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- Li, Long, et al. Show all 9 Authors
- Journal of the American Chemical Society 2018 v.140 no.43 pp. 14314-14323
- epitopes; microtubules; neurodegenerative diseases; nucleotide aptamers; oligomerization; phosphorylation; protein aggregates; therapeutics
- ... Tau proteins are proteins that stabilize microtubules, but their hyperphosphorylation can result in the formation of protein aggregates and, over time, neurodegeneration. This phenomenon, termed tauopathy, is pathologically involved in several neurodegenerative disorders. DNA aptamers are single-stranded oligonucleotides capable of specific binding to target molecules. Using tau epitopes predispos ...
- Li, Long, et al. Show all 11 Authors
- Journal of the American Chemical Society 2018 v.140 no.41 pp. 13335-13339
- DNA; binding capacity; blood serum; cellular microenvironment; circular dichroism spectroscopy; cytosine; energy transfer; oligonucleotides; pH; receptors; therapeutics
- ... Aptamers that recognize specific cells in a complex environment have emerged as invaluable molecular tools in bioanalysis and in the development of targeted therapeutics. The selective recognition of aptamers, however, can be compromised by the coexistence of target receptors on both target cells and other cells. To address this problem, we constructed a structure-switchable aptamer (SW-Apt) with ...