstract:
- ... Epidemiological data show that ionising radiation increases the risk of cardiovascular disease. The endothelium is one of the main targets of radiation-induced damage. Rapid radiation-induced alterations in the biological processes were investigated after exposure to a clinically relevant radiation dose (2.5Gy gamma radiation). The changes in protein expression were determined using the human endo ...
- DOI:
- 10.1016/j.jprot.2012.02.009
- PubMed:
- 22370162
- https://doi.org/10.1016/j.jprot.2012.02.009
- Author:
- Mutay Aslan; Serdar Dogan
- Source:
- Journal of proteomics 2011 v.74 no.11 pp. 2274-2288
- ISSN:
- 1874-3919
- Subject:
- actin; albumins; biomarkers; cardiovascular diseases; cytochrome c; histones; human diseases; nitrogen; oxidation; oxidative stress; oxygen; proteomics; superoxide dismutase; tyrosine
- Abstract:
- ... Increased levels of reactive oxygen and nitrogen species are linked to many human diseases and can be formed as an indirect result of the disease process. The accumulation of specific nitroproteins which correlate with pathological processes suggests that nitration of protein tyrosine represents a dynamic and selective process, rather than a random event. Indeed, in numerous clinical disorders ass ...
- DOI:
- 10.1016/j.jprot.2011.05.029
- PubMed:
- 21640858
- https://doi.org/10.1016/j.jprot.2011.05.029
- Author:
- Reema Banarjee; Akshay Sharma; Shakuntala Bai; Arati Deshmukh; Mahesh Kulkarni
- Source:
- Journal of proteomics 2018 pp. -
- ISSN:
- 1874-3919
- Subject:
- advanced glycation end products; apoptosis; bioinformatics; blood coagulation; blood glucose; cardiovascular diseases; cell adhesion; diabetes; genes; human serum albumin; human umbilical vein endothelial cells; humans; intercellular adhesion molecule-1; oxidative stress; patients; proteome; proteomics; quantitative polymerase chain reaction; receptors; therapeutics; transcription (genetics); transcription factor NF-kappa B
- Abstract:
- ... Endothelial dysfunction is one of the primary steps in the development of diabetes associated cardiovascular diseases. Hyperglycemic condition in diabetes promotes accumulation of advanced glycation end products (AGEs) in the plasma, that interact with the receptor for AGEs (RAGE) present on the endothelial cells and negatively affect their function. Using Human umbilical vascular endothelial cell ...
- DOI:
- 10.1016/j.jprot.2018.06.009
- https://doi.org/10.1016/j.jprot.2018.06.009
22. Proteomics of Lipoprotein(a) identifies a protein complement associated with response to wounding
- Author:
- Anne von Zychlinski; Torsten Kleffmann; Michael J.A. Williams; Sally P. McCormick
- Source:
- Journal of proteomics 2011 v.74 no.12 pp. 2881-2891
- ISSN:
- 1874-3919
- Subject:
- proteome; complement; quantitative analysis; coagulation; humans; cardiovascular diseases; lipoproteins; inflammation; risk factors; proteomics; pathogenicity; stoichiometry; mass spectrometry; lipid metabolism
- Abstract:
- ... Lipoprotein(a) [Lp(a)] is a major independent risk factor for cardiovascular disease. Twenty percent of the general population exhibit levels above the risk threshold highlighting the importance for clinical and basic research. Comprehensive proteomics of human Lp(a) will provide significant insights into Lp(a) physiology and pathogenicity. Using liquid chromatography-coupled mass spectrometry, we ...
- DOI:
- 10.1016/j.jprot.2011.07.008
- PubMed:
- 21802535
- https://doi.org/10.1016/j.jprot.2011.07.008
- Author:
- Xiangmin Zhang; Danjun Ma; Michael Caruso; Monique Lewis; Yue Qi; Zhengping Yi
- Source:
- Journal of proteomics 2014 v.109 pp. 63-75
- ISSN:
- 1874-3919
- Subject:
- cardiovascular diseases; dephosphorylation; insulin; insulin resistance; noninsulin-dependent diabetes mellitus; phosphoproteins; phosphorylation; protein subunits; proteomics; skeletal muscle
- Abstract:
- ... Serine/threonine protein phosphatase 1 regulatory subunit 12A (PPP1R12A) modulates the activity and specificity of the catalytic subunit of protein phosphatase 1, regulating various cellular processes via dephosphorylation. Nonetheless, little is known about phosphorylation events controlled by PPP1R12A in skeletal muscle insulin signaling. Here, we used quantitative phosphoproteomics to generate ...
- DOI:
- 10.1016/j.jprot.2014.06.010
- PubMed:
- 24972320
- PubMed Central:
- PMC4254023
- https://doi.org/10.1016/j.jprot.2014.06.010
- Author:
- Zhong-Wei Xu; Xi Chen; Xiao-Han Jin; Xiang-Yan Meng; Xin Zhou; Feng-Xu Fan; Shi-Yun Mao; Yue Wang; Wen-Cheng Zhang; Na-Na Shan; Yu-Ming Li; Rui-Cheng Xu
- Source:
- Journal of proteomics 2016 v.130 pp. 211-220
- ISSN:
- 1874-3919
- Subject:
- acetyl coenzyme A; adenosine triphosphate; anaerobic conditions; apoptosis; bioinformatics; calcium; cardiomyocytes; cardiovascular diseases; caspase-3; cobalt; energy metabolism; membrane potential; mitochondrial membrane; proteins; proteomics; reactive oxygen species; tricarboxylic acid cycle
- Abstract:
- ... Hypoxic status alters the energy metabolism and induces cell injury in cardiomyocytes, and it further triggers the occurrence and development of cardiovascular diseases. Our previous studies have shown that salidroside (SAL) exhibits anti-hypoxic activity. However, the mechanisms remain obscure. In the present study, we successfully screened 92 different expression proteins in CoCl2-induced hypoxi ...
- DOI:
- 10.1016/j.jprot.2015.09.028
- https://doi.org/10.1016/j.jprot.2015.09.028
- Author:
- Arturo Roca-Rivada; Jana Alonso; Omar Al-Massadi; Cecilia Castelao; Juan Ramón Peinado; Luisa María Seoane; Felipe F. Casanueva; María Pardo
- Source:
- Journal of proteomics 2011 v.74 no.7 pp. 1068-1079
- ISSN:
- 1874-3919
- Subject:
- adipokines; adipose tissue; cardiovascular diseases; death; developed countries; explants; neoplasms; noninsulin-dependent diabetes mellitus; obesity; pandemic; proteins; public health; rats; risk; visceral fat
- Abstract:
- ... Obesity prevalence is reaching pandemic proportions becoming a major public health threat for many industrialized nations. It is especially worrying as it causes a higher risk of premature death due to associated diseases such as type 2 diabetes, cardiovascular disease, and some cancers. Current evidence shows biological and genetic differences between adipose tissues depending on its anatomical l ...
- DOI:
- 10.1016/j.jprot.2011.03.010
- PubMed:
- 21439414
- https://doi.org/10.1016/j.jprot.2011.03.010