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- Lominadze, David; Saari, Jack T.; Miller, Frederick N.; Catalfamo, James L.; Percival, Susan S.; Schuschke, Dale A.
- Journal of trace elements in experimental medicine 1999 v.12 no.1 pp. 25
- blood platelets; cell adhesion; endothelial cells; copper; deficiency diseases; dietary minerals; hemostasis; weanlings; in vitro studies; cultured cells; chelating agents; blood coagulation factors; thrombosis; shear strength
- ... Dietary copper restriction impairs thrombogenesis and hemostasis in rat microcirculation. In this study, the role of wall shear rate in platelet-to-endothelial cell adhesion in vitro was studied during copper deficiency. Platelets were obtained from male, weanling Sprague-Dawley rats fed purified diets, which were either copper-adequate (CuA, 6.3 μg Cu/g) or copper-deficient (CuD, 0.3 μg Cu/g), fo ...