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Lisa A. Murphy; Maria L. Wang; Brian O’Malley; Donald P. Schrope; Justin W. Allen; Emily H. Chapel; Nicholas J. Russell; Sarah A. Zimmerman; Caroline Q. Sloan; Reid K. Nakamura
... To evaluate owners’ chronic medication adherence for management of feline cardiovascular disease in the small animal referral setting. A questionnaire-based study of owners at five multi-specialty, small animal referral centers was conducted. Owners completed a written survey evaluating demographics, degree of medication adherence, and difficulties encountered for medication adherence. Owners were ...
... Systemic administration of tissue plasminogen activator (tPA) is seldomly reported in dogs and cats. Client-owned animals receiving tPA (2010–2020). Medical records of dogs and cats receiving tPA for distant known/suspected thrombus were reviewed. Fourteen dog visits (24 injections) and five cat visits (six injections) were included. Canine known/suspected thrombus included pulmonary thromboemboli ...
... The objectives were to conduct a survey of cardiologists on their recent experiences with cats that have dilated cardiomyopathy (DCM) and to retrospectively review individual cases of feline DCM. Part one: A survey was distributed to cardiologists with questions regarding caseload and clinical management of cats with DCM diagnosed over the past two years. Part two: Cardiologists completing the sur ...
... Diastolic dysfunction is an early clinical feature of feline hypertrophic cardiomyopathy (HCM). The left ventricular filling in early diastole is facilitated by the diastolic intraventricular pressure gradient (IVPG). The study objectives were to evaluate color Doppler M-mode-derived IVPG calculation in cats as a non-invasive assessment of the left ventricular relaxation property to determine the ...
... The objective of this retrospective study was to describe the indications, complications, and long-term outcomes in a group of cats that received an epicardial pacing (EP) system.Twenty client-owned cats.Medical records were reviewed for signalment, presenting complaint, primary electrocardiogram (ECG) diagnosis, presence of structural heart disease, presence of congestive heart failure (CHF), pre ...
... Anterior mitral valve leaflet (AMVL) elongation is a recognised feature of hypertrophic cardiomyopathy (HCM). However, whether AMVL elongation precedes left ventricular hypertrophy in cats is currently unknown. The aim of this study was to explore the risk of developing an HCM phenotype in cats with an elongated AMVL.This was a retrospective longitudinal study. Cats at the baseline were grouped ba ...
... The left ventricular systolic longitudinal function, traditionally measured by M-mode–derived mitral annular plane systolic excursion (MAPSE), is reduced in feline hypertrophic cardiomyopathy (HCM) and further reduced in cats with left-sided congestive heart failure (CHF). The objectives of this study were to compare longitudinal displacement measured by tissue tracking (TT-LD) and MAPSE in feline ...
... A 10-year-old male American Shorthair cat was presented after a witnessed syncopal event. A Holter monitor demonstrated a long QT interval and revealed a rhythm characteristic of torsades de pointes (TdP) coincident with a bout of syncope. On subsequent Holter monitor recordings, sotalol did not prolong the QT interval further and did not reduce the severity of the underlying ventricular tachyarrh ...
... The aim of this study was to evaluate cardiac morphology, indices of systolic and diastolic function, systolic blood pressure (SBP), and uterine artery resistance index (RI) during normal feline pregnancy.Twenty domestic short-hair pregnant queens, weighing 2.4–3.9 kg. Animals were assessed by two-dimensional, M-mode, and Doppler echocardiography, non-invasive SBP measurement, and uterine Doppler ...
... A 5-month old, intact, female domestic shorthair cat was referred for evaluation of a heart murmur. Echocardiography revealed a large, left-to-right shunting patent ductus arteriosus (PDA). One month after initial presentation, the cat underwent transvenous PDA occlusion via Amplatz occlusion device. A 4-mm Canine Duct Occluder (ACDO) was successfully placed via introduction into the right jugular ...
cardiomyopathy; cats; congenital abnormalities; echocardiography; fibrosis; heart ventricle; image analysis; magnetic resonance imaging; muscles; myocardium; phenotype; troponin I
Abstract:
... A left ventricular accessory chamber is a complex and uncommon phenotype consisting in a subdivision of the left ventricle by a thick-walled muscle bundle or septum into two cavities. Multiple aetiologies such as congenital double-chambered left ventricle and acquired endomyocardial form of restrictive cardiomyopathy have been reported.The endomyocardial form of restrictive cardiomyopathy, owing t ...
... – To evaluate the effect of a single dose of pimobendan on left atrial (LA) function in healthy cats.– Eleven client owned healthy cats.– Standardized and repeated echocardiographic examinations were performed on healthy and conscious cats before and after a single dose of orally administered pimobendan (1.25 mg/cat). Left atrial systolic functional parameters were assessed.– Some of the tested pa ...
... Hemangioarcoma in the cat is an infrequently diagnosed tumor, and cardiac involvement is rare. We report a previously healthy, 8-year-old, domestic shorthair cat with acute collapse associated with pericardial effusion and cardiac tamponade. Following pericardiocentesis and removal of 15 mL of fluid, the cat improved rapidly. A massive, space-occupying, intrapericardial tumor adhered to and compre ...
... Disopyramide reduces the left ventricular outflow tract (LVOT) pressure gradient and improves symptoms in humans with hypertrophic obstructive cardiomyopathy (HOCM). However, the efficacy of disopyramide in cats has not been reported. We treated a cat with HOCM with carvedilol and disopyramide cotherapy and monitored the changes in LVOT flow velocity and N-terminal pro B-type natriuretic peptide ( ...
... Histoplasmosis is the second most common fungal infection reported among domestic felines in the United States. Dissemination of the organism after inoculation is common and affected organ systems include the respiratory tract, gastrointestinal tract, reticuloendothelial organs, skeletal system, integument, and ocular system. However, histoplasmosis presenting as a discrete granulomatous mass iden ...
... Recognition of congestive heart failure (CHF) in dyspnoeic cats is crucial for correct intervention. The pulmonary vein (PV) to pulmonary artery (PA) ratio (PV/PA) has been proposed as an index that might help discriminate dogs suffering from CHF but has never been studied in cats. We sought to determine reference intervals for various PV and PA variables in healthy cats. We then examined these va ...
... A seven-year-old, spayed female, domestic longhair cat was referred for management of a sudden aortic thromboembolism (ATE). Echocardiography showed hypertrophic cardiomyopathy with severe left atrial enlargement. Ultrasonography of the abdominal aorta confirmed a large thrombus at the level of the aortic trifurcation, involving both iliac arteries. Considering the recent onset and bilateral invol ...
blood; cats; image analysis; latex; magnetic materials; magnetic resonance imaging; myocardium
Abstract:
... In human medicine, non-contrast cardiac magnetic resonance imaging (CMRI) is routinely used to assess the cardiovascular system. In this study, using non-contrast CMRI, we provide a thorough description of the normal appearance of the intrathoracic cardiovascular structures in one healthy cat using a magnet operating at a field of 1.5-Tesla. The CMRI protocol was based on the use of fast spin-echo ...
... Aortic dissection (AD) is characterized by bleeding within the aortic wall or a tear in the intimal layer of the aortic wall, resulting in the passage of blood from the aortic lumen into the tunica media. In cases of AD, a floating, intimal flap in the aortic lumen divides the lumen into a true portion, with flow present, and a false portion, with no flow. We describe a series of 4 cats with AD of ...
case studies; catheters; cats; guidelines; hemodynamics; pulmonary artery; surgery
Abstract:
... Pulmonary artery banding (PAB) is a viable but underreported palliative option for hemodynamically significant ventricular septal defect in small animals. A significant challenge associated with PAB is judging the degree of band tightening, which can be further complicated when animals are immature and still growing at the time of PAB. If a pulmonary artery band is overtightened or becomes progres ...
... Pulmonary hypertension (PH) caused by left-sided congestive heart failure (L-CHF) is common in dogs and contributes to clinical signs and outcome. The aim of this study was to evaluate the prevalence of Doppler echocardiography–derived PH in a population of cats with L-CHF.The study involved 131 cats with L-CHF and 56 control cats.The study design is retrospective, observational study. Tricuspid r ...
... Myocardial diseases are the most common acquired cardiac diseases in cats and may result in left atrial enlargement and congestive heart failure (CHF). Volume calculations have replaced linear measurements for chamber quantification in humans but are not commonly measured in cats. The aims of this retrospective study were to compare the left atrial (LA) size by two-dimensional linear measurements ...
body condition; cardiomyopathy; cats; heart failure; humans; hypertrophy; liquid chromatography; mice; myostatin; tandem mass spectrometry
Abstract:
... Growth differentiation factor (GDF) 11 has been shown to reduce cardiac hypertrophy in mice. Low levels of GDF-11 are associated with cardiac hypertrophy in humans. The authors hypothesized that plasma GDF-11 level is decreased in cats with hypertrophic cardiomyopathy (HCM). Given the close homology between GDF-11 and myostatin/GDF-8, GDF-8 levels were also assessed.Thirty-seven client-owned cats ...
aorta; case studies; cats; congenital abnormalities; heart failure; prognosis
Abstract:
... Aortic stenosis affects 0.028% of cats in a shelter population, with valvular aortic stenosis compromising almost half of these cases. Of congenital heart diseases reported in cats, aortic stenosis is the second most common one, affecting 17% of these cases. Existing literature on valvular aortic stenosis is scant, and thus, presentation and prognosis of affected animals is poorly understood. In t ...
cats; electrocardiography; heart; myocarditis; troponin I
Abstract:
... This report describes transient trifascicular block in three cats presented with lethargy and inappetence, and elevated cardiac troponin I concentrations.The electrocardiogram (ECG) of cat 1 showed a sinus rhythm with pronounced first-degree atrioventricular (AV) block, right bundle branch block, and left anterior fascicular block. The ECG of cat 2 showed truncular left bundle branch block alterna ...
... Plasma atrial natriuretic peptide (ANP) levels have been reported to be elevated in cats with cardiomyopathy. We investigated the diagnostic accuracy of plasma ANP concentration as an indicator of the severity of cardiomyopathies.This study included 78 control cats and 83 cats with various types of cardiomyopathy.This was a prospective multicentre study. Control cats were determined to have a norm ...
... To assess the ability of electrocardiography (ECG) to predict left ventricular hypertrophy (LVH) in the cat and to investigate the prognostic value of selected ECG variables in cats with LVH.Fifty-seven privately owned cats: 22 clinically healthy cats and 35 cats with LVH.This is a clinical cohort study. Echocardiographic diagnosis and surface ECG were available. Electrocardiography analysis inclu ...
... Pacemaker implantation is considered as a standard procedure for treatment of symptomatic bradycardia in both dogs and cats. Advanced second-degree and third-degree atrioventricular blocks, sick sinus syndrome, persistent atrial standstill, and vasovagal syncope are the most common rhythm disturbances that require pacing to either alleviate clinical signs or prolong survival. Most pacemakers are i ...
... Hypertrophic cardiomyopathy (HCM) has a variable prognosis; left atrial size, presence of clinical signs and left ventricular systolic function have been shown to predict outcomes. Mitral annular plane systolic excursion (MAPSE) and tricuspid annular plane systolic excursion (TAPSE) assess longitudinal ventricular systolic function and are decreased in cats with HCM. The aim of the study was to as ...
... The pathophysiology of heart failure involves activation of several neurohormonal systems including the renin-angiotensin-aldosterone system. The mineralocorticoid receptor antagonist spironolactone has been shown to be beneficial in humans and dogs with heart failure. The objective of this pilot study was to investigate the efficacy and safety of spironolactone in cats with heart failure secondar ...
... False tendons (FTs) are string-like structures in the left ventricle. A FT might produce focal thickening at its insertion region of the left ventricle, which could be mistaken for focal hypertrophic cardiomyopathy.To perform a prospective, echocardiographic follow-up examination of feline FTs and compare the wall thickness at the FT insertion region and a normal region without FTs at both examina ...
... To describe signalment, clinical characteristics, diagnostic, treatment, and outcome data in a large case series of cats with patent ductus arteriosus (PDA).Fifty cats with confirmed PDA.Retrospective review of medical records from five referral veterinary hospitals for cats with PDA between 2000 and 2015. Cats were included if a PDA was visualized echocardiographically, during surgery, or on post ...
... A 7-year-old male castrated domestic short-haired cat suddenly died. Gross examination revealed severe right-sided haemothorax with blood clots, four adult filarial nematodes in the blood clots and the caudal vena cava and haemorrhage dissecting into the tunica media of the right pulmonary artery. Histopathological investigation showed fibrosis of the tunica intima and disorganization/fragmentatio ...
... Two domestic shorthair cats, a 6-month-old castrated male and a 7-month-old intact female, were diagnosed with complex congenital heart disease. Transthoracic echocardiography in both cats revealed a dilated arterial trunk overriding the interventricular septum with a large ventricular septal defect. The pulmonary trunk and branch pulmonary arteries were not visible using standard echocardiographi ...
... Two cats (2.5 months and 8 months old) were each evaluated due to a loud systolic murmur, and each was diagnosed with severe pulmonary artery stenosis at the bifurcation of the main pulmonary artery. Echocardiograms confirmed significant right atrial dilation and right ventricular dilation and/or hypertrophy that was progressive in one cat. Atenolol was initiated and the cats were referred for int ...
... Systemic arterial hypertension (SHT) has been widely described in the domestic cat (Felis catus). In these feline patients, SHT is considered as the most common vascular disorder of middle-aged to older animals, and secondary SHT related to chronic kidney disease (CKD) represents the most common form of the disease.We describe here the first two cases of spontaneous SHT in large felids, i.e. one 1 ...
ambient temperature; blood; cats; high performance liquid chromatography; metabolites; pharmacokinetics; quality control; tandem mass spectrometry
Abstract:
... The clopidogrel active metabolite (CAM) is unstable and challenging to quantitate. The objective was to validate a new method for stabilization and quantitation of CAM, clopidogrel, and the inactive metabolites clopidogrel carboxylic acid and 2-oxo-clopiodgrel in feline plasma.Two healthy cats administered clopidogrel to demonstrate assay in vivo utility.Stabilization of CAM was achieved by adding ...
... Systolic anterior (septal) motion of the mitral valve (SAM) is a common secondary phenomenon in hypertrophic cardiomyopathy (HCM) in people and cats. In humans, it is increasingly recognized that SAM may be found in other cardiac and non-cardiac disease states. In small animal cardiology, SAM unassociated with HCM has been described in dogs with mitral valve dysplasia and right ventricular pressur ...
... To describe the clinical presentation, clinicopathological abnormalities and outcomes of a series of cats diagnosed with infective endocarditis (IE) at two tertiary care referral institutions.Thirteen client-owned cats presenting to the cardiology or emergency services of tertiary referral institutions with a diagnosis of endocarditis based on the modified Duke criteria.Retrospective case series. ...
... The objective of our study was to quantitatively measure systolic torsional deformations in cats with hypertrophic cardiomyopathy (HCM) and in controls.Twenty-six client-owned cats with HCM and 14 healthy cats. HCM cats were categorized based on their symptoms (asymptomatic and symptomatic) and with or without left ventricular outflow tract obstruction (obstructive and non-obstructive).The cats we ...
allometry; body weight; cardiomyopathy; cats; cohort studies; heart failure; hypertrophy; image analysis; normal values; regression analysis; statistical models
Abstract:
... To evaluate right ventricular (RV) wall thickness and chamber dimensions in cats with hypertrophic cardiomyopathy (HCM).One hundred fifty-one healthy control cats and 200 cats with HCM.Retrospective, observational, clinical cohort study. Two-dimensional echocardiograms from all cats were analyzed. Right atrial diameter, RV free wall thickness, and RV chamber diameter were quantified using multiple ...
adults; blood; blood pressure; cats; cross-over studies; dogs; echocardiography; half life; medicine; metabolites; pharmacokinetics; tandem mass spectrometry; ultra-performance liquid chromatography
Abstract:
... To investigate the pharmacokinetics and pharmacodynamics of oral pimobendan in conscious, healthy cats.Eight healthy adult cats.A randomised, single-blinded, crossover design was used. Two oral doses of pimobendan (0.625-mg [LD], 1.25-mg [HD]) and a control substance (3-mL water) were administered to each cat. Blood collection, echocardiography, and oscillometric blood pressure measurements were p ...
... Diastolic aortic valve measurements are used to obtain weight-independent cardiac ratiometric indices. However, whether clinically important variations in valve measurements occur during diastole remains undetermined.One hundred sixty-three dogs and 40 cats; a mixture of healthy animals and patients with heart disease.Aortic valve diameter and area were measured at three time-points: early diastol ...
cats; disease severity; heart failure; hospitals; natriuretic peptides; pet ownership; quality of life; questionnaires
Abstract:
... To evaluate the responsiveness and optimal timing of a validated health-related quality of life questionnaire, and to assess the relationship between quality of life, severity of disease, and N-terminal pro B-type natriuretic peptide (NT-proBNP) in cats with acute congestive heart failure (CHF).Thirty client-owned cats with acute CHF.Echocardiography, International Small Animal Cardiac Health Coun ...
... Cardiac biomarkers have been used in cats as part of the clinical assessment of heart disease for over a decade. They are widely available to practitioners through commercial reference laboratories. The evidence base for the use of cardiac biomarkers (primarily N-terminal pro-B type natriuretic peptide and cardiac troponin I) in cats is comprehensively reviewed in this article, focusing on each of ...
analysis of variance; body weight; cardiomyopathy; cats; death; euthanasia; fibrosis; heart; heart failure; histopathology; necropsy; poisoning; veterinary clinics
Abstract:
... To report necropsy and myocardial histopathology in cats with unexpected death and expected death/euthanasia, comparing findings in 4 groups of cats: unexpected death with noncardiac disease (UD-NC); unexpected death with cardiac disease (UD-C); expected death/euthanasia due to noncardiac disease with incidental cardiac disease (OD + HD); and expected death/euthanasia due to congestive heart failu ...
... Cardiogenic embolism (CE) in the cat, which has also been referred to as arterial thromboembolism, feline arterial thromboembolism, and saddle thrombus has been identified clinically in cats for decades and is an important clinical development and cause of death in cats with underlying heart disease. While a better understanding of this condition has been developed over the decades it is extremely ...
adults; body condition; body weight; cardiomyopathy; cats; confidence interval; cross-sectional studies; echocardiography; heart; males; regression analysis; systolic blood pressure
Abstract:
... Hypertrophic cardiomyopathy (HCM) appears to be common in cats and, based on pilot data, a prevalence of 15% has been hypothesized. The objectives were to screen a large population of apparently healthy adult cats for cardiac disease, and identify factors associated with a diagnosis of HCM.A total of 1007 apparently healthy cats ≥6 months of age.In this prospective, cross-sectional study, the incl ...
... To study the prevalence and distribution of congenital heart defects in cats presented at two referral centers in Sweden between 1996 and 2013.162 client-owned cats with congenital heart defects.Case records of cats diagnosed with congenital heart disease were reviewed retrospectively.The overall prevalence of congenital heart disease was 0.2% of the total number of patient cats, and 8% of cats di ...
... Left ventricular (LV) diastolic dysfunction is highly prevalent in cats and is a functional hallmark of feline cardiomyopathy. The majority of cats with hypertrophic, restrictive, and dilated cardiomyopathy have echocardiographic evidence of abnormal LV filling, even during the occult (preclinical) phase. Moderate and severe diastolic dysfunction is an indicator of advanced myocardial disease, is ...
... To investigate the negative chronotropic, antiarrhythmic, and obstruction-relieving effects of atenolol in cats with subclinical hypertrophic cardiomyopathy (HCM).Seventeen cats with HCM.Results for echocardiography, electrocardiography, Doppler blood pressure, and 24 h Holter monitoring were compared in cats before and 2–4 weeks after atenolol therapy (6.25–12.5 mg PO q 12 h).The left ventricular ...
... Red blood cell distribution width (RDW) is a measurement of variability in circulating erythrocytes size, and has recently been shown to correlate with prognosis in a variety of human diseases, including acute and chronic heart failure.To determine if RDW differs between healthy controls, cats with hypertrophic cardiomyopathy (HCM) without congestive heart failure (CHF) and cats with HCM and CHF, ...
... Feline heartworm disease presents a unique diagnostic, therapeutic, and preventive challenge for veterinarians. Due to the elusive clinical nature and peculiar physiopathology of heartworm infection in cats, a multistep diagnostic process is mandatory. Clinical signs may be absent or atypical. At the present time there is no single ante mortem diagnostic test that can reach a high level of sensiti ...
... A missense mutation (A31P) in the cardiac myosin binding protein C gene has been associated with hypertrophic cardiomyopathy (HCM) in Maine Coon cats. The aim of this study was to investigate the effect of A31P on development of HCM, myocardial diastolic dysfunction detected by color tissue Doppler imaging and occurrence of cardiac death during longitudinal follow-up in a cohort of Maine Coon cats ...
... To highlight similarities in hypertrophic cardiomyopathy (HCM) that are shared between humans and domestic cats.Contemporary clinical and scientific findings were selected from the literature. Evidence is provided to support the concept that HCM in humans and felines are fundamentally the same disease.A number of remarkable similarities have been reported in certain spontaneously occurring myocard ...
... To estimate heart rate-normalized pulmonary transit times (nPTTs) in cardiomyopathic cats with or without congestive heart failure (CHF). To assess potential associations of echocardiographic variables and nPTT and to evaluate nPTT as a test for the presence of CHF.Forty-eight privately owned cats.nPTT was measured using echocardiography and the ultrasound contrast media SonoVue® in 3 groups of ca ...
... Acute heart failure in cats represents a complex clinical situation in feline practice and this review has been designed to focus on the description of acute heart failure in cats, the diagnostic approach and clinical management of acutely decompensated feline cardiac patients. The authors acknowledge the lack of scientific evidence regarding many treatments used for heart disease in cats, and hen ...
... Cardiomyopathy distinguishes a heterogeneous group of myocardial disorders that represent the most prevalent cause of feline heart disease. Etiology is uncertain and the natural history is presently unresolved. Hypertrophic cardiomyopathy is the most common of these conditions, and while the majority of affected cats are asymptomatic, a proportion is at risk to develop serious morbidities – the mo ...
... A dog or a cat has an incidentally detected heart murmur if the murmur is an unexpected discovery during a veterinary consultation that was not initially focused on the cardiovascular system. This document presents approaches for managing dogs and cats that have incidentally-detected heart murmurs, with an emphasis on murmur characteristics, signalment profiling, and multifactorial decision-making ...
... The natural progression of cardiomyopathy in cats can lead to congestive heart failure. This review enumerates commonly and uncommonly used medications that can be used for the long-term treatment of cats that have positively responded to initial management of acute heart failure. The advantages, drawbacks, and authors' preferred approach are presented for each medication. ...
... Assess the prevalence of congenital heart disease (CHD) in a large population of mixed-breed dogs and cats.76,301 mixed-breed dogs and 57,025 mixed-breed cats.Retrospective review of records and examinations based on specified diagnostic criteria.Among mixed-breed dogs, the prevalence of CHD was 0.13% (51.4% female) and of innocent murmurs was 0.10% (53.0% male). Pulmonic stenosis was the most com ...
... The Bengal is a relatively new hybrid breed, reported to develop hypertrophic cardiomyopathy. The aim of this study was to determine reference intervals for echocardiographic measurements in Bengal cats.Sixty-six apparently healthy Bengal cats.The study included a retrospective review of echocardiograms from 39 Bengal cats evaluated from March 2004 to June 2012 and reported to be normal by a board ...
... To evaluate risk factors associated with different types of cardiac death in cats with hypertrophic cardiomyopathy (HCM).Two hundred fifty-five cats with HCM referred to a veterinary teaching hospital.This is a retrospective study. Cats with HCM were identified that had either died within 2 years of diagnosis or were known to be alive 2 years after initial examination. Signalment, physical exam, e ...
... Hypertrophic cardiomyopathy (HCM) is the most common heart disease in cats, and it can lead to increased morbidity and mortality. Cats are often screened for HCM because of the presence of a heart murmur, but screening for breeding purposes has also become common. These cats are usually purebred cats of breeding age, and generally do not present with severe disease or with any clinical signs. This ...
Maine coon; adverse effects; aspirin; cats; death; heart diseases; long term effects; males; mixed breeds
Abstract:
... To determine if clopidogrel administration is associated with a reduced likelihood of recurrent cardiogenic arterial thromboembolism (CATE) in cats compared to aspirin administration. Secondary aims were to determine if clopidogrel administration had an effect on the composite endpoint of recurrent CATE and cardiac death and to identify adverse effects of chronic clopidogrel or aspirin therapy.Sev ...
adults; cardiomyopathy; cats; children; congenital abnormalities; prognosis; therapeutics; veterinary medicine
Abstract:
... Feline congenital heart disease is less commonly encountered in veterinary medicine than acquired feline heart diseases such as cardiomyopathy. Understanding the wide spectrum of congenital cardiovascular disease demands a familiarity with a variety of lesions, occurring both in isolation and in combination, along with an appreciation of complex nomenclature and variable classification schemes. Th ...
Maine coon; adenosine triphosphate; cardiomyopathy; cats; genes; genetic disorders; human genetics; humans; muscle contraction; muscles; mutation; myosin heavy chains; pathogenesis; regulatory proteins; sarcomeres; veterinarians
Abstract:
... Mutations in genes that encode for muscle sarcomeric proteins have been identified in humans and two breeds of domestic cats with hypertrophic cardiomyopathy (HCM). This article reviews the history, genetics, and pathogenesis of HCM in the two species in order to give veterinarians a perspective on the genetics of HCM.Hypertrophic cardiomyopathy in people is a genetic disease that has been called ...
... To investigate the effect of various genetic and environmental modifiers on left ventricular (LV) wall thickness in a cohort of cats genotyped for the myosin binding protein C3 mutation (MYBPC3).Sixty-four Ragdoll cats.All cats were screened for HCM with echocardiography and genotyping for the HCM-associated MYBPC3:R820W mutation. Cats were also genotyped for previously identified variant polymorp ...
... Thoracic radiography is one of the most commonly employed diagnostic tools for the clinical evaluation of cats with suspected heart disease and is the standard diagnostic method in the confirmation of cardiogenic pulmonary edema. In the past, interpretation of feline radiographs focused on a description of the qualitative radiographic features of feline heart disease or the measurement of the card ...
... Hypertrophic cardiomyopathy (HCM) is the most common heart disease in cats and shares clinical and pathological characteristics with human HCM. Little is known about the pathogenic mechanisms underlying development of spontaneous feline HCM.The study population consisted of seven cats diagnosed with HCM and eight age-matched cats with no evidence of cardiac disease.Fresh myocardial biopsies taken ...
... A mutation identified in the myosin binding protein C3 gene (MYBPC3 R820W) has been associated with hypertrophic cardiomyopathy (HCM) in Ragdoll cats. Ragdolls with HCM are reported to have a poor prognosis and homozygous cats seem particularly likely to develop severe HCM, although the outcome in Ragdolls tested for the MYBPC3 mutation has not been reported. We aimed to determine the influence of ...
... Double-chambered left ventricle is a rare congenital disorder in which the left ventricular cavity is subdivided into two cavities by an anomalous septum or muscle band. We describe a case of double-chambered left ventricle, most likely caused by the presence of excessive left ventricular bands, in an asymptomatic cat. ...
case studies; cats; echocardiography; heart; humans; tachycardia
Abstract:
... Double-outlet right atrium (DORA) is a type of atrioventricular septal defect that is described as an extreme leftward deviation of the lower portion of the interatrial septum, resulting in insertion into the atrial wall left and posterior to the mitral orifice. This rare anomaly, which has been reported in humans and only just recently in cats, was identified by transthoracic echocardiography in ...
... To compare heart rate and arrhythmia frequency and complexity in a normal population of cats to a population of cats with hypertrophic cardiomyopathy (HCM).17 cats with HCM and 15 cats with normal echocardiograms.Results for echocardiography, electrocardiography, Doppler blood pressure, and 24-h Holter monitoring were compared between groups.There was no difference in heart rate between HCM cats a ...
Kiira T. Rodriguez; Mauria A. O'Brien; Susan K. Hartman; Allison C. Mulherin; Casie J. McReynolds; Maureen McMichael; Gregg Rapoport; Robert T. O'Brien
... To determine if microdose contrast-enhanced multi-detector computed tomographic angiography (MDCTA) allows characterization of cardiac chambers in lightly sedated normal cats.Seven healthy domestic cats.Lightly sedated normal cats were imaged pre-contrast and with microdose (0.22 ml/kg of non-ionic iodinated contrast medium, 300 mg I/ml) triple-phase MDCTA in a motion restriction device.On pre-con ...
Maggie C. Machen; Mark A. Oyama; Sonya G. Gordon; John E. Rush; Sarah E. Achen; Rebecca L. Stepien; Philip R. Fox; Ashley B. Saunders; Suzanne M. Cunningham; Pamela M. Lee; Heidi B. Kellihan
... To prospectively evaluate the diagnostic accuracy of a point-of-care (POC) N-terminal pro-B-type natriuretic peptide (NT-proBNP) ELISA to assess the likelihood of moderate to severe occult heart disease (OcHD) in a clinical population of cats suspected to have heart disease.One hundred and forty-six asymptomatic client-owned cats with a heart murmur, gallop rhythm, arrhythmia, or cardiomegaly.Phys ...
... Right-sided congestive heart failure (CHF) developed secondary to severe pulmonary hypertension (PH) in an 8-year-old cat with a left-to-right shunting patent ductus arteriosus (PDA). Vascular reactivity was tested prior to shunt ligation by treatment with oxygen and sildenafil. This treatment was associated with a significant decrease in pulmonary artery pressure as assessed by echocardiography. ...
... To evaluate signalment, echocardiographic, electrocardiographic, and radiographic findings as well as natural history in a group of cats with atrioventricular septal defects (AVSD).26 client owned cats.Medical records were reviewed retrospectively for signalment, morphologic type of AVSD, presence of concurrent congenital heart disease (ConcCHD), diagnostic findings, and natural history.Seventeen ...
... To compare two echocardiographic methods of measuring aortic diameter in short-axis projections.Right-parasternal short-axis 2-dimensional projections of the left atrium and aorta were obtained from dogs and cats undergoing routine cardiac evaluation. Two investigators measured the aortic valve linear dimension using 2 methods: along the commissure between the non-coronary and right-coronary cusps ...
body weight; cardiomyopathy; cats; cohort studies; death; echocardiography; gender; mortality
Abstract:
... To investigate the effect of treatment with atenolol on 5-year survival in cats with preclinical hypertrophic cardiomyopathy (HCM).63 Client-owned cats with preclinical HCM and 31 healthy control cats.Prospective, observational, open-label, clinical cohort study. Cats with HCM were diagnosed by echocardiography, treated with atenolol (6.25–12.5 mg q12h, PO; n = 42) or untreated (n = 21), and were ...
... Evaluation of left ventricular (LV) diastole is clinically important in cats with heart disease. Diastolic dysfunction is a main characteristic of feline cardiomyopathy and is associated with clinical signs and poor outcome. Numerous echocardiographic indices characterizing LV diastole exist, of which Doppler variables of transmitral flow and mitral annular motion are used most often. However, rap ...
cats; cor triatriatum; heart; heart failure; hybrids; surgery
Abstract:
... A hybrid surgical approach and balloon dilatation were performed successfully in a cat with cor triatriatum sinister and clinical signs of congestive heart failure. Left lateral thoracotomy was used to access the heart and cutting balloon followed by standard balloon dilatation were utilized to dilate the perforation in the anomalous left atrial membrane. Clinical signs resolved completely after d ...
... To evaluate the feasibility of measuring pulmonary transit time (PTT) in healthy cats by transthoracic echocardiography using the ultrasound contrast agent Sonovue®. To determine normalized PTT (nPTT) values in 42 healthy cats and to estimate the interobserver variability and the within-day repeatability of nPTT measurements.Forty-two privately owned healthy cats of different breeds, gender and ag ...
... Unilateral absence of the left or right pulmonary artery with concurrent contralateral pulmonary arterial branch stenoses is an exceptionally rare disorder. We describe this anomaly in a cat with severe exercise intolerance and respiratory distress. Transthoracic echocardiography and angiography demonstrated the absence of the left pulmonary artery with concurrent right pulmonary branch stenosis. ...
... OBJECTIVES: The pathogenesis and presentation of aortic thrombosis (AT) in dogs is not well characterized and an effective antithrombotic therapy for AT in dogs has not been identified. Our goal is to report the clinical presentation and results of therapies in dogs with AT. ANIMALS: Twenty-six client-owned dogs. METHODS: Retrospective review of medical records of dogs diagnosed with AT between 20 ...
... OBJECTIVES: To describe the clinical features of congenital supravalvular mitral stenosis (SVMS) in cats. BACKGROUND: Supravalvular mitral stenosis is an uncommon congenital cardiac defect that has not been previously reported in a series of cats. ANIMALS: 14 cats with SVMS. METHODS: Medical records, relevant diagnostic studies and preserved pathology specimens were reviewed. RESULTS: Cats were pr ...
... OBJECTIVES: The aims of this study were to compare the effect of sample volume (SV) size settings and sampling method on measurement variability and peak systolic (s′), and early (e′) and late (a′) diastolic longitudinal myocardial velocities using color tissue Doppler imaging (cTDI) in cats. ANIMALS: Twenty cats with normal echocardiograms and 20 cats with hypertrophic cardiomyopathy. METHODS: We ...
analysis of variance; cardiomyopathy; cats; clinical trials; drugs; echocardiography; heart; medical treatment; models; probability
Abstract:
... OBJECTIVES: Data on reproducibility of echocardiographic indices in cats are commonly derived from studies in healthy, non-treated animals. However, medical treatment may alter reproducibility of such data possibly influencing interpretation of results of clinical trials assessing the effects of drugs on cardiovascular function. The objectives were therefore to investigate the effects of ivabradin ...
absorption; adverse effects; bioavailability; blood; cats; dogs; drugs; gastrointestinal system; half life; high performance liquid chromatography; models; pharmacokinetics; tandem mass spectrometry
Abstract:
... OBJECTIVE: To describe the pharmacokinetics of oral pimobendan in healthy cats. ANIMALS: 18 purpose-bred cats. METHODS: In 10 cats, blood samples were collected before, and at multiple time points after, a single oral dose of pimobendan (0.28 ± 0.04 mg/kg). In 8 cats, blood samples were collected at 3 various time points on the first and third days of twice daily oral dosing of pimobendan for a to ...
... OBJECTIVES: (1) To investigate heart morphology and function using echocardiography and tissue Doppler imaging (TDI), (2) to determine heart disease prevalence and characteristics, and (3) to assess potential genetic features in a population of Sphynx cats presented for cardiovascular screening. ANIMALS: A total of 147 echocardiographic examinations, including 33 follow-ups, were performed by trai ...
... OBJECTIVE: To determine two-dimensionally-guided (2D-guided) M-mode and pulsed-wave (PW) Doppler echocardiographic reference intervals range of healthy non-sedated cats. ANIMALS: Fifty-three healthy, unsedated domestic cats. MATERIALS AND METHODS: Cats were interrogated via standard imaging planes with 2D-guided PW Doppler, using 5.0 and 7.5 MHz duplex imaging transducers. Left ventricular (LV) M- ...
adverse effects; analysis of variance; blood pressure; cat diseases; cats; hairs; heart rate; ischemia; linear models; oxygen consumption; placebos; radio telemetry; stress response
Abstract:
... OBJECTIVE: To determine the pharmacodynamic effects of oral ivabradine in cats. ANIMALS: Eight healthy, adult domestic short hair cats. METHODS: Each cat underwent four study periods of 24 h, receiving either one dose of placebo or ivabradine (0.1 mg/kg, 0.3 mg/kg, and 0.5 mg/kg) in a single-blind randomized crossover study. Clinical tolerance was assessed hourly for the first 8 h, at 12 h, and at ...
... A 4-year old female spayed domestic short hair cat presented for evaluation of a tachyarrhythmia identified on routine physical examination. Supraventricular tachycardia (SVT) was identified on electrocardiogram (ECG). Echocardiogram failed to identify any structural heart disease. A positive Bartonella antibody titer was identified on serological evaluation. The cat received anti-arrhythmics for ...
... OBJECTIVES: To evaluate whether the addition of a protease inhibitor (PI) to feline plasma improves the temporal stability of N-terminal pro-B-type natriuretic peptide (NT-proBNP). ANIMALS, MATERIALS AND METHODS: Forty-four EDTA blood samples were collected from 42 cats with cardiac disease or hyperthyroidism. Samples were separated within 15 min of collection and the plasma stored at −80 °C. Samp ...
John M. MacGregor; John E. Rush; Nancy J. Laste; Rebecca L. Malakoff; Suzanne M. Cunningham; Natalie Aronow; Daniel J. Hall; Justin Williams; Lori L. Price
... HYPOTHESIS/OBJECTIVES: To describe the therapeutic use of pimobendan in cats, describe the patient population to which it was administered, document potential side effects and report the clinical course following administration of pimobendan in conjunction with standard heart failure therapy. It is hypothesized that cats with advanced heart disease including congestive heart failure from a variety ...