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- Li, Long, et al. Show all 9 Authors
- Journal of the American Chemical Society 2018 v.140 no.43 pp. 14314-14323
- epitopes; microtubules; neurodegenerative diseases; nucleotide aptamers; oligomerization; phosphorylation; protein aggregates; therapeutics
- ... Tau proteins are proteins that stabilize microtubules, but their hyperphosphorylation can result in the formation of protein aggregates and, over time, neurodegeneration. This phenomenon, termed tauopathy, is pathologically involved in several neurodegenerative disorders. DNA aptamers are single-stranded oligonucleotides capable of specific binding to target molecules. Using tau epitopes predispos ...
- Li, Long, et al. Show all 12 Authors
- Journal of the American Chemical Society 2017 v.139 no.15 pp. 5289-5292
- DNA; biocompatibility; cell communication; exosomes; genetic engineering; hybridization chain reaction; nanocarriers; nucleotide aptamers; proteins
- ... Exosomes are membrane-enclosed extracellular vesicles derived from cells, carrying biomolecules that include proteins and nucleic acids for intercellular communication. Owning to their advantages of size, structure, stability, and biocompatibility, exosomes have been used widely as natural nanocarriers for intracellular delivery of theranostic agents. Meanwhile, surface modifications needed to end ...
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