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- UENO, D.; YABUKI, A.; OBI, T.; SHIRAISHI, M.; NISHIO, A.; MIYAMOTO, A.
- Journal of veterinary pharmacology and therapeutics 2009 v.32 no.3 pp. 264-270
- indomethacin, etc ; horses; bradykinin; endothelium; endothelial cells; prostaglandins; nordihydroguaiaretic acid; quinacrine; tetrodotoxin; norepinephrine; arachidonic acid; metabolites; neurotransmitters; pharmacokinetics; arteries; muscle contraction; Show all 16 Subjects
- ... We investigated the effect of bradykinin (BK) on isolated equine basilar arterial rings with and without endothelium. BK induced concentration-dependent contraction of resting arterial rings and no relaxation when the rings were precontracted by prostaglandin F₂α. The maximal response and pD₂ value were 161.2 ± 28.1% (to 60 m m KCl-induced contraction) and 8.24 ± 0.25 respectively. The cumulative ...