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- Green, Anthony P.; Hayashi, Takahiro; Mittl, Peer R. E.; Hilvert, Donald
- Journal of the American Chemical Society 2016 v.138 no.35 pp. 11344-11352
- histidine, etc ; active sites; ascorbate peroxidase; catalytic activity; genetic code; heme; hydrogen bonding; ligands; proteins; spectroscopy; Show all 10 Subjects
- ... Enzymes rely on complex interactions between precisely positioned active site residues as a mechanism to compensate for the limited functionality contained within the genetic code. Heme enzymes provide a striking example of this complexity, whereby the electronic properties of reactive ferryl intermediates are finely tuned through hydrogen bonding interactions between proximal ligands and neighbor ...