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... A fibrous band connecting the middle of the free edge (nodulus Arantii) of the non-coronary aortic valve cusp to the ascending aorta just above the level of the non-coronary sinus of Valsalva was observed in an asymptomatic, 11-year-old, male Border Collie. The fibrous band was unrelated to the cause of the death in this dog. Such fibrous bands are usually reported in humans with congenital bicusp ...
... Accessory bypass tracts are rarely documented in horses. Here, we present a case of an accessory bypass tract which was initially masked by the presence of atrial fibrillation. Evidence of ventricular pre-excitation was recognized after cardioversion to normal sinus rhythm and the horse was diagnosed with Wolff–Parkinson–White Syndrome. In people, atrial fibrillation in the presence of an accessor ...
... Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited myocardial disease seen in dogs, cats, and humans. A common entity in Boxers and the related English bulldog, the disease is characterized by fatty or fibrofatty replacement of the myocardium, ventricular arrhythmias, and the potential for syncope or sudden death. In some individuals, concomitant left ventricular involvement re ...
... This study aimed to characterize the clinical and histopathological features of arrhythmogenic right ventricular cardiomyopathy (ARVC) in English Bulldogs, American Bulldogs, and Bulldog-type mixed breed dogs and assess affected Bulldogs for a striatin gene mutation previously reported in Boxers with ARVC. Seventy-one Bulldogs fit the inclusion criteria. Genetic analysis was performed on five dogs ...
artificial pacemaker; death; dogs; medical records; myocarditis; troponin I
Abstract:
... Artificial cardiac pacemakers (APs) are a common treatment for symptomatic bradyarrhythmias in dogs, some of which may be triggered by underlying myocarditis. Severely elevated cardiac troponin I (cTnI) concentrations support a diagnosis of myocarditis. The association of ultrasensitive-cTnI (US-cTnI) concentration with survival in a large cohort of dogs receiving APs is not described.The study in ...
... A mutation identified in the myosin binding protein C3 gene (MYBPC3 R820W) has been associated with hypertrophic cardiomyopathy (HCM) in Ragdoll cats. Ragdolls with HCM are reported to have a poor prognosis and homozygous cats seem particularly likely to develop severe HCM, although the outcome in Ragdolls tested for the MYBPC3 mutation has not been reported. We aimed to determine the influence of ...
... To evaluate associations between N-terminal procollagen type III (PIIINP), a serum biomarker of collagen biosynthesis, and myocardial fibrosis in dogs with naturally-occurring myxomatous mitral valve disease (MMVD).Twenty-two dogs with echocardiographically-confirmed MMVD were prospectively recruited from a hospital population. All died as a result of MMVD and their hearts were available for post ...
... To evaluate signalment, echocardiographic, electrocardiographic, and radiographic findings as well as natural history in a group of cats with atrioventricular septal defects (AVSD).26 client owned cats.Medical records were reviewed retrospectively for signalment, morphologic type of AVSD, presence of concurrent congenital heart disease (ConcCHD), diagnostic findings, and natural history.Seventeen ...
analysis of variance; body weight; cardiomyopathy; cats; death; euthanasia; fibrosis; heart; heart failure; histopathology; necropsy; poisoning; veterinary clinics
Abstract:
... To report necropsy and myocardial histopathology in cats with unexpected death and expected death/euthanasia, comparing findings in 4 groups of cats: unexpected death with noncardiac disease (UD-NC); unexpected death with cardiac disease (UD-C); expected death/euthanasia due to noncardiac disease with incidental cardiac disease (OD + HD); and expected death/euthanasia due to congestive heart failu ...
... Cardiogenic embolism (CE) in the cat, which has also been referred to as arterial thromboembolism, feline arterial thromboembolism, and saddle thrombus has been identified clinically in cats for decades and is an important clinical development and cause of death in cats with underlying heart disease. While a better understanding of this condition has been developed over the decades it is extremely ...
Sophy A. Jesty; Seung Woo Jung; Jonathan M. Cordeiro; Teresa M. Gunn; José M. Di Diego; Shari Hemsley; Bruce G. Kornreich; Giles Hooker; Charles Antzelevitch; N. Sydney Moïse
... To further characterize arrhythmic mechanisms in German shepherd dogs (GSDs) affected with inherited ventricular arrhythmias by evaluating intracellular calcium cycling and expression of calcium handling genes.Twenty five GSDs, 9 backcross dogs, and 6 normal mongrel dogs (controls) were studied. The GSDs and backcross dogs were from a research colony of inherited ventricular arrhythmias. The contr ...
P. Mahadappa; K. Mahendran; R.L. Winter; V. Umapathi; N. Krishnaswamy; A. Gopalakrishnan; S. Rao; M. Gangaiah; S. Kumar; B.H.M. Patel; N. Gautam; R. Hegde; H.J. Dechamma; A. Sanyal
... Foot-and-mouth disease (FMD) causes mortality in calves due to myocarditis; however, the effects of FMD virus on cardiac arrhythmogenesis and Purkinje cells are unknown. Identifying diagnostic and prognostic markers in FMD-affected calves may be useful in disease management in the endemic countries.A total of 81 FMD-affected calves were prospectively monitored till death or recovery. Foot-and-mout ...
... In veterinary medicine, prospective clinical trials are increasingly utilized to address questions regarding effectiveness of therapies and patient prognosis. A large number of these trials involve time-to-event (TTE) endpoints, which require special methods of analysis to handle data in which not all subjects are observed to have the event of interest. Analyses and interpretation of the results c ...
M. Borgarelli; L. Ferasin; K. Lamb; C. Bussadori; D. Chiavegato; G. D'Agnolo; F. Migliorini; M. Poggi; R.A. Santilli; E. Guillot; C. Garelli-Paar; R. Toschi Corneliani; F. Farina; A. Zani; M. Dirven; P. Smets; C. Guglielmini; P. Oliveira; M. Di Marcello; F. Porciello; S. Crosara; P. Ciaramella; D. Piantedosi; S. Smith; S. Vannini; E. Dall’Aglio; P. Savarino; C. Quintavalla; M. Patteson; J. Silva; C. Locatelli; M. Baron Toaldo
... Efficacy of renin-angiotensin-aldosterone system (RAAS) blockade using angiotensin-converting enzyme inhibitors (ACEi) in dogs with preclinical myxomatous mitral valve disease (MMVD) is controversial.Administration of spironolactone (2–4 mg q 24 h) and benazepril (0.25–0.5 mg q 24 h) in dogs with preclinical MMVD, not receiving any other cardiac medications, delays the onset of heart failure (HF) ...
... To assess the ability of electrocardiography (ECG) to predict left ventricular hypertrophy (LVH) in the cat and to investigate the prognostic value of selected ECG variables in cats with LVH.Fifty-seven privately owned cats: 22 clinically healthy cats and 35 cats with LVH.This is a clinical cohort study. Echocardiographic diagnosis and surface ECG were available. Electrocardiography analysis inclu ...
... Irregularities in cardiac repolarization are known to predispose for arrhythmias and sudden cardiac death in humans. The QT interval is a quantitative measurement of repolarization, and clinically, the QTc (QT interval corrected for heart rate) and Tpeak to Tend intervals (TpTe) are used as repolarization markers. To support the use of these markers in horses, we sought to describe the possible in ...
... Dilated cardiomyopathy (DCM) is a frequent cause of cardiac disability, congestive heart failure (CHF), and arrhythmic death in dogs. The etiology of DCM is usually idiopathic/genetic, but some causes of a DCM phenotype are reversible. The disease is classified into preclinical (occult) and clinical (overt) stages; the latter stems from heart failure with reduced ejection fraction. DCM is further ...
... To investigate the negative chronotropic, antiarrhythmic, and obstruction-relieving effects of atenolol in cats with subclinical hypertrophic cardiomyopathy (HCM).Seventeen cats with HCM.Results for echocardiography, electrocardiography, Doppler blood pressure, and 24 h Holter monitoring were compared in cats before and 2–4 weeks after atenolol therapy (6.25–12.5 mg PO q 12 h).The left ventricular ...
body weight; cardiomyopathy; cats; cohort studies; death; echocardiography; gender; mortality
Abstract:
... To investigate the effect of treatment with atenolol on 5-year survival in cats with preclinical hypertrophic cardiomyopathy (HCM).63 Client-owned cats with preclinical HCM and 31 healthy control cats.Prospective, observational, open-label, clinical cohort study. Cats with HCM were diagnosed by echocardiography, treated with atenolol (6.25–12.5 mg q12h, PO; n = 42) or untreated (n = 21), and were ...
... Ebstein's anomaly (EA) is a congenital heart disease characterized by apical displacement of the tricuspid valve leaflets in the right ventricle. The objective of this retrospective study was to investigate the signalment, clinical features, echocardiographic findings, and outcome of dogs with EA.Medical records of 40 dogs with EA were reviewed. Echocardiographic variables used to assess EA severi ...
... Red blood cell distribution width (RDW) is a measurement of variability in circulating erythrocytes size, and has recently been shown to correlate with prognosis in a variety of human diseases, including acute and chronic heart failure.To determine if RDW differs between healthy controls, cats with hypertrophic cardiomyopathy (HCM) without congestive heart failure (CHF) and cats with HCM and CHF, ...
... A missense mutation (A31P) in the cardiac myosin binding protein C gene has been associated with hypertrophic cardiomyopathy (HCM) in Maine Coon cats. The aim of this study was to investigate the effect of A31P on development of HCM, myocardial diastolic dysfunction detected by color tissue Doppler imaging and occurrence of cardiac death during longitudinal follow-up in a cohort of Maine Coon cats ...
... To compare heart rate and arrhythmia frequency and complexity in a normal population of cats to a population of cats with hypertrophic cardiomyopathy (HCM).17 cats with HCM and 15 cats with normal echocardiograms.Results for echocardiography, electrocardiography, Doppler blood pressure, and 24-h Holter monitoring were compared between groups.There was no difference in heart rate between HCM cats a ...
... Inherited or acquired arrhythmic disorders and cardiac disease have been associated with sudden cardiac death (SCD) in dogs. The electrical mechanism related to death in most of these cases is unknown. This retrospective study aimed to describe arrhythmic events in dogs that experienced SCD during Holter monitoring.Nineteen client-owned dogs that experienced SCD during Holter examination were incl ...
aorta; cohort studies; confidence interval; death; echocardiography; hazard characterization; hazard ratio; heart valve diseases; medical records; prognosis; telephones; veterinary medicine
Abstract:
... Few studies have evaluated the utility of echocardiographic indices of right ventricular (RV) function in predicting prognosis in dogs with myxomatous mitral valve disease (MMVD). Sixty-seven client-owned dogs were diagnosed with MMVD. clinical cohort study. Dogs diagnosed with American college of veterinary internal medicine (ACVIM) stage B2, C or D between April 2014 and March 2017 were enrolled ...
... To evaluate the frequency of dilated cardiomyopathy (DCM) and cardiac death (CD) in Irish wolfhounds (IW) with subclinical atrial fibrillation (AF) and to compare cardiac and all-cause mortality to those of a contemporaneous control group of apparently healthy IW with sinus rhythm.Fifty-two IW with AF, but without echocardiographic evidence of DCM or other cardiac disease, and an age- and gender-m ...
English bulldog; abnormal development; aneurysm; branching; cattle; death; dog diseases; dogs; edema; histopathology; humans; males; pancreatitis; pulmonary artery; veterinary medicine
Abstract:
... The unexpected demise of a 12-year-old male neutered English bulldog solicited a gross examination, which revealed a blood-filled space occurring in the proximal left subclavian artery (LSA). It originated about 1 cm from the branching point of the vessel and progressively dilated for 3 cm distal to this origin. Histopathological investigation showed that the tunica media of the LSA was more than ...
... Cardiomyopathy distinguishes a heterogeneous group of myocardial disorders that represent the most prevalent cause of feline heart disease. Etiology is uncertain and the natural history is presently unresolved. Hypertrophic cardiomyopathy is the most common of these conditions, and while the majority of affected cats are asymptomatic, a proportion is at risk to develop serious morbidities – the mo ...
... Mitral valve (MV) regurgitation due to degenerative MV disease is the leading cause of cardiac death in dogs. We carried out preliminary experiments to determine the feasibility and short-term effects of beating-heart MV repair using an expanded polytetrafluorethylene (ePTFE) chordal implantation device (Harpoon TSD-5) in dogs.This study involved six healthy purpose-bred Beagles (weight range 8.9– ...
... Cardiac repolarization, measured as QT and Tpeak to Tend (TpTe) intervals on the ECG, is important, as irregularities caused by diseases, ventricular hypertrophy, drugs and genetic defects can trigger arrhythmias which predispose human patients to syncope and sudden cardiac death. In horses, repolarization is not well described and therefore QT analysis cannot yet be used diagnostically. Therefore ...
... Both paroxysmal high-grade second-degree and persistent third-degree atrioventricular block (AVB) are recognised in cats. Our aim was to document the presentation, echocardiographic data, comorbidities and outcome in affected cats from a single referral hospital, including those that underwent epicardial pacemaker implantation (EPI).This retrospective study included 64 cats diagnosed with persiste ...
... A 6-month-old, female, domestic shorthair cat weighing 1.8 kg presented with cardiomegaly seen on radiographs taken at a primary care veterinary center. Echocardiography revealed a single enlarged vessel overriding a ventricular septal defect and severe hypertrophy of the right ventricular free wall. There was no evidence of a pulmonary arterial trunk originating from the heart. The blood flow thr ...
... The study objectives were to determine the prevalence and geographic distribution of a dilated cardiomyopathy (DCM)-associated RNA-binding motif protein 20 (RBM20) variant in canine DNA samples submitted for testing and to evaluate the influence of the genotype on cardiac phenotype and lifespan. Samples from 2136 dogs including 1834 Standard Schnauzers (SSNZ), 266 Giant Schnauzers (GSNZ), and 36 d ...
... Whether the aldosterone antagonist spironolactone has beneficial survival effects in dogs with dilated cardiomyopathy (DCM) is not known. The primary objective of the study was to evaluate the effect of spironolactone, when added to conventional therapy, on survival time in Doberman pinschers with congestive heart failure (CHF) due to DCM. Sixty-seven client-owned Doberman pinschers with CHF due t ...
... The goal of this study was to evaluate the number and frequency of adverse effects in a population of clinical canine patients receiving Nexterone.Seventeen canine patients receiving Nexterone (five of which were treated during cardiopulmonary arrest).An electronic records search for canine patients receiving intravenous Nexterone at the Michigan State University Veterinary Teaching Hospital was p ...
... To evaluate risk factors associated with different types of cardiac death in cats with hypertrophic cardiomyopathy (HCM).Two hundred fifty-five cats with HCM referred to a veterinary teaching hospital.This is a retrospective study. Cats with HCM were identified that had either died within 2 years of diagnosis or were known to be alive 2 years after initial examination. Signalment, physical exam, e ...
Maine coon; adverse effects; aspirin; cats; death; heart diseases; long term effects; males; mixed breeds
Abstract:
... To determine if clopidogrel administration is associated with a reduced likelihood of recurrent cardiogenic arterial thromboembolism (CATE) in cats compared to aspirin administration. Secondary aims were to determine if clopidogrel administration had an effect on the composite endpoint of recurrent CATE and cardiac death and to identify adverse effects of chronic clopidogrel or aspirin therapy.Sev ...
French Bulldog; cohort studies; death; echocardiography; heart failure; heart valve diseases; prognosis; risk factors; signs and symptoms (animals and humans)
Abstract:
... The objectives of this study were to characterize the epidemiological, clinical, and echocardiographic features of French bulldogs (FBs) with congenital pulmonic stenosis and document their survival times and risk factors for cardiac death (CD).This study included 66 FBs with congenital pulmonic stenosis.Prospective cohort study including a survival analysis to assess time to CD.In most cases (53/ ...
... Heart-base tumors are increasingly treated with radiotherapy, yet safety and efficacy are incompletely understood. This case series describes outcomes after stereotactic body radiation therapy (SBRT) for presumed chemodectoma.Six pet dogs.A retrospective study was performed, including dogs with a clinical diagnosis of chemodectoma and treatment with three-fraction SBRT (30 Gy total).Heart-base tum ...
Golden Retriever; atrial fibrillation; cardiac arrest; case studies; death; digoxin; dogs; drug therapy; drugs; electrocardiography; heart rate; males; monitoring; patients; risk factors; tachycardia
Abstract:
... A 6-year-old castrated male Golden Retriever was diagnosed with severe subaortic stenosis with severe left atrial enlargement and high heart rate due to atrial fibrillation. Treatment with digoxin and diltiazem to control ventricular response rate was initiated. Ambulatory electrocardiographic monitoring (Holter monitoring) was performed at the beginning of treatment and was repeated to evaluate t ...
... Supraventricular tachycardia (SVT) has not been well described in cats. The aim of this study was to describe the signalment, clinical findings, and outcome for cats with SVT versus cats with atrial fibrillation (AF).Forty-four client owned cats are included in the study. 23 cats with SVT and 21 with AF.This is a retrospective study. Clinical characteristics were compared between groups using a tw ...
... The pathophysiology of heart failure involves activation of several neurohormonal systems including the renin-angiotensin-aldosterone system. The mineralocorticoid receptor antagonist spironolactone has been shown to be beneficial in humans and dogs with heart failure. The objective of this pilot study was to investigate the efficacy and safety of spironolactone in cats with heart failure secondar ...
antibiotics; catheters; compliance; death; dogs; medical records; veterinarians
Abstract:
... To determine whether use of a surgical safety checklist (SSC) would reduce the rate of major complications after permanent transvenous pacemaker implantation in dogs.The study included one hundred ninety-nine dogs undergoing pacemaker implantation for bradyarrhythmias at an academic teaching hospital.A service-specific SSC was developed and implemented for cardiac catheterization procedures in 201 ...
M. Borgarelli; L. Ferasin; K. Lamb; D. Chiavegato; C. Bussadori; G. D'Agnolo; F. Migliorini; M. Poggi; R.A. Santilli; E. Guillot; C. Garelli-Paar; R. Toschi Corneliani; F. Farina; A. Zani; M. Dirven; P. Smets; C. Guglielmini; P. Oliveira; M. Di Marcello; F. Porciello; S. Crosara; P. Ciaramella; D. Piantedosi; S. Smith; S. Vannini; E. Dall’Aglio; P. Savarino; C. Quintavalla; M. Patteson; J. Silva; C. Locatelli; M. Baron Toaldo
... To identify the predictive value on time to onset of heart failure (HF) or cardiac death of clinical, radiographic, and echocardiographic variables, as well as cardiac biomarkers N-terminal pro brain natriuretic peptide (NT-proBNP) and cardiac troponin I in dogs with preclinical myxomatous mitral valve disease (MMVD).One hundred sixty-eight dogs with preclinical MMVD and left atrium to aortic root ...
Cavalier King Charles Spaniel; data analysis; death; disease course; dogs; echocardiography; heart failure; heart valve diseases; hypertension; lungs; mortality
Abstract:
... Pulmonary hypertension (PH) is a common consequence of myxomatous mitral valve disease (MMVD). Cavalier King Charles spaniels (CKCS) are frequently affected with MMVD and appear to have different disease progression compared to other dogs. This study aimed to determine if CKCS are more likely to develop PH as a result of MMVD than dogs of other breeds. A secondary aim was to explore whether breed ...
... There is little published regarding the association between canine cardiovascular disease and the hepatic system. The objective of the study was to evaluate the relationship between hepatic parameters, survival, and disease stages of dogs with either dilated cardiomyopathy (DCM) or degenerative valvular disease (DVD). Animals, materials, and methods: Retrospective study analyzing hepatic parameter ...
death; dogs; hospitals; medical records; nerve tissue; paralysis; patients; respiratory tract diseases; risk factors; surgery
Abstract:
... Unilateral diaphragmatic paralysis (UDP) due to phrenic nerve injury is a potential complication of thoracic surgery. This study evaluated the prevalence of UDP associated with surgical mitral valve repair (MVR) and its effect on surgical outcomes in dogs.Two hundred ninety-four dogs that underwent MVR were included in the study. A retrospective review of medical records was performed for dogs sur ...
arrhythmia; clinical examination; death; dogs; echocardiography; electrocardiography; inheritance (genetics); laboratory experimentation; monitoring; necropsy; pedigree; signs and symptoms (animals and humans)
Abstract:
... To describe unexpected sudden cardiac death (SCD) in young Leonbergers (<3 years) and to review the circumstances before death and necropsy findings; to prospectively evaluate the presence of possible arrhythmias in young Leonbergers; and to examine pedigrees for determining potential modes of inheritance.Postmortem evaluations included 21 Leonbergers. Clinical evaluation consisted of 46 apparentl ...