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- Raghu, Chantel; Ekena, Joanne; Cullen, John M.; Webb, Craig B.; Trepanier, Lauren A.
- Journal of veterinary internal medicine 2018 v.32 no.3 pp. 1009-1018
- C-reactive protein; alanine transaminase; aspartate transaminase; biomarkers; biopsy; blood serum; chemokine CCL2; dogs; fibrosis; histopathology; humans; interleukin-6; laparoscopy; laparotomy; ligands; liver; liver cirrhosis; medicine; monitoring
- ... BACKGROUND: Serum interleukin 6 (IL‐6), chemokine ligand 2 (CCL2), C‐reactive protein (CRP), and the ratio of aspartate transaminase to alanine transaminase (AST:ALT) have been correlated with fibrosis and necroinflammatory activity in humans with various hepatopathies. HYPOTHESIS/OBJECTIVES: To determine whether increases in serum IL‐6, CCL2, CRP, or AST:ALT were associated with moderate to sever ...
- Eulenberg, V.M.; Lidbury, J.A.
- Journal of veterinary internal medicine 2018 v.32 no.1 pp. 26-41
- animal models; biomarkers; biopsy; blood serum; chronic hepatitis; dogs; fibrosis; histopathology; liver; liver cirrhosis; medicine; pathogenesis; pathophysiology; patients; veterinary medicine
- ... Hepatic fibrosis is commonly diagnosed in dogs, often as a sequela to chronic hepatitis (CH). The development of fibrosis is a crucial event in the progression of hepatic disease that is of prognostic value. The pathophysiology of hepatic fibrosis in human patients and rodent models has been studied extensively. Although less is known about this process in dogs, evidence suggests that fibrogenic m ...
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