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- Uddowla, Sabena; Hollister, Jason; Pacheco, Juan M.; Rodriguez, Luis L.; Rieder, Elizabeth
- Journal of virology 2012 v.86 no.21 pp. 11675
- Foot-and-mouth disease virus; aerosols; biocontainment; biomarkers; cattle; clones; complementary DNA; control methods; disease control; enzyme-linked immunosorbent assay; fever; foot-and-mouth disease; monoclonal antibodies; mutation; proteins; restriction endonucleases; swine; tongue; vaccination; vaccine development; virus transmission; viruses
- ... Vaccination of domestic animals with chemically inactivated foot-and-mouth disease virus (FMDV) is widely practiced to control FMD. Currently, FMD vaccine manufacturing requires the growth of large volumes of virulent FMDV in biocontainment-level facilities. Here, two marker FMDV vaccine candidates (A ₂₄LL3D YR and A ₂₄LL3B PVKV3D YR) featuring the deletion of the leader coding region (L ᵖʳᵒ) and ...
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