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You searched for: Journal name Journal of veterinary cardiology Remove constraint Journal name: Journal of veterinary cardiology Publication year rev 7988-2012 Remove constraint Publication year rev: 7988-2012 Source 2012 v.14 no.1 Remove constraint Source: 2012 v.14 no.1
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1. Auscultatory, echocardiographic, biochemical, nutritional, and environmental characteristics of mitral valve disease in Norfolk terriers

Author:
Dennis J. Trafny; Lisa M. Freeman; Barret J. Bulmer; John M. MacGregor; John E. Rush; Kathryn M. Meurs; Mark A. Oyama
Source:
Journal of veterinary cardiology 2012 v.14 no.1 pp. 261-267
ISSN:
1760-2734
Subject:
C-reactive protein; amino acid composition; animal health; biomarkers; blood sampling; clinical examination; dogs; echocardiography; environmental factors; heart; image analysis; nutrition; serotonin; terriers; veterinary clinics
Abstract:
... OBJECTIVES: In order to more fully understand degenerative mitral valve disease (DMVD) in the Norfolk terrier, we sought to characterize findings from the physical and echocardiographic examination; biochemical, biomarker, and nutritional profiles; and select environmental variables from a cohort of apparently healthy Norfolk terriers. ANIMALS, MATERIALS AND METHODS: Overtly healthy Norfolk terrie ...
DOI:
10.1016/j.jvc.2011.10.002
PubMed:
22364691

2. Congenital supravalvular mitral stenosis in 14 cats

Author:
Fiona E. Campbell; William P. Thomas
Source:
Journal of veterinary cardiology 2012 v.14 no.1 pp. 281-292
ISSN:
1760-2734
Subject:
heart failure; cats; prognosis; males; hypertension; congenital abnormalities; young adults; breeds; heart; paralysis; distress; echocardiography
Abstract:
... OBJECTIVES: To describe the clinical features of congenital supravalvular mitral stenosis (SVMS) in cats. BACKGROUND: Supravalvular mitral stenosis is an uncommon congenital cardiac defect that has not been previously reported in a series of cats. ANIMALS: 14 cats with SVMS. METHODS: Medical records, relevant diagnostic studies and preserved pathology specimens were reviewed. RESULTS: Cats were pr ...
DOI:
10.1016/j.jvc.2011.10.003
PubMed:
22386585

3. Differentiating the aging of the mitral valve from human and canine myxomatous degeneration

Author:
Patrick S. Connell; Richard I. Han; K. Jane Grande-Allen
Source:
Journal of veterinary cardiology 2012 v.14 no.1 pp. 31-45
ISSN:
1760-2734
Subject:
dogs; endothelial cells; extracellular matrix; humans; morbidity; mortality
Abstract:
... During the course of both canine and human aging, the mitral valve remodels in generally predictable ways. The connection between these aging changes and the morbidity and mortality that accompany pathologic conditions has not been made clear. By exploring work that has investigated the specific valvular changes in both age and disease, with respect to the cells and the extracellular matrix found ...
DOI:
10.1016/j.jvc.2011.11.003
PubMed:
22364720
PubMed Central:
PMC3307912

4. Echocardiographic assessment of canine degenerative mitral valve disease

Author:
Valérie Chetboul; Renaud Tissier
Source:
Journal of veterinary cardiology 2012 v.14 no.1 pp. 127-148
ISSN:
1760-2734
Subject:
aorta; deformation; disease course; dog diseases; dogs; echocardiography; heart; heart diseases; hypertension; image analysis; risk; ultrasonics
Abstract:
... Degenerative mitral valve disease (MVD), the most common acquired heart disease in small-sized dogs, is characterized by valvular degeneration resulting in systolic mitral valve regurgitation (MR). Worsening of MR leads to several combined complications including cardiac remodeling, increased left ventricular filling pressure, pulmonary arterial hypertension, and myocardial dysfunction. Convention ...
DOI:
10.1016/j.jvc.2011.11.005
PubMed:
22366573

5. Effect of torsemide and furosemide on clinical, laboratory, radiographic and quality of life variables in dogs with heart failure secondary to mitral valve disease

Author:
Gordon D. Peddle; Gretchen E. Singletary; Caryn A. Reynolds; Dennis J. Trafny; Maggie C. Machen; Mark A. Oyama
Source:
Journal of veterinary cardiology 2012 v.14 no.1 pp. 253-259
ISSN:
1760-2734
Subject:
carbon dioxide; furosemide; albumins; drug therapy; radiography; heart failure; antagonists; urine; dogs; chlorides; anions; creatinine; quality of life; specific gravity; urea nitrogen; diuretics; heart; clinical trials; diuresis; phosphorus
Abstract:
... OBJECTIVES: Diuretic therapy reduces preload and relieves congestion secondary to cardiac dysfunction. Torsemide (torasemide) is a loop diuretic with longer duration of action, decreased susceptibility to diuretic resistance, and adjunctive aldosterone antagonist properties compared with furosemide. We hypothesized that torsemide would be well tolerated and no less effective than furosemide at diu ...
DOI:
10.1016/j.jvc.2012.01.003
PubMed:
22364690

