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You searched for: Subject "regioselectivity" Remove constraint Subject: "regioselectivity" Journal Journal of the American Chemical Society Remove constraint Journal: Journal of the American Chemical Society Publication Year 2019 Remove constraint Publication Year: 2019 Subject organic chemistry Remove constraint Subject: organic chemistry
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1. CuH-Catalyzed Enantioselective Alkylation of Indole Derivatives with Ligand-Controlled Regiodivergence

Author:
Ye, Yuxuan; Kim, Seoung-Tae; Jeong, Jinhoon; Baik, Mu-Hyun; Buchwald, Stephen L.
Source:
Journal of the American Chemical Society 2019 v.141 no.9 pp. 3901-3909
ISSN:
1520-5126
Subject:
regioselectivity,   etc   ; Lewis acids; Lewis bases; alkylation; catalysts; copper; density functional theory; enantioselectivity; hydrides; indoles; ligands; organic chemistry;     Show all 12 Subjects
Abstract:
... Enantioenriched molecules bearing indole-substituted stereocenters form a class of privileged compounds in biological, medicinal, and organic chemistry. Thus, the development of methods for asymmetric indole alkylation is highly valuable in organic synthesis. Traditionally, achieving N-selectivity in indole alkylation reactions is a significant challenge, since there is an intrinsic preference for ...
DOI:
10.1021/jacs.8b11838

2. Chiral Bidentate Boryl Ligand Enabled Iridium-Catalyzed Asymmetric C(sp²)–H Borylation of Diarylmethylamines

Author:
Zou, Xiaoliang; Zhao, Haonan; Li, Yinwu; Gao, Qian; Ke, Zhuofeng; Senmiao Xu,
Source:
Journal of the American Chemical Society 2019 v.141 no.13 pp. 5334-5342
ISSN:
1520-5126
Subject:
regioselectivity,   etc   ; acids; catalytic activity; chemical bonding; enantioselectivity; ligands; organic chemistry;     Show all 7 Subjects
Abstract:
... Optically active organoboronic acids and their derivatives are an important family of target compounds in organic chemistry, catalysis, and medicinal chemistry. Yet there are rare asymmetric catalytic examples reported for the synthesis of these compounds via atom and step economic ways. Herein, we report a chelate-directed iridium-catalyzed asymmetric C(sp²)–H borylation of aromatic C–H bonds dir ...
DOI:
10.1021/jacs.8b13756