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- Qin, Hongshuang; Zhao, Chuanqi; Sun, Yuhuan; Ren, Jinsong; Qu, Xiaogang
- Journal of the American Chemical Society 2017 v.139 no.45 pp. 16201-16209
- DNA; DNA damage; apoptosis; breasts; carcinogenesis; cell growth; drug design; drug resistance; drugs; enantiomers; enantioselectivity; enzyme activity; ligands; metastasis; neoplasm cells; neoplasms; stem cells; telomerase; telomeres
- ... Cancer stem cells (CSCs) are responsible for drug resistance, metastasis and recurrence of cancers. However, there is still no clinically approved drug that can effectively eradicate CSCs. Thus, it is crucial and important to develop specific CSC-targeting agents. Chiral molecular recognition of DNA plays an important role in rational drug design. Among them, polymorphic telomeric G-quadruplex DNA ...
- Bandlow, Victor; Liese, Susanne; Lauster, Daniel; Ludwig, Kai; Netz, Roland R.; Herrmann, Andreas; Seitz, Oliver
- Journal of the American Chemical Society 2017 v.139 no.45 pp. 16389-16397
- DNA; Influenza A virus; binding sites; hemagglutinins; ligands; mechanics; models; polyethylene glycol; screening; virion; viruses
- ... Attachment of the Influenza A virus onto host cells involves multivalent interactions between virus surface hemagglutinin (HA) and sialoside-containing glyco ligands. Despite the development of extremely powerful multivalent binders of the Influenza virus and other viruses, comparably little is known about the optimal spacing of HA ligands, which ought to bridge binding sites within or across the ...