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- Leisinger, Florian; Burn, Reto; Meury, Marcel; Lukat, Peer; Seebeck, Florian P.
- Journal of the American Chemical Society 2019 v.141 no.17 pp. 6906-6914
- histidine, etc ; Chlorobium limicola; active sites; anaerobic conditions; bacteria; biosynthesis; catalytic activity; chemical bonding; crystal structure; humans; metabolites; reactive oxygen species; virulent strains; Show all 13 Subjects
- ... Ergothioneine is an emergent factor in cellular redox biochemistry in humans and pathogenic bacteria. Broad consensus has formed around the idea that ergothioneine protects cells against reactive oxygen species. The recent discovery that anaerobic microorganisms make the same metabolite using oxygen-independent chemistry indicates that ergothioneine also plays physiological roles under anoxic cond ...
- Stunkard, Lee M.; Dixon, Austin D.; Huth, Tyler J.; Lohman, Jeremy R.
- Journal of the American Chemical Society 2019 v.141 no.13 pp. 5121-5124
- histidine, etc ; Escherichia coli; active sites; biosynthesis; decarboxylation; fatty acids; hydrolysis; hydrophobicity; metabolites; methylmalonyl-CoA decarboxylase; methylmalonyl-coenzyme A; moieties; polyketides; structure-activity relationships; sulfonates; thioesters; transferases; Show all 17 Subjects
- ... Malonyl-thioesters are reactive centers of malonyl-CoA and malonyl-S-acyl carrier protein, essential to fatty acid, polyketide and various specialized metabolite biosynthesis. Enzymes that create or use malonyl-thioesters spontaneously hydrolyze or decarboxylate reactants on the crystallographic time frame preventing determination of structure–function relationships. To address this problem, we ha ...