6. Interactions between TGFβ1 and cyclic strain in modulation of myofibroblastic differentiation of canine mitral valve interstitial cells in 3D culture

Author:
Andrew S. Waxman; Bruce G. Kornreich; Russell A. Gould; N. Sydney Moïse; Jonathan T. Butcher
Source:
Journal of veterinary cardiology 2012 v.14 no.1 pp. 211-221
ISSN:
1760-2734
Subject:
actin; cell culture; cell growth; collagen; dogs; gene expression; hydrocolloids; mechanical stress; phenotype; protein synthesis
Abstract:
... OBJECTIVES: The mechanisms of myxomatous valve degeneration (MVD) are poorly understood. Transforming growth factor-beta1 (TGFβ1) induces myofibroblastic activation in mitral valve interstitial cells (MVIC) in static 2D culture, but the roles of more physiological 3D matrix and cyclic mechanical strain are unclear. In this paper, we test the hypothesis that cyclic strain and TGFβ1 interact to modi ...
DOI:
10.1016/j.jvc.2012.02.006
PubMed:
22386586
PubMed Central:
PMC3535465

7. Left ventricular remodeling in preclinical experimental mitral regurgitation of dogs

Author:
A. Ray Dillon; Louis J. Dell’Italia; Michael Tillson; Cheryl Killingsworth; Thomas Denney; John Hathcock; Logan Botzman
Source:
Journal of veterinary cardiology 2012 v.14 no.1 pp. 73-92
ISSN:
1760-2734
Subject:
renin-angiotensin system; calcium; dogs; stress response; collagen; genes; heart; extracellular matrix; disease course; hypertrophy
Abstract:
... Dogs with experimental mitral regurgitation (MR) provide insights into the left ventricular remodeling in preclinical MR. The early preclinical left ventricular (LV) changes after mitral regurgitation represent progressive dysfunctional remodeling, in that no compensatory response returns the functional stroke volume (SV) to normal even as total SV increases. The gradual disease progression leads ...
DOI:
10.1016/j.jvc.2012.01.012
PubMed:
22386719

8. Myxomatous mitral valve disease in dogs: Does size matter?

Author:
Heidi G. Parker; Paul Kilroy-Glynn
Source:
Journal of veterinary cardiology 2012 v.14 no.1 pp. 19-29
ISSN:
1760-2734
Subject:
cardiovascular diseases; dog diseases; dogs; genetic disorders; humans; miniature breeds; risk
Abstract:
... Myxomatous mitral valve disease (MMVD) is the most commonly diagnosed cardiovascular disease in the dog accounting for more than 70% of all cardiovascular disease in dogs. As are most canine diseases with genetic underpinnings, risk of MMVD is greatly increased in a subset of breeds. What is uncommon is that the vast majority of the breeds at elevated risk for MMVD are small or toy breeds with ave ...
DOI:
10.1016/j.jvc.2012.01.006
PubMed:
22356836
PubMed Central:
PMC3307894

9. Pathology of myxomatous mitral valve disease in the dog

Author:
Philip R. Fox
Source:
Journal of veterinary cardiology 2012 v.14 no.1 pp. 103-126
ISSN:
1760-2734
Subject:
risk; genetics; humans; heart failure; dog diseases; muscles; dogs; myocardium; abnormal development; heart valves; extracellular matrix; disease course; dog breeds
Abstract:
... Mitral valve competence requires complex interplay between structures that comprise the mitral apparatus – the mitral annulus, mitral valve leaflets, chordae tendineae, papillary muscles, and left atrial and left ventricular myocardium. Myxomatous mitral valve degeneration is prevalent in the canine, and most adult dogs develop some degree of mitral valve disease as they age, highlighting the appa ...
DOI:
10.1016/j.jvc.2012.02.001
PubMed:
22386587

10. Pharmacologic management of myxomatous mitral valve disease in dogs

Author:
Clarke E. Atkins; Jens Häggström
Source:
Journal of veterinary cardiology 2012 v.14 no.1 pp. 165-184
ISSN:
1760-2734
Subject:
chronic diseases; clinical trials; dog diseases; heart diseases; medicine
Abstract:
... Myxomatous mitral valve disease (MMVD) causing mitral regurgitation is the most important disease of the heart in small animal cardiovascular medicine. Because MMVD is an example of a chronic disease that progresses from mild to severe over years, treatment strategies change with the stage of the disease. In this review the treatment options are compared and contrasted as they are discussed relati ...
DOI:
10.1016/j.jvc.2012.02.002
PubMed:
22386553

