Jump to Main Content
- Matos, Maria J.; Oliveira, Bruno L.; Martínez-Sáez, Nuria; Guerreiro, Ana; Cal, Pedro M. S. D.; Bertoldo, Jean; Maneiro, María; Perkins, Elizabeth; Howard, Julie; Deery, Michael J.; Chalker, Justin M.; Corzana, Francisco; Jiménez-Osés, Gonzalo; Bernardes, Gonçalo J. L.
- Journal of the American Chemical Society 2018 v.140 no.11 pp. 4004-4017
- Lewis acids; Lewis bases; acrylates; amino acid sequences; antibodies; apoptosis; chemical bonding; chemoselectivity; cysteine; fluorescent dyes; genetic engineering; image analysis; lysine; pH; proteins; regioselectivity; therapeutics
- ... Site-selective chemical conjugation of synthetic molecules to proteins expands their functional and therapeutic capacity. Current protein modification methods, based on synthetic and biochemical technologies, can achieve site selectivity, but these techniques often require extensive sequence engineering or are restricted to the N- or C-terminus. Here we show the computer-assisted design of sulfony ...
- PubMed Central: