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- Caplazi, Patrick; O'Rourke, Katherine; Wolf, Cynthia; Shaw, Daniel; Baszler, Timothy V.
- Journal of veterinary diagnostic investigation 2004 v.16 no.6 pp. 489
- sheep; scrapie; PrPSc proteins; pathogenesis; tissue distribution; immunohistochemistry; disease prevalence; disease resistance; genetic resistance; genotype; animal age; disease transmission; flocks; Midwestern United States; Pacific States
- ... Sheep scrapie is a prion disease that requires interaction of exogenous prions with host prion protein (PrP) supporting prion formation. Disease is associated with deposition of a host-generated conformational variant of PrP, PrPsc, in a variety of tissues, including brain, resulting in fatal spongiform encephalopathy. Efficiency of PrPsc formation is determined by polymorphisms in the PrP-coding ...