11. Prediction of first onset of congestive heart failure in dogs with degenerative mitral valve disease: The PREDICT cohort study

Author:
Caryn A. Reynolds; Dorothy Cimino Brown; John E. Rush; Philip R. Fox; Thaibihn P. Nguyenba; Linda B. Lehmkuhl; Sonya G. Gordon; Heidi B. Kellihan; Rebecca L. Stepien; Bonnie K. Lefbom; C. Kate Meier; Mark A. Oyama
Source:
Journal of veterinary cardiology 2012 v.14 no.1 pp. 193-202
ISSN:
1760-2734
Subject:
risk estimate; heart failure; cohort studies; dogs; models; logit analysis; odds ratio; confidence interval; risk factors; heart; roots; prediction
Abstract:
... OBJECTIVE: To identify risk factors for first-onset congestive heart failure (CHF) in dogs with degenerative mitral valve disease (DMVD). ANIMALS: Eighty-two dogs with and without CHF secondary to DMVD were retrospectively assigned to a derivation cohort. Sixty-five dogs with asymptomatic DMVD were recruited into a prospective validation cohort. METHODS: Variables associated with risk of CHF in do ...
DOI:
10.1016/j.jvc.2012.01.008
PubMed:
22366568

12. Pulmonary hypertension in canine degenerative mitral valve disease

Author:
Heidi B. Kellihan; Rebecca L. Stepien
Source:
Journal of veterinary cardiology 2012 v.14 no.1 pp. 149-164
ISSN:
1760-2734
Subject:
dogs; echocardiography; hypertension; quality of life; therapeutics; veterinary medicine
Abstract:
... Pulmonary hypertension secondary to degenerative mitral valve disease has been recognized clinically for many years in veterinary medicine, and clinical diagnosis of this syndrome in dogs has been enhanced greatly by widespread use of echocardiography and Doppler echocardiography. Medical therapy is now available to treat this clinical complication of mitral valve disease, making timely diagnosis ...
DOI:
10.1016/j.jvc.2012.01.001
PubMed:
22364721

13. Retrospective review of carvedilol administration in 38 dogs with preclinical chronic valvular heart disease

Author:
Sonya G. Gordon; Ashley B. Saunders; Crystal D. Hariu; May M. Boggess; Matthew W. Miller
Source:
Journal of veterinary cardiology 2012 v.14 no.1 pp. 243-252
ISSN:
1760-2734
Subject:
adverse effects; blood pressure; clinical examination; dog breeds; dogs; heart diseases; interviews; prospective studies; titration; veterinarians
Abstract:
... OBJECTIVES: Report the effect of carvedilol administration on clinical and echocardiographic parameters and outcome in dogs with preclinical (ACVIM Stage B) chronic valvular heart disease (CVD). ANIMALS, MATERIALS AND METHODS: Retrospective case series of 38 client-owned dogs. Demographic, physical examination and diagnostic imaging findings, blood pressure (BP), administration details and outcome ...
DOI:
10.1016/j.jvc.2012.01.007
PubMed:
22364694

14. Selected echocardiographic variables change more rapidly in dogs that die from myxomatous mitral valve disease

Author:
Melanie J. Hezzell; Adrian Boswood; Walasinee Moonarmart; Jonathan Elliott
Source:
Journal of veterinary cardiology 2012 v.14 no.1 pp. 269-279
ISSN:
1760-2734
Subject:
body weight; dogs; echocardiography; linear models; mortality; prospective studies; risk; roots; statistical analysis
Abstract:
... OBJECTIVES: To determine if echocardiographic measurements change at a greater rate in dogs with myxomatous mitral valve disease (MMVD) that die of cardiac mortality. ANIMALS: Client-owned dogs (n = 242) with MMVD of varying severity were recruited from first opinion private practice. Only dogs which died during the study period (n = 102) were included in statistical analyses. METHODS: Prospective ...
DOI:
10.1016/j.jvc.2012.01.009
PubMed:
22366569

15. Signaling pathways in mitral valve degeneration

Author:
E. Christopher Orton; Carla M.R. Lacerda; Holly B. MacLea
Source:
Journal of veterinary cardiology 2012 v.14 no.1 pp. 7-17
ISSN:
1760-2734
Subject:
bone formation; bones; cartilage; continuous systems; disease course; dogs; drugs; extracellular matrix; genes; heart diseases; heart valves; homeostasis; humans; nitric oxide; proteins; serotonin; transforming growth factors
Abstract:
... Heart valves exhibit a highly-conserved stratified structure exquisitely designed to counter biomechanical forces delivered over a lifetime. Heart valve structure and competence is maintained by heart valve cells through a process of continuous turnover extracellular matrix (ECM). Degenerative (myxomatous) mitral valve disease (DMVD) is an important disease associated with aging in both dogs and h ...
DOI:
10.1016/j.jvc.2011.12.001
PubMed:
22364692

16. Static and cyclic tensile strain induce myxomatous effector proteins and serotonin in canine mitral valves

Author:
Carla M.R. Lacerda; Holly B. MacLea; John D. Kisiday; E. Christopher Orton
Source:
Journal of veterinary cardiology 2012 v.14 no.1 pp. 223-230
ISSN:
1760-2734
Subject:
cardiovascular diseases; chondrogenesis; dogs; enzyme-linked immunosorbent assay; enzymes; human diseases; immunoblotting; phenotype; protein synthesis; proteins; serotonin; tryptophan
Abstract:
... OBJECTIVES: Degenerative (myxomatous) mitral valve disease is an important cardiac disease in dogs and humans. The mechanisms that initiate and propagate myxomatous pathology in mitral valves are poorly understood. We investigated the hypothesis that tensile strain initiates expression of proteins that mediate myxomatous pathology. We also explored whether tensile strain could induce the serotonin ...
DOI:
10.1016/j.jvc.2011.12.002
PubMed:
22364693

17. Use of computed tomography and silicon endocasts to identify pulmonary veins with echocardiography

Author:
Fred C. Brewer; N. Sydney Moïse; Bruce G. Kornreich; Abraham J. Bezuidenhout
Source:
Journal of veterinary cardiology 2012 v.14 no.1 pp. 293-300
ISSN:
1760-2734
Subject:
computed tomography; dogs; echocardiography; heart; image analysis; lungs; models; silicon; silicone
Abstract:
... The pulmonary veins were identified from the silicone endocast heart models of 19 dogs. Although variation in the number of the more peripheral veins on each specimen existed, all of the casts had a consistency with regards to the most proximal coalescence of the pulmonary veins as they entered the body of the left atrium. That is, the confluence of the veins formed three ostia at the atrial entry ...
DOI:
10.1016/j.jvc.2012.02.004
PubMed:
22386718

18. Historical review, epidemiology and natural history of degenerative mitral valve disease

Author:
Michele Borgarelli; James W. Buchanan
Source:
Journal of veterinary cardiology 2012 v.14 no.1 pp. 93-101
ISSN:
1760-2734
Subject:
heart failure; dog diseases; natural history; epidemiology
Abstract:
... Chronic mitral valve disease due to myxomatous degeneration (MMVD) is the most common cardiovascular disease in dogs and has been known to cause congestive heart failure for more than 100 years. This article presents an historical perspective of the disease and reviews the most updated data on epidemiology and natural history of MMVD in dogs. ...
DOI:
10.1016/j.jvc.2012.01.011

19. Left ventricular function quantified by myocardial strain imaging in small-breed dogs with chronic mitral regurgitation

Author:
Danielle N. Smith; John D. Bonagura; Nicole M. Culwell; Karsten E. Schober
Source:
Journal of veterinary cardiology 2012 v.14 no.1 pp. 231-242
ISSN:
1760-2734
Subject:
algorithms; body weight; deformation; echocardiography; heart rate; image analysis; linear models; prognosis; therapy dogs
Abstract:
... BACKGROUND: The presence of left ventricular (LV) systolic dysfunction may influence prognosis or therapy in dogs with chronic mitral regurgitation (MR). Assessment of LV function in MR by conventional echocardiography is confounded by altered ventricular loading. Myocardial deformation (strain) imaging might offer more sensitive estimates of LV function in this disease. OBJECTIVE: Prospectively m ...
DOI:
10.1016/j.jvc.2011.11.002
PubMed:
22361170

20. Mitral valve dysplasia characterized by isolated cleft of the anterior leaflet resulting in fixed left ventricular outflow tract obstruction

Author:
Cristiane Otoni; Jonathan A. Abbott
Source:
Journal of veterinary cardiology 2012 v.14 no.1 pp. 301-305
ISSN:
1760-2734
Subject:
dogs; echocardiography; humans
Abstract:
... A 7-month-old, sexually intact male English toy spaniel weighing 4 kg was referred for evaluation of a subclinical cardiac murmur. Echocardiography disclosed fixed left ventricular outflow tract obstruction that was caused by attachment of a cleft anterior mitral valve leaflet to the interventricular septum. Neither atrial nor ventricular septal defects were detected. Fixed obstruction of the left ...
DOI:
10.1016/j.jvc.2012.01.010
PubMed:
22377653