Jump to Main Content
- Islam, Zahidul; Strutzenberg, Timothy S.; Gurevic, Ilya; Kohen, Amnon
- Journal of the American Chemical Society 2014 v.136 no.28 pp. 9850-9853
- DNA; active sites; antibiotics; arginine; biomimetics; catalysts; catalytic activity; cysteine; drug therapy; drugs; hydrides; isotopes; mutagenesis; thymidylate synthase
- ... Thymidylate synthase (TSase) catalyzes the intracellular de novo formation of thymidylate (a DNA building block) in most living organisms, making it a common target for chemotherapeutic and antibiotic drugs. Two mechanisms have been proposed for the rate-limiting hydride transfer step in TSase catalysis: a stepwise mechanism in which the hydride transfer precedes the cleavage of the covalent bond ...
- PubMed Central: