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- Brown-Borg, Holly; Johnson, W. Thomas; Rakoczy, Sharlene; Romanick, Mark
- Journal of the American Aging Association 2001 v.24 no.3 pp. 85
- senescence; liver; brain; mitochondria; somatotropin; antioxidant activity; hydrogen peroxide; lipid peroxidation; reactive oxygen species; mice; transgenic animals; protein content; DNA damage
- ... Aging is associated with an accumulation of oxidative damage to proteins, lipids and DNA. Cellular mechanisms designed to prevent oxidative damage decline with aging and in diseases associated with aging. A long-lived mouse, the Ames dwarf, exhibits growth hormone deficiency and heightened antioxidative defenses. In contrast, animals that over express GH have suppressed antioxidative capacity and ...