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- Strickland, Jaimie M.; Buchweitz, John P.; Smedley, Rebecca C.; Olstad, Katherine J.; Schultz, Ryan S.; Oliver, N. Bari; Langlois, Daniel K.
- Journal of veterinary internal medicine 2018 v.32 no.6 pp. 1943-1950
- atomic absorption spectrometry; copper; copper metabolism; databases; dogs; epidemiological studies; hepatitis; histology; histopathology; liver; retrospective studies; Michigan
- ... BACKGROUND: Copper associated hepatitis (CAH) has been increasingly recognized in dogs, and speculation exists that hereditary defects in copper metabolism have been exacerbated by increased environmental copper exposure. However, no broad epidemiological investigations have been performed to investigate quantitative hepatic copper concentrations ([Cu]H) over time in both dogs that are (predispose ...
- Oosthuyzen, W.; Ten Berg, P.W.L.; Francis, B.; Campbell, S.; Macklin, V.; Milne, E.; Gow, A. G.; Fisher, C.; Mellanby, R.J.; Dear, J.W.
- Journal of veterinary internal medicine 2018 v.32 no.5 pp. 1637-1644
- biomarkers; blood serum; dog diseases; dogs; liver; liver diseases; medical records; polymerase chain reaction; retrospective studies
- ... BACKGROUND: Current tests for diagnosing liver disease in dogs are sub‐optimal. MicroRNA‐122 (miR‐122) is a sensitive and specific biomarker of liver injury in humans and rodents. Circulating miR‐122 could have utility in identifying dogs with liver disease. OBJECTIVE: Establish the reference interval for miR‐122 in healthy dogs and determine performance in a range of dog breeds with liver disease ...